Pharmacophore hybridization approach to discover novel pyrazoline-based hydantoin analogs with anti-tumor efficacy
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Pharmacophore hybridization approach to discover novel pyrazoline-based hydantoin analogs with anti-tumor efficacy
Authors
Keywords
Pyrazoline, Hydantoin, Hybrid, Caspase activation, Cell cycle, Bcl-2, DNA damage
Journal
BIOORGANIC CHEMISTRY
Volume -, Issue -, Pages 104527
Publisher
Elsevier BV
Online
2020-12-04
DOI
10.1016/j.bioorg.2020.104527
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- New chalcone-type compounds and 2-pyrazoline derivatives: synthesis and caspase-dependent anticancer activity
- (2020) Mohamed I Chouiter et al. Future Medicinal Chemistry
- Antiproliferative and antimigratory effects of 3-(4-substituted benzyl)-5- isopropyl-5-phenylhydantoin derivatives in human breast cancer cells
- (2020) Ana Obradović et al. SAUDI PHARMACEUTICAL JOURNAL
- Discovery of novel N-substituted thiazolidinediones (TZDs) as HDAC8 inhibitors: in-silico studies, synthesis, and biological evaluation
- (2020) Neha Upadhyay et al. BIOORGANIC CHEMISTRY
- Synthesis and biological evaluation of pyrazoline and pyrrolidine‐2,5‐dione hybrids as potential antitumor agents.
- (2020) Kalpana Tilekar et al. ChemMedChem
- Discovery of Novel Janus Kinase (JAK) and Histone Deacetylase (HDAC) Dual Inhibitors for the Treatment of Hematological Malignancies
- (2019) Xuewu Liang et al. JOURNAL OF MEDICINAL CHEMISTRY
- Hydroxamic Acid-Based Histone Deacetylase (HDAC) Inhibitors Bearing a Pyrazole Scaffold and a Cinnamoyl Linker
- (2019) Chiara Zagni et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Repositioning of Difluorinated Propanediones as Inhibitors of Histone Methyltransferases and their Biological Evaluation in Human Leukemic Cell Lines
- (2019) Tanushree Pal et al. Anti-Cancer Agents in Medicinal Chemistry
- Cytotoxic Effects of Newly Synthesized Heterocyclic Candidates Containing Nicotinonitrile and Pyrazole Moieties on Hepatocellular and Cervical Carcinomas
- (2019) Amira A. El-Sayed et al. MOLECULES
- Synthesis, anticancer, apoptosis-inducing activities and EGFR and VEGFR2 assay mechanistic studies of 5,5-diphenylimidazolidine-2,4-dione derivatives: Molecular docking studies
- (2019) Hamad M. Alkahtani et al. SAUDI PHARMACEUTICAL JOURNAL
- Exosomes and their role in tumorigenesis and anticancer drug resistance
- (2019) Neta Milman et al. DRUG RESISTANCE UPDATES
- Design, Synthesis, and Biological Evaluation of 2,4-Imidazolinedione Derivatives as HDAC6 Isoform-Selective Inhibitors
- (2019) Tao Liang et al. ACS Medicinal Chemistry Letters
- Establishing Drug Discovery and Identification of Hit Series for the Anti-apoptotic Proteins, Bcl-2 and Mcl-1
- (2019) James B. Murray et al. ACS Omega
- Pyrazolo-benzothiazole hybrids: Synthesis, anticancer properties and evaluation of antiangiogenic activity using in vitro VEGFR-2 kinase and in vivo transgenic zebrafish model
- (2019) Velma Ganga Reddy et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Design, synthesis and anticancer evaluation of β-carboline-1-one hydantoins
- (2019) Chun-Hsu Yao et al. Future Medicinal Chemistry
- Design, synthesis and biological evaluation of novel hydroxamic acid based histone deacetylase 6 selective inhibitors bearing phenylpyrazol scaffold as surface recognition motif
- (2018) Jinyu Yang et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Spirohydantoins and 1,2,4-triazole-3-carboxamide derivatives as inhibitors of histone deacetylase: Design, synthesis, and biological evaluation
- (2018) Alshimaa M.A. Aboeldahab et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Dual or multi-targeting inhibitors: The next generation anticancer agents
- (2018) Nulgumnalli Manjunathaiah Raghavendra et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of Novel Pazopanib-Based HDAC and VEGFR Dual Inhibitors Targeting Cancer Epigenetics and Angiogenesis Simultaneously
- (2018) Jie Zang et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of Asciminib (ABL001), an Allosteric Inhibitor of the Tyrosine Kinase Activity of BCR-ABL1
- (2018) Joseph Schoepfer et al. JOURNAL OF MEDICINAL CHEMISTRY
- A Molecular Hybridization Approach for the Design of Potent, Highly Selective, and Brain-Penetrant N-Myristoyltransferase Inhibitors
- (2018) Justin R. Harrison et al. JOURNAL OF MEDICINAL CHEMISTRY
- The Enzyme Activity of Histone Deacetylase 8 is Modulated by a Redox-Switch
- (2018) Niklas Jänsch et al. Redox Biology
- Kinase and Histone Deacetylase Hybrid Inhibitors for Cancer Therapy
- (2018) Yepeng Luan et al. JOURNAL OF MEDICINAL CHEMISTRY
- Recent applications of hydantoin and thiohydantoin in medicinal chemistry
- (2018) SeoHyun Cho et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Designing multi-targeted agents: An emerging anticancer drug discovery paradigm
- (2017) Rong-geng Fu et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Design and Synthesis of Ligand Efficient Dual Inhibitors of Janus Kinase (JAK) and Histone Deacetylase (HDAC) Based on Ruxolitinib and Vorinostat
- (2017) Lianbin Yao et al. JOURNAL OF MEDICINAL CHEMISTRY
- Design, synthesis and in vitro evaluation of some small molecules malonyl CoA decarboxylase inhibitors containing pyrazoline scaffold and study of their binding interactions with malonyl CoA decarboxylase via preliminary docking simulation
- (2017) Deepali M. Jagdale et al. MEDICINAL CHEMISTRY RESEARCH
- A New Series of Cytotoxic Pyrazoline Derivatives as Potential Anticancer Agents that Induce Cell Cycle Arrest and Apoptosis
- (2017) Hong Wang et al. MOLECULES
- Synthesis and Evaluation of New Pyrazoline Derivatives as Potential Anticancer Agents in HepG-2 Cell Line
- (2017) Weijie Xu et al. MOLECULES
- From basic apoptosis discoveries to advanced selective BCL-2 family inhibitors
- (2017) Avi Ashkenazi et al. NATURE REVIEWS DRUG DISCOVERY
- SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules
- (2017) Antoine Daina et al. Scientific Reports
- Novel thiol-based histone deacetylase inhibitors bearing 3-phenyl-1 H -pyrazole-5-carboxamide scaffold as surface recognition motif: Design, synthesis and SAR study
- (2016) Jiachen Wen et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- The p38 MAPK inhibitor BIRB796 enhances the antitumor effects of VX680 in cervical cancer
- (2016) Xin Jin et al. CANCER BIOLOGY & THERAPY
- Potent and Selective Non-hydroxamate Histone Deacetylase 8 Inhibitors
- (2016) Alexander Kleinschek et al. ChemMedChem
- Synthesis and Biological Evaluation of 1-Methyl-1H-indole-Pyrazoline Hybrids as Potential Tubulin Polymerization Inhibitors
- (2016) Ya-Liang Zhang et al. ChemMedChem
- A BOILED-Egg To Predict Gastrointestinal Absorption and Brain Penetration of Small Molecules
- (2016) Antoine Daina et al. ChemMedChem
- Novel pyrazolopyridine derivatives as potential angiogenesis inhibitors: Synthesis, biological evaluation and transcriptome-based mechanistic analysis
- (2016) Maria Michailidou et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis and cytotoxic activities of some pyrazoline derivatives bearing phenyl pyridazine core as new apoptosis inducers
- (2016) Riham F. George et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- An overview of molecular hybrids in drug discovery
- (2016) Gervais Bérubé Expert Opinion on Drug Discovery
- The aurora kinase inhibitor VX-680 shows anti-cancer effects in primary metastatic cells and the SW13 cell line
- (2016) Raffaele Pezzani et al. INVESTIGATIONAL NEW DRUGS
- Biological Validation of Novel Polysubstituted Pyrazole Candidates with in Vitro Anticancer Activities
- (2016) Hoda Fahmy et al. MOLECULES
- The MET Inhibitor AZD6094 (Savolitinib, HMPL-504) Induces Regression in Papillary Renal Cell Carcinoma Patient-Derived Xenograft Models
- (2015) A. G. Schuller et al. CLINICAL CANCER RESEARCH
- Design, synthesis and biological evaluation of novel pyrazoline-containing derivatives as potential tubulin assembling inhibitors
- (2015) Ya-Juan Qin et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis and Evaluation of New Pyrazoline Derivatives as Potential Anticancer Agents
- (2015) Muhammed Karabacak et al. MOLECULES
- Novel pyrazoline derivatives as bi-inhibitor of COX-2 and B-Raf in treating cervical carcinoma
- (2014) Minmin Yu et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Design, synthesis and anticancer evaluation of tetrahydro-β-carboline-hydantoin hybrids
- (2014) Nagula Shankaraiah et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- YC-1 inhibits proliferation of breast cancer cells by down-regulating EZH2 expression via activation of c-Cbl and ERK
- (2014) Ling-Chu Chang et al. BRITISH JOURNAL OF PHARMACOLOGY
- Rational approaches, design strategies, structure activity relationship and mechanistic insights for anticancer hybrids
- (2014) Kunal Nepali et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis and in Vitro Antitumor Activity of a Novel Series of 2-Pyrazoline Derivatives Bearing the 4-Aryloxy-7-chloroquinoline Fragment
- (2014) Alba Montoya et al. MOLECULES
- New derivatives of hydantoin as potential antiproliferative agents: biological and structural characterization in combination with quantum chemical calculations
- (2014) Sleem Hmuda et al. MONATSHEFTE FUR CHEMIE
- Pyrazoles as potential anti-angiogenesis agents: a contemporary overview
- (2014) Konstantinos M. Kasiotis et al. Frontiers in Chemistry
- Pazopanib a tyrosine kinase inhibitor with strong anti-angiogenetic activity: A new treatment for metastatic soft tissue sarcoma
- (2013) Girolamo Ranieri et al. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
- Synthesis of some dihydropyrimidine-based compounds bearing pyrazoline moiety and evaluation of their antiproliferative activity
- (2013) Fadi M. Awadallah et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Advances in the development of hybrid anticancer drugs
- (2013) Sébastien Fortin et al. Expert Opinion on Drug Discovery
- New Potential Antitumor Pyrazole Derivatives: Synthesis and Cytotoxic Evaluation
- (2013) George Nitulescu et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Discovery of Potent Mcl-1/Bcl-xL Dual Inhibitors by Using a Hybridization Strategy Based on Structural Analysis of Target Proteins
- (2013) Yuta Tanaka et al. JOURNAL OF MEDICINAL CHEMISTRY
- Structure–Activity Relationship Studies of Pyrazolo[3,4-d]pyrimidine Derivatives Leading to the Discovery of a Novel Multikinase Inhibitor That Potently Inhibits FLT3 and VEGFR2 and Evaluation of Its Activity against Acute Myeloid Leukemia in Vitro and in Vivo
- (2013) Ling-Ling Yang et al. JOURNAL OF MEDICINAL CHEMISTRY
- Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy
- (2013) Peter E. Czabotar et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Clustered DNA damage induces pan-nuclear H2AX phosphorylation mediated by ATM and DNA–PK
- (2013) Barbara Meyer et al. NUCLEIC ACIDS RESEARCH
- Synthesis and antiproliferative activity of some 3-(pyrid-2-yl)-pyrazolines
- (2013) Alexander Ciupa et al. MedChemComm
- Development of a Chimeric c-Src Kinase and HDAC Inhibitor
- (2013) Kristin S. Ko et al. ACS Medicinal Chemistry Letters
- Synthesis, Characterisation, andIn VitroAnticancer Activity of Curcumin Analogues Bearing Pyrazole/Pyrimidine Ring Targeting EGFR Tyrosine Kinase
- (2013) Mohamed Jawed Ahsan et al. Biomed Research International
- Cardiac Toxicity of Anticancer Agents
- (2013) Alessandro Colombo et al. Current Cardiology Reports
- Synthesis, molecular docking and evaluation of thiazolyl-pyrazoline derivatives containing benzodioxole as potential anticancer agents
- (2012) Hai-Hong Wang et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Identification of a phenylacylsulfonamide series of dual Bcl-2/Bcl-xL antagonists
- (2012) Heidi L. Perez et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Pyrazole and pyrimidine phenylacylsulfonamides as dual Bcl-2/Bcl-xL antagonists
- (2012) Gretchen M. Schroeder et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- 2H-chromene derivatives bearing thiazolidine-2,4-dione, rhodanine or hydantoin moieties as potential anticancer agents
- (2012) Mohammad Azizmohammadi et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Recent advances in the therapeutic applications of pyrazolines
- (2012) Mohamed R Shaaban et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- Synthesis of 1-acetyl-3-(2-thienyl)-5-aryl-2-pyrazoline derivatives and evaluation of their anticancer activity
- (2012) Ahmet Özdemir et al. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
- Synthesis of New 4-Thiazolidinone-, Pyrazoline-, and Isatin-Based Conjugates with Promising Antitumor Activity
- (2012) Dmytro Havrylyuk et al. JOURNAL OF MEDICINAL CHEMISTRY
- MK-0457, an Aurora kinase and BCR–ABL inhibitor, is active in patients with BCR–ABL T315I leukemia
- (2012) F J Giles et al. LEUKEMIA
- N-benzyl-5-phenyl-1H-pyrazole-3-carboxamide promotes vascular endothelial cell angiogenesis and migration in the absence of serum and FGF-2
- (2011) Hai-yan Zhang et al. ACTA PHARMACOLOGICA SINICA
- Synthesis and Anticancer Activity of Isatin-Based Pyrazolines and Thiazolidines Conjugates
- (2011) Dmytro Havrylyuk et al. ARCHIV DER PHARMAZIE
- Synthesis and in vitro screening of novel N-benzyl aplysinopsin analogs as potential anticancer agents
- (2011) Narsimha Reddy Penthala et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Synthesis, molecular docking and evaluation of thiazolyl-pyrazoline derivatives as EGFR TK inhibitors and potential anticancer agents
- (2011) Peng-Cheng Lv et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Caspases and cancer
- (2011) M Olsson et al. CELL DEATH AND DIFFERENTIATION
- Synthesis and biological evaluation of some new 2-pyrazolines bearing benzene sulfonamide moiety as potential anti-inflammatory and anti-cancer agents
- (2011) Sameena Bano et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Design, Synthesis, Docking, and Biological Evaluation of Novel Diazide-Containing Isoxazole- and Pyrazole-Based Histone Deacetylase Probes
- (2011) Raghupathi Neelarapu et al. JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis, Characterization and Biological Evaluation of Ureidofibrate-Like Derivatives Endowed with Peroxisome Proliferator-Activated Receptor Activity
- (2011) L. Porcelli et al. JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis and In Vitro Antitumor Activity of Novel Fluorine Containing Pyrazoles and Pyrazolines
- (2011) Ashish Sharma et al. Letters in Drug Design & Discovery
- Synthesis and preliminary evaluation of difluorinated 1,3-propanediones as potential agents in the treatment of breast cancer
- (2011) Tabreskhan Pathan et al. MEDICINAL CHEMISTRY RESEARCH
- Analysis of anticancer drugs: A review
- (2011) Susanne Nussbaumer et al. TALANTA
- Novel pyrazole derivatives: Synthesis and evaluation of anti-angiogenic activity
- (2010) Michael S. Christodoulou et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Aplysinopsin analogs: Synthesis and anti-proliferative activity of substituted (Z)-5-(N-benzylindol-3-ylmethylene)imidazolidine-2,4-diones
- (2010) Y. Thirupathi Reddy et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Microwave assisted synthesis and in vitro cytotoxicities of substituted (Z)-2-amino-5-(1-benzyl-1H-indol-3-yl)methylene-1-methyl-1H-imidazol-4(5H)-ones against human tumor cell lines
- (2009) Narsimha Reddy Penthala et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- 5-Benzylidene-hydantoins: Synthesis and antiproliferative activity on A549 lung cancer cell line
- (2009) Valentina Zuliani et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Phase II trial of pyrazoloacridine (NSC#366140) in patients with metastatic breast cancer
- (2009) Bhuvaneswari Ramaswamy et al. INVESTIGATIONAL NEW DRUGS
- AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading
- (2009) Oleg Trott et al. JOURNAL OF COMPUTATIONAL CHEMISTRY
- Tetrahydroisoquinoline amide substituted phenyl pyrazoles as selective Bcl-2 inhibitors
- (2008) John Porter et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor
- (2008) C. Tse et al. CANCER RESEARCH
- Discovery of ABT-263, a Bcl-family protein inhibitor: observations on targeting a large protein–protein interaction
- (2008) Michael D Wendt Expert Opinion on Drug Discovery
- Discovery of an Orally Bioavailable Small Molecule Inhibitor of Prosurvival B-Cell Lymphoma 2 Proteins
- (2008) Cheol-Min Park et al. JOURNAL OF MEDICINAL CHEMISTRY
- Silencing Bcl-2 in models of mantle cell lymphoma is associated with decreases in cyclin D1, nuclear factor- B, p53, bax, and p27 levels
- (2008) C. A. Tucker et al. MOLECULAR CANCER THERAPEUTICS
- Dual mechanisms of action of the 5-benzylidene-hydantoin UPR1024 on lung cancer cell lines
- (2008) A. Cavazzoni et al. MOLECULAR CANCER THERAPEUTICS
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now