Clustered DNA damage induces pan-nuclear H2AX phosphorylation mediated by ATM and DNA–PK

The N-terminal Region of the DNA-dependent Protein Kinase Catalytic Subunit Is Required for Its DNA Double-stranded Break-mediated Activation

(2013) Anthony J. Davis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Spatiotemporal Dynamics of Early DNA Damage Response Proteins on Complex DNA Lesions

(2013) Frank Tobias et al.   PLoS One

PCNA-dependent accumulation of CDKN1A into nuclear foci after ionizing irradiation

(2012) Claudia Wiese et al.   DNA REPAIR

The dynamics of Ku70/80 and DNA-PKcs at DSBs induced by ionizing radiation is dependent on the complexity of damage

(2012) Pamela Reynolds et al.   NUCLEIC ACIDS RESEARCH

The apoptotic ring: A novel entity with phosphorylated histones H2AX and H2B, and activated DNA damage response kinases

(2011) Stéphanie Solier et al.   CELL CYCLE

Factors determining DNA double-strand break repair pathway choice in G2 phase

(2011) Atsushi Shibata et al.   EMBO JOURNAL

N-terminal constraint activates the catalytic subunit of the DNA-dependent protein kinase in the absence of DNA or Ku

(2011) K. Meek et al.   NUCLEIC ACIDS RESEARCH

DNA double-strand breaks in heterochromatin elicit fast repair protein recruitment, histone H2AX phosphorylation and relocation to euchromatin

(2011) Burkhard Jakob et al.   NUCLEIC ACIDS RESEARCH

Unrepaired clustered DNA lesions induce chromosome breakage in human cells

(2011) A. Asaithamby et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional relevance of the histone  H2Ax in the response to DNA damaging agents

(2011) I. Revet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sequences in PSF/SFPQ mediate radioresistance and recruitment of PSF/SFPQ-containing complexes to DNA damage sites in human cells

(2010) Kyungsoo Ha et al.   DNA REPAIR

Characteristics of DNA-binding proteins determine the biological sensitivity to high-linear energy transfer radiation

(2010) H. Wang et al.   NUCLEIC ACIDS RESEARCH

A minority of foci or pan-nuclear apoptotic staining of  H2AX in the S phase after UV damage contain DNA double-strand breaks

(2010) S. de Feraudy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNF168 Binds and Amplifies Ubiquitin Conjugates on Damaged Chromosomes to Allow Accumulation of Repair Proteins

(2009) Carsten Doil et al.   CELL

Small-Molecule Drugs Mimicking DNA Damage: A New Strategy for Sensitizing Tumors to Radiotherapy

(2009) M. Quanz et al.   CLINICAL CANCER RESEARCH

Ku and DNA-dependent Protein Kinase Dynamic Conformations and Assembly Regulate DNA Binding and the Initial Non-homologous End Joining Complex

(2009) Michal Hammel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MRE11-RAD50-NBS1 Complex Dictates DNA Repair Independent of H2AX

(2009) Jingsong Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adeno-Associated Virus Replication Induces a DNA Damage Response Coordinated by DNA-Dependent Protein Kinase

(2009) R. A. Schwartz et al.   JOURNAL OF VIROLOGY

Single-Stranded DNA Orchestrates an ATM-to-ATR Switch at DNA Breaks

(2009) Bunsyo Shiotani et al.   MOLECULAR CELL

Charged particles in radiation oncology

(2009) Marco Durante et al.   Nature Reviews Clinical Oncology

CK2 phosphorylation-dependent interaction between aprataxin and MDC1 in the DNA damage response

(2009) Olivier J. Becherel et al.   NUCLEIC ACIDS RESEARCH

Hyperactivation of DNA-PK by Double-Strand Break Mimicking Molecules Disorganizes DNA Damage Response

(2009) Maria Quanz et al.   PLoS One

Live cell microscopy analysis of radiation-induced DNA double-strand break motion

(2009) B. Jakob et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Positional Stability of Damaged Chromatin Domains along Radiation Tracks in Mammalian Cells

(2009) B. Jakob et al.   RADIATION RESEARCH

Distribution of Double-Strand Breaks Induced by Ionizing Radiation at the Level of Single DNA Molecules Examined by Atomic Force Microscopy

(2009) K. Psonka-Antonczyk et al.   RADIATION RESEARCH

Recombinant Adeno-Associated Viral Vectors Are Deficient in Provoking a DNA Damage Response

(2008) M. Fragkos et al.   JOURNAL OF VIROLOGY

Histone H2AX phosphorylation in response to changes in chromatin structure induced by altered osmolarity

(2008) J. Baure et al.   MUTAGENESIS

 -H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin

(2008) A. Kinner et al.   NUCLEIC ACIDS RESEARCH

p53 stabilization in response to DNA damage requires Akt/PKB and DNA-PK

(2008) K. A. Boehme et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation of MCM3 on Ser-112 regulates its incorporation into the MCM2-7 complex

(2008) D. I. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA