Journal
DRUG DISCOVERY TODAY
Volume 21, Issue 5, Pages 856-863Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2016.04.007
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Funding
- National Natural Science Foundation of China [81373356, 81573378]
- 'Science and Technology Innovation Action Plan for Basic Research' of Shanghai [14JC1493200]
- [CASIMM0120153020]
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The intestinal epithelium is the main barrier restricting the oral delivery of low-permeability drugs. Over recent years, numerous nanocarriers have been designed to improve the efficiency of oral drug delivery. However, the intracellular processes determining the transport of nanocarriers across the intestinal epithelium remain elusive, and only limited enhancement of the oral bioavailability of drugs has been achieved. Here, we review the processes involved in nanocarrier trafficking across the intestinal epithelium, including apical endocytosis, intracellular transport, and basolateral exocytosis. Understanding the complex intracellular processes of nanocarrier trafficking is particularly essential for the rational design of oral drug delivery systems.
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