A strategy for developing effective orally-delivered nanoparticles through modulation of the surface “hydrophilicity/hydrophobicity balance”

Oral absorption of peptides and nanoparticles across the human intestine: Opportunities, limitations and studies in human tissues

(2016) P. Lundquist et al.   ADVANCED DRUG DELIVERY REVIEWS

Sub-50 nm Nanoparticles with Biomimetic Surfaces to Sequentially Overcome the Mucosal Diffusion Barrier and the Epithelial Absorption Barrier

(2016) Xi Zhu et al.   ADVANCED FUNCTIONAL MATERIALS

Polymeric Nanoparticles Amenable to Simultaneous Installation of Exterior Targeting and Interior Therapeutic Proteins

(2016) Xi Zhu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Efficient mucus permeation and tight junction opening by dissociable “mucus-inert” agent coated trimethyl chitosan nanoparticles for oral insulin delivery

(2016) Min Liu et al.   JOURNAL OF CONTROLLED RELEASE

Short- and Longterm Glycemic Control of Streptozotocin-Induced Diabetic Rats Using Different Insulin Preparations

(2016) Gerd Luippold et al.   PLoS One

Overcoming the Diffusion Barrier of Mucus and Absorption Barrier of Epithelium by Self-Assembled Nanoparticles for Oral Delivery of Insulin

(2015) Wei Shan et al.   ACS Nano

Sustained-release of Cyclosporin A pellets: preparation, in vitro release, pharmacokinetic studies and in vitro–in vivo correlation in beagle dogs

(2015) Dongmei Jiang et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

pH-sensitive chitosan/alginate core-shell nanoparticles for efficient and safe oral insulin delivery

(2015) Piyasi Mukhopadhyay et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Effect of surface chemistry on nanoparticle interaction with gastrointestinal mucus and distribution in the gastrointestinal tract following oral and rectal administration in the mouse

(2015) Katharina Maisel et al.   JOURNAL OF CONTROLLED RELEASE

Transepithelial Transport of Fc-Targeted Nanoparticles by the Neonatal Fc Receptor for Oral Delivery

(2013) E. M. Pridgen et al.   Science Translational Medicine

Protease inhibition and absorption enhancement by functional nanoparticles for effective oral insulin delivery

(2012) Fang-Yi Su et al.   BIOMATERIALS

Modified Rose Bengal assay for surface hydrophobicity evaluation of cationic solid lipid nanoparticles (cSLN)

(2012) S. Doktorovova et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Mechanism and consequence of chitosan-mediated reversible epithelial tight junction opening

(2011) Tzyy-Harn Yeh et al.   BIOMATERIALS

A review of the prospects for polymeric nanoparticle platforms in oral insulin delivery

(2011) Mei-Chin Chen et al.   BIOMATERIALS

Goblet cell-targeting nanoparticles for oral insulin delivery and the influence of mucus on insulin transport

(2011) Yun Jin et al.   BIOMATERIALS

Do HPMA copolymer conjugates have a future as clinically useful nanomedicines? A critical overview of current status and future opportunities☆

(2009) Ruth Duncan et al.   ADVANCED DRUG DELIVERY REVIEWS

Nanodiamond–insulin complexes as pH-dependent protein delivery vehicles

(2009) Rafael A. Shimkunas et al.   BIOMATERIALS

Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues

(2008) Samuel K. Lai et al.   ADVANCED DRUG DELIVERY REVIEWS

Chitosan-NAC nanoparticles as a vehicle for nasal absorption enhancement of insulin

(2008) Xin Wang et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS

Recombinant therapeutic proteins: Production platforms and challenges

(2007) Theo Dingermann   Biotechnology Journal

Protein therapeutics: a summary and pharmacological classification

(2007) Benjamin Leader et al.   NATURE REVIEWS DRUG DISCOVERY