Specialized proresolving mediators in infection and lung injury

The Inflammatory and Hemostatic Response in Sepsis and Meningococcemia

(2020) Navin P. Boeddha et al.   CRITICAL CARE CLINICS

Pro-resolving lipid mediators in sepsis and critical illness

(2020) Michele G. Padovan et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Oral Microbes and Mucosal Dendritic Cells, “Spark and Flame” of Local and Distant Inflammatory Diseases

(2020) Mohamed M. Meghil et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak

(2020) Hussin A. Rothan et al.   JOURNAL OF AUTOIMMUNITY

Hormonal Dysregulation and Unbalanced Specialized Pro‐Resolving Mediator Biosynthesis Contribute Toward Impaired B cell Outcomes in Obesity

(2020) Miranda Crouch et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Can Bioactive Lipids Inactivate Coronavirus (COVID-19)?

(2020) Undurti N. Das   ARCHIVES OF MEDICAL RESEARCH

Inflammation resolution: a dual-pronged approach to averting cytokine storms in COVID-19?

(2020) Dipak Panigrahy et al.   CANCER AND METASTASIS REVIEWS

Shifting the paradigm from inhibitors of inflammation to resolvers of inflammation in periodontitis

(2020) Thomas E. Van Dyke   JOURNAL OF PERIODONTOLOGY

15-Epi-LXA4and 17-epi-RvD1 restore TLR9-mediated impaired neutrophil phagocytosis and accelerate resolution of lung inflammation

(2020) Meriem Sekheri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resolvin D1 Reduces Lung Infection and Inflammation Activating Resolution in Cystic Fibrosis

(2020) Elisa Isopi et al.   Frontiers in Immunology

Eicosanoids

(2020) Bruce D. Hammock et al.   AMERICAN JOURNAL OF PATHOLOGY

Resolvin D1 protects against sepsis‐induced cardiac injury in mice

(2020) Menglong Wang et al.   BIOFACTORS

Harnessing inflammation resolving‐based therapeutic agents to treat pulmonary viral infections: What can the future offer to COVID‐19?

(2020) Lirlândia P. Sousa et al.   BRITISH JOURNAL OF PHARMACOLOGY

Obesity-Driven Deficiencies of Specialized Pro-resolving Mediators May Drive Adverse Outcomes During SARS-CoV-2 Infection

(2020) Anandita Pal et al.   Frontiers in Immunology

Arachidonic Acid Derived Lipid Mediators Influence Kaposi’s Sarcoma-Associated Herpesvirus Infection and Pathogenesis

(2019) Jayashree A. Chandrasekharan et al.   Frontiers in Microbiology

Quenching the fires: Pro-resolving mediators, air pollution, and smoking

(2019) Thomas H. Thatcher et al.   PHARMACOLOGY & THERAPEUTICS

Roles, Actions, and Therapeutic Potential of Specialized Pro-resolving Lipid Mediators for the Treatment of Inflammation in Cystic Fibrosis

(2019) Antonio Recchiuti et al.   Frontiers in Pharmacology

Salivary levels of specialized pro‐resolving lipid mediators as indicators of periodontal health/disease status

(2019) S I Tobón‐Arroyave et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Resolvin D1 (RvD1) and maresin 1 (Mar1) contribute to human macrophage control of M. tuberculosis infection while resolving inflammation

(2019) Andy Ruiz et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Arachidonic Acid and Docosahexaenoic Acid Metabolites in the Airways of Adults With Cystic Fibrosis: Effect of Docosahexaenoic Acid Supplementation

(2019) Elisabetta Teopompi et al.   Frontiers in Pharmacology

Proresolving mediator profiles in cerebrospinal fluid are linked with disease severity and outcome in adults with tuberculous meningitis

(2019) Romain A. Colas et al.   FASEB JOURNAL

RvD1 ameliorates LPS-induced acute lung injury via the suppression of neutrophil infiltration by reducing CXCL2 expression and release from resident alveolar macrophages

(2019) Hua-Wei Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Lipoxin suppresses inflammation via the TLR4/MyD88/NF‐κB pathway in periodontal ligament cells

(2019) Muhanad Ali et al.   ORAL DISEASES

Identification and structure elucidation of the pro-resolving mediators provides novel leads for resolution pharmacology

(2018) Jesmond Dalli et al.   BRITISH JOURNAL OF PHARMACOLOGY

Specialized Pro-resolving Mediators Regulate Alveolar Fluid Clearance during Acute Respiratory Distress Syndrome

(2018) Sheng-Wei Jin et al.   CHINESE MEDICAL JOURNAL

Protectin DX Exhibits Protective Effects in Mouse Model of Lipopolysaccharide-Induced Acute Lung Injury

(2018) You Shang et al.   CHINESE MEDICAL JOURNAL

Immunoregulatory role of 15-lipoxygenase in the pathogenesis of bacterial keratitis

(2018) Thomas W. Carion et al.   FASEB JOURNAL

AT-RVD1 repairs mouse lung after cigarette smoke-induced emphysema via downregulation of oxidative stress by NRF2/KEAP1 pathway

(2018) Sara Vergel Posso et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Specialized Proresolving Mediators in Innate and Adaptive Immune Responses in Airway Diseases

(2018) Nandini Krishnamoorthy et al.   PHYSIOLOGICAL REVIEWS

Bioactive Lipids and Chronic Inflammation: Managing the Fire Within

(2018) Valerio Chiurchiù et al.   Frontiers in Immunology

Arachidonic acid and other unsaturated fatty acids and some of their metabolites function as endogenous antimicrobial molecules: A review

(2018) Undurti N. Das   Journal of Advanced Research

Resolution of inflammation is altered in chronic heart failure and entails a dysfunctional responsiveness of T lymphocytes

(2018) Valerio Chiurchiù et al.   FASEB JOURNAL

Specialized Pro-Resolving Lipid Mediators in Cystic Fibrosis

(2018) Réginald Philippe et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Specialized Pro-Resolving Lipid Mediators in Experimental Periodontitis:A Systematic Review

(2018) Marcela Maria Osorio Parra et al.   ORAL DISEASES

Lipoxin B4 Enhances Human Memory B Cell Antibody Production via Upregulating Cyclooxygenase-2 Expression

(2018) Nina Kim et al.   JOURNAL OF IMMUNOLOGY

Resolving Viral-Induced Secondary Bacterial Infection in COPD: A Concise Review

(2018) Hao Wang et al.   Frontiers in Immunology

Dynamic differences in dietary polyunsaturated fatty acid metabolism in sputum of COPD patients and controls

(2018) Anne M. van der Does et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Pro-Resolving Molecules—New Approaches to Treat Sepsis?

(2017) Christa Buechler et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

B Cell Activity Is Impaired in Human and Mouse Obesity and Is Responsive to an Essential Fatty Acid upon Murine Influenza Infection

(2017) Rasagna Kosaraju et al.   JOURNAL OF IMMUNOLOGY

Bronchoprotective mechanisms for specialized pro-resolving mediators in the resolution of lung inflammation

(2017) Melody G. Duvall et al.   MOLECULAR ASPECTS OF MEDICINE

New pro-resolving n-3 mediators bridge resolution of infectious inflammation to tissue regeneration

(2017) Charles N. Serhan et al.   MOLECULAR ASPECTS OF MEDICINE

Inflammatory responses and inflammation-associated diseases in organs

(2017) Linlin Chen et al.   Oncotarget

Protectin DX increases survival in a mouse model of sepsis by ameliorating inflammation and modulating macrophage phenotype

(2017) Haifa Xia et al.   Scientific Reports

Phase I Studies of Acebilustat: Biomarker Response and Safety in Patients with Cystic Fibrosis

(2016) JS Elborn et al.   CTS-Clinical and Translational Science

Epidemiology, Patterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries

(2016) Giacomo Bellani et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Proresolving lipid mediators resolvin D1, resolvin D2, and maresin 1 are critical in modulating T cell responses

(2016) Valerio Chiurchiù et al.   Science Translational Medicine

Resolvin D1 Reduces Emphysema and Chronic Inflammation

(2015) Hsi-Min Hsiao et al.   AMERICAN JOURNAL OF PATHOLOGY

Role of omega-3 PUFA-derived mediators, the protectins, in influenza virus infection

(2015) Yumiko Imai   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Critical role of phospholipase A2group IID in age-related susceptibility to severe acute respiratory syndrome–CoV infection

(2015) Rahul Vijay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Maresin-1 reduces airway inflammation associated with acute and repetitive exposures to organic dust

(2015) Tara M. Nordgren et al.   Translational Research

Lipoxins exert antiangiogenic and anti-inflammatory effects on Kaposi's sarcoma cells

(2015) Alexandru Marginean et al.   Translational Research

Combination Therapy of 15-Epi-Lipoxin A4 With Antibiotics Protects Mice From Escherichia coli–Induced Sepsis*

(2014) Tomomi Ueda et al.   CRITICAL CARE MEDICINE

The Specialized Proresolving Mediator 17-HDHA Enhances the Antibody-Mediated Immune Response against Influenza Virus: A New Class of Adjuvant?

(2014) Sesquile Ramon et al.   JOURNAL OF IMMUNOLOGY

Resolvin D1 Stimulates Alveolar Fluid Clearance through Alveolar Epithelial Sodium Channel, Na,K-ATPase via ALX/cAMP/PI3K Pathway in Lipopolysaccharide-Induced Acute Lung Injury

(2014) Q. Wang et al.   JOURNAL OF IMMUNOLOGY

Pro-resolving lipid mediators are leads for resolution physiology

(2014) Charles N. Serhan   NATURE

Plasma Metabolomics in Human Pulmonary Tuberculosis Disease: A Pilot Study

(2014) Jennifer K. Frediani et al.   PLoS One

Lipoxin A4Activates Alveolar Epithelial Sodium Channel, Na,K-ATPase, and Increases Alveolar Fluid Clearance

(2013) Qian Wang et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Confusion between protectin D1 (PD1) and its isomer protectin DX (PDX). An overview on the dihydroxy-docosatrienes described to date

(2013) Laurence Balas et al.   BIOCHIMIE

The Lipid Mediator Protectin D1 Inhibits Influenza Virus Replication and Improves Severe Influenza

(2013) Masayuki Morita et al.   CELL

International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma

(2013) K. F. Chung et al.   EUROPEAN RESPIRATORY JOURNAL

The role of pro-resolution lipid mediators in infectious disease

(2013) Clark D. Russell et al.   IMMUNOLOGY

Dual role of lipoxin A4 in pneumosepsis pathogenesis

(2013) Regina Sordi et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Exhaled breath condensate eicosanoid levels associate with asthma and its severity

(2013) Shamsah Kazani et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Contribution of CFTR to Alveolar Fluid Clearance by Lipoxin A4via PI3K/Akt Pathway in LPS-Induced Acute Lung Injury

(2013) Yi Yang et al.   MEDIATORS OF INFLAMMATION

Role of the lipoxygenase pathway in RSV-induced alternatively activated macrophages leading to resolution of lung pathology

(2013) K A Shirey et al.   Mucosal Immunology

Treating neutrophilic inflammation in COPD by targeting ALX/FPR2 resolution pathways

(2013) Steven Bozinovski et al.   PHARMACOLOGY & THERAPEUTICS

A Novel Anti-Inflammatory and Pro-Resolving Role for Resolvin D1 in Acute Cigarette Smoke-Induced Lung Inflammation

(2013) Hsi-Min Hsiao et al.   PLoS One

Host Genotype-Specific Therapies Can Optimize the Inflammatory Response to Mycobacterial Infections

(2012) David M. Tobin et al.   CELL

Metabolomic profiling of regulatory lipid mediators in sputum from adult cystic fibrosis patients

(2012) Jun Yang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Infection regulates pro-resolving mediators that lower antibiotic requirements

(2012) Nan Chiang et al.   NATURE

Resolvin E1 promotes phagocytosis-induced neutrophil apoptosis and accelerates resolution of pulmonary inflammation

(2012) D. El Kebir et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Serum amyloid A opposes lipoxin A4 to mediate glucocorticoid refractory lung inflammation in chronic obstructive pulmonary disease

(2012) S. Bozinovski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resolvins and Protectins in Inflammation Resolution

(2011) Charles N. Serhan et al.   CHEMICAL REVIEWS

Impaired Phagocytosis in Localized Aggressive Periodontitis: Rescue by Resolvin E1

(2011) Gabrielle Fredman et al.   PLoS One

Lipoxin A4 Increases Survival by Decreasing Systemic Inflammation and Bacterial Load in Sepsis

(2011) Jean Walker et al.   SHOCK

The lta4h Locus Modulates Susceptibility to Mycobacterial Infection in Zebrafish and Humans

(2010) David M. Tobin et al.   CELL

Nonresolving Inflammation

(2010) Carl Nathan et al.   CELL

Controlling Herpes Simplex Virus-Induced Ocular Inflammatory Lesions with the Lipid-Derived Mediator Resolvin E1

(2010) N. K. Rajasagi et al.   JOURNAL OF IMMUNOLOGY

Lethal Dissemination of H5N1 Influenza Virus Is Associated with Dysregulation of Inflammation and Lipoxin Signaling in a Mouse Model of Infection

(2010) C. Cilloniz et al.   JOURNAL OF VIROLOGY

15-Epi-lipoxin A4Inhibits Myeloperoxidase Signaling and Enhances Resolution of Acute Lung Injury

(2009) Driss El Kebir et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Anti-Inflammatory and Proresolving Mediator Resolvin E1 Protects Mice from Bacterial Pneumonia and Acute Lung Injury

(2009) H. Seki et al.   JOURNAL OF IMMUNOLOGY

Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis

(2009) Matthew Spite et al.   NATURE

Endogenous pro-resolving and anti-inflammatory lipid mediators: a new pharmacologic genus

(2007) C N Serhan et al.   BRITISH JOURNAL OF PHARMACOLOGY