Article
Medicine, Research & Experimental
Da-Wei Chen, Tian Kang, Xiu-Zhang Xu, Wen-Jie Xia, Xin Ye, Yong-Bin Wu, Yao-Ri Xu, Jing Liu, Hui Ren, Jing Deng, Yang-Kai Chen, Hao-Qiang Ding, Muhammad Aslam, Wioleta M. Zelek, B. Paul Morgan, Rick Kapur, Sentot Santoso, Yong-Shui Fu
Summary: Anti-CD36 antibodies can cause transfusion-related acute lung injury (TRALI), especially in Asian populations. However, the pathological mechanism of anti-CD36 Ab-mediated TRALI and potential therapies are not well understood. In this study, a mouse model of anti-CD36 Ab-mediated TRALI was developed, and it was found that TRALI could be prevented and treated by targeting Fc and complement C5 activation. These findings suggest the potential for anti-C5 drugs in the treatment of TRALI caused by anti-CD36 antibodies.
Article
Critical Care Medicine
Luyao Zhang, Jun Lu, Zhiyang Wu
Summary: This study demonstrates the significant effects of auricular vagus nerve stimulation (AVNS) on systemic inflammation, lung injury, neutrophil infiltration, and neutrophil extracellular traps (NETs) formation in LPS mice.
Article
Critical Care Medicine
Stephanie Arnold, Sajeel A. Shah, Simon J. Cleary, Blaze G. O'Shaughnessy, Richard T. Amison, Kate Arkless, Clive P. Page, Simon C. Pitchford
Summary: Intravascular hemolysis in disorders like sickle cell disease and malaria leads to inflammation and platelet activation. Research shows that introduction of whole or lysed red blood cells into the airways of mice triggers different levels of inflammatory responses, with potential involvement of platelets in inflammation modulation. A better understanding of the role platelets play in lung inflammation caused by red blood cells could offer new therapeutic approaches for conditions related to alveolar hemorrhage.
Article
Immunology
Katharina Jandl, Johannes Lorenz Berg, Anna Birnhuber, Elisabeth Fliesser, Izabela Borek, Benjamin Seeliger, Sascha David, Julius J. Schmidt, Gregor Gorkiewicz, Martin Zacharias, Tobias Welte, Horst Olschewski, Akos Heinemann, Malgorzata Wygrecka, Grazyna Kwapiszewska
Summary: Immune cell recruitment, endothelial cell barrier disruption, and platelet activation are common in lung injuries like COVID-19-induced ARDS. In this study, we investigated the role of endostatin, a bioactive fragment of the basement membrane protein collagen XVIII alpha 1, on cellular functions associated with ARDS. Our results showed that endostatin enhanced neutrophil and platelet activity, as well as induced microvascular barrier disruption.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Nursel Dikmen, Mustafa Cellat, Muhammed Etyemez, Cafer Tayer Isler, Ahmet Uyar, Tuba Aydin, Mehmet Guvenc
Summary: The study demonstrated that oleuropein, a component of olive leaf, has protective effects against LPS-induced ALI in rats, reducing inflammatory cytokines and oxidative stress, and improving the histopathological conditions of lung tissue.
Article
Clinical Neurology
Yunke Li, Dingke Wen, Wenyao Cui, Yuqi Chen, Fazhen Zhang, Maolin Yuan, Han Xiao, Hao Li, Lu Ma, Xin Hu, Chao You
Summary: The systemic immune-inflammation index (SII) is a novel prognostic index highly associated with 90-day functional outcomes in patients with intracerebral hemorrhage (ICH), with day-1 SII being particularly predictive of poor outcomes.
FRONTIERS IN NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Paulette A. Krishack, Maile K. Hollinger, Timothy G. Kuzel, Trevor S. Decker, Tyler J. Louviere, Cara L. Hrusch, Anne Sperling, Philip A. Verhoef
Summary: Recent studies suggest that patients with allergies/asthma have a higher survival rate against pulmonary infections, and there is a correlation between survival from acute respiratory distress syndrome and higher eosinophil counts. Research indicates that eosinophils play a key role in protecting against lung injury, and modulation of pulmonary type 2 immunity may represent a novel therapeutic strategy.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Xin Lv, Tingting Yao, Rongling He, Yijun He, Mengyu Li, Yuanyuan Han, Yan Zhang, Lingzhi Long, Guoliang Jiang, Xiaoyun Cheng, Yanyun Xie, Ling Huang, Zhangzhe Peng, Gaoyun Hu, Qianbin Li, Lijian Tao, Jie Meng
Summary: Fluorofenidone demonstrates protective effects against LPS-induced ALI by alleviating lung tissue injury, reducing inflammation, and inhibiting the activation of the MAPK/NF-κB signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Yuehong Chen, Huan Liu, Yunru Tian, Zhongling Luo, Jingjing Ran, Zhiyong Miao, Qiuping Zhang, Geng Yin, Qibing Xie
Summary: This study evaluated the therapeutic effects of FFD, a small-molecule drug that targets cPLA2, on LPS-induced ALI. FFD inhibited cPLA2 activity and the cPLA2/ERK/p65 signaling pathway, suppressed p65 translocation, and reduced the production of cytokines, chemokines, and downstream hydrolysates. These findings suggest that FFD holds promise as a therapeutic option for cPLA2-involved diseases, particularly ALI.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Agriculture, Multidisciplinary
Jingjing Guo, Ying Luo, Jingru Zuo, Jiang Teng, Bingyu Shen, Xiaoqiang Liu
Summary: Our study investigated the protective effect of Echinacea polyphenols (EPP) against LPS-induced acute lung injury (ALI) and the underlying mechanisms. We found that EPP pretreatment significantly alleviated lung tissue injury and pulmonary edema caused by LPS. EPP inhibited PANoptosis by regulating the expression of inflammasome proteins, gasdermin D, caspase-8, caspase-3, and mixed lineage kinase domain-like protein.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Hematology
Abhishek Joshi, Lukas E. Schmidt, Sean A. Burnap, Ruifang Lu, Melissa V. Chan, Paul C. Armstrong, Ferheen Baig, Clemens Gutmann, Peter Willeit, Peter Santer, Temo Barwari, Konstantinos Theofilatos, Stefan Kiechl, Johann Willeit, Timothy D. Warner, Anthony Mathur, Manuel Mayr
Summary: This study found that the proteome of platelets is altered during acute myocardial infarction (MI), and the elevated levels of S100A8 and S100A9 proteins are associated with neutrophil abundance. The study also demonstrated the transfer of proteins between platelets and neutrophils, and the negative correlation between plasma S100A8/A9 and platelet reactivity.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Cell Biology
Yashuan Chao, Johan Rebetz, Anna Blackberg, Gisela Hovold, Torgny Sunnerhagen, Magnus Rasmussen, John W. Semple, Oonagh Shannon
Summary: This study found that in patients with COVID-19, platelets are more responsive during the acute phase while neutrophils are less responsive, potentially associated with disease severity and cytokine levels.
Article
Cell Biology
Shengwei Jin, Siyuan Sun, Hanzhi Ling, Jinglan Ma, Xu Zhang, Zhen Xie, Ning Zhan, Wenjie Zheng, Man Li, Yang Qin, Heping Zhao, Yan Chen, Xinyu Yang, Jianguang Wang
Summary: Protectin DX (PDX) was found to effectively ameliorate the progression of collagen-induced arthritis by restoring Treg/T(h)17 cell balance, and this effect was mediated by inhibiting the NLRP3 inflammasome pathway via miR-20a.
CELL DEATH & DISEASE
(2021)
Article
Pharmacology & Pharmacy
Yunduan Song, Chunyan Xu, Jiaoxiang Wu, Jie Shu, Huiming Sheng, Yao Shen
Summary: Palmatine (PAL) can alleviate acute lung injury (ALI) by inhibiting macrophage activation and attenuating the inflammatory response. PAL has inhibitory effects on the production of inflammatory mediators in cells and fluids. Additionally, PAL regulates macrophage function by inhibiting the activation of NF-KB and p38 MAPK signaling pathways.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Zhiyang Wu, Luyao Zhang, Xiangyang Zhao, Zhi Li, Haining Lu, Chanyuan Bu, Rui Wang, Xiaofei Wang, Tiantian Cai, Dawei Wu
Summary: PD1 derived from DHA has anti-inflammatory and pro-resolving properties, and has shown therapeutic effects on LPS-induced ALI in mice by inhibiting neutrophil extracellular trap formation in lung tissue, suggesting a potential new strategy for treating ALI.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Xiang-Zhi Fang, Ting Zhou, Ji-Qian Xu, Ya-Xin Wang, Miao-Miao Sun, Ya-Jun He, Shang-Wen Pan, Wei Xiong, Zhe-Kang Peng, Xue-Hui Gao, You Shang
Summary: Mechanotransduction, Piezo channels, and their mutations play crucial roles in various biological processes, including touch sensation, balance, and cardiovascular regulation. The kinetics of Piezo channels are critical for normal physiological functions. Mutations in Piezo genes have been linked to hereditary human disorders.
CELL AND BIOSCIENCE
(2021)
Editorial Material
Medicine, General & Internal
Yue-Tian Yu, Jiao Liu, Bo Hu, Rui-Lan Wang, Xiang-Hong Yang, Xiu-Ling Shang, Gang Wang, Chang-Song Wang, Bai-Ling Li, Ye Gong, Sheng Zhang, Xin Li, Lu Wang, Min Shao, Mei Meng, Feng Zhu, You Shang, Qiang-Hong Xu, Zhi-Xiong Wu, De-Chang Chen
CHINESE MEDICAL JOURNAL
(2021)
Article
Medicine, Research & Experimental
Lin Chen, Azeem Alam, Aurelie Pac-Soo, Qian Chen, You Shang, Hailin Zhao, Shanglong Yao, Daqing Ma
Summary: The study found that VPA prevented EMT in a time- and concentration-dependent manner both in vitro and in vivo, leading to improvement in lung structure. Pretreatment with VPA increased the survival rate and prevented weight loss in mice, associated with Smad2/3 deactivation.
LABORATORY INVESTIGATION
(2021)
Article
Critical Care Medicine
Yaxin Wang, Xiangzhi Fang, Yiyi Yang, Lin Chen, Wei Xiong, Limin Song, Bo Li, Ting Zhou, Yuan Yu, Xiaobo Yang, Huaqing Shu, Shiying Yuan, Shanglong Yao, You Shang
Summary: In this study, it was found that DAPK1 mediated cyclic stretch-induced alveolar epithelial cell apoptosis and ventilator-induced lung injury through the P53 pathway. Inhibition of DAPK1 or P53 can alleviate high tidal volume ventilation-induced lung injury and alveolar epithelial cell apoptosis.
Article
Cell Biology
Ruiting Li, Xuemei Hu, Huibin Chen, Yue Zhao, Xuehui Gao, Yin Yuan, Huiling Guo, Haiyan Huang, Xiaojing Zou, Hong Qi, Hong Liu, You Shang
Summary: This study suggests that the cholinergic anti-inflammatory pathway contributes to the reduction in the inflammatory response in ALI by regulating the maturation, phenotype, and quantity of DCs and conventional DCs.
MEDIATORS OF INFLAMMATION
(2022)
Review
Respiratory System
Xuehui Gao, Xiaojing Zou, Ruiting Li, Huaqing Shu, Yuan Yu, Xiaobo Yang, You Shang
Summary: COVID-19 has been a global challenge for more than two years. The recent emergence of mutant virus strains has posed even greater obstacles to disease prevention and treatment. Point-of-care ultrasound (POCUS) is recommended for regular use in COVID-19 patients, particularly in respiratory failure management. This review summarizes the ultrasound characteristics of COVID-19 patients, focusing on lung ultrasound and echocardiography, and discusses the experience of using POCUS to manage COVID-19-related acute respiratory distress syndrome (ARDS).
BMC PULMONARY MEDICINE
(2022)
Article
Medicine, General & Internal
Shangwen Pan, Huaqing Shu, Yaxin Wang, Ruiting Li, Ting Zhou, Yuan Yu, Jiqian Xu, Wei Xiong, Xiaobo Yang, Jiancheng Zhang, Yin Yuan, Shiying Yuan, You Shang
Summary: By analyzing data from 118 confirmed SARS-CoV-2 patients, it was found that characteristics such as lymphocyte and platelet levels, as well as lesion areas on CT scans, were associated with disease severity. The study suggests that combining clinical features with specific CT levels can effectively predict severe/critical cases of SARS-CoV-2 pneumonia.
FRONTIERS IN MEDICINE
(2021)
Editorial Material
Emergency Medicine
Rui-ting Li, Yue Zhao, Xiao-jing Zou, Hua-qing Shu, Ting Zhou, Shang-wen Pan, Xue-hui Gao, Hai-yan Huang, Hong Liu, You Shang
WORLD JOURNAL OF EMERGENCY MEDICINE
(2022)
Article
Immunology
Wei Xiong, Han Wang, Hongyan Zhang, Yanmei Xing, Wenli Gao, Lengfeng Chen, Lixin Chen, Zhongliang Dai
Summary: It has been discovered that neuroinflammation caused by microglial activation is the cause of depression associated with sepsis. An endogenous lipid mediator called resolvin D1 (RvD1) has anti-inflammatory effects in a sepsis model. However, it is still unclear if the effects of RvD1 on inflammatory responses are regulated by microglial autophagy.
INFLAMMOPHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Shang-wen Pan, Li-sha Hu, Han Wang, Rui-ting Li, Ya-jun He, You Shang, Zhong-liang Dai, Li-xin Chen, Wei Xiong
Summary: Resolvin D1 (RvD1) promotes autophagy in microglial cells by favoring autophagosome maturation and fusion with lysosomes, independent of mTOR signaling. Furthermore, RvD1 suppresses phagocytic activity by downregulating ATG5-dependent autophagy.
CURRENT MEDICAL SCIENCE
(2023)
Article
Biotechnology & Applied Microbiology
Hong Qi, Jiancheng Zhang, You Shang, Shiying Yuan, Chunqing Meng
Summary: Argon preconditioning can inhibit the PDCD4/PTEN pathway through miR-21, reducing oxidative stress and inflammatory factor levels, protecting cardiomyocytes from MI/R injury.
Article
Biochemistry & Molecular Biology
Yufen Zhang, Sehui Ma, Xiao Ke, Yao Yi, Hongyan Yu, Dian Yu, Qiang Li, You Shang, Youming Lu, Lei Pei
Summary: The study reveals that Annexin A1 (ANXA1) exerts analgesic effects at the dorsal root ganglia (DRG) level through targeting TRPV1 and can desensitize TRPV1 via activation of the FPR2 receptor by specific peptide, potentially providing a target for developing novel analgesic drugs.
CELL AND BIOSCIENCE
(2021)
Article
Obstetrics & Gynecology
Yin Zhao, Bangxing Huang, Hui Ma, You Shang, Xiu Nie, Li Zou
Summary: This study analyzed the clinical data of 5 pregnant women who were infected with COVID-19 in early pregnancy, showing that infants were healthy and asymptomatic at 3-6 months after birth, with no adverse outcomes observed. Placental pathology revealed chronic ischemia changes, suggesting that COVID-19 may cause placental injury.
MATERNAL-FETAL MEDICINE
(2021)
Article
Immunology
Jingyi Yang, Maohua Zhong, Ke Hong, Qingyu Yang, Ejuan Zhang, Dihan Zhou, Jianbo Xia, Yao-Qing Chen, Mingbo Sun, Bali Zhao, Jie Xiang, Ying Liu, Yang Han, Mengxin Xu, Xi Zhou, Chaolin Huang, You Shang, Huimin Yan
Summary: Prolonged SARS-CoV-2 positivity (PP) is associated with suppressed CD8(+) T-cell differentiation, which may serve as an indicator for predicting prolonged positivity in COVID-19 patients. Additionally, PP cohort showed a weaker SARS-CoV-2 N protein-specific IFN-gamma(+) T-cell response and a higher frequency of Tregs.
CLINICAL & TRANSLATIONAL IMMUNOLOGY
(2021)
