Review
Immunology
Toshihiko Taya, Fumiya Teruyama, Satoshi Gojo
Summary: Bacterial infections continue to be a burden on humanity, and antimicrobial resistance poses a growing threat. Unlike cancer treatment, which has shifted focus to include host immunity, therapies that strengthen the immune system in infectious diseases are still in the early stages. This article reviews the host defense mechanisms and bacterial evasion mechanisms, and discusses the potential of host-directed therapy by intervening in the phagolysosome pathway for bacterial infection.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Aryashree Arunima, Erin J. van Schaik, James E. Samuel
Summary: Long non-coding RNAs (lncRNAs) are conserved non-coding regulatory transcripts that play a role in various biological processes. They regulate chromatin function and mRNA stability and translation. Increasing evidence suggests that lncRNAs are involved in immune responses, microbiome development, and diseases such as neurological disorders, cancer, and infections. This review discusses the regulatory roles of lncRNAs in immune responses, host-microbe interactions, and bacterial infections. The study of lncRNAs is important for the development of alternative therapies for severe infections and the diagnosis and prognosis of human diseases.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Immunology
Pamella Constantino-Teles, Albane Jouault, Lhousseine Touqui, Alessandra Mattos Saliba
Summary: Pseudomonas aeruginosa, an opportunistic pathogen, causes respiratory infections by utilizing various virulence factors, such as bacterial lipids and enzymes, and by interacting with host lipids. These mechanisms play important roles in the establishment and persistence of P. aeruginosa in the lungs, as well as in modulating host immune responses.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Suborno Jati, Soham Sengupta, Malini Sen
Summary: The study found that the Wnt5A signaling pathway plays different roles in handling pathogenic and non-pathogenic infections, with a potentially crucial role in regulating intracellular actin organization of bacteria.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Justin B. Schaal, Yoshihiro Eriguchi, Dat Q. Tran, Patti A. Tran, Chase Hawes, Anthony E. Cabebe, Kaitlyn Pike, Katie Trinh, Andre J. Ouellette, Michael E. Selsted
Summary: Infections by carbapenem resistant Enterobacteriaceae (CRE) pathogens are a global public health threat, requiring urgent development of new preventive and therapeutic strategies. The novel macrocyclic peptide MTD12813 shows efficacy in combating CRE infections in vivo, enhancing survival in mouse septicemia models through host-mediated bacterial clearance and modulating pathologic cytokine responses.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Joshua T. Thaden, Richard Ahn, Felicia Ruffin, David W. Gjertson, Alexander Hoffmann, Vance G. Fowler, Michael R. Yeaman
Summary: This study identifies reduced host transcriptional signatures involving mitochondrial energy transduction in methicillin-resistant Staphylococcus aureus compared to methicillin-susceptible Staphylococcus aureus. Patients with gram-negative infection had increased activation of the classic complement system.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Microbiology
Jean-Philippe Barnier, Daniel Euphrasie, Olivier Join-Lambert, Mathilde Audry, Sophia Schonherr-Hellec, Taliah Schmitt, Sandrine Bourdoulous, Mathieu Coureuil, Xavier Nassif, Mohamed El Behi
Summary: Neisseria meningitidis is a major cause of bacterial meningitis and fatal sepsis, as it can adhere to human endothelial cells and colonize microvessels using type IV pili (TFP). TFP dynamics, facilitated by PilT ATPase, play a crucial role in promoting sustained bacteremia and lethality in a humanized mouse model, highlighting the significance of pilus retraction in the pathogenesis and outcome of meningococcal sepsis.
Article
Immunology
Madhu Shankar, Nathalie Uwamahoro, Emelie Backman, Sandra Holmberg, Maria Joanna Niemiec, Johannes Roth, Thomas Vogl, Constantin F. Urban
Summary: S100A8/A9 protein complex plays a critical role in inflammatory collateral tissue damage, with its deficiency reducing tissue injury and increasing fungal clearance. Restoring S100A8/A9 levels can increase tissue damage and fungal clearance, indicating that targeting S100A8/A9 could serve as a promising adjunct therapy against challenging intra-abdominal infections.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Bich-Tram Huynh, Elsa Kermorvant-Duchemin, Rattanak Chheang, Frederique Randrianirina, Abdoulaye Seck, Elisoa Hariniaina Ratsima, Zafitsara Zo Andrianirina, Jean-Baptiste Diouf, Armya Youssouf Abdou, Sophie Goyet, Veronique Ngo, Siyin Lach, Long Pring, Touch Sok, Michael Padget, Fatoumata Diene Sarr, Laurence Borand, Benoit Garin, Jean-Marc Collard, Perlinot Herindrainy, Agathe de lauzanne, Muriel Vray, Elisabeth Delarocque-Astagneau, Didier Guillemot
Summary: This study found a high incidence of neonatal severe bacterial infections in the community of 3 low- and middle-income countries, particularly in the first 3 days of life. Treatment for neonatal infections is hindered by antimicrobial resistance. Microbiological diagnosis remains a challenge in these settings, supporting further research on causes of neonatal death and early interventions.
Review
Chemistry, Multidisciplinary
Xiaomin Huang, Luoyuan Li, Zhongxing Chen, Haoyu Yu, Xinru You, Na Kong, Wei Tao, Xingtao Zhou, Jinhai Huang
Summary: Ocular bacterial infection, a common cause of blindness, has significant consequences for daily life. The rapid advancement of nanoscience and biomedicine has led to the increasing attention on multifunctional nanosystems as a potential solution to ocular bacterial infections. This review highlights the challenges faced by ocular medicine and encourages basic research and future clinical transformation based on ophthalmic antibacterial nanomedicine.
ADVANCED MATERIALS
(2023)
Article
Hematology
Oscar Negron, Miranda Weggeman, Jos Grimbergen, Emily G. Clark, Sara Abrahams, Woosuk S. Hur, Jaap Koopman, Matthew J. Flick
Summary: This study found that changing the ratio of naturally occurring fibrinogen variants in blood could offer significant therapeutic potential against bacterial infection and potentially other diseases.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Review
Microbiology
Amanda de Oliveira Matos, Pedro Henrique dos Santos Dantas, Marcelle Silva-Sales, Helioswilton Sales-Campos
Summary: TREM-1 is an innate immunity receptor associated with inflammation, with its two isoforms (mTREM-1 and sTREM-1) being extensively studied in bacterial diseases and sepsis. The inhibition of the receptor and the use of sTREM-1 as a biomarker have shown promise in treating and diagnosing bacterial infections.
CRITICAL REVIEWS IN MICROBIOLOGY
(2021)
Article
Immunology
Joe Amoah, Eili Y. Klein, Kathleen Chiotos, Sara E. Cosgrove, Pranita D. Tamma
Summary: According to a multicenter observational study, prioritizing administration of beta-lactam over vancomycin for critically ill patients with suspected bloodstream infections may reduce early mortality, highlighting the significant impact of a simple practice change on improving patient survival.
CLINICAL INFECTIOUS DISEASES
(2022)
Review
Chemistry, Analytical
Alejandra Alba-Patino, Andreu Vaquer, Enrique Baron, Steven M. Russell, Marcio Borges, Roberto de la Rica
Summary: This article reviews recent advances in diagnostic tools for managing sepsis based on micro- and nanostructured materials. It discusses popular biomarkers and detection methods for sepsis diagnosis, and highlights the role of micro- and nanostructured materials in developing biosensors to meet the specific needs of different points of sepsis care. The article also summarizes the most utilized materials and points out future challenges for development.
Review
Immunology
Yugo Morita, Elysia A. Masters, Edward M. Schwarz, Gowrishankar Muthukrishnan
Summary: IL-27 is a complex cytokine with both pro-inflammatory and immunosuppressive effects, making its exact role in infectious diseases unclear and in need of further research. Furthermore, as interest grows in managing acute and chronic infections, as well as severe cytokine storms from sepsis, understanding IL-27's dual functions could lead to therapeutic strategies to improve patient outcomes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Critical Care Medicine
Dhruv Sarma, Jacob C. Jentzer
CRITICAL CARE CLINICS
(2024)
Article
Critical Care Medicine
Gurleen Kaur, David D. Berg
CRITICAL CARE CLINICS
(2024)
Article
Critical Care Medicine
Leon Zhou, Brandon M. Wiley
CRITICAL CARE CLINICS
(2024)
Article
Critical Care Medicine
Emily K. Zern, Rachel C. Frank, Evin Yucel
CRITICAL CARE CLINICS
(2024)
Article
Critical Care Medicine
Damien Smith, Benjamin B. Kenigsberg
CRITICAL CARE CLINICS
(2024)
Article
Critical Care Medicine
Gozde Demiralp, Robert T. Arrigo, Christopher Cassara, Maryl R. Johnson
CRITICAL CARE CLINICS
(2024)
Article
Critical Care Medicine
Katie P. Truong, James N. Kirkpatrick
Summary: The increasing use of MCS in advanced heart failure patients has led to a greater need for end-of-life management, including MCS device withdrawal and advance care planning. Preparedness planning and palliative care services are important in ensuring a smooth transition to the end of life. Ethical dilemmas can complicate end-of-life care, and withdrawal/deactivation should follow a set protocol that addresses psychosocial/spiritual needs and patient comfort.
CRITICAL CARE CLINICS
(2024)
Article
Critical Care Medicine
Brent Klinkhammer, Taya V. Glotzer
CRITICAL CARE CLINICS
(2024)
Article
Critical Care Medicine
Jacob B. Pierce, Willard N. Applefeld, Balimkiz Senman, Daniel B. Loriaux, Patrick R. Lawler, Jason N. Katz
Summary: Due to the increasing medical complexity of patients, heterogeneity of treatment effects in broad clinical syndromes, and significant competing risks for morbidity and mortality, future clinical trials in the CICU are likely to benefit from innovative approaches to trial design, analysis, and execution, such as incorporating novel trial endpoints, Bayesian analysis strategies, trial networks and clinical registries, adaptive platform trials, and comprehensive research programs. It will be crucial for the authors as a field to articulate priorities for future research and embrace these novel techniques that will ultimately help take better care of patients in the contemporary CICU.
CRITICAL CARE CLINICS
(2024)
