Prolonged cultured human hepatocytes as an in vitro experimental system for the evaluation of potency and duration of activity of RNA therapeutics: Demonstration of prolonged duration of gene silencing effects of a GalNAc-conjugated human hypoxanthine phosphoribosyl transferase (HPRT1) siRNA

POE Immunoassay: Plate-based oligonucleotide electro-chemiluminescent immunoassay for the quantification of nucleic acids in biological matrices

(2020) Mai B. Thayer et al.   Scientific Reports

Investigating the pharmacodynamic durability of GalNAc–siRNA conjugates

(2020) Christopher R Brown et al.   NUCLEIC ACIDS RESEARCH

Enhancing anti-melanoma outcomes in mice using novel chitooligosaccharide nanoparticles loaded with therapeutic survivin-targeted siRNA

(2020) Xuan Liu et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Dedifferentiation of Primary Hepatocytes is Accompanied with Reorganization of Lipid Metabolism Indicated by Altered Molecular Lipid and miRNA Profiles

(2019) Mostafa Kiamehr et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Enhanced Potency of GalNAc-Conjugated Antisense Oligonucleotides in Hepatocellular Cancer Models

(2019) Youngsoo Kim et al.   MOLECULAR THERAPY

Co-delivery of pretubulysin and siEG5 to EGFR overexpressing carcinoma cells

(2019) Ines Truebenbach et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Nonclinical Safety Profile of Revusiran, a 1st-Generation GalNAc-siRNA Conjugate for Treatment of Hereditary Transthyretin-Mediated Amyloidosis

(2019) Jessica E. Sutherland et al.   Nucleic Acid Therapeutics

Complexation of Chol-DsiRNA in place of Chol-siRNA greatly increases the duration of mRNA suppression by polyplexes of PLL(30)-PEG(5K) in primary murine syngeneic breast tumors after i.v. administration

(2018) Vishakha V. Ambardekar et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Advanced siRNA Designs Further Improve In Vivo Performance of GalNAc-siRNA Conjugates

(2018) Donald J. Foster et al.   MOLECULAR THERAPY

Selection of GalNAc-conjugated siRNAs with limited off-target-driven rat hepatotoxicity

(2018) Maja M. Janas et al.   Nature Communications

GalNAc-siRNA Conjugates: Leading the Way for Delivery of RNAi Therapeutics

(2018) Aaron D. Springer et al.   Nucleic Acid Therapeutics

Receptor-mediated delivery of therapeutic RNA by peptide functionalized curdlan nanoparticles

(2018) Tsogzolmaa Ganbold et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Development of antibody-siRNA conjugate targeted to cardiac and skeletal muscles

(2016) Tsukasa Sugo et al.   JOURNAL OF CONTROLLED RELEASE

Human hepatocytes as an effective alternative experimental system for the evaluation of human drug properties: General concepts and assay procedures

(2016) Albert Li   ALTEX-Alternatives to Animal Experimentation

Biomarkers and human hepatocytes

(2014) Albert P Li   Biomarkers in Medicine

Adenovirus Vectors for Gene Therapy, Vaccination and Cancer Gene Therapy

(2014) William Wold et al.   CURRENT GENE THERAPY

In Vitro Human Hepatocyte-Based Experimental Systems for the Evaluation of Human Drug Metabolism, Drug-Drug Interactions, and Drug Toxicity in Drug Development

(2014) Albert Li   CURRENT TOPICS IN MEDICINAL CHEMISTRY

HepaRG culture in tethered spheroids as anin vitrothree-dimensional model for drug safety screening

(2014) Zenan Wang et al.   JOURNAL OF APPLIED TOXICOLOGY

Co-cultures of enterocytes and hepatocytes for retinoid transport and metabolism

(2012) Carlotta Rossi et al.   TOXICOLOGY IN VITRO

The construction of transgenic and gene knockout/knockin mouse models of human disease

(2011) Alfred Doyle et al.   TRANSGENIC RESEARCH

The siRNA sequence and guide strand overhangs are determinants of in vivo duration of silencing

(2010) Walter R. Strapps et al.   NUCLEIC ACIDS RESEARCH

Evaluation of a microfluidic based cell culture platform with primary human hepatocytes for the prediction of hepatic clearance in human

(2009) P. Chao et al.   BIOCHEMICAL PHARMACOLOGY

Maintaining hepatocyte differentiation in vitro through co-culture with hepatic stellate cells

(2009) Petra Krause et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

Metabolism Comparative Cytotoxicity Assay (MCCA) and Cytotoxic Metabolic Pathway Identification Assay (CMPIA) with cryopreserved human hepatocytes for the evaluation of metabolism-based cytotoxicity in vitro: Proof-of-concept study with aflatoxin B1

(2008) Albert P. Li   CHEMICO-BIOLOGICAL INTERACTIONS