The role of CD23 in the regulation of allergic responses

The mechanistic and functional profile of the therapeutic anti-IgE antibody ligelizumab differs from omalizumab

(2020) Pascal Gasser et al.   Nature Communications

CD23 expression on switched memory B cells bridges T-B cell interaction in allergic rhinitis

(2020) Yin Yao et al.   ALLERGY

Sialylation of immunoglobulin E is a determinant of allergic pathogenicity

(2020) Kai-Ting C. Shade et al.   NATURE

Glycan-specific IgG anti-IgE autoantibodies are protective against allergic anaphylaxis in a murine model

(2020) Paul Engeroff et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IgE re-programs alternatively-activated human macrophages towards pro-inflammatory anti-tumoural states

(2019) Giulia Pellizzari et al.   EBioMedicine

CD23 provides a non-inflammatory pathway for IgE-allergen complexes

(2019) Paul Engeroff et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Allergen-specific IgE levels and ability of IgE-allergen complexes to cross-link determine extent of CD23-mediated T cell activation

(2019) Sergio Villazala-Merino et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

CD23 is a glycan-binding receptor in some mammalian species

(2019) Sabine A. F. Jégouzo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting IgE in allergic disease

(2018) Pascal Gasser et al.   CURRENT OPINION IN IMMUNOLOGY

Trapping IgE in a closed conformation by mimicking CD23 binding prevents and disrupts FcεRI interaction

(2018) Frederic Jabs et al.   Nature Communications

Immunoglobulin E-Mediated Autoimmunity

(2018) Marcus Maurer et al.   Frontiers in Immunology

C-Type Lectin Receptor CD23 Is Required for Host Defense against Candida albicans and Aspergillus fumigatus Infection

(2018) Yahui Guo et al.   JOURNAL OF IMMUNOLOGY

Structural basis for selective inhibition of immunoglobulin E-receptor interactions by an anti-IgE antibody

(2018) Jiun-Bo Chen et al.   Scientific Reports

Nasal Allergen Neutralising IgG4 Antibodies Block IgE-mediated Responses: Novel biomarker of Subcutaneous Grass Pollen Immunotherapy

(2018) Mohamed H. Shamji et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

CD23 surface density on B cells is associated with IgE levels and determines IgE-facilitated allergen uptake, as well as activation of allergen-specific T cells

(2017) Regina Selb et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A novel recycling mechanism of native IgE-antigen complexes in human B cells facilitates transfer of antigen to dendritic cells for antigen presentation

(2017) Paul Engeroff et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Distinct Expression and Function of FcεRII in Human B Cells and Monocytes

(2017) Wenming Peng et al.   JOURNAL OF IMMUNOLOGY

JNK1 negatively controls antifungal innate immunity by suppressing CD23 expression

(2017) Xueqiang Zhao et al.   NATURE MEDICINE

Increasing the breadth and potency of response to the seasonal influenza virus vaccine by immune complex immunization

(2017) Jad Maamary et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IgE binds asymmetrically to its B cell receptor CD23

(2017) Balvinder Dhaliwal et al.   Scientific Reports

A2.12 Increased CXCR5 B cell expression, CXCL13 and SCD23 serum levels in untreated early rheumatoid arthritis patients support B cell activation since the initial phase of the disease

(2016) RA Moura et al.   ANNALS OF THE RHEUMATIC DISEASES

Human IgE-independent systemic anaphylaxis

(2016) Fred D. Finkelman et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Efficacy and safety of multiple doses of QGE031 (ligelizumab) versus omalizumab and placebo in inhibiting allergen-induced early asthmatic responses

(2016) Gail M. Gauvreau et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

International Consensus on Allergen Immunotherapy II: Mechanisms, standardization, and pharmacoeconomics

(2016) Marek Jutel et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Structural basis of omalizumab therapy and omalizumab-mediated IgE exchange

(2016) Luke F. Pennington et al.   Nature Communications

CD23 can negatively regulate B-cell receptor signaling

(2016) Chaohong Liu et al.   Scientific Reports

IgE-mediated enhancement of CD4+ T cell responses requires antigen presentation by CD8α− conventional dendritic cells

(2016) Zhoujie Ding et al.   Scientific Reports

Anti-HA Glycoforms Drive B Cell Affinity Selection and Determine Influenza Vaccine Efficacy

(2015) Taia T. Wang et al.   CELL

Structure and dynamics of IgE-receptor interactions: FcεRI and CD23/FcεRII

(2015) Brian J. Sutton et al.   IMMUNOLOGICAL REVIEWS

International consensus on allergy immunotherapy

(2015) Marek Jutel et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A single glycan on IgE is indispensable for initiation of anaphylaxis

(2015) Kai-Ting C. Shade et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inhibition of CD23-mediated IgE transcytosis suppresses the initiation and development of allergic airway inflammation

(2015) S Palaniyandi et al.   Mucosal Immunology

“Auto-anti-IgE”: Naturally occurring IgG anti-IgE antibodies may inhibit allergen-induced basophil activation

(2014) Yih-Chih Chan et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A Novel B Cell-Mediated Transport of IgE-Immune Complexes to the Follicle of the Spleen

(2014) F. Hjelm et al.   JOURNAL OF IMMUNOLOGY

Antigen Transfer from Exosomes to Dendritic Cells as an Explanation for the Immune Enhancement Seen by IgE Immune Complexes

(2014) Rebecca K. Martin et al.   PLoS One

Antigen Conjugated to Anti-CD23 Antibodies is Rapidly Transported to Splenic Follicles by Recirculating B Cells

(2014) H. Xu et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Allergic diseases and asthma: a global public health concern and a call to action

(2014) Ruby Pawankar   World Allergy Organization Journal

Ca2+-dependent Structural Changes in the B-cell Receptor CD23 Increase Its Affinity for Human Immunoglobulin E

(2013) Daopeng Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adrenergic Regulation of IgE Involves Modulation of CD23 and ADAM10 Expression on Exosomes

(2013) C. J. Padro et al.   JOURNAL OF IMMUNOLOGY

IgG Antibodies in Food Allergy Influence Allergen-Antibody Complex Formation and Binding to B Cells: A Role for Complement Receptors

(2013) L. A. P. M. Meulenbroek et al.   JOURNAL OF IMMUNOLOGY

Conformational plasticity at the IgE-binding site of the B-cell receptor CD23

(2013) Balvinder Dhaliwal et al.   MOLECULAR IMMUNOLOGY

General mechanism for modulating immunoglobulin effector function

(2013) P. Sondermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Different modes of IgE binding to CD23 revealed with major birch allergen, Bet v 1-specific monoclonal IgE

(2012) Kavita Reginald et al.   IMMUNOLOGY AND CELL BIOLOGY

Mapping of the CD23 Binding Site on Immunoglobulin E (IgE) and Allosteric Control of the IgE-FcϵRI Interaction

(2012) Susmita Borthakur et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IgE and mast cells in allergic disease

(2012) Stephen J Galli et al.   NATURE MEDICINE

An anti-IgE monoclonal antibody that binds to IgE on CD23 but not on high-affinity IgE.Fc receptors

(2011) Yu-Yu Shiung et al.   IMMUNOBIOLOGY

Soluble IgE receptors—Elements of the IgE network

(2011) Barbara Platzer et al.   IMMUNOLOGY LETTERS

Facilitated antigen presentation and its inhibition by blocking IgG antibodies depends on IgE repertoire complexity

(2011) Jens Holm et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mechanisms of allergen-specific immunotherapy

(2011) Cezmi A. Akdis et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

CD23-Dependent Transcytosis of IgE and Immune Complex across the Polarized Human Respiratory Epithelial Cells

(2011) S. Palaniyandi et al.   JOURNAL OF IMMUNOLOGY

Conformational changes in IgE contribute to its uniquely slow dissociation rate from receptor FcɛRI

(2011) Mary D Holdom et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

IgE-Mediated Enhancement of CD4+ T Cell Responses in Mice Requires Antigen Presentation by CD11c+ Cells and Not by B Cells

(2011) Frida Henningsson et al.   PLoS One

CD23/FcεRII: molecular multi-tasking

(2010) M. Acharya et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

CD23-mediated cell signaling in human B cells differs from signaling in cells of the monocytic lineage

(2010) Marcia A. Chan et al.   CLINICAL IMMUNOLOGY

CD23 Sheddase A Disintegrin and Metalloproteinase 10 (ADAM10) Is Also Required for CD23 Sorting into B Cell-derived Exosomes

(2010) Joel A. Mathews et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Murine B Cells Regulate Serum IgE Levels in a CD23-Dependent Manner

(2010) L. E. Cheng et al.   JOURNAL OF IMMUNOLOGY

Antigen-loaded exosomes alone induce Th1-type memory through a B cell-dependent mechanism

(2009) K. R. Qazi et al.   BLOOD

CD23 Mediates Antimycobacterial Activity of Human Macrophages

(2009) M. D. Mossalayi et al.   INFECTION AND IMMUNITY

Omalizumab for the treatment of exacerbations in children with inadequately controlled allergic (IgE-mediated) asthma

(2009) Bob Lanier et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The development of allergic inflammation

(2008) Stephen J. Galli et al.   NATURE