Structure and dynamics of IgE-receptor interactions: FcεRI and CD23/FcεRII

A single glycan on IgE is indispensable for initiation of anaphylaxis

(2015) Kai-Ting C. Shade et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inhibition of CD23-mediated IgE transcytosis suppresses the initiation and development of allergic airway inflammation

(2015) S Palaniyandi et al.   Mucosal Immunology

Structure of FcγRI in complex with Fc reveals the importance of glycan recognition for high-affinity IgG binding

(2015) Jinghua Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for binding of human IgG1 to its high-affinity human receptor FcγRI

(2015) Masato Kiyoshi et al.   Nature Communications

Accelerated dissociation of IgE-FcεRI complexes by disruptive inhibitors actively desensitizes allergic effector cells

(2014) Alexander Eggel et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The ensemble nature of allostery

(2014) Hesam N. Motlagh et al.   NATURE

Human immunoglobulin E flexes between acutely bent and extended conformations

(2014) Nyssa Drinkwater et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

How calcium makes endocytic receptors attractive

(2014) Christian B.F. Andersen et al.   TRENDS IN BIOCHEMICAL SCIENCES

Ca2+-dependent Structural Changes in the B-cell Receptor CD23 Increase Its Affinity for Human Immunoglobulin E

(2013) Daopeng Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Site-Specific N-Glycosylation Analysis of Human Immunoglobulin E

(2013) Rosina Plomp et al.   JOURNAL OF PROTEOME RESEARCH

IgE immunotherapy

(2013) Debra H Josephs et al.   mAbs

Conformational plasticity at the IgE-binding site of the B-cell receptor CD23

(2013) Balvinder Dhaliwal et al.   MOLECULAR IMMUNOLOGY

Mapping of the CD23 Binding Site on Immunoglobulin E (IgE) and Allosteric Control of the IgE-FcϵRI Interaction

(2012) Susmita Borthakur et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Fluorescent Biosensor Reveals Conformational Changes in Human Immunoglobulin E Fc

(2012) James Hunt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Soluble CD23 Controls IgE Synthesis and Homeostasis in Human B Cells

(2012) A. M. Cooper et al.   JOURNAL OF IMMUNOLOGY

Accelerated disassembly of IgE–receptor complexes by a disruptive macromolecular inhibitor

(2012) Beomkyu Kim et al.   NATURE

Antibody-enabled small-molecule drug discovery

(2012) Alastair D. G. Lawson   NATURE REVIEWS DRUG DISCOVERY

Crystal structure of IgE bound to its B-cell receptor CD23 reveals a mechanism of reciprocal allosteric inhibition with high affinity receptor Fc RI

(2012) B. Dhaliwal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Basis of the Intrinsic Flexibility of the Cε3 Domain of IgE

(2011) Susmita Borthakur et al.   BIOCHEMISTRY

Recombinant IgE antibodies for passive immunotherapy of solid tumours: from concept towards clinical application

(2011) Sophia N. Karagiannis et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Comparative binding of soluble fragments (derCD23, sCD23, and exCD23) of recombinant human CD23 to CD21 (SCR 1-2) and native IgE, and their effect on IgE regulation

(2011) Sandra Lyn Bowles et al.   CELLULAR IMMUNOLOGY

An anti-IgE monoclonal antibody that binds to IgE on CD23 but not on high-affinity IgE.Fc receptors

(2011) Yu-Yu Shiung et al.   IMMUNOBIOLOGY

Crystal Structure of Fcγ Receptor I and Its Implication in High Affinity γ-Immunoglobulin Binding

(2011) Jinghua Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CD23-Dependent Transcytosis of IgE and Immune Complex across the Polarized Human Respiratory Epithelial Cells

(2011) S. Palaniyandi et al.   JOURNAL OF IMMUNOLOGY

Conformational changes in IgE contribute to its uniquely slow dissociation rate from receptor FcɛRI

(2011) Mary D Holdom et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

CD23/FcεRII: molecular multi-tasking

(2010) M. Acharya et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

The High Affinity IgE Receptor FcεRI Is Expressed by Human Intestinal Epithelial Cells

(2010) Eva Untersmayr et al.   PLoS One

Conformational Flexibility in Immunoglobulin E-Fc3–4 Revealed in Multiple Crystal Forms

(2009) Beth A. Wurzburg et al.   JOURNAL OF MOLECULAR BIOLOGY