Article
Allergy
Mohamed H. Shamji, David Larson, Aarif Eifan, Guy W. Scadding, Tielin Qin, Kaitie Lawson, Michelle L. Sever, Ellen Macfarlane, Janice A. Layhadi, Peter A. Wurtzen, Rebecca Parkin, Srinath Sanda, Kristina M. Harris, Gerald T. Nepom, Alkis Togias, Stephen R. Durham
Summary: The study compared allergic responses in nasal and systemic fluids during sublingual immunotherapy (SLIT) and subcutaneous immunotherapy (SCIT) for grass pollen allergy, suggesting key differences in immunological mechanisms between the two treatments.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Review
Allergy
Mohamed H. Shamji, Rudolf Valenta, Theodore Jardetzky, Valerie Verhasselt, Stephen R. Durham, Peter A. Wurtzen, R. J. Joost van Neerven
Summary: IgE-mediated allergy is a common hypersensitivity disease impacting over 30% of the population. Allergen-specific IgE triggers release of inflammatory mediators, while inducing IgG and IgA antibodies can compete with IgE for allergen binding to prevent allergic responses. Anti-IgE treatment can also prevent IgE from binding to receptors on mast cells and basophils to inhibit allergic reactions.
Article
Immunology
Yasmeen S. El Ansari, Cynthia Kanagaratham, Oliver T. Burton, Jenna V. Santos, Brianna-Marie A. Hollister, Owen L. Lewis, Harald Renz, Hans C. Oettgen
Summary: Mast cells and basophils play important roles in IgE-mediated hypersensitivity reactions. IgG and IgA antibodies can regulate the activation of these cells by activating or inhibiting receptors. This study found that IgA antibodies can bind to mast cells and basophils, and inhibit their activation to maintain immune homeostasis at mucosal sites.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Simon Zinkhan, Franziska Thoms, Gilles Augusto, Monique Vogel, Martin F. Bachmann
Summary: Comparing the abilities of IgG1 and IgG4 to inhibit allergic reactions, the study found that both subclasses have similar effects in neutralizing allergens and engaging the inhibitory receptor Fc gamma RIIb. Therefore, the role of IgG subclasses in the protective efficacy of allergen-specific immunotherapy is limited.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Soheila Asoudeh Moghanloo, Mohsen Forouzanfar, Mojtaba Jafarinia, Mohammad R. Fazlollahi, Gholam Ali Kardar
Summary: This study aimed to construct a recombinant protein derived from rDer p1 peptides and evaluate its immunotherapy efficiency by measuring the response of IgE and IgG antibodies. The results showed that the recombinant protein increased IgG antibody levels, decreased IgE-dependent reactivity to rDer p1, and reduced inflammatory cytokines IL-4 and IL-13.
IMMUNITY INFLAMMATION AND DISEASE
(2023)
Review
Allergy
Syed Hasan Arshad
Summary: Asthma and allergic rhinitis share similar features and can be treated with allergen immunotherapy (AIT) to improve symptoms and reduce medication usage. AIT is the only known treatment that can modify the natural course of allergic disease and induce long-term remission. However, more research is needed to determine the effectiveness of AIT in preventing asthma, and studies with larger sample sizes and cost-effectiveness evaluations are necessary.
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2022)
Article
Allergy
Maria R. Strobl, Hilal Demir, Gabriela Sanchez Acosta, Anja Drescher, Claudia Kitzmueller, Christian Moebs, Wolfgang Pfuetzner, Barbara Bohle
Summary: The blocking activity and avidity of allergen-specific IgG1 and IgG4 antibodies were monitored throughout 3 years of allergen immunotherapy (AIT). It was found that IgG1 dominated in the early stage of AIT, while IgG4 played an important role in IgE-blocking activity. Depletion of IgG1 significantly reduced the inhibition of basophil activation in the first year of therapy, while the absence of IgG4 hardly affected IgE-blocking.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Review
Health Care Sciences & Services
Kawita Atipas, Dichapong Kanjanawasee, Pongsakorn Tantilipikorn
Summary: This review examines the use of intradermal immunotherapy (IDIT) in the treatment of allergic rhinitis, including its advantages and effects. However, the current evidence on IDIT is conflicting, and further clinical trials are needed to determine its clinical utility and optimal treatment protocols.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Allergy
Oliver Pfaar, Angelika Sager, Ralph Moesges, Margitta Worm
Summary: This study aimed to evaluate the efficacy of different doses of depigmented, polymerized birch pollen extract in treating patients with birch-pollen-induced allergic rhinitis or rhinoconjunctivitis. The results showed that higher doses had better treatment outcomes, with mild or moderate adverse events.
CLINICAL AND TRANSLATIONAL ALLERGY
(2023)
Article
Immunology
Haifeng Zhong, Xuxin Lai, Jing Li, Xiaoxiong Xiao, Shi Chen, Peter Adler Wuertzen
Summary: This study introduced a novel ELIFAB assay for monitoring IgE-blocking activity induced by allergen immunotherapy, which can help understand the long-term effects of immunotherapy.
Article
Allergy
Paul Engeroff, Kevin Plattner, Federico Storni, Franziska Thoms, Kayluz Frias Boligan, Lukas Muerner, Alexander Eggel, Stephan von Gunten, Martin F. Bachmann, Monique Vogel
Summary: The study demonstrates that glycan-specific IgG anti-IgE autoantibodies can downregulate serum IgE levels and anaphylactic activity, providing potential therapeutic implications for allergic diseases.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Immunology
I-Hui Lin, Ming-Chin Tsai, Jun-Peng Chen, Lin-Shien Fu
Summary: The study found that for two thirds of atopic children, a specific allergen could be identified during follow-up tests. Specific allergens could be identified through MAST tests and further assist in treatment options.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2021)
Review
Immunology
Nishelle D'souza, Milena Weber, Eszter Sarzsinszky, Susanne Vrtala, Mirela Curin, Mirjam Schaar, Victoria Garib, Margarete Focke-Tejkl, Yanqiu Li, Richard Jones, Hao Chen, Rudolf Valenta, Baoqing Sun
Summary: Approximately 30% of the global population suffers from IgE-mediated allergy, with China having the largest population and over 400 million allergic patients. Allergy prevention and treatment strategies include allergen avoidance, vaccination, and tolerance induction, requiring a detailed understanding of relevant allergen molecules affecting specific populations.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Medicine, Research & Experimental
Kevin Tie, Craig Miller, Adam M. Zanation, Charles S. Ebert
Summary: The study found that SCIT and SLIT are equally effective treatments for adults with AR/C, but more randomized controlled trials are needed to directly compare the two methods.
Review
Food Science & Technology
Ziye Zhang, Xiu-Min Li, Hao Wang, Hong Lin, Hang Xiao, Zhenxing Li
Summary: This paper provides an overview of seafood allergens, IgE-binding epitopes, and allergen immunotherapy for seafood allergies, highlighting the importance of identifying and characterizing allergens for allergy diagnosis and treatment.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Allergy
Mariana Farraia, Ines Paciencia, Francisca Castro Mendes, Joao Cavaleiro Rufo, Mohamed Shamji, Ioana Agache, Andre Moreira
Summary: This study aimed to assess the preventive role of allergen immunotherapy (AIT) in asthma onset. The findings suggest a potential preventive effect of AIT in asthma onset, particularly in children completing 3 years of therapy and in mono-sensitized patients.
Review
Biochemistry & Molecular Biology
Ioana Agache, Elizabeth Palmer, Didem Sanver, Max Kirtland, Mohamed H. Shamji
Summary: Allergic asthma, a commonly encountered subtype of asthma, lacks precise understanding of its mechanisms and targeted interventions for optimal response. This article explores the potential of molecular allergology approach in achieving better understanding, accurate diagnosis, and optimal management of allergic asthma patients.
MOLECULAR ASPECTS OF MEDICINE
(2022)
Letter
Allergy
Marina Labella, Jose Antonio Cespedes, Inmaculada Dona, Mohamed H. Shamji, Ioana Agache, Cristobalina Mayorga, Maria Jose Torres
Article
Immunology
Leonardo Cristinziano, Luca Modestino, Mariaelena Capone, Gabriele Madonna, Domenico Mallardo, Diana Giannarelli, Grazia DAngelo, Anne Lise Ferrara, Stefania Loffredo, Gilda Varricchi, Vito Vanella, Lucia Festino, Paolo Antonio Ascierto, Maria Rosaria Galdiero
Summary: PD-L1(+) PMN frequency emerges as a novel biomarker in stage IV BRAF wild type melanoma patients undergoing anti-PD-1 immunotherapy. This study found that neutrophils in melanoma patients displayed an activated phenotype and increased PD-L1 levels, and patients with lower PD-L1(+) PMN frequencies showed better survival outcomes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Gilda Varricchi, Remo Poto, Anne Lise Ferrara, Giuseppina Gambino, Gianni Marone, Giuseppe Rengo, Stefania Loffredo, Leonardo Bencivenga
Summary: This study analyzed the plasma concentrations of angiogenic and lymphangiogenic factors as well as the plasma activity of sPLA2 in patients with HFpEF and HFrEF. The results showed selective alterations of these factors in HFrEF and HFpEF patients, indicating the importance of further studies to determine the clinical implications.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Allergy
Mohamed H. Shamji, Markus Ollert, Ian M. Adcock, Oscar Bennett, Alberto Favaro, Roudin Sarama, Carmen Riggioni, Isabella Annesi-Maesano, Adnan Custovic, Sara Fontanella, Claudia Traidl-Hoffmann, Kari Nadeau, Lorenzo Cecchi, Magdalena Zemelka-Wiacek, Cezmi A. Akdis, Marek Jutel, Ioana Agache
Summary: Allergic diseases and asthma are closely connected to our living environment and patterns of exposure. The utilization of artificial intelligence and machine-learning methods can help unlock the potential of complex environmental data sets for understanding causality models of exposure and intervention. This article discusses the progress and future prospects of applying these approaches, as well as examples of machine learning in allergic disease research and its integration with representative exposome data. The promise of artificial intelligence in personalized medicine and improving public health is also explored.
Review
Allergy
Vanitha Sampath, Omar Shalakhti, Erika Veidis, Jo Ann Ifeoma Efobi, Mohamed H. Shamji, Ioana Agache, Chrysanthi Skevaki, Harald Renz, Kari C. Nadeau
Summary: Heat waves are becoming more intense, frequent, and long-lasting, causing significant heat stress on living organisms. This stress negatively impacts plants, animals, and humans, affecting various aspects of their functioning and leading to physiological and behavioral changes. This review summarizes the effects of heat stress on plants and animals and explores the adaptive mechanisms evolved to mitigate this stress.
Review
Allergy
Jean Bousquet, Mohamed H. Shamji, Josep M. Anto, Holger J. Schuenemann, G. Walter Canonica, Marek Jutel, Stefano Del Giacco, Torsten Zuberbier, Oliver Pfaar, Joao A. Fonseca, Bernardo Sousa-Pinto, Ludger Klimek, Wienczyslawa Czarlewski, Anna Bedbrook, Rita Amaral, Ignacio J. Ansotegui, Sinthia Bosnic-Anticevich, Fulvio Braido, Claudia Chaves Loureiro, Bilun Gemicioglu, Tari Haahtela, Marek Kulus, Piotr Kuna, Maciej Kupczyk, Paolo M. Matricardi, Frederico S. Regateiro, Boleslaw Samolinski, Mikhail Sofiev, Sanna Toppila-Salmi, Arunas Valiulis, Maria Teresa Ventura, Cristina Barbara, Karl C. Bergmann, Michael Bewick, Hubert Blain, Matteo Bonini, Louis-Philippe Boulet, Rodolphe Bourret, Guy Brusselle, Luisa Brussino, Roland Buhl, Victoria Cardona, Thomas Casale, Lorenzo Cecchi, Denis Charpin, Ivan Cherrez-Ojeda, Derek K. Chu, Cemal Cingi, Elisio M. Costa, Alvaro A. Cruz, Philippe Devillier, Stephanie Dramburg, Wytske J. Fokkens, Maia Gotua, Enrico Heffler, Zhanat Ispayeva, Juan Carlos Ivancevich, Guy Joos, Igor Kaidashev, Helga Kraxner, Violeta Kvedariene, Desiree E. Larenas-Linnemann, Daniel Laune, Olga Lourenco, Renaud Louis, Mika Makela, Michael Makris, Marcus Maurer, Erik Melen, Yann Micheli, Mario Morais-Almeida, Joaquim Mullol, Marek Niedoszytko, Robyn O'Hehir, Yoshitaka Okamoto, Heidi Olze, Nikolaos G. Papadopoulos, Alberto Papi, Vincenzo Patella, Benoit Petre, Nhan Pham-Thi, Francesca Puggioni, Santiago Quirce, Nicolas Roche, Philip W. Rouadi, Ana Sa-Sousa, Hironori Sagara, Joaquin Sastre, Nicola Scichilone, Aziz Sheikh, Milan Sova, Charlotte Suppli Ulrik, Luis Taborda-Barata, Ana Todo-Bom, Maria J. Torres, Ioanna Tsiligianni, Omar S. Usmani, Erkka Valovirta, Tuula Vasankari, Rafael Jose Vieira, Dana Wallace, Susan Waserman, Mihaela Zidarn, Arzu Yorgancioglu, Luo Zhang, Tomas Chivato, Markus Ollert
Summary: Biomarkers, especially digital biomarkers, are urgently needed in the diagnosis, treatment and follow-up of patients with rhinitis and/or asthma. The lack of validated biomarkers in primary care poses a challenge, but the digital transformation of health care holds potential in improving allergy management. The Allergic Rhinitis and its Impact on Asthma (ARIA) and the European Academy of Allergy and Clinical Immunology (EAACI) have developed patient-reported outcome measures (PROMs) as digital biomarkers for rhinitis and asthma, including control biomarkers and quality-of-life biomarkers.
Article
Biochemistry & Molecular Biology
Francesco Palestra, Remo Poto, Renato Ciardi, Giorgia Opromolla, Agnese Secondo, Valentina Tedeschi, Anne Lise Ferrara, Rosa Maria Di Crescenzo, Maria Rosaria Galdiero, Leonardo Cristinziano, Luca Modestino, Gianni Marone, Alfonso Fiorelli, Gilda Varricchi, Stefania Loffredo
Summary: COVID-19 is a viral disease caused by SARS-CoV-2, primarily characterized by respiratory tract inflammation. Spike protein plays a key role in SARS-CoV-2 infection by binding to ACE2 and activating TMPRSS2. Lung macrophages are important immune cells in the lung and their activation and expression of ACE2 and TMPRSS2 are influenced by spike protein.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Allergy
M. Pascal, S. M. Edelman, A. Nopp, C. Moebs, W. J. Geilenkeuser, E. F. Knol, D. G. Ebo, C. Mertens, M. H. Shamji, A. F. Santos, S. Patil, B. Eberlein, C. Mayorga, H. J. Hoffmann
Article
Allergy
Ralph Moesges, Christoph Zeyen, Esther Raskopf, Cengizhan Acikel, Hacer Sahin, Silke Allekotte, Mandy Cuevas, Mohamed H. Shamji, Jose Luis Subiza, Miguel Casanovas
Summary: The aim of this study was to determine the optimal dose of mannan-conjugated birch pollen allergoids for the treatment of birch pollen-induced allergies. The results showed that all doses of mannan-conjugated birch pollen allergoids were safe, with the highest dose of 10,000 mTU/mL demonstrating the greatest efficacy.
Correction
Medicine, Research & Experimental
Remo Poto, Gianluca Ianiro, Amato de Paulis, Giuseppe Spadaro, Gianni Marone, Antonio Gasbarrini, Gilda Varricchi
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Review
Medicine, Research & Experimental
Remo Poto, Gianluca Laniro, Amato de Paulis, Giuseppe Spadaro, Gianni Marone, Antonio Gasbarrini, Gilda Varricchi
Summary: Common variable immunodeficiency (CVID) is a primary immunodeficiency characterized by low immunoglobulin levels and susceptibility to infections, autoimmune disorders, and cancer. The exact cause of CVID is unknown, but there is evidence supporting a link between the gut microbiome and CVID pathogenesis. This suggests that microbiome-based treatments, such as diet, prebiotics, probiotics, postbiotics, and fecal microbiota transplantation, could be potential therapeutic approaches for CVID.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Remo Poto, Vincenzo Patella, Gjada Criscuolo, Gianni Marone, Enrico Coscioni, Gilda Varricchi
Summary: Mast cells have complex functions in tissue homeostasis and disease. Cardiac mast cells express the high-affinity receptor for IgE and can be activated by anti-IgE. The presence of functional anti-IgE autoantibodies can strongly activate mast cells to release proinflammatory and vasoactive mediators.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Gilda Varricchi, Remo Poto, Bianca Covelli, Gaetano Di Spigna, Maria Rosaria Galdiero, Gianni Marone, Loredana Postiglione, Giuseppe Spadaro
Summary: Immunoglobulin A plays a crucial role in mucosal homeostasis. This study found that asthmatics have higher levels of total IgA compared to healthy controls, with male asthmatics showing a more significant increase. Male asthmatics also have increased levels of IgA1, while female asthmatics do not. The concentrations of IgG2 are reduced in asthmatics, and female asthmatics have lower levels of IgG4 compared to males.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)