Photoactivated inhibition of cathepsin K in a 3D tumor model

Inhibition of Cathepsin Activity in a Cell-Based Assay by a Light-Activated Ruthenium Compound

(2014) Tomasz Respondek et al.   ChemMedChem

Ruthenium Tris(2-pyridylmethyl)amine as an Effective Photocaging Group for Nitriles

(2014) Rajgopal Sharma et al.   INORGANIC CHEMISTRY

Efficacy of a Cathepsin K Inhibitor in a Preclinical Model for Prevention and Treatment of Breast Cancer Bone Metastasis

(2014) L. T. Duong et al.   MOLECULAR CANCER THERAPEUTICS

Two-Photon Optical Interrogation of Individual Dendritic Spines with Caged Dopamine

(2013) Roberto Araya et al.   ACS Chemical Neuroscience

Light-Controlled Tools

(2012) Clara Brieke et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Trans,trans,trans-[PtIV(N3)2(OH)2(py)(NH3)]: A Light-Activated Antitumor Platinum Complex That Kills Human Cancer Cells by an Apoptosis-Independent Mechanism

(2012) A. F. Westendorf et al.   MOLECULAR CANCER THERAPEUTICS

Macrophage cathepsin K promotes prostate tumor progression in bone

(2012) M K Herroon et al.   ONCOGENE

Optical control of focal epilepsy in vivo with caged γ-aminobutyric acid

(2011) Xiaofeng Yang et al.   ANNALS OF NEUROLOGY

Morphea-like skin reactions in patients treated with the cathepsin K inhibitor balicatib

(2011) Thomas M. Rnger et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Keys for Unlocking Photolabile Metal-Containing Cages

(2010) Katie L. Ciesienski et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Highly Potent and Selective Caspase 1 Inhibitor that Utilizes a Key 3-Cyanopropanoic Acid Moiety

(2010) Matthew B. Boxer et al.   ChemMedChem

Development of Nitrile-Based Peptidic Inhibitors of Cysteine Cathepsins

(2010) Maxim Frizler et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Nitrile-Containing Pharmaceuticals: Efficacious Roles of the Nitrile Pharmacophore

(2010) Fraser F. Fleming et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Review of Three-Dimensional In Vitro Tissue Models for Drug Discovery and Transport Studies

(2010) Nelita T. Elliott et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Illuminating the Chemistry of Life: Design, Synthesis, and Applications of “Caged” and Related Photoresponsive Compounds

(2009) Hsien-Ming Lee et al.   ACS Chemical Biology

Photochemotherapy: Targeted Activation of Metal Anticancer Complexes

(2009) Nicola J. Farrer et al.   AUSTRALIAN JOURNAL OF CHEMISTRY

Photoactivated chemotherapy (PACT): the potential of excited-state d-block metals in medicine

(2009) Nicola J. Farrer et al.   DALTON TRANSACTIONS

The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K

(2008) Jacques Yves Gauthier et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS