Recognition and Removal of Amyloid‐β by a Heteromultivalent Macrocyclic Coassembly: A Potential Strategy for the Treatment of Alzheimer's Disease

Inhibition of insulin fibrillation by amphiphilic sulfonatocalixarene

(2020) Hong Zhao et al.   CHINESE CHEMICAL LETTERS

Drug repositioning and repurposing for Alzheimer disease

(2020) Clive Ballard et al.   Nature Reviews Neurology

Amyloidosis inhibition, a new frontier of the protein corona

(2020) Pengyu Chen et al.   Nano Today

A critical appraisal of amyloid-β-targeting therapies for Alzheimer disease

(2019) Francesco Panza et al.   Nature Reviews Neurology

Alzheimer's Disease: Microenvironment Remodeling Micelles for Alzheimer's Disease Therapy by Early Modulation of Activated Microglia (Adv. Sci. 4/2019)

(2019) Yifei Lu et al.   Advanced Science

Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease

(2019) D. Allan Butterfield et al.   NATURE REVIEWS NEUROSCIENCE

Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer’s disease

(2019) Antonio Boza-Serrano et al.   ACTA NEUROPATHOLOGICA

Association of Amyloid Positron Emission Tomography With Subsequent Change in Clinical Management Among Medicare Beneficiaries With Mild Cognitive Impairment or Dementia

(2019) Gil D. Rabinovici et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Tetrameric Aβ40 and Aβ42 β-Barrel Structures by Extensive Atomistic Simulations. I. In a Bilayer Mimicking a Neuronal Membrane

(2019) Phuong H. Nguyen et al.   JOURNAL OF PHYSICAL CHEMISTRY B

General Method for Peptide Recognition in Water through Bioinspired Complementarity

(2019) Shixin Fa et al.   CHEMISTRY OF MATERIALS

Tetrameric Aβ40 and Aβ42 β-Barrel Structures by Extensive Atomistic Simulations. II. In Aqueous Solution

(2019) Phuong H. Nguyen et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Selenium Nanoparticles as an Efficient Nanomedicine for the Therapy of Huntington’s Disease

(2019) Wenshu Cong et al.   ACS Applied Materials & Interfaces

Inhibition of amyloid beta toxicity in zebrafish with a chaperone-gold nanoparticle dual strategy

(2019) Ibrahim Javed et al.   Nature Communications

Toward a Rational Design to Regulate β-Amyloid Fibrillation for Alzheimer’s Disease Treatment

(2018) Xu Han et al.   ACS Chemical Neuroscience

Tau-Targeted Multifunctional Nanocomposite for Combinational Therapy of Alzheimer’s Disease

(2018) Qing Chen et al.   ACS Nano

The antioxidant xanthorrhizol prevents amyloid-β-induced oxidative modification and inactivation of neprilysin

(2018) Chol Seung Lim et al.   BIOSCIENCE REPORTS

Graphene quantum dots prevent α-synucleinopathy in Parkinson’s disease

(2018) Donghoon Kim et al.   Nature Nanotechnology

Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer’s Disease Models

(2018) C.Y. Daniel Lee et al.   NEURON

Resveratrol attenuates oxidative damage through activating mitophagy in an in vitro model of Alzheimer’s disease

(2018) Hui Wang et al.   TOXICOLOGY LETTERS

Gantenerumab: A Novel Human Anti-Aβ Antibody Demonstrates Sustained Cerebral Amyloid-β Binding and Elicits Cell-Mediated Removal of Human Amyloid-β

(2018) Bernd Bohrmann et al.   JOURNAL OF ALZHEIMERS DISEASE

Evidence for Early Cognitive Impairment Related to Frontal Cortex in the 5XFAD Mouse Model of Alzheimer's Disease

(2018) Stéphane D. Girard et al.   JOURNAL OF ALZHEIMERS DISEASE

Focused ultrasound combined with microbubble-mediated intranasal delivery of gold nanoclusters to the brain

(2018) Dezhuang Ye et al.   JOURNAL OF CONTROLLED RELEASE

Nanocomposites Inhibit the Formation, Mitigate the Neurotoxicity, and Facilitate the Removal of β-Amyloid Aggregates in Alzheimer’s Disease Mice

(2018) Yu Zhao et al.   NANO LETTERS

Heteromultivalent peptide recognition by co-assembly of cyclodextrin and calixarene amphiphiles enables inhibition of amyloid fibrillation

(2018) Zhe Xu et al.   Nature Chemistry

Stabilization, Assembly, and Toxicity of Trimers Derived from Aβ

(2017) Adam G. Kreutzer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer’s disease

(2017) Carmen Venegas et al.   NATURE

Anti-inflammatory (M2) macrophage media reduce transmission of oligomeric amyloid beta in differentiated SH-SY5Y cells

(2017) Valerie Sackmann et al.   NEUROBIOLOGY OF AGING

A Near-Infrared Responsive Drug Sequential Release System for Better Eradicating Amyloid Aggregates

(2017) Mengmeng Ma et al.   Small

A resorcinarene for inhibition of Aβ fibrillation

(2017) Xu Han et al.   Chemical Science

Neuroinflammation in Alzheimer's Disease: Mechanisms, Pathologic Consequences, and Potential for Therapeutic Manipulation

(2017) Kenneth Hensley   JOURNAL OF ALZHEIMERS DISEASE

para-Sulfonatocalix[n]arenes Inhibit Amyloid β-Peptide Fibrillation and Reduce Amyloid Cytotoxicity

(2016) Ziyuan Wang et al.   Chemistry-An Asian Journal

Rapamycin Effectively Impedes Melamine-Induced Impairments of Cognition and Synaptic Plasticity in Wistar Rats

(2016) Jingxuan Fu et al.   MOLECULAR NEUROBIOLOGY

Failed Alzheimer’s trial does not kill leading theory of disease

(2016) Alison Abbott et al.   NATURE

The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

(2016) Jeff Sevigny et al.   NATURE

HP-β-cyclodextrin as an inhibitor of amyloid-β aggregation and toxicity

(2016) Baiping Ren et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Structure of Crenezumab Complex with Aβ Shows Loss of β-Hairpin

(2016) Mark Ultsch et al.   Scientific Reports

Microglial M1/M2 polarization and metabolic states

(2015) Ruben Orihuela et al.   BRITISH JOURNAL OF PHARMACOLOGY

Amyloid β Protein and Alzheimer’s Disease: When Computer Simulations Complement Experimental Studies

(2015) Jessica Nasica-Labouze et al.   CHEMICAL REVIEWS

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Autophagy Alleviates Melamine-Induced Cell Death in PC12 Cells Via Decreasing ROS Level

(2015) Hui Wang et al.   MOLECULAR NEUROBIOLOGY

Maintenance of Amyloid β Peptide Homeostasis by Artificial Chaperones Based on Mixed-Shell Polymeric Micelles

(2014) Fan Huang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Appraisal of the effect of brain impregnation duration on neuronal staining and morphology in a modified Golgi–Cox method

(2014) Sareesh Naduvil Narayanan et al.   JOURNAL OF NEUROSCIENCE METHODS

Lipid–polymer hybrid nanoparticles as a new generation therapeutic delivery platform: A review

(2013) Kunn Hadinoto et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

The interplay between Hebbian and homeostatic synaptic plasticity

(2013) Nathalia Vitureira et al.   JOURNAL OF CELL BIOLOGY

Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study

(2013) Victor L Villemagne et al.   LANCET NEUROLOGY

Oxidative stress in cells near amyloid plaques linked to neuronal death

(2013) Bryony Jones   Nature Reviews Neurology

Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β

(2012) Justin M. Nussbaum et al.   NATURE

TLR2 Is a Primary Receptor for Alzheimer's Amyloid   Peptide To Trigger Neuroinflammatory Activation

(2011) S. Liu et al.   JOURNAL OF IMMUNOLOGY

Molecular mechanism of Thioflavin-T binding to amyloid fibrils

(2010) Matthew Biancalana et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Bioconjugation of Ultrabright Semiconducting Polymer Dots for Specific Cellular Targeting

(2010) Changfeng Wu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Caspases first

(2010) Jesús Avila   Nature Reviews Neurology

Protection of PC12 cells from chemical ischemia induced oxidative stress by Fagonia arabica

(2009) Ravindra M. Satpute et al.   FOOD AND CHEMICAL TOXICOLOGY

A  Immunotherapy: Intracerebral Sequestration of A  by an Anti-A  Monoclonal Antibody 266 with High Affinity to Soluble A 

(2009) K. Yamada et al.   JOURNAL OF NEUROSCIENCE

Alzheimer's disease: a global challenge for the 21st century

(2009) Jean François Dartigues   LANCET NEUROLOGY

Detection of behavioral alterations and learning deficits in mice lacking synaptophysin

(2009) U. Schmitt et al.   NEUROSCIENCE

Oligomeric amyloid   associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques

(2009) R. M. Koffie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SYMPOSIUM: Clearance of Aβ from the Brain in Alzheimer's Disease: Aβ-Degrading Enzymes in Alzheimer's Disease

(2008) James Scott Miners et al.   BRAIN PATHOLOGY

Quantitative Prediction of Amyloid Fibril Growth of Short Peptides from Simulations: Calculating Association Constants To Dissect Side Chain Importance

(2008) Maarten G. Wolf et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Inhibition of Amyloid β Protein Fibrillation by Polymeric Nanoparticles

(2008) Celia Cabaleiro-Lago et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Impairments in remote memory stabilization precede hippocampal synaptic and cognitive failures in 5XFAD Alzheimer mouse model

(2008) Ryoichi Kimura et al.   NEUROBIOLOGY OF DISEASE