Thioridazine requires calcium influx to induce MLL-AF6–rearranged AML cell death

Cancer and the dopamine D2 receptor: a pharmacological perspective

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A high-throughput screen indicates gemcitabine and JAK inhibitors may be useful for treating pediatric AML

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Thioridazine enhances sensitivity to carboplatin in human head and neck cancer cells through downregulation of c-FLIP and Mcl-1 expression

(2017) Seung Un Seo et al.   Cell Death & Disease

Dopamine receptor D2 is correlated with gastric cancer prognosis

(2017) Jiasheng Mu et al.   Oncology Letters

Evolution of AF6-RAS association and its implications in mixed-lineage leukemia

(2017) Matthew J. Smith et al.   Nature Communications

Annexin A6—A multifunctional scaffold in cell motility

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Targeting calcium signaling in cancer therapy

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Characterization of Rare, Dormant, and Therapy-Resistant Cells in Acute Lymphoblastic Leukemia

(2016) Sarah Ebinger et al.   CANCER CELL

Actin ADP-ribosylation at Threonine148 by Photorhabdus luminescens toxin TccC3 induces aggregation of intracellular F-actin

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NUP98-fusion transcripts characterize different biological entities within acute myeloid leukemia: a report from the AIEOP-AML group

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Targeting Lung Cancer Stem Cells with Antipsychological Drug Thioridazine

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Dopamine receptor antagonist thioridazine inhibits tumor growth in a murine breast cancer model

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Identification of thioridazine, an antipsychotic drug, as an antiglioblastoma and anticancer stem cell agent using public gene expression data

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Calcium and ROS: A mutual interplay

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Pediatric AML: From Biology to Clinical Management

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MLL-AF6 fusion oncogene sequesters AF6 into the nucleus to trigger RAS activation in myeloid leukemia

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AF10 Regulates Progressive H3K79 Methylation and HOX Gene Expression in Diverse AML Subtypes

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Thioridazine specifically sensitizes drug-resistant cancer cells through highly increase in apoptosis and P-gp inhibition

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Structural Analysis of Phenothiazine Derivatives as Allosteric Inhibitors of the MALT1 Paracaspase

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CBFA2T3-GLIS2 fusion transcript is a novel common feature in pediatric, cytogenetically normal AML, not restricted to FAB M7 subtype

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Results of the AIEOP AML 2002/01 multicenter prospective trial for the treatment of children with acute myeloid leukemia

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AF-6 is a positive modulator of the PINK1/parkin pathway and is deficient in Parkinson's disease

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Dasatinib in Children and Adolescents With Relapsed or Refractory Leukemia: Results of the CA180-018 Phase I Dose-Escalation Study of the Innovative Therapies for Children With Cancer Consortium

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New drugs for children and adolescents with cancer: the need for novel development pathways

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Identification of Drugs Including a Dopamine Receptor Antagonist that Selectively Target Cancer Stem Cells

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MLL partner genes drive distinct gene expression profiles and genomic alterations in pediatric acute myeloid leukemia: an AIEOP study

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Self-association mediated by the Ras association 1 domain of AF6 activates the oncogenic potential of MLL-AF6

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A gene signature-based approach identifies thioridazine as an inhibitor of phosphatidylinositol-3′-kinase (PI3K)/AKT pathway in ovarian cancer cells

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Phenothiazines inhibit S100A4 function by inducing protein oligomerization

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Novel prognostic subgroups in childhood 11q23/MLL-rearranged acute myeloid leukemia: results of an international retrospective study

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Stepping test in mice: A reliable approach in determining forelimb akinesia in MPTP-induced Parkinsonism

(2009) Shannon R. Blume et al.   EXPERIMENTAL NEUROLOGY

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Identifying the proteins to which small-molecule probes and drugs bind in cells

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Interaction between S100A8/A9 and Annexin A6 Is Involved in the Calcium-induced Cell Surface Exposition of S100A8/A9

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