MLL-AF6 fusion oncogene sequesters AF6 into the nucleus to trigger RAS activation in myeloid leukemia

Results of the AIEOP AML 2002/01 multicenter prospective trial for the treatment of children with acute myeloid leukemia

(2013) A. Pession et al.   BLOOD

Leukemic transformation by the MLL-AF6 fusion oncogene requires the H3K79 methyltransferase Dot1l

(2013) A. J. Deshpande et al.   BLOOD

Farnesyltransferase inhibitor tipifarnib inhibits Rheb prenylation and stabilizes Bax in acute myelogenous leukemia cells

(2013) H. Ding et al.   HAEMATOLOGICA

Frequencies and prognostic impact of RAS mutations in MLL-rearranged acute lymphoblastic leukemia in infants

(2013) E. M. C. Driessen et al.   HAEMATOLOGICA

Sox4 cooperates with CREB in myeloid transformation

(2012) S. Sandoval et al.   BLOOD

The Histone Demethylase KDM1A Sustains the Oncogenic Potential of MLL-AF9 Leukemia Stem Cells

(2012) William J. Harris et al.   CANCER CELL

Model for MLL translocations in therapy-related leukemia involving topoisomerase II -mediated DNA strand breaks and gene proximity

(2012) I. G. Cowell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytotoxicity of farnesyltransferase inhibitors in lymphoid cells mediated by MAPK pathway inhibition and Bim up-regulation

(2011) H. Ding et al.   BLOOD

Multi-institutional phase 2 study of the farnesyltransferase inhibitor tipifarnib (R115777) in patients with relapsed and refractory lymphomas

(2011) T. E. Witzig et al.   BLOOD

A Phase I Clinical-Pharmacodynamic Study of the Farnesyltransferase Inhibitor Tipifarnib in Combination with the Proteasome Inhibitor Bortezomib in Advanced Acute Leukemias

(2011) J. E. Lancet et al.   CLINICAL CANCER RESEARCH

Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis

(2011) J. Y. Guo et al.   GENES & DEVELOPMENT

Prevalence and clinical implications of NRAS mutations in childhood AML: a report from the Children's Oncology Group

(2011) J N Berman et al.   LEUKEMIA

MLL partner genes drive distinct gene expression profiles and genomic alterations in pediatric acute myeloid leukemia: an AIEOP study

(2011) M Pigazzi et al.   LEUKEMIA

The heterogeneity of pediatric MLL-rearranged acute myeloid leukemia

(2011) B V Balgobind et al.   LEUKEMIA

Loss of AF6/afadin, a marker of poor outcome in breast cancer, induces cell migration, invasiveness and tumor growth

(2011) G Fournier et al.   ONCOGENE

BAG1: The Guardian of Anti-Apoptotic Proteins in Acute Myeloid Leukemia

(2011) Sanja Aveic et al.   PLoS One

Self-association mediated by the Ras association 1 domain of AF6 activates the oncogenic potential of MLL-AF6

(2010) M. Liedtke et al.   BLOOD

A phase 1-2 study of a farnesyltransferase inhibitor, tipifarnib, combined with idarubicin and cytarabine for patients with newly diagnosed acute myeloid leukemia and high-risk myelodysplastic syndrome

(2010) Elias Jabbour et al.   CANCER

Novel Therapies for Myelodysplastic Syndromes

(2010) David P. Steensma   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Gene Expression–Based Classification As an Independent Predictor of Clinical Outcome in Juvenile Myelomonocytic Leukemia

(2010) Silvia Bresolin et al.   JOURNAL OF CLINICAL ONCOLOGY

Pediatric early T-cell precursor leukemia with NF1 deletion and high-sensitivity in vitro to tipifarnib

(2010) C Biagi et al.   LEUKEMIA

Novel prognostic subgroups in childhood 11q23/MLL-rearranged acute myeloid leukemia: results of an international retrospective study

(2009) B. V. Balgobind et al.   BLOOD

Mixed-lineage-leukemia (MLL) fusion protein collaborates with Ras to induce acute leukemia through aberrant Hox expression and Raf activation

(2009) R Ono et al.   LEUKEMIA

RAS oncogene suppression induces apoptosis followed by more differentiated and less myelosuppressive disease upon relapse of acute myeloid leukemia

(2008) W.-I. Kim et al.   BLOOD

The Signaling Adaptor p62 Is an Important NF-κB Mediator in Tumorigenesis

(2008) Angeles Duran et al.   CANCER CELL

Targeting Ras in Myeloid Leukemias

(2008) B. S. Braun et al.   CLINICAL CANCER RESEARCH