Translating microfluidics: Cell separation technologies and their barriers to commercialization

Experimental and numerical studies on standing surface acoustic wave microfluidics

(2016) Zhangming Mao et al.   LAB ON A CHIP

Continuous Flow Deformability-Based Separation of Circulating Tumor Cells Using Microfluidic Ratchets

(2016) Emily S. Park et al.   Small

Microfluidics: The Challenge Is to Bridge the Gap Instead of Looking for a ‘Killer App’

(2016) Hector Hugo Caicedo et al.   TRENDS IN BIOTECHNOLOGY

Characterizing the Switching Thresholds of Magnetophoretic Transistors

(2015) Roozbeh Abedini-Nassab et al.   ADVANCED MATERIALS

Acoustofluidic Fluorescence Activated Cell Sorter

(2015) Ahmad Ahsan Nawaz et al.   ANALYTICAL CHEMISTRY

Large-Volume Microfluidic Cell Sorting for Biomedical Applications

(2015) Majid Ebrahimi Warkiani et al.   Annual Review of Biomedical Engineering

Two-dimensional spatial manipulation of microparticles in continuous flows in acoustofluidic systems

(2015) Lu Gao et al.   Biomicrofluidics

Circulating tumor cell detection using a parallel flow micro-aperture chip system

(2015) Chun-Li Chang et al.   LAB ON A CHIP

A high-throughput acoustic cell sorter

(2015) Liqiang Ren et al.   LAB ON A CHIP

High purity microfluidic sorting and analysis of circulating tumor cells: towards routine mutation detection

(2015) Julien Autebert et al.   LAB ON A CHIP

3D-printed microfluidic automation

(2015) Anthony K. Au et al.   LAB ON A CHIP

Entrepreneurship

(2015) Ali K. Yetisen et al.   LAB ON A CHIP

Lab on a chip for continuous-flow magnetic cell separation

(2015) Majid Hejazian et al.   LAB ON A CHIP

Microfluidic cell sorting: a review of the advances in the separation of cells from debulking to rare cell isolation

(2015) C. Wyatt Shields IV et al.   LAB ON A CHIP

The Poisson distribution and beyond: methods for microfluidic droplet production and single cell encapsulation

(2015) David J. Collins et al.   LAB ON A CHIP

A microfluidic device for label-free, physical capture of circulating tumor cell clusters

(2015) A Fatih Sarioglu et al.   NATURE METHODS

Acoustic separation of circulating tumor cells

(2015) Peng Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Flow cytometry strikes gold

(2015) J. Paul Robinson et al.   SCIENCE

Microbial abundance in surface ice on the Greenland Ice Sheet

(2015) Marek Stibal et al.   Frontiers in Microbiology

Parallel Affinity-Based Isolation of Leukocyte Subsets Using Microfluidics: Application for Stroke Diagnosis

(2014) Swathi R. Pullagurla et al.   ANALYTICAL CHEMISTRY

Perspective on Microfluidic Cell Separation: A Solved Problem?

(2014) Brian D. Plouffe et al.   ANALYTICAL CHEMISTRY

Nucleation and Growth Synthesis of Siloxane Gels to Form Functional, Monodisperse, and Acoustically Programmable Particles

(2014) C. Wyatt Shields et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Magnetographic array for the capture and enumeration of single cells and cell pairs

(2014) C. Wyatt Shields et al.   Biomicrofluidics

Purification of regulatory T cells with the use of a fully enclosed high-speed microfluidic system

(2014) Ruud Hulspas et al.   CYTOTHERAPY

Microfluidic PMMA interfaces for rectangular glass capillaries

(2014) Mikael Evander et al.   JOURNAL OF MICROMECHANICS AND MICROENGINEERING

Acoustic actuated fluorescence activated sorting of microparticles

(2014) Ola Jakobsson et al.   LAB ON A CHIP

Microfluidics for single-cell genetic analysis

(2014) A. M. Thompson et al.   LAB ON A CHIP

Two-dimensional acoustic particle focusing enables sheathless chip Coulter counter with planar electrode configuration

(2014) Carl Grenvall et al.   LAB ON A CHIP

Rare cell isolation and analysis in microfluidics

(2014) Yuchao Chen et al.   LAB ON A CHIP

Continuous-flow microfluidic blood cell sorting for unprocessed whole blood using surface-micromachined microfiltration membranes

(2014) Xiang Li et al.   LAB ON A CHIP

Sorting drops and cells with acoustics: acoustic microfluidic fluorescence-activated cell sorter

(2014) Lothar Schmid et al.   LAB ON A CHIP

Mail-order microfluidics: evaluation of stereolithography for the production of microfluidic devices

(2014) Anthony K. Au et al.   LAB ON A CHIP

The intersection of flow cytometry with microfluidics and microfabrication

(2014) Menake E. Piyasena et al.   LAB ON A CHIP

Elastomeric Negative Acoustic Contrast Particles for Capture, Acoustophoretic Transport, and Confinement of Cells in Microfluidic Systems

(2014) C. Wyatt Shields et al.   LANGMUIR

The present and future role of microfluidics in biomedical research

(2014) Eric K. Sackmann et al.   NATURE

Single-cell technologies for monitoring immune systems

(2014) Pratip K Chattopadhyay et al.   NATURE IMMUNOLOGY

Microfluidic, marker-free isolation of circulating tumor cells from blood samples

(2014) Nezihi Murat Karabacak et al.   Nature Protocols

Circulating Tumor Cells: Clinically Relevant Molecular Access Based on a Novel CTC Flow Cell

(2014) Jessamine P. Winer-Jones et al.   PLoS One

Discrete elements for 3D microfluidics

(2014) Krisna C. Bhargava et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Industrial lab-on-a-chip: Design, applications and scale-up for drug discovery and delivery

(2013) Goran T. Vladisavljević et al.   ADVANCED DRUG DELIVERY REVIEWS

Magnetophoresis-Integrated Hydrodynamic Filtration System for Size- and Surface Marker-Based Two-Dimensional Cell Sorting

(2013) Masahiro Mizuno et al.   ANALYTICAL CHEMISTRY

An Automated High-Throughput Counting Method for Screening Circulating Tumor Cells in Peripheral Blood

(2013) Mengxia Zhao et al.   ANALYTICAL CHEMISTRY

Manufacturing and wetting low-cost microfluidic cell separation devices

(2013) Ryan S. Pawell et al.   Biomicrofluidics

A simple add-on microfluidic appliance for accurately sorting small populations of cells with high fidelity

(2013) Michael Grad et al.   JOURNAL OF MICROMECHANICS AND MICROENGINEERING

A cell rolling cytometer reveals the correlation between mesenchymal stem cell dynamic adhesion and differentiation state

(2013) Sungyoung Choi et al.   LAB ON A CHIP

Emerging microfluidic devices for cell lysis: a review

(2013) Lang Nan et al.   LAB ON A CHIP

Single-cell analysis and sorting using droplet-based microfluidics

(2013) Linas Mazutis et al.   Nature Protocols

Inertial Focusing for Tumor Antigen-Dependent and -Independent Sorting of Rare Circulating Tumor Cells

(2013) E. Ozkumur et al.   Science Translational Medicine

Isolation and retrieval of circulating tumor cells using centrifugal forces

(2013) Han Wei Hou et al.   Scientific Reports

Elastomeric microparticles for acoustic mediated bioseparations

(2013) Leah M Johnson et al.   JOURNAL OF NANOBIOTECHNOLOGY

Circulating Tumor Cells: Liquid Biopsy of Cancer

(2012) C. Alix-Panabieres et al.   CLINICAL CHEMISTRY

Cell separation based on size and deformability using microfluidic funnel ratchets

(2012) Sarah M. McFaul et al.   LAB ON A CHIP

Cell sorting by deterministic cell rolling

(2012) Sungyoung Choi et al.   LAB ON A CHIP

Surface acoustic wave (SAW) acoustophoresis: now and beyond

(2012) Sz-Chin Steven Lin et al.   LAB ON A CHIP

Standing surface acoustic wave (SSAW) based multichannel cell sorting

(2012) Xiaoyun Ding et al.   LAB ON A CHIP

Commercialization of microfluidic point-of-care diagnostic devices

(2012) Curtis D. Chin et al.   LAB ON A CHIP

Acoustofluidics 8: Applications of acoustophoresis in continuous flow microsystems

(2012) Andreas Lenshof et al.   LAB ON A CHIP

Microfluidic Chips for Point-of-Care Immunodiagnostics

(2011) Luc Gervais et al.   ADVANCED MATERIALS

Specific Sorting of Single Bacterial Cells with Microfabricated Fluorescence-Activated Cell Sorting and Tyramide Signal Amplification Fluorescence in Situ Hybridization

(2011) Chun H. Chen et al.   ANALYTICAL CHEMISTRY

Rare Cell Separation and Analysis by Magnetic Sorting

(2011) Maciej Zborowski et al.   ANALYTICAL CHEMISTRY

Optofluidic Fluorescent Imaging Cytometry on a Cell Phone

(2011) Hongying Zhu et al.   ANALYTICAL CHEMISTRY

Microfluidic Mixing: A Review

(2011) Chia-Yen Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Disposable microfluidic substrates: Transitioning from the research laboratory into the clinic

(2011) Jason S. Kuo et al.   LAB ON A CHIP

Optoelectronic tweezers

(2011) Ming C Wu   Nature Photonics

Screening of Peptide Libraries against Protective Antigen of Bacillus anthracis in a Disposable Microfluidic Cartridge

(2011) Joshua M. Kogot et al.   PLoS One

Label-free cell separation and sorting in microfluidic systems

(2010) Daniel R. Gossett et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Versatile label free biochip for the detection of circulating tumor cells from peripheral blood in cancer patients

(2010) Swee Jin Tan et al.   BIOSENSORS & BIOELECTRONICS

Isolation of circulating tumor cells using a microvortex-generating herringbone-chip

(2010) S. L. Stott et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microfluidic sorting and multimodal typing of cancer cells in self-assembled magnetic arrays

(2010) A.-E. Saliba et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Review of cell and particle trapping in microfluidic systems

(2009) J. Nilsson et al.   ANALYTICA CHIMICA ACTA

Microdevice for the isolation and enumeration of cancer cells from blood

(2009) Swee Jin Tan et al.   BIOMEDICAL MICRODEVICES

Microfluidic cell sorter with integrated piezoelectric actuator

(2009) Chun H. Chen et al.   BIOMEDICAL MICRODEVICES

Chips, money, industry, education and the “killer application”

(2009) Holger Becker   LAB ON A CHIP

Inertial microfluidics

(2009) Dino Di Carlo   LAB ON A CHIP

Continuous particle separation in a microfluidic channel via standing surface acoustic waves (SSAW)

(2009) Jinjie Shi et al.   LAB ON A CHIP

Simultaneous sorting of multiple bacterial targets using integrated Dielectrophoretic–Magnetic Activated Cell Sorter

(2009) Unyoung Kim et al.   LAB ON A CHIP

Fluorescence-activated droplet sorting (FADS): efficient microfluidic cell sorting based on enzymatic activity

(2009) Jean-Christophe Baret et al.   LAB ON A CHIP

A multi-layer microfluidic device for efficient culture and analysis of renal tubular cells

(2009) Kyung-Jin Jang et al.   LAB ON A CHIP

An integrated optofluidic platform for Raman-activated cell sorting

(2008) Adrian Y. Lau et al.   LAB ON A CHIP

Microvortex for focusing, guiding and sorting of particles

(2008) Chia-Hsien Hsu et al.   LAB ON A CHIP

Droplet microfluidics

(2008) Shia-Yen Teh et al.   LAB ON A CHIP