Probiotics: A Dietary Factor to Modulate the Gut Microbiome, Host Immune System, and Gut–Brain Interaction

Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding

(2020) Roujian Lu et al.   LANCET

Ongoing Supplementation of Probiotics to Cesarean-Born Neonates during the First Month of Life may Impact the Gut Microbial

(2020) Wenqing Yang et al.   AMERICAN JOURNAL OF PERINATOLOGY

Effects of probiotic supplementation on serum trimethylamine-N-oxide level and gut microbiota composition in young males: a double-blinded randomized controlled trial

(2020) Si Chen et al.   EUROPEAN JOURNAL OF NUTRITION

COVID-19: A New Virus, but a Familiar Receptor and Cytokine Release Syndrome

(2020) Toshio Hirano et al.   IMMUNITY

Expression of SARS-CoV-2 Entry Molecules ACE2 and TMPRSS2 in the Gut of Patients With IBD

(2020) Juan F Burgueño et al.   INFLAMMATORY BOWEL DISEASES

The liver–brain–gut neural arc maintains the Treg cell niche in the gut

(2020) Toshiaki Teratani et al.   NATURE

Dynamic analysis of human small intestinal microbiota after an ingestion of fermented milk by small-intestinal fluid perfusion using an endoscopic retrograde bowel insertion technique

(2020) Toshihiko Takada et al.   Gut Microbes

Current Understanding of Gut Microbiota in Mood Disorders: An Update of Human Studies

(2019) Ting-Ting Huang et al.   Frontiers in Genetics

Lactobacillus plantarum DR7 alleviates stress and anxiety in adults: a randomised, double-blind, placebo-controlled study

(2019) H.X. Chong et al.   Beneficial Microbes

Probiotic Bacteria: A Promising Tool in Cancer Prevention and Therapy

(2019) Agata Górska et al.   CURRENT MICROBIOLOGY

Lactobacillus plantarum DR7 improved upper respiratory tract infections via enhancing immune and inflammatory parameters: A randomized, double-blind, placebo-controlled study

(2019) Hui-Xian Chong et al.   JOURNAL OF DAIRY SCIENCE

Daily intake of Lactobacillus gasseri CP2305 relieves fatigue and stress-related symptoms in male university Ekiden runners: A double-blind, randomized, and placebo-controlled clinical trial

(2019) Daisuke Sawada et al.   Journal of Functional Foods

Propionic Acid Induces Gliosis and Neuro-inflammation through Modulation of PTEN/AKT Pathway in Autism Spectrum Disorder

(2019) Latifa S. Abdelli et al.   Scientific Reports

Probiotics and Psychobiotics: the Role of Microbial Neurochemicals

(2019) Alexander V. Oleskin et al.   Probiotics and Antimicrobial Proteins

Immunomodulatory and anti-inflammatory effects of probiotics in multiple sclerosis: a systematic review

(2019) Mohammad Morshedi et al.   Journal of Neuroinflammation

Health Benefits of Lactobacillus gasseri CP2305 Tablets in Young Adults Exposed to Chronic Stress: A Randomized, Double-Blind, Placebo-Controlled Study

(2019) Kensei Nishida et al.   Nutrients

The molecular mechanism for activating IgA production by Pediococcus acidilactici K15 and the clinical impact in a randomized trial

(2018) Tadaomi Kawashima et al.   Scientific Reports

Health Related Quality of Life Among Patients With Multiple Sclerosis: The Role of Psychosocial Adjustment to Illness

(2018) Saba Yaseen Hyarat et al.   ARCHIVES OF PSYCHIATRIC NURSING

Post-Antibiotic Gut Mucosal Microbiome Reconstitution Is Impaired by Probiotics and Improved by Autologous FMT

(2018) Jotham Suez et al.   CELL

The Lactobacillus casei Group: History and Health Related Applications

(2018) Daragh Hill et al.   Frontiers in Microbiology

Probiotic Bifidobacterium longum NCC3001 Reduces Depression Scores and Alters Brain Activity: A Pilot Study in Patients With Irritable Bowel Syndrome

(2017) Maria Ines Pinto-Sanchez et al.   GASTROENTEROLOGY

Intestinal dysbiosis and probiotic applications in autoimmune diseases

(2017) Gislane Lelis Vilela de Oliveira et al.   IMMUNOLOGY

Immunomodulation and signaling mechanism of Lactobacillus rhamnosus GG and its components on porcine intestinal epithelial cells stimulated by lipopolysaccharide

(2017) Kan Gao et al.   JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION

Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics

(2017) Glenn R. Gibson et al.   Nature Reviews Gastroenterology & Hepatology

Kynurenine pathway metabolism and the microbiota-gut-brain axis

(2017) P.J. Kennedy et al.   NEUROPHARMACOLOGY

Tryptophan availability for kynurenine pathway metabolism across the life span: Control mechanisms and focus on aging, exercise, diet and nutritional supplements

(2017) Abdulla A-B. Badawy   NEUROPHARMACOLOGY

Daily administration of paraprobiotic Lactobacillus gasseri CP2305 ameliorates chronic stress-associated symptoms in Japanese medical students

(2017) Kensei Nishida et al.   Journal of Functional Foods

Beneficial effects of Lactobacillus casei strain Shirota on academic stress-induced sleep disturbance in healthy adults: a double-blind, randomised, placebo-controlled trial

(2017) M. Takada et al.   Beneficial Microbes

Yogurt supplemented with probiotics can protect the healthy elderly from respiratory infections: A randomized controlled open-label trial

(2017) Fangfang Pu et al.   Clinical Interventions in Aging

Fermented Milk Containing Lactobacillus casei Strain Shirota Preserves the Diversity of the Gut Microbiota and Relieves Abdominal Dysfunction in Healthy Medical Students Exposed to Academic Stress

(2016) Akito Kato-Kataoka et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Probiotics, fibre and herbal medicinal products for functional and inflammatory bowel disorders

(2016) Diego Currò et al.   BRITISH JOURNAL OF PHARMACOLOGY

Relationship Between Microbiota of the Colonic Mucosa vs Feces and Symptoms, Colonic Transit, and Methane Production in Female Patients With Chronic Constipation

(2016) Gopanandan Parthasarathy et al.   GASTROENTEROLOGY

Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host’s metabolism

(2016) P Zheng et al.   MOLECULAR PSYCHIATRY

ProbioticLactobacillus caseistrain Shirota relieves stress-associated symptoms by modulating the gut-brain interaction in human and animal models

(2016) M. Takada et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Intragastric injection of Lactobacillus casei strain Shirota suppressed spleen sympathetic activation by central corticotrophin-releasing factor or peripheral 2-deoxy-d-glucose in anesthetized rats

(2016) Mamoru Tanida et al.   NEUROSCIENCE LETTERS

Role and mechanisms of action ofEscherichia coliNissle 1917 in the maintenance of remission in ulcerative colitis patients: An update

(2016) Franco Scaldaferri et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Probiotic Supplements Beneficially Affect Tryptophan–Kynurenine Metabolism and Reduce the Incidence of Upper Respiratory Tract Infections in Trained Athletes: A Randomized, Double-Blinded, Placebo-Controlled Trial

(2016) Barbara Strasser et al.   Nutrients

Effect of dietary heat-killed Lactobacillus brevis SBC8803 (SBL88™) on sleep: a non-randomised, double blind, placebo-controlled, and crossover pilot study

(2016) Y. Nakakita et al.   Beneficial Microbes

Bifidobacterium longum 1714 as a translational psychobiotic: modulation of stress, electrophysiology and neurocognition in healthy volunteers

(2016) A P Allen et al.   Translational Psychiatry

Daily Probiotic’s (Lactobacillus caseiShirota) Reduction of Infection Incidence in Athletes

(2016) Michael Gleeson et al.   INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM

Microbiota of the Small Intestine Is Selectively Engulfed by Phagocytes of the Lamina Propria and Peyer’s Patches

(2016) Masatoshi Morikawa et al.   PLoS One

The Effectiveness of Lactobacillus Beverages in Controlling Infections among the Residents of an Aged Care Facility: A Randomized Placebo-Controlled Double-Blind Trial

(2015) Satoru Nagata et al.   ANNALS OF NUTRITION AND METABOLISM

Daily intake of fermented milk with Lactobacillus casei strain Shirota reduces the incidence and duration of upper respiratory tract infections in healthy middle-aged office workers

(2015) Kan Shida et al.   EUROPEAN JOURNAL OF NUTRITION

Efficacy of pasteurised yoghurt in improving chronic constipation: A randomised, double-blind, placebo-controlled trial

(2015) Zhen-min Liu et al.   INTERNATIONAL DAIRY JOURNAL

Gut/brain axis and the microbiota

(2015) Emeran A. Mayer et al.   JOURNAL OF CLINICAL INVESTIGATION

Host microbiota constantly control maturation and function of microglia in the CNS

(2015) Daniel Erny et al.   NATURE NEUROSCIENCE

The effects of probiotics on mental health and hypothalamic–pituitary–adrenal axis: A randomized, double-blind, placebo-controlled trial in petrochemical workers

(2015) Ali Akbar Mohammadi et al.   NUTRITIONAL NEUROSCIENCE

Bifidobacterium animalis subsp. lactis BB-12 in reducing the risk of infections in early childhood

(2015) Teemu J. Taipale et al.   PEDIATRIC RESEARCH

Change of Fecal Flora and Effectiveness of the Short-term VSL#3 Probiotic Treatment in Patients With Functional Constipation

(2015) Seong-Eun Kim et al.   Journal of Neurogastroenterology and Motility

Modulation of Fecal Clostridiales Bacteria and Butyrate by Probiotic Intervention with Lactobacillus paracasei DG Varies among Healthy Adults

(2014) Chiara Ferrario et al.   JOURNAL OF NUTRITION

Effects of probioticLactobacillus brevisKB290 on incidence of influenza infection among schoolchildren: an open-label pilot study

(2014) N. Waki et al.   LETTERS IN APPLIED MICROBIOLOGY

Dietary heat-killed Lactobacillus brevis SBC8803 promotes voluntary wheel-running and affects sleep rhythms in mice

(2014) Koyomi Miyazaki et al.   LIFE SCIENCES

The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic

(2014) Colin Hill et al.   Nature Reviews Gastroenterology & Hepatology

Pre- and Neonatal Exposure to Lipopolysaccharide or the Enteric Metabolite, Propionic Acid, Alters Development and Behavior in Adolescent Rats in a Sexually Dimorphic Manner

(2014) Kelly A. Foley et al.   PLoS One

Changes of the human gut microbiome induced by a fermented milk product

(2014) Patrick Veiga et al.   Scientific Reports

Decreased duration of acute upper respiratory tract infections with daily intake of fermented milk: A multicenter, double-blinded, randomized comparative study in users of day care facilities for the elderly population

(2013) Retsu Fujita et al.   AMERICAN JOURNAL OF INFECTION CONTROL

Psychobiotics: A Novel Class of Psychotropic

(2013) Timothy G. Dinan et al.   BIOLOGICAL PSYCHIATRY

Cortisol Levels and Risk for Psychosis: Initial Findings from the North American Prodrome Longitudinal Study

(2013) Elaine F. Walker et al.   BIOLOGICAL PSYCHIATRY

Effect of Lactobacillus rhamnosus CGMCC1.3724 supplementation on weight loss and maintenance in obese men and women

(2013) Marina Sanchez et al.   BRITISH JOURNAL OF NUTRITION

Effect of Lactobacillus salivarius Ls-33 on fecal microbiota in obese adolescents

(2013) Nadja Larsen et al.   CLINICAL NUTRITION

Consumption of Fermented Milk Product With Probiotic Modulates Brain Activity

(2013) Kirsten Tillisch et al.   GASTROENTEROLOGY

Probiotic gut effect prevents the chronic psychological stress-induced brain activity abnormality in mice

(2013) A. Ait-Belgnaoui et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk

(2013) W.H. Wilson Tang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Probiotic supplementation improves inflammatory status in patients with rheumatoid arthritis

(2013) Elnaz Vaghef-Mehrabany et al.   NUTRITION

Reduced Incidence of Prevotella and Other Fermenters in Intestinal Microflora of Autistic Children

(2013) Dae-Wook Kang et al.   PLoS One

Consumption of Dairy Products and Colorectal Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)

(2013) Neil Murphy et al.   PLoS One

Mother-to-Infant Transmission of Intestinal Bifidobacterial Strains Has an Impact on the Early Development of Vaginally Delivered Infant's Microbiota

(2013) Hiroshi Makino et al.   PLoS One

HIV Infection is associated with compositional and functional shifts in the rectal mucosal microbiota

(2013) Ian H McHardy et al.   Microbiome

Randomised clinical trial: efficacy of Lactobacillus paracasei-enriched artichokes in the treatment of patients with functional constipation - a double-blind, controlled, crossover study

(2012) G. Riezzo et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Functional dysbiosis within the gut microbiota of patients with constipated-irritable bowel syndrome

(2012) C. Chassard et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Effects of administration of Bifidobacterium animalis subsp. lactis GCL2505 on defecation frequency and bifidobacterial microbiota composition in humans

(2012) Akihiro Ishizuka et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

A marketed fermented dairy product containing Bifidobacterium lactis CNCM I-2494 suppresses gut hypersensitivity and colonic barrier disruption induced by acute stress in rats

(2012) S. Agostini et al.   NEUROGASTROENTEROLOGY AND MOTILITY

The human milk microbiota: Origin and potential roles in health and disease

(2012) Leónides Fernández et al.   PHARMACOLOGICAL RESEARCH

Prevention of gut leakiness by a probiotic treatment leads to attenuated HPA response to an acute psychological stress in rats

(2012) Afifa Ait-Belgnaoui et al.   PSYCHONEUROENDOCRINOLOGY

Transmission of Intestinal Bifidobacterium longum subsp.longumStrains from Mother to Infant, Determined by Multilocus Sequencing Typing and Amplified Fragment Length Polymorphism

(2011) Hiroshi Makino et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Daily intake of Lactobacillus casei Shirota increases natural killer cell activity in smokers

(2011) Marcella Reale et al.   BRITISH JOURNAL OF NUTRITION

Global and Deep Molecular Analysis of Microbiota Signatures in Fecal Samples From Patients With Irritable Bowel Syndrome

(2011) Mirjana Rajilić–Stojanović et al.   GASTROENTEROLOGY

Yogurt consumption and risk of colorectal cancer in the Italian European prospective investigation into cancer and nutrition cohort

(2011) Valeria Pala et al.   INTERNATIONAL JOURNAL OF CANCER

Fermented milk containingLactobacillus caseistrain Shirota reduces incidence of hard or lumpy stools in healthy population

(2011) Takafumi Sakai et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION

Human Milk Probiotic Lactobacillus fermentum CECT5716 Reduces the Incidence of Gastrointestinal and Upper Respiratory Tract Infections in Infants

(2011) José Maldonado et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Poor sleep is associated with exaggerated cortisol response to the combined dexamethasone/CRH test in a non-clinical population

(2011) Hiroaki Hori et al.   JOURNAL OF PSYCHIATRIC RESEARCH

The anxiolytic effect of Bifidobacterium longum NCC3001 involves vagal pathways for gut-brain communication

(2011) P. Bercik et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve

(2011) J. A. Bravo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Normal gut microbiota modulates brain development and behavior

(2011) R. D. Heijtz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Treatment of Relapsing Mild-to-Moderate Ulcerative Colitis With the Probiotic VSL#3 as Adjunctive to a Standard Pharmaceutical Treatment: A Double-Blind, Randomized, Placebo-Controlled Study

(2010) Antonio Tursi et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Assessment of psychotropic-like properties of a probiotic formulation ( Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and human subjects

(2010) Michaël Messaoudi et al.   BRITISH JOURNAL OF NUTRITION

Reducing the risk of infection in the elderly by dietary intake of yoghurt fermented with Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1

(2010) Seiya Makino et al.   BRITISH JOURNAL OF NUTRITION

Use of a fermented dairy probiotic drink containing Lactobacillus casei (DN-114 001) to decrease the rate of illness in kids: the DRINK study A patient-oriented, double-blind, cluster-randomized, placebo-controlled, clinical trial

(2010) D Merenstein et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Immunosuppressive effects via human intestinal dendritic cells of probiotic bacteria and steroids in the treatment of acute ulcerative colitis

(2010) Siew C. Ng et al.   INFLAMMATORY BOWEL DISEASES

Host interactions of probiotic bacterial surface molecules: comparison with commensals and pathogens

(2010) Sarah Lebeer et al.   NATURE REVIEWS MICROBIOLOGY

Identification and genotyping of bacteria from paired vaginal and rectal samples from pregnant women indicates similarity between vaginal and rectal microflora

(2009) Nabil Abdullah El Aila et al.   BMC INFECTIOUS DISEASES

Prenatal probiotic administration can influence Bifidobacterium microbiota development in infants at high risk of allergy

(2009) Sampo J. Lahtinen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The HDAC inhibitor, sodium butyrate, stimulates neurogenesis in the ischemic brain

(2009) Hyeon Ju Kim et al.   JOURNAL OF NEUROCHEMISTRY

Lipoteichoic acids on Lactobacillus plantarum cell surfaces correlate with induction of interleukin-12p40 production

(2009) Yoshitaka Hirose et al.   MICROBIOLOGY AND IMMUNOLOGY

Human gut microbiota and bifidobacteria: from composition to functionality

(2008) Francesca Turroni et al.   ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY

A component of polysaccharide peptidoglycan complex onLactobacillusinduced an improvement of murine model of inflammatory bowel disease and colitis-associated cancer

(2008) S. Matsumoto et al.   IMMUNOLOGY

Prevention of Recurrence With Epirubicin and Lactobacillus Casei After Transurethral Resection of Bladder Cancer

(2008) Seiji Naito et al.   JOURNAL OF UROLOGY

Probiotic food supplement reduces stress-induced gastrointestinal symptoms in volunteers: a double-blind, placebo-controlled, randomized trial

(2008) Laurent Diop et al.   NUTRITION RESEARCH

Differential effects of two probiotic strains with different bacteriological properties on intestinal gene expression, with special reference to indigenous bacteria

(2007) Tatsuichiro Shima et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY