Methylglyoxal-Induced Dysfunction in Brain Endothelial Cells via the Suppression of Akt/HIF-1α Pathway and Activation of Mitophagy Associated with Increased Reactive Oxygen Species

Autophagy-mediated occludin degradation contributes to blood–brain barrier disruption during ischemia in bEnd.3 brain endothelial cells and rat ischemic stroke models

(2020) Kyeong-A Kim et al.   Fluids and Barriers of the CNS

Mitochondrial Dysfunction in Type 2 Diabetes Mellitus: An Organ-Based Analysis

(2019) Mark V Pinti et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Mitochondrial Mass Assessment in a Selected Cell Line under Different Metabolic Conditions

(2019) Anna Costanzini et al.   Cells

SIRT1-Dependent Upregulation of Antiglycative Defense in HUVECs Is Essential for Resveratrol Protection against High Glucose Stress

(2019) Santini et al.   Antioxidants

Reactive Oxygen Species in Metabolic and Inflammatory Signaling

(2018) Steven J. Forrester et al.   CIRCULATION RESEARCH

Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance

(2018) Sarah Pickles et al.   CURRENT BIOLOGY

Altered mitochondrial bioenergetics and ultrastructure in the skeletal muscle of young adults with type 1 diabetes

(2018) Cynthia M. F. Monaco et al.   DIABETOLOGIA

Methylglyoxal induced advanced glycation end products (AGE)/receptor for AGE (RAGE)-mediated angiogenic impairment in bone marrow-derived endothelial progenitor cells

(2018) Jeong-Hyeon Kim et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Role of Autophagy in Endothelial Damage and Blood–Brain Barrier Disruption in Ischemic Stroke

(2018) Kyeong-A Kim et al.   STROKE

Molecular pathways associated with oxidative stress in diabetes mellitus

(2018) Osasenaga Macdonald Ighodaro   BIOMEDICINE & PHARMACOTHERAPY

Mitochondrial biogenesis and metabolic hyperactivation limits the application of MTT assay in the estimation of radiation induced growth inhibition

(2018) Yogesh Rai et al.   Scientific Reports

Methylglyoxal-induced AMPK activation leads to autophagic degradation of thioredoxin 1 and glyoxalase 2 in HT22 nerve cells

(2017) Alcir Luiz Dafre et al.   FREE RADICAL BIOLOGY AND MEDICINE

Methylglyoxal-Glyoxalase 1 Balance: The Root of Vascular Damage

(2017) Cecilia Nigro et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Polydatin Prevents Methylglyoxal-Induced Apoptosis through Reducing Oxidative Stress and Improving Mitochondrial Function in Human Umbilical Vein Endothelial Cells

(2017) Ningbo Pang et al.   Oxidative Medicine and Cellular Longevity

The role of cPLA2 in Methylglyoxal-induced cell apoptosis of HUVECs

(2017) Jie Yuan et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Phosphocreatine protects endothelial cells from Methylglyoxal induced oxidative stress and apoptosis via the regulation of PI3K/Akt/eNOS and NF-κB pathway

(2017) Peng Chu et al.   VASCULAR PHARMACOLOGY

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

Methylglyoxal-Induced Endothelial Cell Loss and Inflammation Contribute to the Development of Diabetic Cardiomyopathy

(2016) Branka Vulesevic et al.   DIABETES

Evaluation of Bioenergetic Function in Cerebral Vascular Endothelial Cells

(2016) Stephanie L. Rellick et al.   Jove-Journal of Visualized Experiments

Autophagy in Vascular Disease

(2015) G. R. Y. De Meyer et al.   CIRCULATION RESEARCH

The role of methylglyoxal and the glyoxalase system in diabetes and other age-related diseases

(2015) Dionne E.M. Maessen et al.   CLINICAL SCIENCE

Pitfalls of the MTT assay: Direct and off-target effects of inhibitors can result in over/underestimation of cell viability

(2015) A.A. Stepanenko et al.   GENE

Autophagy protects human brain microvascular endothelial cells against methylglyoxal-induced injuries, reproducible in a cerebral ischemic model in diabetic rats

(2015) Lili Fang et al.   JOURNAL OF NEUROCHEMISTRY

Mitochondrial Crisis in Cerebrovascular Endothelial Cells Opens the Blood–Brain Barrier

(2015) Danielle N. Doll et al.   STROKE

δ-Tocopherol prevents methylglyoxal-induced apoptosis by reducing ROS generation and inhibiting apoptotic signaling cascades in human umbilical vein endothelial cells

(2015) Moon ho Do et al.   Food & Function

Effects of methylglyoxal on human cardiac fibroblast: roles of transient receptor potential ankyrin 1 (TRPA1) channels

(2014) Gaku Oguri et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

LR-90 prevents methylglyoxal-induced oxidative stress and apoptosis in human endothelial cells

(2014) James L. Figarola et al.   APOPTOSIS

The Receptor for Advanced Glycation End Products (RAGE) Specifically Recognizes Methylglyoxal-Derived AGEs

(2014) Jing Xue et al.   BIOCHEMISTRY

High Glucose Condition Induces Autophagy in Endothelial Progenitor Cells Contributing to Angiogenic Impairment

(2014) Kyeong-A Kim et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Type 1 Diabetes Mellitus and Cardiovascular Disease

(2014) Sarah D. de Ferranti et al.   CIRCULATION

Venlafaxine protects methylglyoxal-induced apoptosis in the cultured human brain microvascular endothelial cells

(2014) Qinghua Lv et al.   NEUROSCIENCE LETTERS

Modulation of Mitochondrial Function and Autophagy Mediates Carnosine Neuroprotection Against Ischemic Brain Damage

(2014) Seung-Hoon Baek et al.   STROKE

Vaspin prevents methylglyoxal-induced apoptosis in human vascular endothelial cells by inhibiting reactive oxygen species generation

(2013) S. Phalitakul et al.   Acta Physiologica

High glucose condition increases NADPH oxidase activity in endothelial microparticles that promote vascular inflammation

(2013) Felix Jansen et al.   CARDIOVASCULAR RESEARCH

Mitochondria and Endothelial Function

(2013) Matthew A. Kluge et al.   CIRCULATION RESEARCH

Development, maintenance and disruption of the blood-brain barrier

(2013) Birgit Obermeier et al.   NATURE MEDICINE

Triggers and Effectors of Oxidative Stress at Blood-Brain Barrier Level: Relevance for Brain Ageing and Neurodegeneration

(2013) Ana-Maria Enciu et al.   Oxidative Medicine and Cellular Longevity

High Glucose Induced Oxidative Stress and Apoptosis in Cardiac Microvascular Endothelial Cells Are Regulated by FoxO3a

(2013) Chaoming Peng et al.   PLoS One

Dietary Fructose Feeding Increases Adipose Methylglyoxal Accumulation in Rats in Association with Low Expression and Activity of Glyoxalase-2

(2013) Christopher Masterjohn et al.   Nutrients

HIF1  is required for survival maintenance of chronic myeloid leukemia stem cells

(2012) H. Zhang et al.   BLOOD

Is diabetes an acquired disorder of reactive glucose metabolites and their intermediates?

(2012) T. Fleming et al.   DIABETOLOGIA

Methylglyoxal modification of Nav1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy

(2012) Angelika Bierhaus et al.   NATURE MEDICINE

Assessing mitochondrial dysfunction in cells

(2011) Martin D. Brand et al.   BIOCHEMICAL JOURNAL

Glyoxalase in diabetes, obesity and related disorders

(2011) Naila Rabbani et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Methylglyoxal, glyoxalase 1 and the dicarbonyl proteome

(2010) Naila Rabbani et al.   AMINO ACIDS

The Interplay Between Mitochondrial Dynamics and Mitophagy

(2010) Gilad Twig et al.   ANTIOXIDANTS & REDOX SIGNALING

Hypoxia-inducible factor 1: Regulator of mitochondrial metabolism and mediator of ischemic preconditioning

(2010) Gregg L. Semenza   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Increased plasma methylglyoxal level, inflammation, and vascular endothelial dysfunction in diabetic nephropathy

(2010) Jianxin Lu et al.   CLINICAL BIOCHEMISTRY

Hyperglycaemia-induced impairment of endothelium-dependent vasorelaxation in rat mesenteric arteries is mediated by intracellular methylglyoxal levels in a pathway dependent on oxidative stress

(2010) O. Brouwers et al.   DIABETOLOGIA

Hypoxia-Inducible Factors and the Response to Hypoxic Stress

(2010) Amar J. Majmundar et al.   MOLECULAR CELL

The Chaperone-Dependent Ubiquitin Ligase CHIP Targets HIF-1α for Degradation in the Presence of Methylglyoxal

(2010) Carla Figueira Bento et al.   PLoS One

Methylglyoxal augments intracellular oxidative stress in human aortic endothelial cells

(2009) Noriko Miyazawa et al.   FREE RADICAL RESEARCH

Structure and function of the blood–brain barrier

(2009) N. Joan Abbott et al.   NEUROBIOLOGY OF DISEASE