Glutathione Supplementation as an Adjunctive Therapy in COVID-19

Hematologic parameters in patients with COVID‐19 infection

(2020) Bingwen Eugene Fan et al.   AMERICAN JOURNAL OF HEMATOLOGY

Regulated Necrosis in Pulmonary Disease: A Focus on Necroptosis and Ferroptosis

(2020) Shunsuke Minagawa et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

Covid-19 — Navigating the Uncharted

(2020) Anthony S. Fauci et al.   NEW ENGLAND JOURNAL OF MEDICINE

Clinical Characteristics of Coronavirus Disease 2019 in China

(2020) Wei-jie Guan et al.   NEW ENGLAND JOURNAL OF MEDICINE

First Case of 2019 Novel Coronavirus in the United States

(2020) Michelle L. Holshue et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Novel Coronavirus from Patients with Pneumonia in China, 2019

(2020) Na Zhu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Time Course of Lung Changes On Chest CT During Recovery From 2019 Novel Coronavirus (COVID-19) Pneumonia

(2020) Feng Pan et al.   RADIOLOGY

High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa

(2020) Hao Xu et al.   International Journal of Oral Science

Real-Time Estimation of the Risk of Death from Novel Coronavirus (COVID-19) Infection: Inference Using Exported Cases

(2020) Sung-mok Jung et al.   Journal of Clinical Medicine

Does comorbidity increase the risk of patients with COVID-19: evidence from meta-analysis

(2020) Bolin Wang et al.   Aging-US

The Incubation Period of Coronavirus Disease 2019 (COVID-19) From Publicly Reported Confirmed Cases: Estimation and Application

(2020) Stephen A. Lauer et al.   ANNALS OF INTERNAL MEDICINE

Dynamic relationship between D‐dimer and COVID‐19 severity

(2020) Yong Li et al.   BRITISH JOURNAL OF HAEMATOLOGY

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

COVID-19: towards understanding of pathogenesis

(2020) Wei Cao et al.   CELL RESEARCH

Hyperglycemia and the worse prognosis of COVID-19. Why a fast blood glucose control should be mandatory

(2020) Antonio Ceriello   DIABETES RESEARCH AND CLINICAL PRACTICE

The role of interleukin‐6 in monitoring severe case of coronavirus disease 2019

(2020) Tao Liu et al.   EMBO Molecular Medicine

Pathogenesis of COVID-19 from a cell biology perspective

(2020) Robert J. Mason   EUROPEAN RESPIRATORY JOURNAL

Lipid peroxidation and ferroptosis: The role of GSH and GPx4

(2020) Fulvio Ursini et al.   FREE RADICAL BIOLOGY AND MEDICINE

Immunology of COVID-19: current state of the science

(2020) Nicolas Vabret et al.   IMMUNITY

Genotype and phenotype of COVID-19: Their roles in pathogenesis

(2020) Leila Mousavizadeh et al.   JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION

Incidence of venous thromboembolism in hospitalized patients with COVID‐19

(2020) Saskia Middeldorp et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Anosmia and Ageusia: Common Findings in COVID-19 Patients

(2020) Luigi A. Vaira et al.   LARYNGOSCOPE

Mild or Moderate Covid-19

(2020) Rajesh T. Gandhi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Clinical Characteristics of Covid-19 in New York City

(2020) Parag Goyal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Chloroquine and hydroxychloroquine in the management of COVID-19: Much kerfuffle but little evidence

(2020) M. Roustit et al.   THERAPIE

Report from the American Society for Microbiology COVID-19 International Summit, 23 March 2020: Value of Diagnostic Testing for SARS–CoV-2/COVID-19

(2020) Robin Patel et al.   mBio

Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China

(2020) Chaomin Wu et al.   JAMA Internal Medicine

Endogenous Deficiency of Glutathione as the Most Likely Cause of Serious Manifestations and Death in COVID-19 Patients

(2020) Alexey Polonikov   ACS Infectious Diseases

Antiviral activities of type I interferons to SARS-CoV-2 infection

(2020) Emily Mantlo et al.   ANTIVIRAL RESEARCH

Redox-Modulating Agents in the Treatment of Viral Infections

(2020) Paola Checconi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The role of biomarkers in diagnosis of COVID-19 – A systematic review

(2020) Muhammed Kermali et al.   LIFE SCIENCES

Association between chest CT features and clinical course of Coronavirus Disease 2019

(2020) Zhibing Luo et al.   RESPIRATORY MEDICINE

Cytokine Storm in COVID-19: The Current Evidence and Treatment Strategies

(2020) Yujun Tang et al.   Frontiers in Immunology

Immune Response, Inflammation, and the Clinical Spectrum of COVID-19

(2020) Luis F. García   Frontiers in Immunology

Association of Cardiac Infection With SARS-CoV-2 in Confirmed COVID-19 Autopsy Cases

(2020) Diana Lindner et al.   JAMA Cardiology

Outcomes of Cardiovascular Magnetic Resonance Imaging in Patients Recently Recovered From Coronavirus Disease 2019 (COVID-19)

(2020) Valentina O. Puntmann et al.   JAMA Cardiology

COVID-19 and anosmia: A review based on up-to-date knowledge

(2020) Xiangming Meng et al.   AMERICAN JOURNAL OF OTOLARYNGOLOGY

Hyperferritinemia in critically ill COVID-19 patients – Is ferritin the product of inflammation or a pathogenic mediator?

(2020) Jenifer Gómez-Pastora et al.   CLINICA CHIMICA ACTA

The ORF6, ORF8 and nucleocapsid proteins of SARS-CoV-2 inhibit type I interferon signaling pathway

(2020) Jin-Yan Li et al.   VIRUS RESEARCH

Counteraction of HCV-Induced Oxidative Stress Concurs to Establish Chronic Infection in Liver Cell Cultures

(2019) Simona Anticoli et al.   Oxidative Medicine and Cellular Longevity

IL-10+ NK and TGF-β+ NK cells play negative regulatory roles in HIV infection

(2018) Yongjun Jiang et al.   BMC INFECTIOUS DISEASES

A dual motif in the hemagglutinin of H5N1 Goose/Guangdong-like HPAIV is conserved from their early evolution and increases both membrane fusion pH and virulence.

(2018) Ute Wessels et al.   JOURNAL OF VIROLOGY

Glutathione metabolism in type 2 diabetes and its relationship with microvascular complications and glycemia

(2018) Fallon K. Lutchmansingh et al.   PLoS One

Redox Biology of Respiratory Viral Infections

(2018) Olga Khomich et al.   Viruses-Basel

Differential Redox State Contributes to Sex Disparities in the Response to Influenza Virus Infection in Male and Female Mice

(2018) Ignacio Celestino et al.   Frontiers in Immunology

N-acetylcysteine improves oxidative stress and inflammatory response in patients with community acquired pneumonia

(2018) Qianwen Zhang et al.   MEDICINE

Therapeutic Modulation of Virus-Induced Oxidative Stress via the Nrf2-Dependent Antioxidative Pathway

(2018) Choongho Lee   Oxidative Medicine and Cellular Longevity

Suppression of Type I Interferon Signaling by Flavivirus NS5

(2018) Stephanie Thurmond et al.   Viruses-Basel

Oral supplementation with liposomal glutathione elevates body stores of glutathione and markers of immune function

(2017) R Sinha et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy

(2017) Eunice E. To et al.   Nature Communications

Does iron deficiency anemia affect olfactory function?

(2016) Mehmet Emre Dinc et al.   ACTA OTO-LARYNGOLOGICA

Zika Virus Targets Human STAT2 to Inhibit Type I Interferon Signaling

(2016) Alesha Grant et al.   Cell Host & Microbe

Ferroptosis is an autophagic cell death process

(2016) Minghui Gao et al.   CELL RESEARCH

Mechanisms of ferroptosis

(2016) Jennifer Yinuo Cao et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Cilia Dysfunction in Lung Disease

(2015) Ann E. Tilley et al.   Annual Review of Physiology

The Angiotensin-Converting Enzyme 2/Angiotensin (1–7)/Mas Axis Protects Against Lung Fibroblast Migration and Lung Fibrosis by Inhibiting the NOX4-Derived ROS-Mediated RhoA/Rho Kinase Pathway

(2015) Ying Meng et al.   ANTIOXIDANTS & REDOX SIGNALING

Regulation of human helper T cell subset differentiation by cytokines

(2015) Nathalie Schmitt et al.   CURRENT OPINION IN IMMUNOLOGY

The Cytokine GM-CSF Drives the Inflammatory Signature of CCR2+ Monocytes and Licenses Autoimmunity

(2015) Andrew L. Croxford et al.   IMMUNITY

TNF Regulates Essential Alternative Complement Pathway Components and Impairs Activation of Protein C in Human Glomerular Endothelial Cells

(2015) Sarah E. Sartain et al.   JOURNAL OF IMMUNOLOGY

Liposomal Glutathione Supplementation Restores TH1 Cytokine Response toMycobacterium tuberculosisInfection in HIV-Infected Individuals

(2015) Judy Ly et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Hydroxychloroquine-Inhibited Dengue Virus Is Associated with Host Defense Machinery

(2015) Li-Fong Wang et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Chloroquine enhances replication of influenza A virus A/WSN/33 (H1N1) in dose-, time-, and MOI-dependent manners in human lung epithelial cells A549

(2015) Liqi Wu et al.   JOURNAL OF MEDICAL VIROLOGY

The role of lipoxygenases in pathophysiology; new insights and future perspectives

(2015) Ryuichi Mashima et al.   Redox Biology

Effects of N-acetylcysteine, oral glutathione (GSH) and a novel sublingual form of GSH on oxidative stress markers: A comparative crossover study.

(2015) Bernard Schmitt et al.   Redox Biology

Influenza virus replication in lung epithelial cells depends on redox-sensitive pathways activated by NOX4-derived ROS

(2014) Donatella Amatore et al.   CELLULAR MICROBIOLOGY

Vitamin D status is independently associated with plasma glutathione and cysteine thiol/disulphide redox status in adults

(2014) Jessica A. Alvarez et al.   CLINICAL ENDOCRINOLOGY

Acute glutathione depletion leads to enhancement of airway reactivity and inflammation via p38MAPK-iNOS pathway in allergic mice

(2014) A. Nadeem et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Dual Role of NOX2 in Respiratory Syncytial Virus- and Sendai Virus-Induced Activation of NF- B in Airway Epithelial Cells

(2014) K. Fink et al.   JOURNAL OF IMMUNOLOGY

The Glutathione System: A New Drug Target in Neuroimmune Disorders

(2014) Gerwyn Morris et al.   MOLECULAR NEUROBIOLOGY

Coronavirus-induced ER stress response and its involvement in regulation of coronavirus–host interactions

(2014) To Sing Fung et al.   VIRUS RESEARCH

The Coronavirus Nucleocapsid Is a Multifunctional Protein

(2014) Ruth McBride et al.   Viruses-Basel

Endocytosis of Viruses and Bacteria

(2014) P. Cossart et al.   Cold Spring Harbor Perspectives in Biology

Vitamin D upregulates glutamate cysteine ligase and glutathione reductase, and GSH formation, and decreases ROS and MCP-1 and IL-8 secretion in high-glucose exposed U937 monocytes

(2013) Sushil K. Jain et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Unusual clotting dynamics of plasma supplemented with iron(III)

(2013) JERZY JANKUN et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Release of Severe Acute Respiratory Syndrome Coronavirus Nuclear Import Block Enhances Host Transcription in Human Lung Cells

(2013) A. C. Sims et al.   JOURNAL OF VIROLOGY

Glutathione and infection

(2012) Devin Morris et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Glutathione synthesis

(2012) Shelly C. Lu   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Redox Regulation of the Influenza Hemagglutinin Maturation Process: A New Cell-Mediated Strategy for Anti-Influenza Therapy

(2011) Rossella Sgarbanti et al.   ANTIOXIDANTS & REDOX SIGNALING

Unveiling the Mechanisms for Decreased Glutathione in Individuals with HIV Infection

(2011) Devin Morris et al.   Clinical & Developmental Immunology

IL-6 promotes nonthyroidal illness syndrome by blocking thyroxine activation while promoting thyroid hormone inactivation in human cells

(2011) Simone Magagnin Wajner et al.   JOURNAL OF CLINICAL INVESTIGATION

Nuclear import by karyopherin-βs: Recognition and inhibition

(2010) Yuh Min Chook et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Coronavirus Genomics and Bioinformatics Analysis

(2010) Patrick C. Y. Woo et al.   Viruses-Basel

Respiratory Syncytial Virus Induces Oxidative Stress by Modulating Antioxidant Enzymes

(2009) Yashoda M. Hosakote et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury

(2008) Yumiko Imai et al.   CELL

Multiple Nuclear Localization Signals Function in the Nuclear Import of the Transcription Factor Nrf2

(2008) Melanie Theodore et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Severe Acute Respiratory Syndrome Coronavirus Triggers Apoptosis via Protein Kinase R but Is Resistant to Its Antiviral Activity

(2008) V. Krahling et al.   JOURNAL OF VIROLOGY

Glutathione levels and immune responses in tuberculosis patients

(2007) Vishwanath Venketaraman et al.   MICROBIAL PATHOGENESIS