Suppression of Type I Interferon Signaling by Flavivirus NS5

Nucleocytoplasmic shuttling of the West Nile virus RNA-dependent RNA polymerase NS5 is critical to infection

(2018) Adam J. Lopez-Denman et al.   CELLULAR MICROBIOLOGY

Glutathionylation of dengue and Zika NS5 proteins affects guanylyltransferase and RNA dependent RNA polymerase activities

(2018) Chonticha Saisawang et al.   PLoS One

Dengue viruses cleave STING in humans but not in nonhuman primates, their presumed natural reservoir

(2018) Alex C Stabell et al.   eLife

Subgenomic flaviviral RNAs: What do we know after the first decade of research

(2018) Andrii Slonchak et al.   ANTIVIRAL RESEARCH

COMRADES determines in vivo RNA structures and interactions

(2018) Omer Ziv et al.   NATURE METHODS

Pervasive tertiary structure in the dengue virus RNA genome

(2018) Elizabeth A. Dethoff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Japanese Encephalitis Virus NS5 Inhibits Type I Interferon (IFN) Production by Blocking the Nuclear Translocation of IFN Regulatory Factor 3 and NF-κB

(2017) Jing Ye et al.   JOURNAL OF VIROLOGY

Selective Activation of Type II Interferon Signaling by Zika Virus NS5 Protein

(2017) Vidyanath Chaudhary et al.   JOURNAL OF VIROLOGY

The structure of Zika virus NS5 reveals a conserved domain conformation

(2017) Boxiao Wang et al.   Nature Communications

Structure and function of the Zika virus full-length NS5 protein

(2017) Baoyu Zhao et al.   Nature Communications

Flavivirus transmission focusing on Zika

(2017) Nikos Vasilakis et al.   Current Opinion in Virology

Zika Virus Infection as a Cause of Congenital Brain Abnormalities and Guillain–Barré Syndrome: Systematic Review

(2017) Fabienne Krauer et al.   PLOS MEDICINE

Causes and Consequences of Flavivirus RNA Methylation

(2017) Shelton S. Bradrick   Frontiers in Microbiology

Crystal structure of full-lengthZika virusNS5 protein reveals a conformation similar toJapanese encephalitis virusNS5

(2017) Anup K. Upadhyay et al.   Acta Crystallographica Section F-Structural Biology Communications

Dengue virus NS2B protein targets cGAS for degradation and prevents mitochondrial DNA sensing during infection

(2017) Sebastian Aguirre et al.   Nature Microbiology

Dengue virus activates cGAS through the release of mitochondrial DNA

(2017) Bo Sun et al.   Scientific Reports

Zika Virus Targets Human STAT2 to Inhibit Type I Interferon Signaling

(2016) Alesha Grant et al.   Cell Host & Microbe

Type III Interferons Produced by Human Placental Trophoblasts Confer Protection against Zika Virus Infection

(2016) Avraham Bayer et al.   Cell Host & Microbe

The unique role of STAT2 in constitutive and IFN-induced transcription and antiviral responses

(2016) Katarzyna Blaszczyk et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Zika virus inhibits type‐I interferon production and downstream signaling

(2016) Anil Kumar et al.   EMBO REPORTS

Host Inflammatory Response to Mosquito Bites Enhances the Severity of Arbovirus Infection

(2016) Marieke Pingen et al.   IMMUNITY

SUMO Modification Stabilizes Dengue Virus Nonstructural Protein 5 To Support Virus Replication

(2016) Chan-I Su et al.   JOURNAL OF VIROLOGY

Dengue Virus Subverts Host Innate Immunity by Targeting Adaptor Protein MAVS

(2016) Zhenjian He et al.   JOURNAL OF VIROLOGY

The Many Faces of the Flavivirus NS5 Protein in Antagonism of Type I Interferon Signaling

(2016) Sonja M. Best   JOURNAL OF VIROLOGY

A phosphomimetic-based mechanism of dengue virus to antagonize innate immunity

(2016) Ying Kai Chan et al.   NATURE IMMUNOLOGY

STAT2 Is a Pervasive Cytokine Regulator due to Its Inhibition of STAT1 in Multiple Signaling Pathways

(2016) Johnathan Ho et al.   PLOS BIOLOGY

A Susceptible Mouse Model for Zika Virus Infection

(2016) Stuart D. Dowall et al.   PLoS Neglected Tropical Diseases

The Dengue Virus NS5 Protein Intrudes in the Cellular Spliceosome and Modulates Splicing

(2016) Federico A. De Maio et al.   PLoS Pathogens

Interim Guidelines for Pregnant Women During a Zika Virus Outbreak — United States, 2016

(2016) Emily E. Petersen et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

STAT2/IRF9 directs a prolonged ISGF3-like transcriptional response and antiviral activity in the absence of STAT1

(2015) Katarzyna Blaszczyk et al.   BIOCHEMICAL JOURNAL

Flavivirus Antagonism of Type I Interferon Signaling Reveals Prolidase as a Regulator of IFNAR1 Surface Expression

(2015) Kirk J. Lubick et al.   Cell Host & Microbe

Interferon-λ: Immune Functions at Barrier Surfaces and Beyond

(2015) Helen M. Lazear et al.   IMMUNITY

Dengue subgenomic RNA binds TRIM25 to inhibit interferon expression for epidemiological fitness

(2015) G. Manokaran et al.   SCIENCE

Interferon-λ restricts West Nile virus neuroinvasion by tightening the blood-brain barrier

(2015) Helen M. Lazear et al.   Science Translational Medicine

A Crystal Structure of the Dengue Virus NS5 Protein Reveals a Novel Inter-domain Interface Essential for Protein Flexibility and Virus Replication

(2015) Yongqian Zhao et al.   PLoS Pathogens

No Love Lost Between Viruses and Interferons

(2015) Volker Fensterl et al.   Annual Review of Virology

The Interferon Signaling Antagonist Function of Yellow Fever Virus NS5 Protein Is Activated by Type I Interferon

(2014) Maudry Laurent-Rolle et al.   Cell Host & Microbe

Flaviviruses, an expanding threat in public health: focus on dengue, West Nile, and Japanese encephalitis virus

(2014) Carlo Amorin Daep et al.   JOURNAL OF NEUROVIROLOGY

The methyltransferase domain of dengue virus protein NS5 ensures efficient RNA synthesis initiation and elongation by the polymerase domain

(2014) Supanee Potisopon et al.   NUCLEIC ACIDS RESEARCH

The eukaryotic N-end rule pathway: conserved mechanisms and diverse functions

(2014) Daniel J. Gibbs et al.   TRENDS IN CELL BIOLOGY

IFNβ-dependent increases in STAT1, STAT2, and IRF9 mediate resistance to viruses and DNA damage

(2013) HyeonJoo Cheon et al.   EMBO JOURNAL

West Nile Virus: Review of the Literature

(2013) Lyle R. Petersen et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Serotype-specific Differences in Dengue Virus Non-structural Protein 5 Nuclear Localization

(2013) Holger Hannemann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mosquito Protein Kinase G Phosphorylates Flavivirus NS5 and Alters Flight Behavior in Aedes aegypti and Anopheles gambiae

(2013) Julie A. Keating et al.   VECTOR-BORNE AND ZOONOTIC DISEASES

West Nile virus methyltransferase domain interacts with protein kinase G

(2013) Julie A Keating et al.   Virology Journal

Sequential Waves of Gene Expression in Patients with Clinically Defined Dengue Illnesses Reveal Subtle Disease Phases and Predict Disease Severity

(2013) Peifang Sun et al.   PLoS Neglected Tropical Diseases

Viperin Is Induced following Dengue Virus Type-2 (DENV-2) Infection and Has Anti-viral Actions Requiring the C-terminal End of Viperin

(2013) Karla J. Helbig et al.   PLoS Neglected Tropical Diseases

Innate Immune Sensing of Flaviviruses

(2013) Mehul S. Suthar et al.   PLoS Pathogens

Dengue Virus Co-opts UBR4 to Degrade STAT2 and Antagonize Type I Interferon Signaling

(2013) Juliet Morrison et al.   PLoS Pathogens

Crystal Structure of the Full-Length Japanese Encephalitis Virus NS5 Reveals a Conserved Methyltransferase-Polymerase Interface

(2013) Guoliang Lu et al.   PLoS Pathogens

Ivermectin is a specific inhibitor of importin α/β-mediated nuclear import able to inhibit replication of HIV-1 and dengue virus

(2012) Kylie M. Wagstaff et al.   BIOCHEMICAL JOURNAL

Dengue Virus Nonstructural Protein 5 Adopts Multiple Conformations in Solution

(2012) Cécile Bussetta et al.   BIOCHEMISTRY

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

Expression of interferon-induced antiviral genes is delayed in a STAT1 knockout mouse model of Crimean-Congo hemorrhagic fever

(2012) Gavin C Bowick et al.   Virology Journal

Animal Models of Dengue Virus Infection

(2012) Simona Zompi et al.   Viruses-Basel

Molecular Basis for Nucleotide Conservation at the Ends of the Dengue Virus Genome

(2012) Barbara Selisko et al.   PLoS Pathogens

Acute dengue virus 2 infection in Gabonese patients is associated with an early innate immune response, including strong interferon alpha production

(2011) Pierre Becquart et al.   BMC INFECTIOUS DISEASES

Characterization of early host responses in adults with dengue disease

(2011) Thomas Tolfvenstam et al.   BMC INFECTIOUS DISEASES

Flavivirus Cell Entry and Membrane Fusion

(2011) Jolanda Smit et al.   Viruses-Basel

RIG-I, MDA5 and TLR3 Synergistically Play an Important Role in Restriction of Dengue Virus Infection

(2011) A. M. A. Nasirudeen et al.   PLoS Neglected Tropical Diseases

STAT2 Mediates Innate Immunity to Dengue Virus in the Absence of STAT1 via the Type I Interferon Receptor

(2011) Stuart T. Perry et al.   PLoS Pathogens

Mouse STAT2 Restricts Early Dengue Virus Replication

(2010) Joseph Ashour et al.   Cell Host & Microbe

The NS5 Protein of the Virulent West Nile Virus NY99 Strain Is a Potent Antagonist of Type I Interferon-Mediated JAK-STAT Signaling

(2010) M. Laurent-Rolle et al.   JOURNAL OF VIROLOGY

The Endoplasmic Reticulum Provides the Membrane Platform for Biogenesis of the Flavivirus Replication Complex

(2010) Leah K. Gillespie et al.   JOURNAL OF VIROLOGY

Identification of Five Interferon-Induced Cellular Proteins That Inhibit West Nile Virus and Dengue Virus Infections

(2010) D. Jiang et al.   JOURNAL OF VIROLOGY

Report of an NIAID workshop on dengue animal models

(2010) M. Cristina Cassetti et al.   VACCINE

The IFITM Proteins Mediate Cellular Resistance to Influenza A H1N1 Virus, West Nile Virus, and Dengue Virus

(2009) Abraham L. Brass et al.   CELL

Composition and Three-Dimensional Architecture of the Dengue Virus Replication and Assembly Sites

(2009) Sonja Welsch et al.   Cell Host & Microbe

CRM1-mediated Nuclear Export of Dengue Virus RNA Polymerase NS5 Modulates Interleukin-8 Induction and Virus Production

(2009) Stephen M. Rawlinson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genomics and evolution of Aedes-borne flaviviruses

(2009) G. Grard et al.   JOURNAL OF GENERAL VIROLOGY

Distinct Antiviral Roles for Human 2',5'-Oligoadenylate Synthetase Family Members against Dengue Virus Infection

(2009) R.-J. Lin et al.   JOURNAL OF IMMUNOLOGY

Dengue Virus NS5 Inhibits Interferon‐α Signaling by Blocking Signal Transducer and Activator of Transcription 2 Phosphorylation

(2009) Michela Mazzon et al.   JOURNAL OF INFECTIOUS DISEASES

NS5 of Dengue Virus Mediates STAT2 Binding and Degradation

(2009) J. Ashour et al.   JOURNAL OF VIROLOGY

Protein Kinase G Phosphorylates Mosquito-Borne Flavivirus NS5

(2009) D. Bhattacharya et al.   JOURNAL OF VIROLOGY

Zika Virus Outbreak on Yap Island, Federated States of Micronesia

(2009) Mark R. Duffy et al.   NEW ENGLAND JOURNAL OF MEDICINE

Unphosphorylated STAT1 prolongs the expression of interferon-induced immune regulatory genes

(2009) H. Cheon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The flavivirus NS5 protein is a true RNA guanylyltransferase that catalyzes a two-step reaction to form the RNA cap structure

(2009) M. Issur et al.   RNA

The flavivirus polymerase as a target for drug discovery

(2008) Hélène Malet et al.   ANTIVIRAL RESEARCH

Tick-borne encephalitis virus NS5 associates with membrane protein scribble and impairs interferon-stimulated JAK-STAT signalling

(2008) Karin Werme et al.   CELLULAR MICROBIOLOGY