BKCa Channels as Targets for Cardioprotection

Heart Disease and Stroke Statistics—2020 Update: A Report From the American Heart Association

(2020) Salim S. Virani et al.   CIRCULATION

Loss-of-function BK channel mutation causes impaired mitochondria and progressive cerebellar ataxia

(2020) Xiaofei Du et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intracellular Chloride Channels: Novel Biomarkers in Diseases

(2020) Shubha Gururaja Rao et al.   Frontiers in Physiology

Insights Into the Role of Mitochondrial Ion Channels in Inflammatory Response

(2020) Devasena Ponnalagu et al.   Frontiers in Physiology

Regulation of BK Channels by Beta and Gamma Subunits

(2019) Vivian Gonzalez-Perez et al.   Annual Review of Physiology

The neuropeptide GsMTx4 inhibits a mechanosensitive BK channel through the voltage-dependent modification specific to mechano-gating

(2019) Hui Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

KCNMA1-linked channelopathy

(2019) Cole S. Bailey et al.   JOURNAL OF GENERAL PHYSIOLOGY

Calcium- and voltage-gated BK channels in vascular smooth muscle

(2018) Alex M. Dopico et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Drosophila Voltage-Gated Calcium Channel α1-Subunits Regulate Cardiac Function in the Aging Heart

(2018) Alexander Lam et al.   Scientific Reports

SERCA, complex I of the respiratory chain and ATP-synthase inhibition are involved in pleiotropic effects of NS1619 on endothelial cells

(2016) Agnieszka Łukasiak et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Molecular identity of cardiac mitochondrial chloride intracellular channel proteins

(2016) Devasena Ponnalagu et al.   MITOCHONDRION

BK Channels Alleviate Lysosomal Storage Diseases by Providing Positive Feedback Regulation of Lysosomal Ca2+ Release

(2015) Qi Cao et al.   DEVELOPMENTAL CELL

Mitochondrial BKCa channel

(2015) Enrique Balderas et al.   Frontiers in Physiology

BK channels regulate sinoatrial node firing rate and cardiac pacing in vivo

(2014) Michael H. Lai et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Nuclear BK channels regulate gene expression via the control of nuclear calcium signaling

(2014) Boxing Li et al.   NATURE NEUROSCIENCE

Mitochondrial Channels: Ion Fluxes and More

(2014) Ildiko Szabo et al.   PHYSIOLOGICAL REVIEWS

KCNMA1 Encoded Cardiac BK Channels Afford Protection against Ischemia-Reperfusion Injury

(2014) Ewa Soltysinska et al.   PLoS One

Phosphorylation of BK channels modulates the sensitivity to hydrogen sulfide (H2S)

(2014) Guzel F. Sitdikova et al.   Frontiers in Physiology

Current understanding of iberiotoxin-resistant BK channels in the nervous system

(2014) Bin Wang et al.   Frontiers in Physiology

BK channel activators and their therapeutic perspectives

(2014) Bo H. Bentzen et al.   Frontiers in Physiology

Pharmacological activation of mitochondrial BKCa channels protects isolated cardiomyocytes against simulated reperfusion-induced injury

(2013) Gudrun H Borchert et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Specific phosphorylation sites underlie the stimulation of a large conductance, Ca2+-activated K+ channel by cGMP-dependent protein kinase

(2013) Barry D. Kyle et al.   FASEB JOURNAL

Myocardial ischemia-reperfusion injury: a neglected therapeutic target

(2013) Derek J. Hausenloy et al.   JOURNAL OF CLINICAL INVESTIGATION

MaxiK channel and cell signalling

(2013) Ligia Toro et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

mitoBKCa is encoded by the Kcnma1 gene, and a splicing sequence defines its mitochondrial location

(2013) H. Singh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A non-cardiomyocyte autonomous mechanism of cardioprotection involving the SLO1 BK channel

(2013) Andrew P. Wojtovich et al.   PeerJ

ABCC6 Localizes to the Mitochondria-Associated Membrane

(2012) Lisa J. Martin et al.   CIRCULATION RESEARCH

Intracellular BKCa(iBKCa) channels

(2012) Harpreet Singh et al.   JOURNAL OF PHYSIOLOGY-LONDON

Hydrogen Sulfide and Cell Signaling

(2011) Ling Li et al.   Annual Review of Pharmacology and Toxicology

Modulation of Ion Channels by Hydrogen Sulfide

(2011) Chris Peers et al.   ANTIOXIDANTS & REDOX SIGNALING

ER Stress and Apoptosis: A New Mechanism for Retinal Cell Death

(2011) Guangjun Jing et al.   Experimental Diabetes Research

Spatial organization of RYRs and BK channels underlying the activation of STOCs by Ca2+sparks in airway myocytes

(2011) Lawrence M. Lifshitz et al.   JOURNAL OF GENERAL PHYSIOLOGY

Enhanced Fibroblast–Myocyte Interactions in Response to Cardiac Injury

(2010) Carolina Vasquez et al.   CIRCULATION RESEARCH

Membrane stretch and cytoplasmic Ca2+ independently modulate stretch-activated BK channel activity

(2010) Hu-cheng Zhao et al.   JOURNAL OF BIOMECHANICS

BK channels and a new form of hypertension

(2010) P Richard Grimm et al.   KIDNEY INTERNATIONAL

Cav1.3 and BK Channels for Timing and Regulating Cell Firing

(2010) David Henry Vandael et al.   MOLECULAR NEUROBIOLOGY

A Role for BK Channels in Heart Rate Regulation in Rodents

(2010) Wendy L. Imlach et al.   PLoS One

Dual role of protein kinase C on BK channel regulation

(2010) Xiao-Bo Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism of inhibition by hydrogen sulfide of native and recombinant BKCa channels

(2010) Vsevolod Telezhkin et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Structure of the Human BK Channel Ca2+-Activation Apparatus at 3.0 A Resolution

(2010) P. Yuan et al.   SCIENCE

Activation of Mitochondrial Large-Conductance Calcium-Activated K+ Channels via Protein Kinase A Mediates Desflurane-Induced Preconditioning

(2009) Andreas Redel et al.   ANESTHESIA AND ANALGESIA

Energetic performance is improved by specific activation of K+ fluxes through KCa channels in heart mitochondria

(2009) Miguel A. Aon et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Modulation of BKCa Channel Gating by Endogenous Signaling Molecules

(2009) Shangwei Hou et al.   PHYSIOLOGY

Characterization of Multiple Ion Channels in Cultured Human Cardiac Fibroblasts

(2009) Gui-Rong Li et al.   PLoS One

Molecular mechanisms of BK channel activation

(2008) J. Cui et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Hypoxia Increases Activity of the BK-Channel in the Inner Mitochondrial Membrane and Reduces Activity of the Permeability Transition Pore

(2008) Yu Cheng et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

BK Channel Modulators: A Comprehensive Overview

(2008) Antonio Nardi et al.   CURRENT MEDICINAL CHEMISTRY

Reciprocal regulation of the Ca2+ and H+ sensitivity in the SLO1 BK channel conferred by the RCK1 domain

(2008) Shangwei Hou et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Control of KCa Channels by Calcium Nano/Microdomains

(2008) Bernd Fakler et al.   NEURON

Activation of big conductance Ca2+-activated K+ channels (BK) protects the heart against ischemia–reperfusion injury

(2008) Bo Hjorth Bentzen et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Genesis and Regulation of the Heart Automaticity

(2008) Matteo E. Mangoni et al.   PHYSIOLOGICAL REVIEWS

The RCK1 high-affinity Ca2+ sensor confers carbon monoxide sensitivity to Slo1 BK channels

(2008) S. Hou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The regulation of mitochondrial respiration by opening of mKCa channels is age-dependent

(2007) André Heinen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY