The neuropeptide GsMTx4 inhibits a mechanosensitive BK channel through the voltage-dependent modification specific to mechano-gating

Mechanosensitivity of mitochondrial large-conductance calcium-activated potassium channels

(2018) Agnieszka Walewska et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mechanosensitive ion channels in articular nociceptors drive mechanical allodynia in osteoarthritis

(2017) B.H. He et al.   OSTEOARTHRITIS AND CARTILAGE

Piezo channels and GsMTx4: Two milestones in our understanding of excitatory mechanosensitive channels and their role in pathology

(2017) Thomas M. Suchyna   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

GsMTx4-D is a cardioprotectant against myocardial infarction during ischemia and reperfusion

(2016) Jinli Wang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Adaptation Independent Modulation of Auditory Hair Cell Mechanotransduction Channel Open Probability Implicates a Role for the Lipid Bilayer

(2016) A. W. Peng et al.   JOURNAL OF NEUROSCIENCE

Structural basis for gating the high-conductance Ca2+-activated K+ channel

(2016) Richard K. Hite et al.   NATURE

Cryo-EM structure of the open high-conductance Ca2+-activated K+ channel

(2016) Xiao Tao et al.   NATURE

Epilepsy-Related Slack Channel Mutants Lead to Channel Over-Activity by Two Different Mechanisms

(2016) Qiong-Yao Tang et al.   Cell Reports

Effects of Lys to Glu mutations in GsMTx4 on membrane binding, peptide orientation, and self-association propensity, as analyzed by molecular dynamics simulations

(2015) Kazuhisa Nishizawa et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Mechanisms of mechanosensing — mechanosensitive channels, function and re-engineering

(2015) Armagan Kocer   CURRENT OPINION IN CHEMICAL BIOLOGY

Single-channel kinetics of BK (Slo1) channels

(2015) Yanyan Geng et al.   Frontiers in Physiology

Structural Determinants of Phosphatidylinositol 4,5-Bisphosphate (PIP2) Regulation of BK Channel Activity through the RCK1 Ca2+Coordination Site

(2014) Qiong-Yao Tang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Piezo Proteins: Regulators of Mechanosensation and Other Cellular Processes

(2014) Sviatoslav N. Bagriantsev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Physiological and Pathological Functions of Mechanosensitive Ion Channels

(2014) Yuanzheng Gu et al.   MOLECULAR NEUROBIOLOGY

Stochastic nanoroughness modulates neuron–astrocyte interactions and function via mechanosensing cation channels

(2014) Nils R. Blumenthal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage

(2014) Whasil Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mitoBKCa is encoded by the Kcnma1 gene, and a splicing sequence defines its mitochondrial location

(2013) H. Singh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Calcium influx through a possible coupling of cation channels impacts skeletal muscle satellite cell activation in response to mechanical stretch

(2012) Minako Hara et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Piezo proteins are pore-forming subunits of mechanically activated channels

(2012) Bertrand Coste et al.   NATURE

The mechanobiology of brain function

(2012) William J. Tyler   NATURE REVIEWS NEUROSCIENCE

The Mechanosensitive Ion Channel Piezo1 Is Inhibited by the Peptide GsMTx4

(2011) Chilman Bae et al.   BIOCHEMISTRY

A Hitchhiker's Guide to Mechanobiology

(2011) Jeroen Eyckmans et al.   DEVELOPMENTAL CELL

Open structure of the Ca2+ gating ring in the high-conductance Ca2+-activated K+ channel

(2011) Peng Yuan et al.   NATURE

Control of Unidirectional Transport of Single-File Water Molecules through Carbon Nanotubes in an Electric Field

(2010) Jiaye Su et al.   ACS Nano

Block of mouse Slo1 and Slo3 K+channels by CTX, IbTX, TEA, 4-AP and quinidine

(2010) Qiong-Yao Tang et al.   Channels

Contactin-2 Expression in the Cardiac Purkinje Fiber Network

(2010) Benedetta A. Pallante et al.   Circulation-Arrhythmia and Electrophysiology

Phosphatidylinositol 4,5-Bisphosphate Activates Slo3 Currents and Its Hydrolysis Underlies the Epidermal Growth Factor-induced Current Inhibition

(2010) Qiong-Yao Tang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coupling and cooperativity in voltage activation of a limited-state BK channel gating in saturating Ca2+

(2010) Christopher Shelley et al.   JOURNAL OF GENERAL PHYSIOLOGY

The RCK2 Domain Uses a Coordination Site Present in Kir Channels to Confer Sodium Sensitivity to Slo2.2 Channels

(2010) Z. Zhang et al.   JOURNAL OF NEUROSCIENCE

Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels

(2010) B. Coste et al.   SCIENCE

Targeting voltage sensors in sodium channels with spider toxins

(2010) Frank Bosmans et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Stress-Axis Regulated Exon (STREX) in the C terminus of BKCa channels is responsible for the stretch sensitivity

(2009) Keiji Naruse et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

CHARMM-GUI Membrane Builder for Mixed Bilayers and Its Application to Yeast Membranes

(2009) Sunhwan Jo et al.   BIOPHYSICAL JOURNAL

CHARMM: The biomolecular simulation program

(2009) B. R. Brooks et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Closed-channel block of BK potassium channels by bbTBA requires partial activation

(2009) Qiong-Yao Tang et al.   JOURNAL OF GENERAL PHYSIOLOGY

Interactions between lipids and voltage sensor paddles detected with tarantula toxins

(2009) Mirela Milescu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Tuning the mechanosensitivity of a BK channel by changing the linker length

(2008) Hucheng Zhao et al.   CELL RESEARCH

Voltage-dependent K+ channel gating and voltage sensor toxin sensitivity depend on the mechanical state of the lipid membrane

(2008) D. Schmidt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA