Calcium- and voltage-gated BK channels in vascular smooth muscle

Effects of mechanical stretch on the functions of BK and L-type Ca 2+ channels in vascular smooth muscle cells

(2018) Zhiguo Zhang et al.   JOURNAL OF BIOMECHANICS

Functional regulation of large conductance Ca 2+ -activated K + channels in vascular diseases

(2018) Yanrong Zhu et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Understanding the conformational motions of RCK gating rings

(2017) Teresa Giraldez et al.   JOURNAL OF GENERAL PHYSIOLOGY

Regulation of Coronary Arterial Large Conductance Ca2+-Activated K+ Channel Protein Expression and Function by n-3 Polyunsaturated Fatty Acids in Diabetic Rats

(2017) Xu Tang et al.   JOURNAL OF VASCULAR RESEARCH

Elevated K+ channel activity opposes vasoconstrictor response to serotonin in cerebral arteries of the Fawn Hooded Hypertensive rat

(2017) Mallikarjuna R. Pabbidi et al.   PHYSIOLOGICAL GENOMICS

Molecular Determinants of BK Channel Functional Diversity and Functioning

(2017) Ramon Latorre et al.   PHYSIOLOGICAL REVIEWS

Microtubule structures underlying the sarcoplasmic reticulum support peripheral coupling sites to regulate smooth muscle contractility

(2017) Harry A. T. Pritchard et al.   Science Signaling

Membrane depolarization activates BK channels through ROCK-mediated β1 subunit surface trafficking to limit vasoconstriction

(2017) M. Dennis Leo et al.   Science Signaling

Microtubule structures underlying the sarcoplasmic reticulum support peripheral coupling sites to regulate smooth muscle contractility

(2017) Harry A. T. Pritchard et al.   Science Signaling

Membrane depolarization activates BK channels through ROCK-mediated β1 subunit surface trafficking to limit vasoconstriction

(2017) M. Dennis Leo et al.   Science Signaling

Alcohol modulation of BK channel gating depends on β subunit composition

(2016) Guruprasad Kuntamallappanavar et al.   JOURNAL OF GENERAL PHYSIOLOGY

Chronic intermittent hypobaric hypoxia antagonizes renal vascular hypertension by enhancement of vasorelaxation via activating BKCa

(2016) Yue Guan et al.   LIFE SCIENCES

Cryo-EM structure of the open high-conductance Ca2+-activated K+ channel

(2016) Xiao Tao et al.   NATURE

Equol increases cerebral blood flow in rats via activation of large-conductance Ca 2+ -activated K + channels in vascular smooth muscle cells

(2016) Wei Yu et al.   PHARMACOLOGICAL RESEARCH

Different Effects of Hypertension and Age on the Function of Large Conductance Calcium‐ and Voltage‐Activated Potassium Channels in Human Mesentery Artery Smooth Muscle Cells

(2016) Jun Cheng et al.   Journal of the American Heart Association

Angiotensin II stimulates internalization and degradation of arterial myocyte plasma membrane BK channels to induce vasoconstriction

(2015) M. Dennis Leo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Long-term hypoxia increases calcium affinity of BK channels in ovine fetal and adult cerebral artery smooth muscle

(2015) Xiaoxiao Tao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Membrane potential and Ca2+concentration dependence on pressure and vasoactive agents in arterial smooth muscle: A model

(2015) Arthur Karlin   JOURNAL OF GENERAL PHYSIOLOGY

BK channel β1-subunit deficiency exacerbates vascular fibrosis and remodelling but does not promote hypertension in high-fat fed obesity in mice

(2015) Hui Xu et al.   JOURNAL OF HYPERTENSION

Intravascular pressure enhances the abundance of functional Kv1.5 channels at the surface of arterial smooth muscle cells

(2015) Michael W. Kidd et al.   Science Signaling

Intravascular pressure enhances the abundance of functional Kv1.5 channels at the surface of arterial smooth muscle cells

(2015) Michael W. Kidd et al.   Science Signaling

Mitochondrial BKCa channel

(2015) Enrique Balderas et al.   Frontiers in Physiology

Tungstate-Targeting of BKαβ1 Channels Tunes ERK Phosphorylation and Cell Proliferation in Human Vascular Smooth Muscle

(2015) Ana Isabel Fernández-Mariño et al.   PLoS One

Dietary Cholesterol Protects Against Alcohol-Induced Cerebral Artery Constriction

(2014) Anna Bukiya et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

LRRC26 Is a Functional BK Channel Auxiliary γ Subunit in Arterial Smooth Muscle Cells

(2014) Kirk W. Evanson et al.   CIRCULATION RESEARCH

The Angiotensin II Type 1 Receptor (AT1R) Closely Interacts with Large Conductance Voltage- and Ca2+-activated K+(BK) Channels and Inhibits Their Activity Independent of G-protein Activation

(2014) Zhu Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of Calcium- and Voltage-gated Potassium Channels of Large Conductance by Leukotriene B4

(2014) Anna N. Bukiya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multi-generational pharmacophore modeling for ligands to the cholane steroid-recognition site in the β1 modulatory subunit of the BKCa channel

(2014) Jacob E. McMillan et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Pituitary Adenylate Cyclase Activating Polypeptide (PACAP) Dilates Cerebellar Arteries Through Activation of Large-Conductance Ca2+-Activated (BK) and ATP-Sensitive (KATP) K+ Channels

(2014) Masayo Koide et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Large Conductance Ca2+-Activated K+ Channel (BKCa) α-Subunit Splice Variants in Resistance Arteries from Rat Cerebral and Skeletal Muscle Vasculature

(2014) Zahra Nourian et al.   PLoS One

Dynamic regulation of β1 subunit trafficking controls vascular contractility

(2014) M. Dennis Leo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid regulation of BK channel function

(2014) Alex M. Dopico et al.   Frontiers in Physiology

The regulation of BK channel activity by pre- and post-translational modifications

(2014) Barry D. Kyle et al.   Frontiers in Physiology

Perivascular adipose tissue-derived adiponectin activates BKCa channels to induce anticontractile responses

(2013) Fiona M. Lynch et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Smooth muscle relaxation and activation of the large conductance Ca++- activated K+(BKCa) channel by novel oestrogens

(2013) J Maher et al.   BRITISH JOURNAL OF PHARMACOLOGY

Potassium Channels and Uterine Vascular Adaptation to Pregnancy and Chronic Hypoxia

(2013) Ronghui Zhu et al.   Current Vascular Pharmacology

Specific phosphorylation sites underlie the stimulation of a large conductance, Ca2+-activated K+ channel by cGMP-dependent protein kinase

(2013) Barry D. Kyle et al.   FASEB JOURNAL

Mechanisms underlying regional differences in the Ca2+sensitivity of BKCacurrent in arteriolar smooth muscle

(2013) Yan Yang et al.   JOURNAL OF PHYSIOLOGY-LONDON

Exchange protein activated by cAMP (Epac) induces vascular relaxation by activating Ca2+-sensitive K+channels in rat mesenteric artery

(2013) Owain Llŷr Roberts et al.   JOURNAL OF PHYSIOLOGY-LONDON

Transduction of Voltage and Ca2+ Signals by Slo1 BK Channels

(2013) T. Hoshi et al.   PHYSIOLOGY

Cholesterol Down-Regulates BK Channels Stably Expressed in HEK 293 Cells

(2013) Wei Wu et al.   PLoS One

Apelin-13 Inhibits Large-Conductance Ca2+-Activated K+ Channels in Cerebral Artery Smooth Muscle Cells via a PI3-Kinase Dependent Mechanism

(2013) Amit Modgil et al.   PLoS One

Mechanism of the modulation of BK potassium channel complexes with different auxiliary subunit compositions by the omega-3 fatty acid DHA

(2013) T. Hoshi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Omega-3 fatty acids lower blood pressure by directly activating large-conductance Ca2+-dependent K+ channels

(2013) T. Hoshi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Docosahexaenoic acid attenuates hypoxic pulmonary vasoconstriction by activating the large conductance Ca2+-activated K+ currents in pulmonary artery smooth muscle cells

(2013) Jinchuan Yan et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Hypoxia sensitivity of a voltage-gated potassium current in porcine intrapulmonary vein smooth muscle cells

(2012) Ciprian Dospinescu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Function and regulation of large conductance Ca2+-activated K+ channel in vascular smooth muscle cells

(2012) Xiang-Qun Hu et al.   DRUG DISCOVERY TODAY

Aerobic exercise increases BKCachannel contribution to regulation of mesenteric arterial tone by upregulating β1-subunit

(2012) Lijun Shi et al.   EXPERIMENTAL PHYSIOLOGY

Multiple Cholesterol Recognition/Interaction Amino Acid Consensus (CRAC) Motifs in Cytosolic C Tail of Slo1 Subunit Determine Cholesterol Sensitivity of Ca2+- and Voltage-gated K+(BK) Channels

(2012) Aditya K. Singh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Influence of methanandamide and CGRP on potassium currents in smooth muscle cells of small mesenteric arteries

(2012) Mélissa Bol et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Large conductance, calcium- and voltage-gated potassium (BK) channels: Regulation by cholesterol

(2012) Alejandro M. Dopico et al.   PHARMACOLOGY & THERAPEUTICS

11,12-EET Stimulates the Association of BK Channel α and β1 Subunits in Mitochondria to Induce Pulmonary Vasoconstriction

(2012) Annemarieke E. Loot et al.   PLoS One

BK potassium channel modulation by leucine-rich repeat-containing proteins

(2012) J. Yan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of G protein-coupled estrogen receptor induces endothelium-independent relaxation of coronary artery smooth muscle

(2011) Xuan Yu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Carbon monoxide as an endogenous vascular modulator

(2011) Charles W. Leffler et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Testosterone-induced relaxation of coronary arteries: activation of BKCa channels via the cGMP-dependent protein kinase

(2011) Viju Deenadayalu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Hypoxia-inducible factor-1α regulates KCNMB1 expression in human pulmonary artery smooth muscle cells

(2011) Yong-Tae Ahn et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

H 2 O 2 Is the Transferrable Factor Mediating Flow-Induced Dilation in Human Coronary Arterioles

(2011) Yanping Liu et al.   CIRCULATION RESEARCH

H 2 O 2 -Induced Dilation in Human Coronary Arterioles: Role of Protein Kinase G Dimerization and Large-Conductance Ca 2+ -Activated K + Channel Activation

(2011) David X. Zhang et al.   CIRCULATION RESEARCH

Acidosis Dilates Brain Parenchymal Arterioles by Conversion of Calcium Waves to Sparks to Activate BK Channels

(2011) Fabrice Dabertrand et al.   CIRCULATION RESEARCH

Vasodilation of retinal arterioles induced by activation of BKCa channels is attenuated in diabetic rats

(2011) Asami Mori et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Pregnancy Upregulates Large-Conductance Ca 2+ -Activated K + Channel Activity and Attenuates Myogenic Tone in Uterine Arteries

(2011) Xiang-Qun Hu et al.   HYPERTENSION

Magnesium increases iberiotoxin-sensitive large conductance calcium activated potassium currents on the basilar artery smooth muscle cells in rabbits

(2011) Kshitiz Upadhyay Dhungel et al.   NEUROLOGICAL RESEARCH

Role of Rab GTPases in Membrane Traffic and Cell Physiology

(2011) Alex H. Hutagalung et al.   PHYSIOLOGICAL REVIEWS

The steroid interaction site in transmembrane domain 2 of the large conductance, voltage- and calcium-gated potassium (BK) channel accessory  1 subunit

(2011) A. N. Bukiya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanosensitivity of STREX-lacking BKCa channels in the colonic smooth muscle of the mouse

(2010) Wei Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Activation of vascular BK channels by docosahexaenoic acid is dependent on cytochrome P450 epoxygenase activity

(2010) R.-x. Wang et al.   CARDIOVASCULAR RESEARCH

Specificity of cholesterol and analogs to modulate BK channels points to direct sterol–channel protein interactions

(2010) Anna N. Bukiya et al.   JOURNAL OF GENERAL PHYSIOLOGY

Structure of the gating ring from the human large-conductance Ca2+-gated K+ channel

(2010) Yunkun Wu et al.   NATURE

LRRC26 auxiliary protein allows BK channel activation at resting voltage without calcium

(2010) Jiusheng Yan et al.   NATURE

The large-conductance ion channels in the nuclear envelope of central neurons

(2010) Olena Fedorenko et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Structure of the Human BK Channel Ca2+-Activation Apparatus at 3.0 A Resolution

(2010) P. Yuan et al.   SCIENCE

Pregnancy modifies the large conductance Ca2+-activated K+ channel and cGMP-dependent signaling pathway in uterine vascular smooth muscle

(2009) Charles R. Rosenfeld et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Mutation of protein kinase C phosphorylation site S1076 on α-subunits affects BKCa channel activity in HEK-293 cells

(2009) Shu Zhu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Channel β2–4 subunits fail to substitute for β1 in sensitizing BK channels to lithocholate

(2009) Anna N. Bukiya et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

α5β1 Integrin Engagement Increases Large Conductance, Ca2+-activated K+Channel Current and Ca2+Sensitivity through c-src-mediated Channel Phosphorylation

(2009) Yan Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The D5 Dopamine Receptor Mediates Large-Conductance, Calcium- and Voltage-Activated Potassium Channel Activation in Human Coronary Artery Smooth Muscle Cells

(2009) A. Natarajan et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

IL-1β modulate the Ca2+-activated big-conductance K channels (BK) via reactive oxygen species in cultured rat aorta smooth muscle cells

(2009) Yuan Gao et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Structure of the BK potassium channel in a lipid membrane from electron cryomicroscopy

(2009) Liguo Wang et al.   NATURE

Ghrelin signalling in guinea-pig femoral artery smooth muscle cells

(2008) M. I. Mladenov et al.   Acta Physiologica

Relaxing effects of 17(18)-EpETE on arterial and airway smooth muscles in human lung

(2008) Caroline Morin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Differential expression of BK channel isoforms and β-subunits in rat neuro-vascular tissues

(2008) Asser Nyander Poulsen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The second transmembrane domain of the large conductance, voltage- and calcium-gated potassium channelβ1subunit is a lithocholate sensor

(2008) Anna N. Bukiya et al.   FEBS LETTERS

Direct Regulation of BK Channels by Phosphatidylinositol 4,5-Bisphosphate as a Novel Signaling Pathway

(2008) Thirumalini Vaithianathan et al.   JOURNAL OF GENERAL PHYSIOLOGY

Structural determinants of monohydroxylated bile acids to activate β1subunit-containing BK channels

(2008) Anna N. Bukiya et al.   JOURNAL OF LIPID RESEARCH

Potentiation of large conductance, Ca2+-activated K+(BK) channels by α5β1 integrin activation in arteriolar smooth muscle

(2008) Xin Wu et al.   JOURNAL OF PHYSIOLOGY-LONDON

Posttranscriptional Regulation of BK Channel Splice Variant Stability by miR-9 Underlies Neuroadaptation to Alcohol

(2008) Andrzej Z. Pietrzykowski et al.   NEURON