Oxidative Stress, Proton Fluxes, and Chloroquine/Hydroxychloroquine Treatment for COVID-19

Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro

(2020) Manli Wang et al.   CELL RESEARCH

Mechanisms of action of hydroxychloroquine and chloroquine: implications for rheumatology

(2020) Eva Schrezenmeier et al.   Nature Reviews Rheumatology

Silent hypoxia: A harbinger of clinical deterioration in patients with COVID-19

(2020) R. Gentry Wilkerson et al.   AMERICAN JOURNAL OF EMERGENCY MEDICINE

Use of Hydroxychloroquine and Chloroquine During the COVID-19 Pandemic: What Every Clinician Should Know

(2020) Jinoos Yazdany et al.   ANNALS OF INTERNAL MEDICINE

Oxidative Stress as Key Player in Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) Infection

(2020) Livan Delgado-Roche et al.   ARCHIVES OF MEDICAL RESEARCH

COVID-19 and its implications for thrombosis and anticoagulation

(2020) Jean Marie Connors et al.   BLOOD

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)

(2020) Xueting Yao et al.   CLINICAL INFECTIOUS DISEASES

The cytokine storm in COVID-19: An overview of the involvement of the chemokine/chemokine-receptor system

(2020) Francesca Coperchini et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Pathogenesis of COVID-19 from a cell biology perspective

(2020) Robert J. Mason   EUROPEAN RESPIRATORY JOURNAL

Rethinking the role of hydroxychloroquine in the treatment of COVID‐19

(2020) Eric A. Meyerowitz et al.   FASEB JOURNAL

Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial

(2020) Philippe Gautret et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

COVID-19: a recommendation to examine the effect of hydroxychloroquine in preventing infection and progression

(2020) Dan Zhou et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Endothelial cell infection and endotheliitis in COVID-19

(2020) Zsuzsanna Varga et al.   LANCET

Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China

(2020) Chaomin Wu et al.   JAMA Internal Medicine

Phagocytosis of Apoptotic Cells in Resolution of Inflammation

(2020) Ioannis Kourtzelis et al.   Frontiers in Immunology

Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro

(2020) Jia Liu et al.   Cell Discovery

Hydroxychloroquine in Nonhospitalized Adults With Early COVID-19

(2020) Caleb P. Skipper et al.   ANNALS OF INTERNAL MEDICINE

COVID-19 and heme oxygenase: novel insight into the disease and potential therapies

(2020) Philip L. Hooper   CELL STRESS & CHAPERONES

A systematic review on the efficacy and safety of chloroquine for the treatment of COVID-19

(2020) Andrea Cortegiani et al.   JOURNAL OF CRITICAL CARE

The pathogenesis and treatment of the `Cytokine Storm' in COVID-19

(2020) Qing Ye et al.   JOURNAL OF INFECTION

Chloroquine does not inhibit infection of human lung cells with SARS-CoV-2

(2020) Markus Hoffmann et al.   NATURE

Hydroxychloroquine with or without Azithromycin in Mild-to-Moderate Covid-19

(2020) Alexandre B. Cavalcanti et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Randomized Trial of Hydroxychloroquine as Postexposure Prophylaxis for Covid-19

(2020) David R. Boulware et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Potential Impact of Zinc Supplementation on COVID-19 Pathogenesis

(2020) Inga Wessels et al.   Frontiers in Immunology

Coagulation disorder in COVID-19

(2020) Thomas Kander   Lancet Haematology

THE CHOLESTEROL METABOLITE 27-HYDROXYCHOLESTEROL INHIBITS SARS-CoV-2 AND IS MARKEDLY DECREASED IN COVID-19 PATIENTS

(2020) Alessandro Marcello et al.   Redox Biology

Effect of surfactant administration on outcomes of adult patients in acute respiratory distress syndrome: a meta-analysis of randomized controlled trials

(2019) Shan-Shan Meng et al.   BMC Pulmonary Medicine

Chemical Basis of Reactive Oxygen Species Reactivity and Involvement in Neurodegenerative Diseases

(2019) Fabrice Collin   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases

(2019) Demine et al.   Cells

Emerging mechanisms of drug-induced phospholipidosis

(2019) Bernadette Breiden et al.   BIOLOGICAL CHEMISTRY

Antimalarial Quinoline Drugs Inhibit β-Hematin and Increase Free Hemin Catalyzing Peroxidative Reactions and Inhibition of Cysteine Proteases

(2019) Tomás Herraiz et al.   Scientific Reports

Physiologic Implications of Reactive Oxygen Species Production by Mitochondrial Complex I Reverse Electron Transport

(2019) John O. Onukwufor et al.   Antioxidants

Hydroxychloroquine: An old drug with new relevance

(2018) E. A. SHIPPEY et al.   CLEVELAND CLINIC JOURNAL OF MEDICINE

Use the Protonmotive Force: Mitochondrial Uncoupling and Reactive Oxygen Species

(2018) Brandon J. Berry et al.   JOURNAL OF MOLECULAR BIOLOGY

The Role of Macrophages in the Pathogenesis of ALI/ARDS

(2018) Xiaofang Huang et al.   MEDIATORS OF INFLAMMATION

Publisher Correction: Chloroquine modulates antitumor immune response by resetting tumor-associated macrophages toward M1 phenotype

(2018) Degao Chen et al.   Nature Communications

The Role of Reactive Oxygen Species in Regulating T Cell-mediated Immunity and Disease

(2018) Emily L. Yarosz et al.   Immune Network

Hydroxychloroquine retinopathy

(2017) I H Yusuf et al.   EYE

NF-κB Signaling Activation Induced by Chloroquine Requires Autophagosome, p62 Protein, and c-Jun N-terminal Kinase (JNK) Signaling and Promotes Tumor Cell Resistance

(2017) Seungwon Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

M1 Means Kill; M2 Means Heal

(2017) Klaus Ley   JOURNAL OF IMMUNOLOGY

Viral Infection and Apoptosis

(2017) Marc Kvansakul   Viruses-Basel

Induction of Apoptosis and Subsequent Phagocytosis of Virus-Infected Cells As an Antiviral Mechanism

(2017) Firzan Nainu et al.   Frontiers in Immunology

Lysosomal adaptation: How cells respond to lysosomotropic compounds

(2017) Shuyan Lu et al.   PLoS One

Implications of oxidative stress on viral pathogenesis

(2016) Fernanda Caetano Camini et al.   ARCHIVES OF VIROLOGY

NOX2-dependent regulation of inflammation

(2016) K. L. Singel et al.   CLINICAL SCIENCE

What drives neutrophils to the alveoli in ARDS?

(2016) Rachel L Zemans et al.   THORAX

Heme: Modulator of Plasma Systems in Hemolytic Diseases

(2016) Lubka T. Roumenina et al.   TRENDS IN MOLECULAR MEDICINE

Effects of primaquine and chloroquine on oxidative stress parameters in rats

(2015) FRANCIANNE GIOVANELLA et al.   ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS

A new role for an old drug: Ambroxol triggers lysosomal exocytosis via pH-dependent Ca2+ release from acidic Ca2+ stores

(2015) Giorgio Fois et al.   CELL CALCIUM

Excess of heme induces tissue factor-dependent activation of coagulation in mice

(2015) E. M. Sparkenbaugh et al.   HAEMATOLOGICA

Selective inhibition of extracellular oxidants liberated from human neutrophils—A new mechanism potentially involved in the anti-inflammatory activity of hydroxychloroquine

(2015) Viera Jančinová et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Chloroquine analogues in drug discovery: new directions of uses, mechanisms of actions and toxic manifestations from malaria to multifarious diseases

(2015) M. A. A. Al-Bari   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Excess of heme induces tissue factor-dependent activation of coagulation in mice

(2015) E. M. Sparkenbaugh et al.   HAEMATOLOGICA

Comet Assay as an Indirect Measure of Systemic Oxidative Stress

(2015) Lei Fang et al.   Jove-Journal of Visualized Experiments

Maintenance of luminal pH and protease activity in lysosomes/late endosomes by vacuolar ATPase in chlorpromazine-treated RAW264 cells accumulating phospholipids

(2014) Ryohei Hamaguchi et al.   CELL BIOLOGY AND TOXICOLOGY

Zinc Ionophore Activity of Quercetin and Epigallocatechin-gallate: From Hepa 1-6 Cells to a Liposome Model

(2014) Husam Dabbagh-Bazarbachi et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Inhibition of Reactive Oxygen Species Production Ameliorates Inflammation Induced by Influenza A Viruses via Upregulation of SOCS1 and SOCS3

(2014) Siying Ye et al.   JOURNAL OF VIROLOGY

Contrasting phagosome pH regulation and maturation in human M1 and M2 macrophages

(2014) Johnathan Canton et al.   MOLECULAR BIOLOGY OF THE CELL

Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal

(2014) Antonio Ayala et al.   Oxidative Medicine and Cellular Longevity

Chloroquine Is a Zinc Ionophore

(2014) Jing Xue et al.   PLoS One

Coronavirus Cell Entry Occurs through the Endo-/Lysosomal Pathway in a Proteolysis-Dependent Manner

(2014) Christine Burkard et al.   PLoS Pathogens

Heme in pathophysiology: a matter of scavenging, metabolism and trafficking across cell membranes

(2014) Deborah Chiabrando et al.   Frontiers in Pharmacology

Regulation Of The NADPH Oxidase And Associated Ion Fluxes During Phagocytosis

(2013) Paula Nunes et al.   TRAFFIC

Redox Reactions and Microbial Killing in the Neutrophil Phagosome

(2012) Christine C. Winterbourn et al.   ANTIOXIDANTS & REDOX SIGNALING

Drug induced phospholipidosis: An acquired lysosomal storage disorder

(2012) James A. Shayman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Effect of hydroxychloroquine treatment on pro-inflammatory cytokines and disease activity in SLE patients: data from LUMINA (LXXV), a multiethnic US cohort

(2012) R Willis et al.   LUPUS

Exogenous pulmonary surfactant for acute respiratory distress syndrome in adults: A systematic review and meta-analysis

(2012) LI-NA ZHANG et al.   Experimental and Therapeutic Medicine

Mitochondria as a source and target of lipid peroxidation products in healthy and diseased heart

(2011) Ethan J Anderson et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Degrees of chloroquine resistance in Plasmodium – Is the redox system involved?

(2011) Adele M. Lehane et al.   International Journal for Parasitology-Drugs and Drug Resistance

Crosstalk of reactive oxygen species and NF-κB signaling

(2010) Michael J Morgan et al.   CELL RESEARCH

Signaling by ROS drives inflammasome activation

(2010) Fabio Martinon   EUROPEAN JOURNAL OF IMMUNOLOGY

Melatonin synergistically increases resveratrol-induced heme oxygenase-1 expression through the inhibition of ubiquitin-dependent proteasome pathway: a possible role in neuroprotection

(2010) Kyoung Ja Kwon et al.   JOURNAL OF PINEAL RESEARCH

A Central Role for Free Heme in the Pathogenesis of Severe Sepsis

(2010) R. Larsen et al.   Science Translational Medicine

Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes

(2010) Robert B. Hamanaka et al.   TRENDS IN BIOCHEMICAL SCIENCES

Zn2+ Inhibits Coronavirus and Arterivirus RNA Polymerase Activity In Vitro and Zinc Ionophores Block the Replication of These Viruses in Cell Culture

(2010) Aartjan J. W. te Velthuis et al.   PLoS Pathogens

Antiviral Activity of Chloroquine against Human Coronavirus OC43 Infection in Newborn Mice

(2009) E. Keyaerts et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Heme Degradation and Vascular Injury

(2009) John D. Belcher et al.   ANTIOXIDANTS & REDOX SIGNALING

Glutathione Peroxidase-1 Regulates Mitochondrial Function to Modulate Redox-dependent Cellular Responses

(2009) Diane E. Handy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL