Antimalarial Quinoline Drugs Inhibit β-Hematin and Increase Free Hemin Catalyzing Peroxidative Reactions and Inhibition of Cysteine Proteases

Multispectral Atomic Force Microscopy-Infrared Nano-Imaging of Malaria Infected Red Blood Cells

(2018) David Perez-Guaita et al.   ANALYTICAL CHEMISTRY

Prediction Model for Antimalarial Activities of Hemozoin Inhibitors by Using Physicochemical Properties

(2018) Farhana Mosaddeque et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Designing novel inhibitors against falcipain-2 of Plasmodium falciparum

(2018) Himangini et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Modulation of mitochondrial metabolism as a biochemical trait in blood feeding organisms: the redox vampire hypothesis redux

(2018) Caroline M. Ferreira et al.   CELL BIOLOGY INTERNATIONAL

Analysis of monoamine oxidase (MAO) enzymatic activity by high-performance liquid chromatography-diode array detection combined with an assay of oxidation with a peroxidase and its application to MAO inhibitors from foods and plants

(2018) Tomás Herraiz et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Chloroquine exposure triggers distinct cellular responses in sensitive versus resistant Plasmodium falciparum parasites

(2018) Sarah J. Reiling et al.   Scientific Reports

Potential role of Plasmodium falciparum exported protein 1 in the chloroquine mode of action

(2018) Andreas Martin Lisewski et al.   International Journal for Parasitology-Drugs and Drug Resistance

Evidence for Regulation of Hemoglobin Metabolism and Intracellular Ionic Flux by the Plasmodium falciparum Chloroquine Resistance Transporter

(2018) Andrew H. Lee et al.   Scientific Reports

Schistosoma hemozoin and its possible roles

(2017) Shu-hua Xiao et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Targeting the active sites of malarial proteases for antimalarial drug discovery: approaches, progress and challenges

(2017) Kuldeep K. Roy   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Iron is a substrate of thePlasmodium falciparumchloroquine resistance transporter PfCRT inXenopusoocytes

(2017) Naziha Bakouh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exploring Heme and Hemoglobin Binding Regions of Plasmodium Heme Detoxification Protein for New Antimalarial Discovery

(2017) Priya Gupta et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Effects of Quinoline and Non-Quinoline Inhibitors on the Kinetics of Lipid-Mediated β-Hematin Crystallization

(2017) Sharné-Maré Fitzroy et al.   LANGMUIR

Unraveling heme detoxification in the malaria parasite by in situ correlative X-ray fluorescence microscopy and soft X-ray tomography

(2017) Sergey Kapishnikov et al.   Scientific Reports

High-throughput screening and prediction models building for novel hemozoin inhibitors using physicochemical properties

(2016) Nguyen Tien Huy et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Biomimetic Assay for Hematin Crystallization Inhibitors: A New Platform To Screen Antimalarial Drugs

(2016) Megan A. Ketchum et al.   CRYSTAL GROWTH & DESIGN

N-methyltetrahydropyridines and pyridinium cations as toxins and comparison with naturally-occurring alkaloids

(2016) Tomás Herraiz   FOOD AND CHEMICAL TOXICOLOGY

Optimization of a multi-well colorimetric assay to determine haem species in Plasmodium falciparum in the presence of anti-malarials

(2015) Jill M. Combrinck et al.   MALARIA JOURNAL

Naturally-occurring tetrahydro-β-carboline alkaloids derived from tryptophan are oxidized to bioactive β-carboline alkaloids by heme peroxidases

(2014) Tomás Herraiz et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Malarial hemozoin: From target to tool

(2014) Lorena M. Coronado et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Identification of β-hematin inhibitors in a high-throughput screening effort reveals scaffolds with in vitro antimalarial activity

(2014) Rebecca D. Sandlin et al.   International Journal for Parasitology-Drugs and Drug Resistance

In vitro antimalarial activity, β-haematin inhibition and structure–activity relationships in a series of quinoline triazoles

(2013) Mukesh C. Joshi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Quinoline Drug–Heme Interactions and Implications for Antimalarial Cytostatic versus Cytocidal Activities

(2013) Alexander P. Gorka et al.   JOURNAL OF MEDICINAL CHEMISTRY

Protein complex directs hemoglobin-to-hemozoin formation in Plasmodium falciparum

(2013) M. Chugh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolite Profile Resulting from the Activation/Inactivation of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 2-Methyltetrahydro-β-carboline by Oxidative Enzymes

(2013) Tomás Herraiz et al.   Biomed Research International

Insights into the Role of Heme in the Mechanism of Action of Antimalarials

(2012) Jill M. Combrinck et al.   ACS Chemical Biology

A simple and inexpensive haemozoin-based colorimetric method to evaluate anti-malarial drug activity

(2012) Tran Men et al.   MALARIA JOURNAL

Redox-Based Inactivation of Cysteine Cathepsins by Compounds Containing the 4-Aminophenol Moiety

(2011) Bojana Mirković et al.   PLoS One

Degrees of chloroquine resistance in Plasmodium – Is the redox system involved?

(2011) Adele M. Lehane et al.   International Journal for Parasitology-Drugs and Drug Resistance

Oxoferryl Porphyrin/Hydrogen Peroxide System Whose Behavior is Equivalent to Hydroperoxoferric Porphyrin

(2010) Hiroaki Kitagishi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Changes in the Plasmodial Surface Anion Channel Reduce Leupeptin Uptake and Can Confer Drug Resistance in Plasmodium falciparum-Infected Erythrocytes

(2008) G. Lisk et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Synthesis and Evaluation of 1,1′-Hydrocarbylenebis(indazol-3-ols) as Potential Antimalarial Drugs

(2008) Miriam Martins Alho et al.   ChemMedChem

Quinine and Chloroquine Differentially Perturb Heme Monomer−Dimer Equilibrium

(2008) Leah B. Casabianca et al.   INORGANIC CHEMISTRY

HDP—A Novel Heme Detoxification Protein from the Malaria Parasite

(2008) Dewal Jani et al.   PLoS Pathogens

Recent advances in understanding the mechanism of hemozoin (malaria pigment) formation

(2007) Timothy J. Egan   JOURNAL OF INORGANIC BIOCHEMISTRY

Haemozoin formation

(2007) Timothy J. Egan   MOLECULAR AND BIOCHEMICAL PARASITOLOGY