Modifying and Integrating in vitro and ex vivo Respiratory Models for Inhalation Drug Screening

Innovative preclinical models for pulmonary drug delivery research

(2020) Stephan Ehrmann et al.   Expert Opinion on Drug Delivery

Drug Absorption Parameters Obtained Using the Isolated Perfused Rat Lung Model Are Predictive of Rat In Vivo Lung Absorption

(2020) Johanna Eriksson et al.   AAPS Journal

Airway organoids as models of human disease

(2020) J. Vaart et al.   JOURNAL OF INTERNAL MEDICINE

Human Nasal Epithelial Organoids for Therapeutic Development in Cystic Fibrosis

(2020) Zhongyu Liu et al.   Genes

In vitro, ex vivo and in vivo methods of lung absorption for inhaled drugs

(2020) Masahiro Sakagami   ADVANCED DRUG DELIVERY REVIEWS

Functional similarity of modified cascade impactor to deposit drug particles on cells

(2020) Virender Kumar et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Generation of lung organoids from human pluripotent stem cells in vitro

(2019) Alyssa J. Miller et al.   Nature Protocols

Strategies to Enhance Drug Absorption via Nasal and Pulmonary Routes

(2019) Maliheh Ghadiri et al.   Pharmaceutics

Rectal Organoids Enable Personalized Treatment of Cystic Fibrosis

(2019) Gitte Berkers et al.   Cell Reports

Mechanosensitive Rap1 activation promotes barrier function of lung vascular endothelium under cyclic stretch

(2019) Yunbo Ke et al.   MOLECULAR BIOLOGY OF THE CELL

Precision-cut lung slices from bleomycin treated animals as a model for testing potential therapies for idiopathic pulmonary fibrosis

(2019) Matea Cedilak et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Mesenchymal Stem Cells Increase Alveolar Differentiation in Lung Progenitor Organoid Cultures

(2019) Kristen T. Leeman et al.   Scientific Reports

Application of Cancer Organoid Model for Drug Screening and Personalized Therapy

(2019) Jumpei Kondo et al.   Cells

An In Vitro System for Evaluating Molecular Targeted Drugs Using Lung Patient-Derived Tumor Organoids

(2019) Takahashi et al.   Cells

Modeling of Fibrotic Lung Disease Using 3D Organoids Derived from Human Pluripotent Stem Cells

(2019) Alexandros Strikoudis et al.   Cell Reports

Multiorgan microfluidic platform with breathable lung chamber for inhalation or intravenous drug screening and development

(2019) Paula G. Miller et al.   BIOTECHNOLOGY AND BIOENGINEERING

Patient-derived lung cancer organoids as in vitro cancer models for therapeutic screening

(2019) Minsuh Kim et al.   Nature Communications

Establishment and comparison of air-liquid interface culture systems for primary and immortalized swine tracheal epithelial cells

(2018) Haiyan Wang et al.   BMC CELL BIOLOGY

Inhaled Therapy in Respiratory Disease: The Complex Interplay of Pulmonary Kinetic Processes

(2018) Jens Markus Borghardt et al.   Canadian Respiratory Journal

Pulmonary absorption – estimation of effective pulmonary permeability and tissue retention of ten drugs using an ex vivo rat model and computational analysis

(2018) Johanna Eriksson et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Air-Liquid Interface: Relevant In Vitro Models for Investigating Air Pollutant-Induced Pulmonary Toxicity

(2018) Swapna Upadhyay et al.   TOXICOLOGICAL SCIENCES

Deposition and transport of linezolid mediated by a synthetic surfactant Synsurf® within a pressurized metered dose inhaler: a Calu-3 model

(2018) Lyné van Rensburg et al.   Drug Design Development and Therapy

Multilayered Cultures of NSCLC cells grown at the Air-Liquid Interface allow the efficacy testing of inhaled anti-cancer drugs

(2018) Dania Movia et al.   Scientific Reports

Human lung tissue provides highly relevant data about efficacy of new anti-asthmatic drugs

(2018) Olga Danov et al.   PLoS One

Mechanical stretch triggers rapid epithelial cell division through Piezo1

(2017) S. A. Gudipaty et al.   NATURE

A three-dimensional model of human lung development and disease from pluripotent stem cells

(2017) Ya-Wen Chen et al.   NATURE CELL BIOLOGY

A Comparison of Drug Transport in Pulmonary Absorption Models: Isolated Perfused rat Lungs, Respiratory Epithelial Cell Lines and Primary Cell Culture

(2017) Cynthia Bosquillon et al.   PHARMACEUTICAL RESEARCH

Bacterial colonization stimulates a complex physiological response in the immature human intestinal epithelium

(2017) David R Hill et al.   eLife

Transport mechanisms at the pulmonary mucosa: implications for drug delivery

(2016) Sabrina Nickel et al.   Expert Opinion on Drug Delivery

Optimization of an air-liquid interface exposure system for assessing toxicity of airborne nanoparticles

(2016) Siiri Latvala et al.   JOURNAL OF APPLIED TOXICOLOGY

Primary Air–Liquid Interface Culture of Nasal Epithelium for Nasal Drug Delivery

(2016) Hui Xin Ong et al.   MOLECULAR PHARMACEUTICS

Prevalidation of the ex-vivo model PCLS for prediction of respiratory toxicity

(2016) A. Hess et al.   TOXICOLOGY IN VITRO

Protocadherin-1 Localization and Cell-Adhesion Function in Airway Epithelial Cells in Asthma

(2016) Grissel Faura Tellez et al.   PLoS One

An Optimised Human Cell Culture Model for Alveolar Epithelial Transport

(2016) Hui Ren et al.   PLoS One

Investigating the Responses of Human Epithelial Cells to Predatory Bacteria

(2016) Ajay K. Monnappa et al.   Scientific Reports

Junctional abnormalities in human airway epithelial cells expressing F508del CFTR

(2015) Samuel A. Molina et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The characterization of the human cell line Calu-3 under different culture conditions and its use as an optimized in vitro model to investigate bronchial epithelial function

(2015) Mateja Erdani Kreft et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Is the cellular uptake of respiratory aerosols delivered from different devices equivalent?

(2015) Hui Xin Ong et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Small airway-on-a-chip enables analysis of human lung inflammation and drug responses in vitro

(2015) Kambez H Benam et al.   NATURE METHODS

Diversity of Epithelial Stem Cell Types in Adult Lung

(2015) Feng Li et al.   Stem Cells International

The Cell Line NCl-H441 Is a Useful in Vitro Model for Transport Studies of Human Distal Lung Epithelial Barrier

(2014) Johanna J. Salomon et al.   MOLECULAR PHARMACEUTICS

In Vitro Cell Integrated Impactor Deposition Methodology for the Study of Aerodynamically Relevant Size Fractions from Commercial Pressurised Metered Dose Inhalers

(2014) Mehra Haghi et al.   PHARMACEUTICAL RESEARCH

Across the pulmonary epithelial barrier: Integration of physicochemical properties and human cell models to study pulmonary drug formulations

(2014) Mehra Haghi et al.   PHARMACOLOGY & THERAPEUTICS

A new adjuvanted nanoparticle-based H1N1 influenza vaccine induced antigen-specific local mucosal and systemic immune responses after administration into the lung

(2014) Vanessa Neuhaus et al.   VACCINE

In vitro, in vivo and ex vivo models for studying particle deposition and drug absorption of inhaled pharmaceuticals

(2013) Kamrun Nahar et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

In vitro and ex vivo methods predict the enhanced lung residence time of liposomal ciprofloxacin formulations for nebulisation

(2013) Hui Xin Ong et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

In vitroandex vivotoxicological testing of sildenafil-loaded solid lipid nanoparticles

(2013) M. Paranjpe et al.   INHALATION TOXICOLOGY

A functional CFTR assay using primary cystic fibrosis intestinal organoids

(2013) Johanna F Dekkers et al.   NATURE MEDICINE

Functional Testing of an Inhalable Nanoparticle Based Influenza Vaccine Using a Human Precision Cut Lung Slice Technique

(2013) Vanessa Neuhaus et al.   PLoS One

Metabolic characterization of cell systems used in in vitro toxicology testing: Lung cell system BEAS-2B as a working example

(2013) Carolina Garcia-Canton et al.   TOXICOLOGY IN VITRO

Systemic cancer therapy: achievements and challenges that lie ahead

(2013) Michael O. Palumbo et al.   Frontiers in Pharmacology

Pulmonary drug delivery: from generating aerosols to overcoming biological barriers—therapeutic possibilities and technological challenges

(2013) Christian A Ruge et al.   Lancet Respiratory Medicine

Dry Powder Inhalation Exposures of the Endotracheally Intubated Rat Lung, Ex Vivo and In Vivo: The Pulmonary Pharmacokinetics of Fluticasone Furoate

(2012) Ewa Selg et al.   Journal of Aerosol Medicine and Pulmonary Drug Delivery

Deposition, Diffusion and Transport Mechanism of Dry Powder Microparticulate Salbutamol, at the Respiratory Epithelia

(2012) Mehra Haghi et al.   MOLECULAR PHARMACEUTICS

Critical Characteristics for Corticosteroid Solution Metered Dose Inhaler Bioequivalence

(2012) C. I. Grainger et al.   MOLECULAR PHARMACEUTICS

A Human Disease Model of Drug Toxicity–Induced Pulmonary Edema in a Lung-on-a-Chip Microdevice

(2012) Dongeun Huh et al.   Science Translational Medicine

Epithelial Profiling of Antibiotic Controlled Release Respiratory Formulations

(2011) Hui Xin Ong et al.   PHARMACEUTICAL RESEARCH

The air-liquid interface and use of primary cell cultures are important to recapitulate the transcriptional profile of in vivo airway epithelia

(2010) Alejandro A. Pezzulo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

A toxicological evaluation of inhaled solid lipid nanoparticles used as a potential drug delivery system for the lung

(2010) M. Nassimi et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Prediction of the Deposition of Dry Powder Aerosols

(2009) Pedro J. Mendes et al.   AAPS Journal

Low cytotoxicity of solid lipid nanoparticles inin vitroandex vivolung models

(2009) Matthias Nassimi et al.   INHALATION TOXICOLOGY

Pulmonary Targeting with Biodegradable Salbutamol-Loaded Nanoparticles

(2009) Moritz Beck-Broichsitter et al.   Journal of Aerosol Medicine and Pulmonary Drug Delivery

Miniature inhalation therapy platform using surface acoustic wave microfluidic atomization

(2009) Aisha Qi et al.   LAB ON A CHIP

Pulmonary drug delivery with aerosolizable nanoparticles in an ex vivo lung model

(2008) Moritz Beck-Broichsitter et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Short Inhalation Exposures of the Isolated and Perfused Rat Lung to Respirable Dry Particle Aerosols; the Detailed Pharmacokinetics of Budesonide, Formoterol, and Terbutaline

(2008) Per Ewing et al.   Journal of Aerosol Medicine and Pulmonary Drug Delivery

Modeling human lung disease in animals

(2007) Lorraine B. Ware   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY