Amino Acid Transporter SLC6A14 (ATB0,+) – A Target in Combined Anti-cancer Therapy

Endocytosis of ATB0,+(SLC6A14)-targeted liposomes for drug delivery and its therapeutic application for pancreatic cancer

(2020) Longfa Kou et al.   Expert Opinion on Drug Delivery

An Integrated Microarray Analysis Reveals Significant Diagnostic and Prognostic Biomarkers in Pancreatic Cancer

(2020) Zhi-Qiang Yang et al.   MEDICAL SCIENCE MONITOR

Glutamine transporters as pharmacological targets: From function to drug design

(2020) Mariafrancesca Scalise et al.   Asian Journal of Pharmaceutical Sciences

SLC6A14, a Na+/Cl−-coupled amino acid transporter, functions as a tumor promoter in colon and is a target for Wnt signaling

(2020) Mohd O. F. Sikder et al.   BIOCHEMICAL JOURNAL

Update on SLC6A14 in lung and gastrointestinal physiology and physiopathology: focus on cystic fibrosis

(2020) Manon Ruffin et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Identification of candidate diagnostic and prognostic biomarkers for pancreatic carcinoma

(2019) Yang Cheng et al.   EBioMedicine

SLC1A5 glutamine transporter is a target of MYC and mediates reduced mTORC1 signaling and increased fatty acid oxidation in long‐lived Myc hypomorphic mice

(2019) Xiaoai Zhao et al.   AGING CELL

Reprogramming of Amino Acid Transporters to Support Aspartate and Glutamate Dependency Sustains Endocrine Resistance in Breast Cancer

(2019) Marina Bacci et al.   Cell Reports

Differentially Expressed Genes Associated With Prognosis in Locally Advanced Lymph Node-Negative Prostate Cancer

(2019) Elena A. Pudova et al.   Frontiers in Genetics

SLC6A14, a Pivotal Actor on Cancer Stage: When Function Meets Structure

(2019) Luca Palazzolo et al.   SLAS Discovery

Amino acid transporter SLC6A14 depends on heat shock protein HSP90 in trafficking to the cell surface

(2019) Karolina Rogala-Koziarska et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

SLC22A5 (OCTN2) Carnitine Transporter—Indispensable for Cell Metabolism, a Jekyll and Hyde of Human Cancer

(2019) Barbara Juraszek et al.   MOLECULES

SLC6A14, an amino acid transporter, modifies the primary CF defect in fluid secretion

(2018) Saumel Ahmadi et al.   eLife

mTOR and Tumor Cachexia

(2018) Adrian Duval et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Wnt Effector TCF4 Is Dispensable for Wnt Signaling in Human Cancer Cells

(2018) Dusan Hrckulak et al.   Genes

mTOR Complexes as a Nutrient Sensor for Driving Cancer Progression

(2018) Mio Harachi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Trafficking of the amino acid transporter B0,+ (SLC6A14) to the plasma membrane involves an exclusive interaction with SEC24C for its exit from the endoplasmic reticulum

(2018) Vasylyna Kovalchuk et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Control of amino acid transport coordinates metabolic reprogramming in T-cell malignancy

(2017) K M Grzes et al.   LEUKEMIA

Glutamine Transporters Are Targets of Multiple Oncogenic Signaling Pathways in Prostate Cancer

(2017) Mark A. White et al.   MOLECULAR CANCER RESEARCH

Heat Shock Proteins and Cancer

(2017) Jianming Wu et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The prognostic value of GLUT1 in cancers: a systematic review and meta-analysis

(2017) Min Yu et al.   Oncotarget

ATB0,+ transporter-mediated targeting delivery to human lung cancer cells via aspartate-modified docetaxel-loading stealth liposomes

(2017) Qiuhua Luo et al.   Biomaterials Science

Inhibition of malic enzyme 1 disrupts cellular metabolism and leads to vulnerability in cancer cells in glucose-restricted conditions

(2017) S Murai et al.   Oncogenesis

Glutamine Transport and Mitochondrial Metabolism in Cancer Cell Growth

(2017) Mariafrancesca Scalise et al.   Frontiers in Oncology

The SLC28 (CNT) and SLC29 (ENT) nucleoside transporter families: a 30-year collaborative odyssey

(2016) J. D. Young   BIOCHEMICAL SOCIETY TRANSACTIONS

Glutamine transport. From energy supply to sensing and beyond

(2016) Mariafrancesca Scalise et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Amino acid transporter SLC6A14 is a novel and effective drug target for pancreatic cancer

(2016) V Coothankandaswamy et al.   BRITISH JOURNAL OF PHARMACOLOGY

X-ray structures and mechanism of the human serotonin transporter

(2016) Jonathan A. Coleman et al.   NATURE

Deletion of the amino acid transporter Slc6a14 suppresses tumour growth in spontaneous mouse models of breast cancer

(2015) Ellappan Babu et al.   BIOCHEMICAL JOURNAL

The role of heat shock proteins in cancer

(2015) Georgios D. Lianos et al.   CANCER LETTERS

Amino Acid Transporters in Cancer and Their Relevance to "Glutamine Addiction": Novel Targets for the Design of a New Class of Anticancer Drugs

(2015) Y. D. Bhutia et al.   CANCER RESEARCH

Cysteine is not a substrate but a specific modulator of human ASCT2 (SLC1A5) transporter

(2015) Mariafrancesca Scalise et al.   FEBS LETTERS

LAT1 is the transport competent unit of the LAT1/CD98 heterodimeric amino acid transporter

(2015) Lara Napolitano et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Nutrient-sensing mechanisms and pathways

(2015) Alejo Efeyan et al.   NATURE

SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1

(2015) Manuele Rebsamen et al.   NATURE

Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1

(2015) S. Wang et al.   SCIENCE

Ganetespib: research and clinical development

(2015) Shanu Modi et al.   OncoTargets and Therapy

Transcriptomic and Immunohistochemical Profiling of SLC6A14 in Pancreatic Ductal Adenocarcinoma

(2015) Alan R. Penheiter et al.   Biomed Research International

Nucleoside transporter proteins as biomarkers of drug responsiveness and drug targets

(2015) Marçal Pastor-Anglada et al.   Frontiers in Pharmacology

Study of Three Single Nucleotide Polymorphisms in the Slc6a14 Gene in Association with Male Infertility

(2015) P. Noveski et al.   Balkan Journal of Medical Genetics

Protein kinase C restricts transport of carnitine by amino acid transporter ATB0,+ apically localized in the blood–brain barrier

(2014) Katarzyna Michalec et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

A Cytosolic Relay of Heat Shock Proteins HSP70-1A and HSP90β Monitors the Folding Trajectory of the Serotonin Transporter

(2014) Ali El-Kasaby et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structures of the Sec61 complex engaged in nascent peptide translocation or membrane insertion

(2014) Marko Gogala et al.   NATURE

The amino acid transporter SLC6A14 in cancer and its potential use in chemotherapy

(2014) Yangzom D. Bhutia et al.   Asian Journal of Pharmaceutical Sciences

Differential Gene Expression Landscape of Co-Existing Cervical Pre-Cancer Lesions Using RNA-seq

(2014) Kathryn E. Royse et al.   Frontiers in Oncology

The HSP70 family and cancer

(2013) M. E. Murphy   CARCINOGENESIS

COPII — a flexible vesicle formation system

(2013) Elizabeth A Miller et al.   CURRENT OPINION IN CELL BIOLOGY

Recruitment of a Cytoplasmic Chaperone Relay by the A2AAdenosine Receptor

(2013) Christian Bergmayr et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Switching the Clientele

(2013) Sonja Sucic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Imaging Tumour ATB0,+ Transport Activity by PET with the Cationic Amino Acid O-2((2-[18F]fluoroethyl)methyl-amino)ethyltyrosine

(2013) Adrienne Müller et al.   MOLECULAR IMAGING AND BIOLOGY

Caveolin-1 - A Novel Interacting Partner of Organic Cation/Carnitine Transporter (Octn2): Effect of Protein Kinase C on This Interaction in Rat Astrocytes

(2013) Magdalena Czeredys et al.   PLoS One

Mechanisms of Sec61/SecY-Mediated Protein Translocation Across Membranes

(2012) Eunyong Park et al.   Annual Review of Biophysics

The Cystine/Glutamate Antiporter System xc− in Health and Disease: From Molecular Mechanisms to Novel Therapeutic Opportunities

(2012) Jan Lewerenz et al.   ANTIOXIDANTS & REDOX SIGNALING

Protein kinase C regulates amino acid transporter ATB0,+

(2012) Łukasz Samluk et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The solute carrier 6 family of transporters

(2012) Stefan Bröer et al.   BRITISH JOURNAL OF PHARMACOLOGY

Multiple apical plasma membrane constituents are associated with susceptibility to meconium ileus in individuals with cystic fibrosis

(2012) Lei Sun et al.   NATURE GENETICS

Vertebrate protein glycosylation: diversity, synthesis and function

(2012) Kelley W. Moremen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

c-Myc is crucial for the expression of LAT1 in MIA Paca-2 human pancreatic cancer cells

(2012) KEITARO HAYASHI et al.   ONCOLOGY REPORTS

Receptor-Specific Mechanisms Regulate Phosphorylation of AKT at Ser473: Role of RICTOR in β1 Integrin-Mediated Cell Survival

(2012) Anjum Riaz et al.   PLoS One

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Membrane protein integration into the endoplasmic reticulum

(2011) Luis Martínez-Gil et al.   FEBS Journal

GATA2 negatively regulates PTEN by preventing nuclear translocation of androgen receptor and by androgen-independent suppression of PTEN transcription in breast cancer

(2011) Yu Wang et al.   HUMAN MOLECULAR GENETICS

SLC6A14 (ATB0,+) Protein, a Highly Concentrative and Broad Specific Amino Acid Transporter, Is a Novel and Effective Drug Target for Treatment of Estrogen Receptor-positive Breast Cancer

(2011) Senthil Karunakaran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

From cradle to twilight: The carboxyl terminus directs the fate of the A2A-adenosine receptor

(2010) Simon Keuerleber et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Regulation of amino acid/carnitine transporter B0,+ (ATB0,+) in astrocytes by protein kinase C: independent effects on raft and non-raft transporter subpopulations

(2010) Łukasz Samluk et al.   JOURNAL OF NEUROCHEMISTRY

Akt Phosphorylates Sec24: New Clues into the Regulation of ER-to-Golgi Trafficking

(2010) Laura J. Sharpe et al.   TRAFFIC

Glutamine addiction: a new therapeutic target in cancer

(2010) David R. Wise et al.   TRENDS IN BIOCHEMICAL SCIENCES

Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy

(2009) Paul Nicklin et al.   CELL

Glycoprotein folding, quality control and ER-associated degradation

(2009) Gerardo Z Lederkremer   CURRENT OPINION IN STRUCTURAL BIOLOGY

Real-time PCR quantification analysis of five mucosal transcripts in patients with Crohnʼs disease

(2009) Anders Eriksson et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Synaptic Vesicle Protein NTT4/XT1 (SLC6A17) Catalyzes Na+-coupled Neutral Amino Acid Transport

(2009) Kimberly A. Zaia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calnexin phosphorylation: Linking cytoplasmic signalling to endoplasmic reticulum lumenal functions

(2009) Eric Chevet et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Interaction of tryptophan derivatives with SLC6A14 (ATB0,+) reveals the potential of the transporter as a drug target for cancer chemotherapy

(2008) Senthil Karunakaran et al.   BIOCHEMICAL JOURNAL

l-type amino acid transporter 1 and CD98 expression in primary and metastatic sites of human neoplasms

(2008) Kyoichi Kaira et al.   CANCER SCIENCE

Human solute carrier SLC6A14 is the β-alanine carrier

(2008) Catriona M. H. Anderson et al.   JOURNAL OF PHYSIOLOGY-LONDON

The Orphan Transporter Rxt1/NTT4 (SLC6A17) Functions as a Synaptic Vesicle Amino Acid Transporter Selective for Proline, Glycine, Leucine, and Alanine

(2008) L. A. Parra et al.   MOLECULAR PHARMACOLOGY

Functional relevance of carnitine transporter OCTN2 to brain distribution of l-carnitine and acetyl-l-carnitine across the blood-brain barrier

(2003) Yasuto Kido et al.   JOURNAL OF NEUROCHEMISTRY