The Heparan Sulfate Sulfotransferases HS2ST1 and HS3ST2 Are Novel Regulators of Breast Cancer Stem-Cell Properties

The heparan sulfate proteoglycan syndecan‐1 regulates colon cancer stem cell function via a focal adhesion kinase—Wnt signaling axis

(2020) Sampath Kumar Katakam et al.   FEBS Journal

Syndecan-1-Dependent Regulation of Heparanase Affects Invasiveness, Stem Cell Properties, and Therapeutic Resistance of Caco2 Colon Cancer Cells

(2020) Sampath Kumar Katakam et al.   Frontiers in Oncology

HS2ST1‐dependent signaling pathways determine breast cancer cell viability, matrix interactions, and invasive behavior

(2020) Archana Vijaya Kumar et al.   CANCER SCIENCE

Sulfated syndecan 1 is critical to preventing cellular senescence by modulating fibroblast growth factor receptor endocytosis

(2020) Donghee Kang et al.   FASEB JOURNAL

Heparanase-enhanced Shedding of Syndecan-1 and Its Role in Driving Disease Pathogenesis and Progression

(2020) Sunil Rangarajan et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Glycosaminoglycans and Glycosaminoglycan Mimetics in Cancer and Inflammation

(2019) Shravan Morla   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Proteoglycans and glycosaminoglycans as regulators of cancer stem cell function and therapeutic resistance

(2019) Daiana Vitale et al.   FEBS Journal

Role of cell surface proteoglycans in cancer immunotherapy

(2019) Nancy A. Espinoza-Sánchez et al.   SEMINARS IN CANCER BIOLOGY

γ‐Secretase inhibition affects viability, apoptosis, and the stem cell phenotype of endometriotic cells

(2019) Laura Ramirez Williams et al.   ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA

The role of heparan sulfate maturation in cancer: A focus on the 3O-sulfation and the enigmatic 3O-sulfotransferases (HS3STs)

(2019) Sandrine Gulberti et al.   SEMINARS IN CANCER BIOLOGY

The heparan sulfate 3-O-sulfotransferases (HS3ST) 2, 3B and 4 enhance proliferation and survival in breast cancer MDA-MB-231 cells

(2018) Charles Hellec et al.   PLoS One

Proteoglycan Chemical Diversity Drives Multifunctional Cell Regulation and Therapeutics

(2018) Nikos K. Karamanos et al.   CHEMICAL REVIEWS

Epithelial-to-mesenchymal transition in cancer: complexity and opportunities

(2018) Yun Zhang et al.   Frontiers of Medicine

Dendrimer Heparan Sulfate Glycomimetics: Potent Heparanase Inhibitors for Anticancer Therapy

(2018) Olga V. Zubkova et al.   ACS Chemical Biology

A reproducible scaffold-free 3D organoid model to study neoplastic progression in breast cancer

(2018) Sabra I. Djomehri et al.   Journal of Cell Communication and Signaling

Dynamic changes in heparan sulfate during muscle differentiation and ageing regulate myoblast cell fate and FGF2 signalling

(2017) R.S. Ghadiali et al.   MATRIX BIOLOGY

Syndecan-1 is a novel molecular marker for triple negative inflammatory breast cancer and modulates the cancer stem cell phenotype via the IL-6/STAT3, Notch and EGFR signaling pathways

(2017) Sherif Abdelaziz Ibrahim et al.   Molecular Cancer

Breast cancer stem cell: the roles and therapeutic implications

(2016) Fang Yang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Syndecan4 coordinates Wnt/JNK and BMP signaling to regulate foregut progenitor development

(2016) Zheng Zhang et al.   DEVELOPMENTAL BIOLOGY

DrosophilaSulf1 is required for the termination of intestinal stem cell division during regeneration

(2016) Masahiko Takemura et al.   JOURNAL OF CELL SCIENCE

Targeting Notch, Hedgehog and Wnt pathways in cancer stem cells: clinical update

(2015) Naoko Takebe et al.   Nature Reviews Clinical Oncology

A cytoplasmic C-terminal fragment of syndecan-1 is generated by sequential proteolysis and antagonizes syndecan-1 dependent lung tumor cell migration

(2015) Tobias Pasqualon et al.   Oncotarget

HS3ST2modulates breast cancer cell invasiveness via MAP kinase- and Tcf4 (Tcf7l2)-dependent regulation of protease and cadherin expression

(2014) Archana Vijaya Kumar et al.   INTERNATIONAL JOURNAL OF CANCER

Syndecan-1 (CD138) Modulates Triple-Negative Breast Cancer Stem Cell Properties via Regulation of LRP-6 and IL-6-Mediated STAT3 Signaling

(2014) Sherif A. Ibrahim et al.   PLoS One

Twist1 induces endothelial differentiation of tumour cells through the Jagged1-KLF4 axis

(2014) Hsiao-Fan Chen et al.   Nature Communications

Breast Cancer Stem Cells Transition between Epithelial and Mesenchymal States Reflective of their Normal Counterparts

(2014) Suling Liu et al.   Stem Cell Reports

Heparan Sulfate Proteoglycans Containing a Glypican 5 Core and 2-O-Sulfo-iduronic Acid Function as Sonic Hedgehog Co-receptors to Promote Proliferation

(2013) Rochelle M. Witt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The transition of mouse pluripotent stem cells from the naïve to the primed state requires Fas signaling through 3-O sulfated heparan sulfate structures recognized by the HS4C3 antibody

(2012) Kazumi Hirano et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Significance of CD44 and CD24 as Cancer Stem Cell Markers: An Enduring Ambiguity

(2012) Appalaraju Jaggupilli et al.   Clinical & Developmental Immunology

Targeting of syndecan-1 by microRNA miR-10b promotes breast cancer cell motility and invasiveness via a Rho-GTPase- and E-cadherin-dependent mechanism

(2012) Sherif A. Ibrahim et al.   INTERNATIONAL JOURNAL OF CANCER

Heparan Sulfate 6-O-endosulfatases (Sulfs) Coordinate the Wnt Signaling Pathways to Regulate Myoblast Fusion during Skeletal Muscle Regeneration

(2012) Thanh H. Tran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Notch Signaling in Glioblastoma Targets Cancer Stem Cells via an Endothelial Cell Intermediate

(2010) Koos E. Hovinga et al.   STEM CELLS

Caveolin-1 (P132L), a Common Breast Cancer Mutation, Confers Mammary Cell Invasiveness and Defines a Novel Stem Cell/Metastasis-Associated Gene Signature

(2009) Gloria Bonuccelli et al.   AMERICAN JOURNAL OF PATHOLOGY

Differential roles for membrane-bound and soluble syndecan-1 (CD138) in breast cancer progression

(2009) Viktoriya Nikolova et al.   CARCINOGENESIS