Heparan Sulfate Proteoglycans Containing a Glypican 5 Core and 2-O-Sulfo-iduronic Acid Function as Sonic Hedgehog Co-receptors to Promote Proliferation

A highly efficient tree structure for the biosynthesis of heparan sulfate accounts for the commonly observed disaccharides and suggests a mechanism for domain synthesis

(2012) Timothy R. Rudd et al.   Molecular BioSystems

Hedgehog-Stimulated Chemotaxis Is Mediated by Smoothened Located Outside the Primary Cilium

(2012) M. F. Bijlsma et al.   Science Signaling

Boc and Gas1 Each Form Distinct Shh Receptor Complexes with Ptch1 and Are Required for Shh-Mediated Cell Proliferation

(2011) Luisa Izzi et al.   DEVELOPMENTAL CELL

Overlapping Roles and Collective Requirement for the Coreceptors GAS1, CDO, and BOC in SHH Pathway Function

(2011) Benjamin L. Allen et al.   DEVELOPMENTAL CELL

Dual Roles of the Cardin-Weintraub Motif in Multimeric Sonic Hedgehog

(2011) Pershang Farshi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glypican-5 stimulates rhabdomyosarcoma cell proliferation by activating Hedgehog signaling

(2011) Fuchuan Li et al.   JOURNAL OF CELL BIOLOGY

Structure of the protein core of the glypican Dally-like and localization of a region important for hedgehog signaling

(2011) Min-Sung Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The cell-surface proteins Dally-like and Ihog differentially regulate Hedgehog signaling strength and range during development

(2010) D. Yan et al.   DEVELOPMENT

The Long-Range Activity of Hedgehog Is Regulated in the Apical Extracellular Space by the Glypican Dally and the Hydrolase Notum

(2010) Katie L. Ayers et al.   DEVELOPMENTAL CELL

Glypican-3: A new target for cancer immunotherapy

(2010) Mitchell Ho et al.   EUROPEAN JOURNAL OF CANCER

Interactions between Hedgehog proteins and their binding partners come into view

(2010) P. A. Beachy et al.   GENES & DEVELOPMENT

In vivo manipulation of heparan sulfate structure and its effect on Drosophila development

(2010) Keisuke Kamimura et al.   GLYCOBIOLOGY

The Primary Cilium as a Complex Signaling Center

(2009) Nicolas F. Berbari et al.   CURRENT BIOLOGY

A Turn-like Structure “KKPE” Segment Mediates the Specific Binding of Viral Protein A27 to Heparin and Heparan Sulfate on Cell Surfaces

(2009) Ping-Chen Shih et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heparan Sulfate Phage Display Antibodies Identify Distinct Epitopes with Complex Binding Characteristics

(2009) Sophie M. Thompson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The repertoire of glycan determinants in the human glycome

(2009) Richard D. Cummings   Molecular BioSystems

Proteoglycan interactions with Sonic Hedgehog specify mitogenic responses

(2009) Jennifer A Chan et al.   NATURE NEUROSCIENCE

Glypican-3 Inhibits Hedgehog Signaling during Development by Competing with Patched for Hedgehog Binding

(2008) Mariana I. Capurro et al.   DEVELOPMENTAL CELL

Cellular Trafficking of the Glypican Dally-like Is Required for Full-Strength Hedgehog Signaling and Wingless Transcytosis

(2008) Armel Gallet et al.   DEVELOPMENTAL CELL

Opposing roles for glypicans in Hedgehog signalling

(2008) Dong Yan et al.   NATURE CELL BIOLOGY