Intestinal Morphogenesis in Development, Regeneration, and Disease: The Potential Utility of Intestinal Organoids for Studying Compartmentalization of the Crypt-Villus Structure

Hedgehog-Activated Fat4 and PCP Pathways Mediate Mesenchymal Cell Clustering and Villus Formation in Gut Development

(2020) Abilasha Rao-Bhatia et al.   DEVELOPMENTAL CELL

Synthetic alternatives to Matrigel

(2020) Elizabeth A. Aisenbrey et al.   Nature Reviews Materials

High-throughput automated organoid culture via stem-cell aggregation in microcavity arrays

(2020) Nathalie Brandenberg et al.   Nature Biomedical Engineering

Differentiation of Human Intestinal Organoids with Endogenous Vascular Endothelial Cells

(2020) Emily M. Holloway et al.   DEVELOPMENTAL CELL

Recapitulating macro-scale tissue self-organization through organoid bioprinting

(2020) Jonathan A. Brassard et al.   NATURE MATERIALS

Elevated apoptosis impairs epithelial cell turnover and shortens villi in TNF-driven intestinal inflammation

(2019) Aimée Parker et al.   Cell Death & Disease

Apical constriction is necessary for crypt formation in small intestinal organoids

(2019) Leonie Hartl et al.   DEVELOPMENTAL BIOLOGY

Stem cells in homeostasis and cancer of the gut

(2019) Maartje van der Heijden et al.   Molecular Cancer

Self-organization and symmetry breaking in intestinal organoid development

(2019) Denise Serra et al.   NATURE

Role of mTORC1 in intestinal epithelial repair and tumorigenesis

(2019) Harleen Kaur et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

GLI2 Modulated by SUFU and SPOP Induces Intestinal Stem Cell Niche Signals in Development and Tumorigenesis

(2019) Sabrina Coquenlorge et al.   Cell Reports

Long-Term Culture Captures Injury-Repair Cycles of Colonic Stem Cells

(2019) Yi Wang et al.   CELL

YAP/TAZ-Dependent Reprogramming of Colonic Epithelium Links ECM Remodeling to Tissue Regeneration

(2018) Shiro Yui et al.   Cell Stem Cell

Morphogenesis and Compartmentalization of the Intestinal Crypt

(2018) Kaelyn D. Sumigray et al.   DEVELOPMENTAL CELL

Not All That Flattens Villi Is Celiac Disease: A Review of Enteropathies

(2018) Claire L. Jansson-Knodell et al.   MAYO CLINIC PROCEEDINGS

The molecular characteristics of colorectal cancer: Implications for diagnosis and therapy (Review)

(2018) Ha Nguyen et al.   Oncology Letters

Parasitic helminths induce fetal-like reversion in the intestinal stem cell niche

(2018) Ysbrand M. Nusse et al.   NATURE

The Intestinal Stem Cell Niche: Homeostasis and Adaptations

(2018) António J.M. Santos et al.   TRENDS IN CELL BIOLOGY

Interleukin-2 induces the in vitro maturation of human pluripotent stem cell-derived intestinal organoids

(2018) Kwang Bo Jung et al.   Nature Communications

Contribution of Wound-Associated Cells and Mediators in Orchestrating Gastrointestinal Mucosal Wound Repair

(2018) Miguel Quirós et al.   Annual Review of Physiology

Prostaglandin E2 Activates YAP and a Positive-Signaling Loop to Promote Colon Regeneration After Colitis but Also Carcinogenesis in Mice

(2017) Han-Byul Kim et al.   GASTROENTEROLOGY

The Crumbs3 Polarity Protein

(2017) Ben Margolis   Cold Spring Harbor Perspectives in Biology

Intestinal stem cells contribute to the maturation of the neonatal small intestine and colon independently of digestive activity

(2017) Hirotsugu Yanai et al.   Scientific Reports

Preterm infant gut microbiota affects intestinal epithelial development in a humanized microbiome gnotobiotic mouse model

(2016) Yueyue Yu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites

(2016) Ara Koh et al.   CELL

The Colonic Crypt Protects Stem Cells from Microbiota-Derived Metabolites

(2016) Gerard E. Kaiko et al.   CELL

Induction of Expandable Tissue-Specific Stem/Progenitor Cells through Transient Expression of YAP/TAZ

(2016) Tito Panciera et al.   Cell Stem Cell

Generation of intestinal surface: an absorbing tale

(2016) Katherine D. Walton et al.   DEVELOPMENT

Regulation and plasticity of intestinal stem cells during homeostasis and regeneration

(2016) Joep Beumer et al.   DEVELOPMENT

Prostaglandin E2 promotes intestinal repair through an adaptive cellular response of the epithelium

(2016) Hiroyuki Miyoshi et al.   EMBO JOURNAL

The clinical and phenotypical assessment of seronegative villous atrophy; a prospective UK centre experience evaluating 200 adult cases over a 15-year period (2000–2015)

(2016) Imran Aziz et al.   GUT

Coordination of signaling and tissue mechanics during morphogenesis of murine intestinal villi: a role for mitotic cell rounding

(2016) Andrew M. Freddo et al.   Integrative Biology

Designer matrices for intestinal stem cell and organoid culture

(2016) Nikolce Gjorevski et al.   NATURE

Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system

(2016) Michael J Workman et al.   NATURE MEDICINE

Plasticity of the brush border — the yin and yang of intestinal homeostasis

(2016) Delphine Delacour et al.   Nature Reviews Gastroenterology & Hepatology

Crumbs 3b promotes tight junctions in an ezrin-dependent manner in mammalian cells

(2016) Andrew M. Tilston-Lünel et al.   Journal of Molecular Cell Biology

Cultivating Healthy Growth and Nutrition through the Gut Microbiota

(2015) Sathish Subramanian et al.   CELL

Bending Gradients: How the Intestinal Stem Cell Gets Its Home

(2015) Amy E. Shyer et al.   CELL

Congenital secretory diarrhoea caused by activating germline mutations inGUCY2C

(2015) Thomas Müller et al.   GUT

Reduced sodium/proton exchanger NHE3 activity causes congenital sodium diarrhea

(2015) Andreas R. Janecke et al.   HUMAN MOLECULAR GENETICS

Rab11a regulates syntaxin 3 localization and microvillus assembly in enterocytes

(2015) B. C. Knowles et al.   JOURNAL OF CELL SCIENCE

Mucosally transplanted mesenchymal stem cells stimulate intestinal healing by promoting angiogenesis

(2015) Nicholas A. Manieri et al.   JOURNAL OF CLINICAL INVESTIGATION

Cloning and variation of ground state intestinal stem cells

(2015) Xia Wang et al.   NATURE

A gp130–Src–YAP module links inflammation to epithelial regeneration

(2015) Koji Taniguchi et al.   NATURE

Mouse Crumbs3 sustains epithelial tissue morphogenesis in vivo

(2015) Lucie E. Charrier et al.   Scientific Reports

Intestinal Brush Border Assembly Driven by Protocadherin-Based Intermicrovillar Adhesion

(2014) Scott W. Crawley et al.   CELL

Shaping the intestinal brush border

(2014) Scott W. Crawley et al.   JOURNAL OF CELL BIOLOGY

Gut microbiota–generated metabolites in animal health and disease

(2014) Won-Jae Lee et al.   Nature Chemical Biology

Capping protein regulators fine-tune actin assembly dynamics

(2014) Marc Edwards et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Surface area of the digestive tract – revisited

(2014) Herbert F Helander et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Rab11a is required for apical protein localisation in the intestine

(2014) T. Sobajima et al.   Biology Open

The Intestinal Crypt, A Prototype Stem Cell Compartment

(2013) Hans Clevers   CELL

Lgr5+ Stem Cells Are Indispensable for Radiation-Induced Intestinal Regeneration

(2013) Ciara Metcalfe et al.   Cell Stem Cell

Syndromic congenital diarrhea because of the SPINT2 mutation showing enterocyte tufting and unique electron microscopy findings

(2013) Mordechai A. Slae et al.   CLINICAL DYSMORPHOLOGY

Crumbs3 Is Essential for Proper Epithelial Development and Viability

(2013) E. L. Whiteman et al.   MOLECULAR AND CELLULAR BIOLOGY

Insights into the Origin of Metazoan Filopodia and Microvilli

(2013) Arnau Sebé-Pedrós et al.   MOLECULAR BIOLOGY AND EVOLUTION

Mitotic cell rounding accelerates epithelial invagination

(2013) Takefumi Kondo et al.   NATURE

Adult intestinal stem cells: critical drivers of epithelial homeostasis and regeneration

(2013) Nick Barker   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Growing Self-Organizing Mini-Guts from a Single Intestinal Stem Cell: Mechanism and Applications

(2013) T. Sato et al.   SCIENCE

Cancer Genome Landscapes

(2013) B. Vogelstein et al.   SCIENCE

Integrins in Wound Healing

(2013) Leeni Koivisto et al.   Advances in Wound Care

Igf2bp1 Is Required for Full Induction of Ptgs2 mRNA in Colonic Mesenchymal Stem Cells in Mice

(2012) Nicholas A. Manieri et al.   GASTROENTEROLOGY

Apoptosis, necrosis and necroptosis: cell death regulation in the intestinal epithelium

(2012) Claudia Günther et al.   GUT

Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow

(2012) Hyun Jung Kim et al.   LAB ON A CHIP

mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake

(2012) Ömer H. Yilmaz et al.   NATURE

Hedgehog-responsive mesenchymal clusters direct patterning and emergence of intestinal villi

(2012) K. D. Walton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wnt5a Potentiates TGF-  Signaling to Promote Colonic Crypt Regeneration After Tissue Injury

(2012) H. Miyoshi et al.   SCIENCE

The Life and Death of Epithelia During Inflammation: Lessons Learned from the Gut

(2011) Stefan Koch et al.   Annual Review of Pathology-Mechanisms of Disease

Cell dynamics in fetal intestinal epithelium: implications for intestinal growth and morphogenesis

(2011) A. S. Grosse et al.   DEVELOPMENT

Vertebrate intestinal endoderm development

(2011) Jason R. Spence et al.   DEVELOPMENTAL DYNAMICS

Dll1- and Dll4-Mediated Notch Signaling Are Required for Homeostasis of Intestinal Stem Cells

(2011) Luca Pellegrinet et al.   GASTROENTEROLOGY

A new role for the architecture of microvillar actin bundles in apical retention of membrane proteins

(2011) Céline Revenu et al.   MOLECULAR BIOLOGY OF THE CELL

Expansion of Intestinal Epithelial Stem Cells during Murine Development

(2011) Jeffrey J. Dehmer et al.   PLoS One

Ezrin-mediated apical integrity is required for intestinal homeostasis

(2011) J. B. Casaletto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wound healing of intestinal epithelial cells

(2011) Masahiro Iizuka   WORLD JOURNAL OF GASTROENTEROLOGY

Inflammatory Bowel Disease

(2010) Arthur Kaser et al.   Annual Review of Immunology

Atm-Deficient Mice Exhibit Increased Sensitivity to Dextran Sulfate Sodium-Induced Colitis Characterized by Elevated DNA Damage and Persistent Immune Activation

(2010) A. M. Westbrook et al.   CANCER RESEARCH

Hedgehog signaling controls mesenchymal growth in the developing mammalian digestive tract

(2010) J. Mao et al.   DEVELOPMENT

The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program

(2010) J. Cai et al.   GENES & DEVELOPMENT

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

(2010) Toshiro Sato et al.   NATURE

Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro

(2010) Jason R. Spence et al.   NATURE

Organizing the cell cortex: the role of ERM proteins

(2010) Richard G. Fehon et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Paracrine Hedgehog Signaling in Stomach and Intestine: New Roles for Hedgehog in Gastrointestinal Patterning

(2009) Åsa Kolterud et al.   GASTROENTEROLOGY

Plastin 1 Binds to Keratin and Is Required for Terminal Web Assembly in the Intestinal Epithelium

(2009) Eva-Maria S. Grimm-Günter et al.   MOLECULAR BIOLOGY OF THE CELL

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche

(2009) Akifumi Ootani et al.   NATURE MEDICINE

Wnt5a is essential for intestinal elongation in mice

(2008) Sara Cervantes et al.   DEVELOPMENTAL BIOLOGY

Morphogenetic movements driving neural tube closure in Xenopus require myosin IIB

(2008) Ana Rolo et al.   DEVELOPMENTAL BIOLOGY

FoxF1 and FoxL1 Link Hedgehog Signaling and the Control of Epithelial Proliferation in the Developing Stomach and Intestine

(2008) Blair B. Madison et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pulsed contractions of an actin–myosin network drive apical constriction

(2008) Adam C. Martin et al.   NATURE

MYO5B mutations cause microvillus inclusion disease and disrupt epithelial cell polarity

(2008) Thomas Müller et al.   NATURE GENETICS

Comparative lesion sequencing provides insights into tumor evolution

(2008) S. Jones et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Efficient colonic mucosal wound repair requires Trem2 signaling

(2008) H. Seno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA