Elevated apoptosis impairs epithelial cell turnover and shortens villi in TNF-driven intestinal inflammation

Identification of G2/M phase transition by sequential nuclear and cytoplasmic changes and molecular markers in mice intestinal epithelial cells

(2018) Jiong Ren et al.   CELL CYCLE

Chronic TNFα-driven injury delays cell migration to villi in the intestinal epithelium

(2018) Daniele Muraro et al.   Journal of the Royal Society Interface

Cell proliferation within small intestinal crypts is the principal driving force for cell migration on villi

(2017) Aimee Parker et al.   FASEB JOURNAL

Inhibitor of Apoptosis Protein-1 Regulates Tumor Necrosis Factor–Mediated Destruction of Intestinal Epithelial Cells

(2017) Thomas Grabinger et al.   GASTROENTEROLOGY

A hierarchical Bayesian model for understanding the spatiotemporal dynamics of the intestinal epithelium

(2017) Oliver J. Maclaren et al.   PLoS Computational Biology

Deciphering the Complex Signaling Systems That Regulate Intestinal Epithelial Cell Death Processes and Shedding

(2017) Angela M. Patterson et al.   Frontiers in Immunology

Death in the intestinal epithelium-basic biology and implications for inflammatory bowel disease

(2016) J. Magarian Blander   FEBS Journal

A Protocol for the Comprehensive Flow Cytometric Analysis of Immune Cells in Normal and Inflamed Murine Non-Lymphoid Tissues

(2016) Yen-Rei A. Yu et al.   PLoS One

Both the anti- and pro-apoptotic functions of villin regulate cell turnover and intestinal homeostasis

(2016) Yaohong Wang et al.   Scientific Reports

Chronic Exposure to TNFα Impairs Secretion of Glucagon-Like Peptide-1

(2015) Jeffrey Gagnon et al.   ENDOCRINOLOGY

Dysbiotic gut microbiota causes transmissible Crohn's disease-like ileitis independent of failure in antimicrobial defence

(2015) Monika Schaubeck et al.   GUT

Cytometry-based single-cell analysis of intact epithelial signaling reveals MAPK activation divergent from TNF- -induced apoptosis in vivo

(2015) A. J. Simmons et al.   Molecular Systems Biology

Network-level effects of kinase inhibitors modulate TNF-α–induced apoptosis in the intestinal epithelium

(2015) Jessica J. Gierut et al.   Science Signaling

Network-level effects of kinase inhibitors modulate TNF-α–induced apoptosis in the intestinal epithelium

(2015) Jessica J. Gierut et al.   Science Signaling

Confocal Endomicroscopy Identifies Loss of Local Barrier Function in the Duodenum of Patients with Crohnʼs Disease and Ulcerative Colitis

(2014) Lee G. Lim et al.   INFLAMMATORY BOWEL DISEASES

Pleiotropic functions of TNF-  in the regulation of the intestinal epithelial response to inflammation

(2014) M. Leppkes et al.   INTERNATIONAL IMMUNOLOGY

Longitudinal analysis of inflammation and microbiota dynamics in a model of mild chronic dextran sulfate sodium-induced colitis in mice

(2014) Luigia De Fazio   WORLD JOURNAL OF GASTROENTEROLOGY

Animal models of inflammatory bowel disease: a review

(2014) Nidhi Goyal et al.   INFLAMMOPHARMACOLOGY

A mouse model of pathological small intestinal epithelial cell apoptosis and shedding induced by systemic administration of lipopolysaccharide

(2013) J. M. Williams et al.   Disease Models & Mechanisms

Safe TNF-based antitumor therapy following p55TNFR reduction in intestinal epithelium

(2013) Filip Van Hauwermeiren et al.   JOURNAL OF CLINICAL INVESTIGATION

Multifunctional role of dextran sulfate sodium for in vivo modeling of intestinal diseases

(2012) William A Rose et al.   BMC IMMUNOLOGY

Apoptosis, necrosis and necroptosis: cell death regulation in the intestinal epithelium

(2012) Claudia Günther et al.   GUT

Mucosal healing in inflammatory bowel diseases: a systematic review

(2012) Markus F Neurath et al.   GUT

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

L-arginine Supplementation Improves Responses to Injury and Inflammation in Dextran Sulfate Sodium Colitis

(2012) Lori A. Coburn et al.   PLoS One

Mesenchymal Cells of the Intestinal Lamina Propria

(2011) D.W. Powell et al.   Annual Review of Physiology

Endothelin system in intestinal villi: A possible role of endothelin-2/vasoactive intestinal contractor in the maintenance of intestinal architecture

(2011) Mariana Bianchi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Local barrier dysfunction identified by confocal laser endomicroscopy predicts relapse in inflammatory bowel disease

(2011) R Kiesslich et al.   GUT

Intestinal epithelial cells as producers but not targets of chronic TNF suffice to cause murine Crohn-like pathology

(2011) M. Roulis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TNF receptor 2 pathway: drug target for autoimmune diseases

(2010) Denise Faustman et al.   NATURE REVIEWS DRUG DISCOVERY

Increased apoptosis and decreased proliferation of colonic epithelium in dextran sulfate sodium-induced colitis in mice

(2010) Araki   ONCOLOGY REPORTS

Role of TNF receptors, TNFR1 and TNFR2, in dextran sodium sulfate-induced colitis

(2009) RoseMarie Stillie et al.   INFLAMMATORY BOWEL DISEASES

Mesenchymal cell targeting by TNF as a common pathogenic principle in chronic inflammatory joint and intestinal diseases

(2008) Maria Armaka et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Rapid Reversal of Human Intestinal Ischemia-Reperfusion Induced Damage by Shedding of Injured Enterocytes and Reepithelialisation

(2008) Joep P. M. Derikx et al.   PLoS One

Efficient colonic mucosal wound repair requires Trem2 signaling

(2008) H. Seno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA