Consecutive Hypoxia Decreases Expression of NOTCH3, HEY1, CC10, and FOXJ1 via NKX2-1 Downregulation and Intermittent Hypoxia-Reoxygenation Increases Expression of BMP4, NOTCH1, MKI67, OCT4, and MUC5AC via HIF1A Upregulation in Human Bronchial Epithelial Cells

HIF1α Regulates Early Metabolic Changes due to Activation of Innate Immunity in Nuclear Reprogramming

(2020) Chun Liu et al.   Stem Cell Reports

Exaggerated BMP4 Signalling Alters Human Airway Basal Progenitor Cell Differentiation to Cigarette Smoking-related Phenotypes

(2019) Wu-Lin Zuo et al.   EUROPEAN RESPIRATORY JOURNAL

The etiologic origins for chronic obstructive pulmonary disease

(2019) Xinwei Huang et al.   International Journal of Chronic Obstructive Pulmonary Disease

A RASSF1A-HIF1α loop drives Warburg effect in cancer and pulmonary hypertension

(2019) Swati Dabral et al.   Nature Communications

Crosstalk between BMP and Notch Induces Sox2 in Cerebral Endothelial Cells

(2019) Xiuju Wu et al.   Cells

STK11 is required for the normal program of ciliated cell differentiation in airways

(2019) Qiqi Chu et al.   Cell Discovery

Altered generation of ciliated cells in chronic obstructive pulmonary disease

(2019) Sophie Gohy et al.   Scientific Reports

Chronic obstructive pulmonary disease (COPD) and lung cancer: common pathways for pathogenesis

(2019) Brielle A. Parris et al.   Journal of Thoracic Disease

Airway epithelial cell differentiation relies on deficient Hedgehog signalling in COPD

(2019) Randa Belgacemi et al.   EBioMedicine

Hypoxic Induction of Vasorin Regulates Notch1 Turnover to Maintain Glioma Stem-like Cells

(2018) Jianghong Man et al.   Cell Stem Cell

Niche-mediated BMP/SMAD signaling regulates lung alveolar stem cell proliferation and differentiation

(2018) Mei-I Chung et al.   DEVELOPMENT

Exposure to hypoxia injures tracheal epithelium (ultrastructural study)

(2018) V. Konrádová et al.   VETERINARNI MEDICINA

COPD-Type lung inflammation promotes K-ras mutant lung cancer through epithelial HIF-1α mediated tumor angiogenesis and proliferation

(2018) Maria Miguelina De la Garza et al.   Oncotarget

The NANCI–Nkx2.1 gene duplex buffers Nkx2.1 expression to maintain lung development and homeostasis

(2017) Michael J. Herriges et al.   GENES & DEVELOPMENT

Hypoxia and the hypoxia-regulated transcription factor HIF-1α suppress the host defence of airway epithelial cells

(2017) Markus Polke et al.   Innate Immunity

Involvement of Notch1 signaling in malignant progression of A549 cells subjected to prolonged cadmium exposure

(2017) Kota Fujiki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Correction: Noncanonical WNT-5A signaling impairs endogenous lung repair in COPD

(2017) Hoeke A. Baarsma et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Oct4 transcriptionally regulates the expression of long non-coding RNAs NEAT1 and MALAT1 to promote lung cancer progression

(2017) Jayu Jen et al.   Molecular Cancer

Development of Inhibitors Targeting Hypoxia-Inducible Factor 1 and 2 for Cancer Therapy

(2017) Tianchi Yu et al.   YONSEI MEDICAL JOURNAL

Hypoxia-Inducible Factor-1α Regulates CD55 in Airway Epithelium

(2016) Pankita H. Pandya et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Thrombopoietin induces hematopoiesis from mouse ES cells via HIF-1α-dependent activation of a BMP4 autoregulatory loop

(2016) Andri Pramono et al.   Annals of the New York Academy of Sciences

Mechanisms of lung ischemia-reperfusion injury

(2016) Victor E. Laubach et al.   Current Opinion in Organ Transplantation

BMP signaling and cellular dynamics during regeneration of airway epithelium from basal progenitors

(2016) Tomomi Tadokoro et al.   DEVELOPMENT

BMP4 promotes a phenotype change of an esophageal squamous epithelium via up-regulation of KLF4

(2016) Wu Yan et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Temporal Patterns of Gene Expression Profiles in the Neonatal Mouse Lung after Hypoxia-Reoxygenation

(2016) Anne Gro W. Rognlien et al.   Neonatology

Notch regulates BMP responsiveness and lateral branching in vessel networks via SMAD6

(2016) Kevin P. Mouillesseaux et al.   Nature Communications

Two-stage induced differentiation of OCT4+/Nanog+ stem-like cells in lung adenocarcinoma

(2016) Rong Li et al.   Oncotarget

Role Of Hif2α Oxygen Sensing Pathway In Bronchial Epithelial Club Cell Proliferation

(2016) Mar Torres-Capelli et al.   Scientific Reports

Regulation of cell proliferation by hypoxia-inducible factors

(2015) Maimon E. Hubbi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Hypoxia inducible factor-1-dependent up-regulation of BMP4 mediates hypoxia-induced increase of TRPC expression in PASMCs

(2015) Jian Wang et al.   CARDIOVASCULAR RESEARCH

Club Cells, Their Secretory Protein, and COPD

(2015) Peter J. Barnes   CHEST

Update on ischemia-reperfusion injury in lung transplantation

(2015) Fengshi Chen et al.   Current Opinion in Organ Transplantation

Notch3-Jagged signaling controls the pool of undifferentiated airway progenitors

(2015) M. Mori et al.   DEVELOPMENT

Anti-inflammatory Effects of Resveratrol on Hypoxia/Reoxygenation-Induced Alveolar Epithelial Cell Dysfunction

(2015) Po-Len Liu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The relationship between COPD and lung cancer

(2015) A.L. Durham et al.   LUNG CANCER

Small airway-on-a-chip enables analysis of human lung inflammation and drug responses in vitro

(2015) Kambez H Benam et al.   NATURE METHODS

YAP1 Regulates OCT4 Activity and SOX2 Expression to Facilitate Self-Renewal and Vascular Mimicry of Stem-Like Cells

(2015) Namrata Bora-Singhal et al.   STEM CELLS

Hypoxia down-regulates expression of secretory leukocyte protease inhibitor in bronchial epithelial cells via TGF-β1

(2015) Lisa I Påhlman et al.   BMC Pulmonary Medicine

The Role of Bronchial Artery Revascularization in Lung Transplantation

(2015) Michael Z. Tong et al.   Thoracic Surgery Clinics

Editorial – Hypoxia and Reoxygenation: From Basic Science to Bedside

(2015) Michele Samaja et al.   Frontiers in Pediatrics

Activation of NOTCH1 or NOTCH3 Signaling Skews Human Airway Basal Cell Differentiation toward a Secretory Pathway

(2015) Kazunori Gomi et al.   PLoS One

Repression of CC16 by Cigarette Smoke (CS) Exposure

(2015) Lingxiang Zhu et al.   PLoS One

Cigarette smoke alters primary human bronchial epithelial cell differentiation at the air-liquid interface

(2015) Andrea C. Schamberger et al.   Scientific Reports

Submersion and Hypoxia Inhibit Ciliated Cell Differentiation in a Notch-Dependent Manner

(2014) Benjamin J. Gerovac et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Hypoxia-Mediated Mechanism of MUC5AC Production in Human Nasal Epithelia and Its Implication in Rhinosinusitis

(2014) Yoon-Ju Kim et al.   PLoS One

Does Ischemia-Reperfusion Injury After Solid Organ Transplantation Damage Native Organs?

(2014) Leonard J. Lobo et al.   TRANSPLANTATION

Efficient delivery of RNA interference oligonucleotides to polarized airway epithelia in vitro

(2013) Shyam Ramachandran et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Hypoxia-induced deoxycytidine kinase expression contributes to apoptosis in chronic lung disease

(2013) Tingting Weng et al.   FASEB JOURNAL

BMP signaling regulates the differentiation of mouse embryonic stem cells into lung epithelial cell lineages

(2013) Naoto Ninomiya et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

Notch1 is required for hypoxia-induced proliferation, invasion and chemoresistance of T-cell acute lymphoblastic leukemia cells

(2013) Jie Zou et al.   Journal of Hematology & Oncology

Nkx2-1 Represses a Latent Gastric Differentiation Program in Lung Adenocarcinoma

(2013) Eric L. Snyder et al.   MOLECULAR CELL

Transcriptome profiling of the newborn mouse lung after hypoxia and reoxygenation: hyperoxic reoxygenation affects mTOR signaling pathway, DNA repair and JNK-pathway regulation

(2013) Embjørg J. Wollen et al.   PEDIATRIC RESEARCH

Hypoxia Modulates Infection of Epithelial Cells by Pseudomonas aeruginosa

(2013) Bettina Schaible et al.   PLoS One

Ectopic Expression of Homeobox Gene NKX2-1 in Diffuse Large B-Cell Lymphoma Is Mediated by Aberrant Chromatin Modifications

(2013) Stefan Nagel et al.   PLoS One

Manipulation of Cell Physiology Enables Gene Silencing in Well-differentiated Airway Epithelia

(2013) Sateesh Krishnamurthy et al.   Molecular Therapy-Nucleic Acids

Oct4+ Stem/Progenitor Swine Lung Epithelial Cells Are Targets for Influenza Virus Replication

(2012) M. Khatri et al.   JOURNAL OF VIROLOGY

Hypoxia induces mucin expression and secretion in human bronchial epithelial cells

(2012) XiangDong Zhou et al.   Translational Research

The loss of Hoxa5 function promotes Notch-dependent goblet cell metaplasia in lung airways

(2012) O. Boucherat et al.   Biology Open

Activation of hypoxia-inducible factor-1 protects airway epithelium against oxidant-induced barrier dysfunction

(2011) Nels Olson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

HIF Induces Human Embryonic Stem Cell Markers in Cancer Cells

(2011) J. Mathieu et al.   CANCER RESEARCH

Hypoxia-inducible factor-1 signalling promotes goblet cell hyperplasia in airway epithelium

(2011) Vasiliy V Polosukhin et al.   JOURNAL OF PATHOLOGY

Identification of valid housekeeping genes for quantitative RT-PCR analysis of cardiosphere-derived cells preconditioned under hypoxia or with prolyl-4-hydroxylase inhibitors

(2011) Suat Cheng Tan et al.   MOLECULAR BIOLOGY REPORTS

Airway Hypoxia, Bronchiolar Artery Revascularization, and Obliterative Bronchiolitis/Bronchiolitis Obliterans Syndrome

(2010) David S. Wilkes   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Lung Cancer in Chronic Obstructive Pulmonary Disease

(2010) Stacy Raviv et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Lung eNOS and iNOS are Reoxygenation Time-Dependent Upregulated After Acute Hypoxia

(2010) Alma Rus et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

18S is an appropriate housekeeping gene for in vitro hypoxia experiments

(2010) A Nagelkerke et al.   BRITISH JOURNAL OF CANCER

Coexpression of Oct4 and Nanog Enhances Malignancy in Lung Adenocarcinoma by Inducing Cancer Stem Cell-Like Properties and Epithelial-Mesenchymal Transdifferentiation

(2010) S.-H. Chiou et al.   CANCER RESEARCH

BMPs functionally replace Klf4 and support efficient reprogramming of mouse fibroblasts by Oct4 alone

(2010) Jiekai Chen et al.   CELL RESEARCH

Bronchial blood supply after lung transplantation without bronchial artery revascularization

(2010) Mark R Nicolls et al.   Current Opinion in Organ Transplantation

Distinct functions of BMP4 during different stages of mouse ES cell neural commitment

(2010) K. Zhang et al.   DEVELOPMENT

Prognostic Significance of OCT4 Expression in Adenocarcinoma of the Lung

(2010) X. Zhang et al.   JAPANESE JOURNAL OF CLINICAL ONCOLOGY

ZFP423 Coordinates Notch and Bone Morphogenetic Protein Signaling, Selectively Up-regulatingHes5Gene Expression

(2010) Giacomo Masserdotti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxia Regulates BMP4 Expression in the Murine Spleen during the Recovery from Acute Anemia

(2010) Dai-Chen Wu et al.   PLoS One

Rat alveolar type I cells proliferate, express OCT-4, and exhibit phenotypic plasticity in vitro

(2009) Robert F. Gonzalez et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

NK-like homeodomain proteins activate NOTCH3-signaling in leukemic T-cells

(2009) Stefan Nagel et al.   BMC CANCER

The Role of Scgb1a1+ Clara Cells in the Long-Term Maintenance and Repair of Lung Airway, but Not Alveolar, Epithelium

(2009) Emma L. Rawlins et al.   Cell Stem Cell

Notch signaling controls the balance of ciliated and secretory cell fates in developing airways

(2009) P.-N. Tsao et al.   DEVELOPMENT

Notch signaling promotes airway mucous metaplasia and inhibits alveolar development

(2009) J. S. Guseh et al.   DEVELOPMENT

Clara cell: Progenitor for the bronchiolar epithelium

(2009) Susan D. Reynolds et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Sox2 Is Required for Maintenance and Differentiation of Bronchiolar Clara, Ciliated, and Goblet Cells

(2009) David H. Tompkins et al.   PLoS One

OCT4 expression in human non-small cell lung cancer: implications for therapeutic intervention,,

(2009) G. Karoubi et al.   Interactive Cardiovascular and Thoracic Surgery

Down-regulation of the Notch Pathway in Human Airway Epithelium in Association with Smoking and Chronic Obstructive Pulmonary Disease

(2008) Ann E. Tilley et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

BMP4 induces an epithelial–mesenchymal transition-like response in adult airway epithelial cells

(2008) Emer L. Molloy et al.   GROWTH FACTORS

Foxj1 transcription factors are master regulators of the motile ciliogenic program

(2008) Xianwen Yu et al.   NATURE GENETICS

Oct-4 Expression Maintained Cancer Stem-Like Properties in Lung Cancer-Derived CD133-Positive Cells

(2008) Yu-Chih Chen et al.   PLoS One

Hypoxia and Reoxygenation of the Lung Tissues Induced mRNA Expressions of Superoxide Dismutase and Catalase and Interventions From Different Antioxidants

(2008) C.Y. Shen et al.   TRANSPLANTATION PROCEEDINGS

Ischemia/Reperfusion Injury in Kidney Transplantation: Mechanisms and Prevention

(2008) M. Kosieradzki et al.   TRANSPLANTATION PROCEEDINGS