Regulation of cell proliferation by hypoxia-inducible factors

An essential role for chaperone-mediated autophagy in cell cycle progression

(2015) Maimon E Hubbi et al.   Autophagy

RHOBTB3 promotes proteasomal degradation of HIFα through facilitating hydroxylation and suppresses the Warburg effect

(2015) Chen-Song Zhang et al.   CELL RESEARCH

Human Ventricular Unloading Induces Cardiomyocyte Proliferation

(2015) Diana C. Canseco et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Oxygen regulates proliferation of neural stem cells through Wnt/β-catenin signalling

(2015) Lena Braunschweig et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

The zinc transporter ZIP12 regulates the pulmonary vascular response to chronic hypoxia

(2015) Lan Zhao et al.   NATURE

Hypoxia fate mapping identifies cycling cardiomyocytes in the adult heart

(2015) Wataru Kimura et al.   NATURE

Therapeutic targeting of autophagy in cancer. Part I: Molecular pathways controlling autophagy

(2015) Anika Nagelkerke et al.   SEMINARS IN CANCER BIOLOGY

The Oxygen-Rich Postnatal Environment Induces Cardiomyocyte Cell-Cycle Arrest through DNA Damage Response

(2014) Bao N. Puente et al.   CELL

A Proliferative Burst during Preadolescence Establishes the Final Cardiomyocyte Number

(2014) Nawazish Naqvi et al.   CELL

Direct measurement of local oxygen concentration in the bone marrow of live animals

(2014) Joel A. Spencer et al.   NATURE

Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1  to promote cell-cycle progression

(2014) M. E. Hubbi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia-Inducible Factor 3 Is an Oxygen-Dependent Transcription Activator and Regulates a Distinct Transcriptional Response to Hypoxia

(2014) Peng Zhang et al.   Cell Reports

Oxygen Sensing, Hypoxia-Inducible Factors, and Disease Pathophysiology

(2013) Gregg L. Semenza   Annual Review of Pathology-Mechanisms of Disease

STUB1/CHIP is required for HIF1A degradation by chaperone-mediated autophagy

(2013) João Vasco Ferreira et al.   Autophagy

CDK1 stabilizes HIF-1α via direct phosphorylation of Ser668 to promote tumor growth

(2013) Noel A Warfel et al.   CELL CYCLE

PHD1 Links Cell-Cycle Progression to Oxygen Sensing through Hydroxylation of the Centrosomal Protein Cep192

(2013) Sandra C. Moser et al.   DEVELOPMENTAL CELL

Chaperone-mediated Autophagy Targets Hypoxia-inducible Factor-1α (HIF-1α) for Lysosomal Degradation

(2013) Maimon E. Hubbi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sirtuin-7 Inhibits the Activity of Hypoxia-inducible Factors

(2013) Maimon E. Hubbi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MYC Degradation under Low O2Tension Promotes Survival by Evading Hypoxia-Induced Cell Death

(2013) Waihay J. Wong et al.   MOLECULAR AND CELLULAR BIOLOGY

Quantitative imaging of haematopoietic stem and progenitor cell localization and hypoxic status in the bone marrow microenvironment

(2013) César Nombela-Arrieta et al.   NATURE CELL BIOLOGY

RUNX3 inhibits hypoxia-inducible factor-1α protein stability by interacting with prolyl hydroxylases in gastric cancer cells

(2013) S H Lee et al.   ONCOGENE

JMJD5 regulates PKM2 nuclear translocation and reprograms HIF-1 -mediated glucose metabolism

(2013) H.-J. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Nontranscriptional Role for HIF-1  as a Direct Inhibitor of DNA Replication

(2013) M. E. Hubbi et al.   Science Signaling

HIF-1  deletion partially rescues defects of hematopoietic stem cell quiescence caused by Cited2 deficiency

(2012) J. Du et al.   BLOOD

Hypoxia Induces Myocardial Regeneration in Zebrafish

(2012) Chris Jopling et al.   CIRCULATION

SHARP1 suppresses breast cancer metastasis by promoting degradation of hypoxia-inducible factors

(2012) Marco Montagner et al.   NATURE

Adaptive and Maladaptive Cardiorespiratory Responses to Continuous and Intermittent Hypoxia Mediated by Hypoxia-Inducible Factors 1 and 2

(2012) Nanduri R. Prabhakar et al.   PHYSIOLOGICAL REVIEWS

Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression

(2012) W. Luo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chaperone-mediated autophagy: a unique way to enter the lysosome world

(2012) Susmita Kaushik et al.   TRENDS IN CELL BIOLOGY

HIF-1 or HIF-2 induction is sufficient to achieve cell cycle arrest in NIH3T3 mouse fibroblasts independent from hypoxia

(2011) Thomas Hackenbeck et al.   CELL CYCLE

Metabolic Regulation of Hematopoietic Stem Cells in the Hypoxic Niche

(2011) Toshio Suda et al.   Cell Stem Cell

Hypoxia-Inducible Factor 1 Is Activated by Dysregulated Cyclin E during Mammary Epithelial Morphogenesis

(2011) T. Sengupta et al.   MOLECULAR AND CELLULAR BIOLOGY

MCM Proteins Are Negative Regulators of Hypoxia-Inducible Factor 1

(2011) Maimon E. Hubbi et al.   MOLECULAR CELL

Chaperone-Mediated Autophagy Is Required for Tumor Growth

(2011) M. Kon et al.   Science Translational Medicine

JNK1 Mediates Degradation HIF-1  by a VHL-Independent Mechanism that Involves the Chaperones Hsp90/Hsp70

(2010) D. Zhang et al.   CANCER RESEARCH

The Distinct Metabolic Profile of Hematopoietic Stem Cells Reflects Their Location in a Hypoxic Niche

(2010) Tugba Simsek et al.   Cell Stem Cell

Regulation of the HIF-1α Level Is Essential for Hematopoietic Stem Cells

(2010) Keiyo Takubo et al.   Cell Stem Cell

Hemodynamic Support by Left Ventricular Assist Devices Reduces Cardiomyocyte DNA Content in the Failing Human Heart

(2010) Jeremias Wohlschlaeger et al.   CIRCULATION

Hypoxia mediates low cell-cycle activity and increases the proportion of long-term–reconstituting hematopoietic stem cells during in vitro culture

(2010) Pernilla Eliasson et al.   EXPERIMENTAL HEMATOLOGY

Activation of the MCM2-7 Helicase by Association with Cdc45 and GINS Proteins

(2010) Ivar Ilves et al.   MOLECULAR CELL

The Dbf4–Cdc7 kinase promotes S phase by alleviating an inhibitory activity in Mcm4

(2010) Yi-Jun Sheu et al.   NATURE

O2 regulates stem cells through Wnt/β-catenin signalling

(2010) Jolly Mazumdar et al.   NATURE CELL BIOLOGY

Murine Neural Stem/Progenitor Cells Protect Neurons against Ischemia by HIF-1α–Regulated VEGF Signaling

(2010) Kate M. Harms et al.   PLoS One

Mild Hypoxia Enhances Proliferation and Multipotency of Human Neural Stem Cells

(2010) Guido Santilli et al.   PLoS One

Hypoxia inducible microRNA 210 attenuates keratinocyte proliferation and impairs closure in a murine model of ischemic wounds

(2010) S. Biswas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Control of Cyclin D1 and Breast Tumorigenesis by the EglN2 Prolyl Hydroxylase

(2009) Qing Zhang et al.   CANCER CELL

Incorporation into the prereplicative complex activates the Mcm2-7 helicase for Cdc7-Dbf4 phosphorylation

(2009) L. I. Francis et al.   GENES & DEVELOPMENT

Hsp70 and CHIP Selectively Mediate Ubiquitination and Degradation of Hypoxia-inducible Factor (HIF)-1α but Not HIF-2α

(2009) Weibo Luo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The hematopoietic stem cell niche: Low in oxygen but a nice place to be

(2009) Pernilla Eliasson et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Integrative analysis of HIF binding and transactivation reveals its role in maintaining histone methylation homeostasis

(2009) X. Xia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evidence for Cardiomyocyte Renewal in Humans

(2009) Olaf Bergmann et al.   SCIENCE

Stem cell factor induces HIF-1α at normoxia in hematopoietic cells

(2008) Malin Pedersen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1α

(2008) Patrick J. Pollard et al.   BIOCHEMICAL JOURNAL

HIF-α Effects on c-Myc Distinguish Two Subtypes of Sporadic VHL-Deficient Clear Cell Renal Carcinoma

(2008) John D. Gordan et al.   CANCER CELL

The Histone Demethylases JMJD1A and JMJD2B Are Transcriptional Targets of Hypoxia-inducible Factor HIF

(2008) Sophie Beyer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxia-Associated Factor, a Novel E3-Ubiquitin Ligase, Binds and Ubiquitinates Hypoxia-Inducible Factor 1 , Leading to Its Oxygen-Independent Degradation

(2008) M. Y. Koh et al.   MOLECULAR AND CELLULAR BIOLOGY

Excess MCM proteins protect human cells from replicative stress by licensing backup origins of replication

(2008) Arkaitz Ibarra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA