Modulating the tension-time integral of the cardiac twitch prevents dilated cardiomyopathy in murine hearts

Depletion of Vasohibin 1 Speeds Contraction and Relaxation in Failing Human Cardiomyocytes

(2020) Christina Yingxian Chen et al.   CIRCULATION RESEARCH

Troponin structure and function: a view of recent progress

(2019) Steven Marston et al.   JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

Cardiac myosin activation with 2-deoxy-ATP via increased electrostatic interactions with actin

(2019) Joseph D. Powers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FRET-based analysis of the cardiac troponin T linker region reveals the structural basis of the hypertrophic cardiomyopathy-causing Δ160E mutation

(2019) Salwa Abdullah et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanism of Cardiac Tropomyosin Transitions on Filamentous Actin As Revealed by All-Atom Steered Molecular Dynamics Simulations

(2018) Michael R. Williams et al.   Journal of Physical Chemistry Letters

Sarcomere-based genetic enhancement of systolic cardiac function in a murine model of dilated cardiomyopathy

(2018) Jiayang Li et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

The structural basis of alpha-tropomyosin linked (Asp230Asn) familial dilated cardiomyopathy

(2017) M.L. Lynn et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Cardiac troponin structure-function and the influence of hypertrophic cardiomyopathy associated mutations on modulation of contractility

(2016) Yuanhua Cheng et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

A Tension-Based Model Distinguishes Hypertrophic versus Dilated Cardiomyopathy

(2016) Jennifer Davis et al.   CELL

Molecular Effects of cTnC DCM Mutations on Calcium Sensitivity and Myofilament Activation—An Integrated Multiscale Modeling Study

(2016) Sukriti Dewan et al.   JOURNAL OF PHYSICAL CHEMISTRY B

AAV6-mediated Cardiac-specific Overexpression of Ribonucleotide Reductase Enhances Myocardial Contractility

(2016) Stephen C Kolwicz et al.   MOLECULAR THERAPY

Atomic resolution probe for allostery in the regulatory thin filament

(2016) Michael R. Williams et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rationally engineered Troponin C modulates in vivo cardiac function and performance in health and disease

(2016) Vikram Shettigar et al.   Nature Communications

Effects of HCM cTnI Mutation R145G on Troponin Structure and Modulation by PKA Phosphorylation Elucidated by Molecular Dynamics Simulations

(2015) Steffen Lindert et al.   BIOPHYSICAL JOURNAL

Ribonucleotide reductase-mediated increase in dATP improves cardiac performance via myosin activation in a large animal model of heart failure

(2015) Shin Kadota et al.   EUROPEAN JOURNAL OF HEART FAILURE

Omecamtiv Mecarbil, a Cardiac Myosin Activator, Increases Ca2+ Sensitivity in Myofilaments With a Dilated Cardiomyopathy Mutant Tropomyosin E54K

(2015) Megan S. Utter et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

2-Deoxy adenosine triphosphate improves contraction in human end-stage heart failure

(2015) Farid Moussavi-Harami et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Structural basis for drug-induced allosteric changes to human β-cardiac myosin motor activity

(2015) Donald A. Winkelmann et al.   Nature Communications

Safety and Tolerability of Omecamtiv Mecarbil During Exercise in Patients With Ischemic Cardiomyopathy and Angina

(2015) Barry H. Greenberg et al.   JACC-Heart Failure

Computational Studies of the Effect of the S23D/S24D Troponin I Mutation on Cardiac Troponin Structural Dynamics

(2014) Yuanhua Cheng et al.   BIOPHYSICAL JOURNAL

Mechanistic Heterogeneity in Contractile Properties of α-Tropomyosin (TPM1) Mutants Associated with Inherited Cardiomyopathies

(2014) Tejas M. Gupte et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell-based delivery of dATP via gap junctions enhances cardiac contractility

(2014) Scott D. Lundy et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Thin filament incorporation of an engineered cardiac troponin C variant (L48Q) enhances contractility in intact cardiomyocytes from healthy and infarcted hearts

(2014) Erik R. Feest et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Structural and functional consequences of cardiac troponin C L57Q and I61Q Ca2+-desensitizing variants

(2013) Dan Wang et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Genetic mutations and mechanisms in dilated cardiomyopathy

(2013) Elizabeth M. McNally et al.   JOURNAL OF CLINICAL INVESTIGATION

Transgenic overexpression of ribonucleotide reductase improves cardiac performance

(2013) S. G. Nowakowski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural and Functional Consequences of the Cardiac Troponin C L48Q Ca2+-Sensitizing Mutation

(2012) Dan Wang et al.   BIOCHEMISTRY

Gene Therapy for Heart Failure

(2012) Lisa Tilemann et al.   CIRCULATION RESEARCH

Truncations of Titin Causing Dilated Cardiomyopathy

(2012) Daniel S. Herman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Molecular Basis of Calcium-Sensitizing and Desensitizing Mutations of the Human Cardiac Troponin C Regulatory Domain: A Multi-Scale Simulation Study

(2012) Peter Michael Kekenes-Huskey et al.   PLoS Computational Biology

Thin Filament Mutations

(2011) Jil C. Tardiff   CIRCULATION RESEARCH

Update 2011: Clinical and Genetic Issues in Familial Dilated Cardiomyopathy

(2011) Ray E. Hershberger et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Cardiac AAV9-S100A1 Gene Therapy Rescues Post-Ischemic Heart Failure in a Preclinical Large Animal Model

(2011) S. T. Pleger et al.   Science Translational Medicine

Improvement of Cardiac Function by a Cardiac Myosin Activator in Conscious Dogs With Systolic Heart Failure

(2010) You-Tang Shen et al.   Circulation-Heart Failure

Clinical and genetic issues in dilated cardiomyopathy: A review for genetics professionals

(2010) Ray E Hershberger et al.   GENETICS IN MEDICINE

Predicting Cardiomyopathic Phenotypes by Altering Ca2+Affinity of Cardiac Troponin C

(2010) Michelle S. Parvatiyar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tropomyosin and Dilated Cardiomyopathy

(2010) Jil C. Tardiff   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Familial Dilated Cardiomyopathy Caused by an Alpha-Tropomyosin Mutation

(2010) Neal K. Lakdawala et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Combinatorial Effects of Double Cardiomyopathy Mutant Alleles in Rodent Myocytes: A Predictive Cellular Model of Myofilament Dysregulation in Disease

(2010) Jennifer Davis et al.   PLoS One

CHARMM: The biomolecular simulation program

(2009) B. R. Brooks et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Simulation of steady state and transient cardiac muscle response experiments with a Huxley-based contraction model

(2008) Jorge A. Negroni et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY