Rationally engineered Troponin C modulates in vivo cardiac function and performance in health and disease

In Vivo Analysis of Troponin C Knock-In (A8V) MiceCLINICAL PERSPECTIVE

(2015) Adriano S. Martins et al.   Circulation-Cardiovascular Genetics

Obligatory role of neuronal nitric oxide synthase in the heart's antioxidant adaptation with exercise

(2015) Steve R. Roof et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Genetic Analysis of Connective Tissue Growth Factor as an Effector of Transforming Growth Factor β Signaling and Cardiac Remodeling

(2015) Federica Accornero et al.   MOLECULAR AND CELLULAR BIOLOGY

Targeting the sarcomere to correct muscle function

(2015) Peter M. Hwang et al.   NATURE REVIEWS DRUG DISCOVERY

In Vivo Analysis of Troponin C Knock-In (A8V) MiceCLINICAL PERSPECTIVE

(2015) Adriano S. Martins et al.   Circulation-Cardiovascular Genetics

Functional Assessment of Heart Failure Patients

(2015) Leonard A. Kaminsky et al.   Heart Failure Clinics

Knock-in mice harboring a Ca2+ desensitizing mutation in cardiac troponin C develop early onset dilated cardiomyopathy

(2015) Bradley K. McConnell et al.   Frontiers in Physiology

Upregulation of Adenosine A1 Receptors Facilitates Sinoatrial Node Dysfunction in Chronic Canine Heart Failure by Exacerbating Nodal Conduction Abnormalities Revealed by Novel Dual-Sided Intramural Optical Mapping

(2014) Qing Lou et al.   CIRCULATION

Ankyrin-G Coordinates Intercalated Disc Signaling Platform to Regulate Cardiac Excitability In Vivo

(2014) Michael A. Makara et al.   CIRCULATION RESEARCH

Combined troponin I Ser-150 and Ser-23/24 phosphorylation sustains thin filament Ca2+ sensitivity and accelerates deactivation in an acidic environment

(2014) Benjamin R. Nixon et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Thin filament incorporation of an engineered cardiac troponin C variant (L48Q) enhances contractility in intact cardiomyocytes from healthy and infarcted hearts

(2014) Erik R. Feest et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Prednisolone Attenuates Improvement of Cardiac and Skeletal Contractile Function and Histopathology by Lisinopril and Spironolactone in the mdx Mouse Model of Duchenne Muscular Dystrophy

(2014) Paul M. L. Janssen et al.   PLoS One

Telomerase expression confers cardioprotection in the adult mouse heart after acute myocardial infarction

(2014) Christian Bär et al.   Nature Communications

Design of a Phase 2b Trial of Intracoronary Administration of AAV1/SERCA2a in Patients With Advanced Heart Failure

(2014) Barry Greenberg et al.   JACC-Heart Failure

Mechanisms of Altered Ca 2+ Handling in Heart Failure

(2013) Min Luo et al.   CIRCULATION RESEARCH

Calsequestrin 2 deletion causes sinoatrial node dysfunction and atrial arrhythmias associated with altered sarcoplasmic reticulum calcium cycling and degenerative fibrosis within the mouse atrial pacemaker complex1

(2013) Alexey V. Glukhov et al.   EUROPEAN HEART JOURNAL

Structural and Functional Consequences of the Cardiac Troponin C L48Q Ca2+-Sensitizing Mutation

(2012) Dan Wang et al.   BIOCHEMISTRY

The Rates of Ca2+Dissociation and Cross-bridge Detachment from Ventricular Myofibrils as Reported by a Fluorescent Cardiac Troponin C

(2012) Sean C. Little et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Engineered Troponin C Constructs Correct Disease-related Cardiac Myofilament Calcium Sensitivity

(2012) Bin Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cardioprotection: chances and challenges of its translation to the clinic

(2012) Gerd Heusch   LANCET

Molecular Basis of Calcium-Sensitizing and Desensitizing Mutations of the Human Cardiac Troponin C Regulatory Domain: A Multi-Scale Simulation Study

(2012) Peter Michael Kekenes-Huskey et al.   PLoS Computational Biology

Early Treatment With Lisinopril and Spironolactone Preserves Cardiac and Skeletal Muscle in Duchenne Muscular Dystrophy Mice

(2011) Jill A. Rafael-Fortney et al.   CIRCULATION

Cardiac inotropes: current agents and future directions

(2011) G. Hasenfuss et al.   EUROPEAN HEART JOURNAL

Sarcolemma instability during mechanical activity in Large myd cardiac myocytes with loss of dystroglycan extracellular matrix receptor function

(2011) Zhyldyz Kabaeva et al.   HUMAN MOLECULAR GENETICS

Effect of Calcium-Sensitizing Mutations on Calcium Binding and Exchange with Troponin C in Increasingly Complex Biochemical Systems

(2010) Svetlana B. Tikunova et al.   BIOCHEMISTRY

Removal of the Cardiac Troponin I N-terminal Extension Improves Cardiac Function in Aged Mice

(2010) Brandon J. Biesiadecki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calcium binding kinetics of troponin C strongly modulate cooperative activation and tension kinetics in cardiac muscle

(2010) Kareen L. Kreutziger et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Left Ventricular and Myocardial Function in Mice Expressing Constitutively Pseudophosphorylated Cardiac Troponin I

(2009) Jonathan A. Kirk et al.   CIRCULATION RESEARCH

Vector-mediated gene transfer engenders long-lived neutralizing activity and protection against SIV infection in monkeys

(2009) Philip R Johnson et al.   NATURE MEDICINE

Inotropes and Vasopressors

(2008) Christopher B. Overgaard et al.   CIRCULATION

Biphasic effect of SIN-1 is reliant upon cardiomyocyte contractile state

(2008) Mark J. Kohr et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mechanisms of Disease: detrimental adrenergic signaling in acute decompensated heart failure

(2008) David S Feldman et al.   Nature clinical practice. Cardiovascular medicine