Article
Cardiac & Cardiovascular Systems
Jose Manuel Pioner, Giulia Vitale, Sonette Steczina, Marianna Langione, Francesca Margara, Lorenzo Santini, Francesco Giardini, Erica Lazzeri, Nicoletta Piroddi, Beatrice Scellini, Chiara Palandri, Maike Schuldt, Valentina Spinelli, Francesca Girolami, Francesco Mazzarotto, Jolanda van der Velden, Elisabetta Cerbai, Chiara Tesi, Iacopo Olivotto, Alfonso Bueno-Orovio, Leonardo Sacconi, Raffaele Coppini, Cecilia Ferrantini, Michael Regnier, Corrado Poggesi
Summary: This study investigates the pathogenesis of MYBPC3-associated hypertrophic cardiomyopathy (HCM) and finds that the MYBPC3:c772G>A mutation impairs sarcomere energetics and cross-bridge cycling, while causing compensatory electrophysiological changes. correcting the primary sarcomeric defects may prevent secondary cardiomyocyte remodeling.
CIRCULATION RESEARCH
(2023)
Article
Biology
Atsuki Fukutani, Shiho Kunimatsu, Tadao Isaka
Summary: The study investigated the impact of 2,3-butanedione monoxime-induced force loss on isometric and eccentric forces, revealing a significant increase in force loss during the pre-stretch phase and a more pronounced mitigated force loss during the eccentric contraction in the long condition.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Michelle L. Law, Joseph M. Metzger
Summary: This study investigates organ and cellular-level functional deficits in cachectic hearts, suggesting that impaired calcium cycling may play a role. These findings demonstrate significant cardiac dysfunction in cachexia outside of the catabolic in vivo environment.
SCIENTIFIC REPORTS
(2021)
Article
Nutrition & Dietetics
Andy J. King, Rebecca C. Hall
Summary: The study found that cyclists training or racing indoors did not meet current carbohydrate intake recommendations for optimal cycling performance, possibly due to the short and high-intensity nature of some training sessions, limiting the need for feeding during exercise.
BRITISH JOURNAL OF NUTRITION
(2022)
Review
Endocrinology & Metabolism
Rui-Jun Bai, Yu-Sheng Li, Fang-Jie Zhang
Summary: This review summarizes the role of osteopontin (OPN) in regulating inflammation activity and bone metabolism in osteoarthritis (OA) and osteoporosis (OP). It also discusses drugs that target OPN for treating OA and OP. However, further research is needed to fully understand the complex mechanism of OPN in regulating these bone diseases.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Pharmacology & Pharmacy
Joachim Neumann, Tom Seidler, Charlotte Fehse, Margareta Marusakova, Britt Hofmann, Ulrich Gergs
Summary: The study revealed that metoclopramide had a partial agonist effect on human cardiac 5-HT4 receptors, while domperidone had no effect at all.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Physiology
Sukriti Dewan, Namthip Witayavanitkul, Mohit Kumar, Beth J. Mayer, Lauren Betancourt, Olivier Cazorla, Pieter P. de Tombe
Summary: By inducing diastolic dysfunction in guinea pigs through pressure overload, we observed myofilament dysfunction and blunted cross-bridge cycle kinetics, which may contribute to the development of diastolic heart failure. Our findings suggest that altered cross-bridge cycling plays a potential role in diastolic heart failure.
JOURNAL OF GENERAL PHYSIOLOGY
(2023)
Article
Environmental Sciences
Flavia Tromboni, Erin R. Hotchkiss, Anne E. Schechner, Walter K. Dodds, Simon R. Poulson, Sudeep Chandra
Summary: Diel variations in the isotopic composition of dissolved oxygen in river water suggest that carbon cycling in rivers may be faster than previously thought. By comparing oxygen concentration data with stable oxygen isotope signatures, researchers found that ecosystem respiration and gross primary production in rivers were higher than predicted by traditional methods.
COMMUNICATIONS EARTH & ENVIRONMENT
(2022)
Review
Cell Biology
Zhu-hui Yuan, Tong Liu, Hao Wang, Li-xiang Xue, Jun-jie Wang
Summary: This review explores the impact of ionizing radiation on tumor cells, specifically focusing on the changes in fatty acid metabolism and activity, and how regulating FA metabolism can influence the fate of ferroptotic cell death induced by ionizing radiation. Targeting key molecules involved in lipid metabolism and ferroptosis may enhance tumor response to IR.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Engineering, Environmental
Fengxiao Zhu, Yuanyuan Yan, Evelyn Doyle, Changyin Zhu, Xin Jin, Zhanghao Chen, Chao Wang, Huan He, Dongmei Zhou, Cheng Gu
Summary: Microplastics, particularly those containing plasticizers, significantly impact soil nitrogen parameters and microbial communities, influencing nutrient cycling. Chemical additives, such as phthalate plasticizers, play a crucial role in the interactions between microplastics, microbes, and soil processes.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Computer Science, Information Systems
Chen Gao, Yong Li, Fuli Feng, Xiangning Chen, Kai Zhao, Xiangnan He, Depeng Jin
Summary: This paper proposes a more practical cross-domain recommendation method that protects user privacy by sharing only item information instead of user behavior data, and utilizes the representation power of neural networks for recommendation. Experimental results demonstrate that this method can achieve similar or even better performance than traditional cross-domain recommendation methods that directly share user-relevant data.
ACM TRANSACTIONS ON KNOWLEDGE DISCOVERY FROM DATA
(2022)
Article
Medicine, General & Internal
Susanne Rysz, Malin Jonsson Fagerlund, Johan Lundberg, Mattias Ringh, Jacob Hollenberg, Marcus Lindgren, Martin Jonsson, Therese Djarv, Per Nordberg
Summary: This retrospective observational study examined the use of Levosimendan in out-of-hospital cardiac arrest patients and its association with outcomes. The results showed that the use of Levosimendan was more common in patients with certain characteristics, such as initial shockable rhythm and acute myocardial infarction. However, the use of Levosimendan was not associated with 30-day mortality.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Kongwei Li, Kaiyue Li, Yuan He, Shan Liang, Xiaorong Shui, Wei Lei
Summary: Cardiovascular disease is the leading cause of death worldwide, with atherosclerosis being a major contributor. AhR plays an important role in atherosclerosis by regulating immuno-inflammatory responses and metabolism pathways, potentially serving as a target for controlling the disease through precise interventions.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Biology
Jaime G. Lopez, Ned S. Wingreen
Summary: This study introduces a novel theory called noise-averaging cooperation (NAC) to explain the emergence of cross-feeding between species. The research shows that metabolite leakage can significantly increase the growth rate of microbial communities. Using single-cell protein abundance data, it is predicted that bacteria may benefit from NAC due to noise-driven growth inefficiencies.
Article
Engineering, Civil
Lubomir Matejicka, Holger H. Koss, Christos T. Georgakis
Summary: This paper investigates the cross-flow aerodynamic behavior of bridge cables fitted with steel wire meshes. The wire mesh generally results in higher levels of aerodynamic drag compared to plain cable sheaths, although the dependence on Reynolds number is reduced. The results show that the use of a steel wire mesh can reduce the risk of falling ice.
JOURNAL OF WIND ENGINEERING AND INDUSTRIAL AERODYNAMICS
(2022)
Article
Cardiac & Cardiovascular Systems
Pei Wang, Shangcheng Xu, Jiqian Xu, Yanguo Xin, Yan Lu, Huiliang Zhang, Bo Zhou, Haodong Xu, Shey-Shing Sheu, Rong Tian, Wang Wang
Summary: This study reveals that chronic stress can upregulate the expression of mitochondrial calcium uniporter (MCU), preserving calcium homeostasis and cardiomyocyte viability to counteract stress-induced pathological cardiac remodeling.
Letter
Cardiac & Cardiovascular Systems
Yunosuke Matsuura, Masami Shimizu-Albergine, Shelley Barnhart, Farah Kramer, Cheng-Chieh Hsu, Vishal Kothari, Jingjing Tang, Sina A. Gharib, Jenny E. Kanter, E. Dale Abel, Rong Tian, Baohai Shao, Karin E. Bornfeldt
CIRCULATION RESEARCH
(2022)
Article
Multidisciplinary Sciences
Jason W. Miklas, Shiri Levy, Peter Hofsteen, Diego Ic Mex, Elisa Clark, Jeanot Muster, Aaron M. Robitaille, Gargi Sivaram, Lauren Abell, Jamie M. Goodson, Inez Pranoto, Anup Madan, Michael T. Chin, Rong Tian, Charles E. Murry, Randall T. Moon, Yuliang Wang, Hannele Ruohola-Baker
Summary: The ability of zebrafish and neonatal mouse myocardial cells to regenerate the heart through dedifferentiation and proliferation is explored. The study demonstrates a unique metabolic state and mitochondrial changes that contribute to this regenerative capability.
Article
Physiology
Lola E. Holcomb, Patrick Rowe, Caitlin C. O'Neill, Elizabeth A. DeWitt, Stephen C. Kolwicz
Summary: Previous studies have shown that female mice have a higher endurance exercise capacity and a greater ability to utilize lipids. This study further confirms these findings and reveals that female mice have higher muscle triglyceride content and gene expression levels associated with fatty acid oxidation in skeletal muscle.
PHYSIOLOGICAL REPORTS
(2022)
Article
Engineering, Multidisciplinary
Jinwei Ma, Qinglin Duan, Rong Tian
Summary: This paper presents a nonlinear generalized finite element method (GFEM) for large deformation analysis of elastic and elastoplastic solids in three dimensions. By eliminating the extra degrees of freedom, the developed method is more convenient to implement than the standard GFEM and does not suffer from singular system matrix. Numerical results demonstrate that the proposed nonlinear GFEM is remarkably more accurate and stable than the traditional finite element method in modeling three-dimensional large elastoplastic deformations.
COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING
(2022)
Article
Engineering, Mechanical
Dongyang Chu, Zhijie Li, Kaili Yao, Yigang Wang, Rong Tian, Zhuo Zhuang, Zhanli Liu
Summary: This paper investigates the strengthening mechanism and thickness effect of polyurea coating under fragment simulating projectiles impact. Experimental and numerical analysis shows that the impact-induced stiffening and strengthening of polyurea and the regulation of impact wave play a key role in improving the ballistic resistance of the steel plate. Increasing the coating thickness has limited benefits for improving the ballistic resistance, and can even reduce the energy dissipation during penetration.
INTERNATIONAL JOURNAL OF IMPACT ENGINEERING
(2022)
Editorial Material
Hospitality, Leisure, Sport & Tourism
Tingting Yang, Meiyu Hu, Michail Spanos, Guoping Li, Stephen C. Kolwicz, Junjie Xiao
JOURNAL OF SPORT AND HEALTH SCIENCE
(2022)
Article
Biophysics
Minghan Li, Shanchuan Chen, Yunjiao Wang, Shaoxia Zhang, Dandan Song, Rong Tian, Jia Geng, Liang Wang
Summary: In this study, a nanopore platform was fabricated to monitor intercellular protein transport and detect the activity of anthrax lethal factor (aLF) at a single molecule level. The aLF activity was successfully inhibited using screening approaches of protein-metal ion acquisition and other condition controlment. Ca2+, Mg2+, Mn2+, Ni2+ in collaboration with Zn2+ were found to promote aLF activity, while Cd2+, Co2+, Cu2+ showed inhibitory effects. The results also revealed that the speed of aLF endopeptidase activity with different ions functions as the nanopore signal frequency in a linear manner. In addition, the strength of the proton or hydroxide, as well as adapted temperature and gamma-ray, played integral roles in inhibiting aLF activity.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Engineering, Multidisciplinary
Guizhong Xiao, Longfei Wen, Rong Tian, Dingguo Zhang
Summary: An improved XFEM (IXFEM) method is proposed for three-dimensional non-planar crack propagation under impact loadings. The method combines IXFEM and the B-spline ruled surface method (BRSM) to overcome the issues of standard XFEM in dynamic crack propagation. The proposed method employs an extra-DOF free PU approximation and tip singularity enrichment to ensure high accuracy. The BRSM is used to model the geometry of 3D dynamic crack propagation, and the interaction integral for 2D dynamic stress intensity factor (SIF) evaluation is extended to 3D. The efficiency of the proposed approach is demonstrated through numerical tests.
COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING
(2023)
Article
Cardiac & Cardiovascular Systems
Ketaki N. Mhatre, Jason D. Murray, Galina Flint, Timothy S. McMillen, Gerhard Weber, Majid Shakeri, An-Yue Tu, Sonette Steczina, Robert Weiss, David J. Marcinek, Charles E. Murry, Daniel Raftery, Rong Tian, Farid Moussavi-Harami, Michael Regnier
Summary: The hallmark features of systolic heart failure involve reduced contractility and impaired metabolic flexibility of the myocardium. Elevated dATP levels in cardiomyocytes (CMs) through overexpression of ribonucleotide reductase (RNR) enzyme can substantially improve contractility. However, the effect of dATP elevation on cardiac metabolism remains unknown.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Rong Tian, Michael Regnier
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2023)
Article
Chemistry, Analytical
Wenhao Ma, Wanyi Xie, Rong Tian, Xiaoqing Zeng, Liyuan Liang, Changjun Hou, Danqun Huo, Deqiang Wang
Summary: Since the outbreak of COVID-19, rapid and effective detection methods have been a focus of research. This study utilized aptamer-functionalized nanopipettes with unique ion current rectification properties to achieve rapid and highly sensitive detection of trace viral protein, reducing the cost of detection. The sensor platform exhibited a wide dynamic working range and a low detection limit, showing great potential as a tool for rapid detection of SARS-CoV-2.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Editorial Material
Biochemistry & Molecular Biology
Stephen C. Kolwicz Jr
Article
Medicine, Research & Experimental
Shanshan Cai, Mingyue Zhao, Bo Zhou, Akira Yoshii, Darrian Bugg, Outi Villet, Anita Sahu, Gregory S. Olson, Jennifer Davis, Rong Tian
Summary: Innate immune cells have a crucial role in tissue injury and repair after acute myocardial infarction (MI). This study uncovered the mechanistic link between macrophage metabolism and phenotype by investigating the myeloid-specific deletion of mitochondrial complex I protein, Ndufs4. The results demonstrated that impaired mitochondrial function in macrophages resulted in an exaggerated inflammatory response, poor scar formation, and worsened cardiac function after MI.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Medicine, Research & Experimental
Bo Zhou, Arianne Caudal, Xiaoting Tang, Juan D. Chavez, Timothy S. McMillen, Andrew Keller, Outi Villet, Mingyue Zhao, Yaxin Liu, Julia Ritterhoff, Pei Wang, Stephen C. Kolwicz, Wang Wang, James E. Bruce, Rong Tian
Summary: This study reveals the mechanism of metabolic rewiring in hypertrophied and failing hearts, showing that increased expression of ATPIF1 leads to a switch towards glucose metabolism and glycolysis.
JOURNAL OF CLINICAL INVESTIGATION
(2022)