Mechanistic Heterogeneity in Contractile Properties of α-Tropomyosin (TPM1) Mutants Associated with Inherited Cardiomyopathies

Using Fluorescent Myosin to Directly Visualize Cooperative Activation of Thin Filaments

(2014) Rama Desai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural basis for the in situ Ca2+ sensitization of cardiac troponin C by positive feedback from force-generating myosin cross-bridges

(2013) Daniel C. Rieck et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Mutations in repeating structural motifs of tropomyosin cause gain of function in skeletal muscle myopathy patients

(2013) Steven Marston et al.   HUMAN MOLECULAR GENETICS

Conserved Asp-137 Is Important for both Structure and Regulatory Functions of Cardiac α-Tropomyosin (α-TM) in a Novel Transgenic Mouse Model Expressing α-TM-D137L

(2013) Sumeyye Yar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alpha-tropomyosin mutations in inherited cardiomyopathies

(2013) Charles Redwood et al.   JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

Effects of Troponin T Cardiomyopathy Mutations on the Calcium Sensitivity of the Regulated Thin Filament and the Actomyosin Cross-Bridge Kinetics of Human β-Cardiac Myosin

(2013) Ruth F. Sommese et al.   PLoS One

Molecular consequences of the R453C hypertrophic cardiomyopathy mutation on human  -cardiac myosin motor function

(2013) R. F. Sommese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The flexibility of two tropomyosin mutants, D175N and E180G, that cause hypertrophic cardiomyopathy

(2012) Xiaochuan (Edward) Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

α-Tropomyosin with a D175N or E180G Mutation in Only One Chain Differs from Tropomyosin with Mutations in Both Chains

(2012) Miro Janco et al.   BIOCHEMISTRY

In Vitro Formation and Characterization of the Skeletal Muscle α·β Tropomyosin Heterodimers

(2012) Athanasia Kalyva et al.   BIOCHEMISTRY

A novel alpha-tropomyosin mutation associates with dilated and non-compaction cardiomyopathy and diminishes actin binding

(2012) Judith B.A. van de Meerakker et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Structure of the Rigor Actin-Tropomyosin-Myosin Complex

(2012) Elmar Behrmann et al.   CELL

Congenital myopathy-causing tropomyosin mutations induce thin filament dysfunction via distinct physiological mechanisms

(2012) J. Ochala et al.   HUMAN MOLECULAR GENETICS

Whole-Body muscle MRI in a series of patients with congenital myopathy related to TPM2 gene mutations

(2012) Mohamed Jarraya et al.   NEUROMUSCULAR DISORDERS

Enhanced Active Cross-Bridges during Diastole: Molecular Pathogenesis of Tropomyosin's HCM Mutations

(2011) Fan Bai et al.   BIOPHYSICAL JOURNAL

Thin Filament Mutations

(2011) Jil C. Tardiff   CIRCULATION RESEARCH

Force Spectroscopy Reveals Multiple “Closed States” of the Muscle Thin Filament

(2011) Vijay S. Rao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Dynamics of C-domain of Cardiac Troponin I Protein in Reconstituted Thin Filament

(2011) Zhiqun Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cellular mechanisms of cardiomyopathy

(2011) Pamela A. Harvey et al.   JOURNAL OF CELL BIOLOGY

Inherited Cardiomyopathies

(2011) Hugh Watkins et al.   NEW ENGLAND JOURNAL OF MEDICINE

Evolutionarily conserved surface residues constitute actin binding sites of tropomyosin

(2011) B. Barua et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rescue of familial cardiomyopathies by modifications at the level of sarcomere and Ca2+ fluxes

(2010) Marco L. Alves et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Functional effects of a tropomyosin mutation linked to FHC contribute to maladaptation during acidosis

(2010) Katherine A. Sheehan et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Familial Dilated Cardiomyopathy Caused by an Alpha-Tropomyosin Mutation

(2010) Neal K. Lakdawala et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Clinical Spectrum in a Family with Tropomyosin-Mediated Hypertrophic Cardiomyopathy and Sudden Death in Childhood

(2010) Majd Makhoul et al.   PEDIATRIC CARDIOLOGY

Dilated cardiomyopathy mutations in α-tropomyosin inhibit its movement during the ATPase cycle

(2009) Yurii S. Borovikov et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cooperative Cross-Bridge Activation of Thin Filaments Contributes to the Frank-Starling Mechanism in Cardiac Muscle

(2009) L. Smith et al.   BIOPHYSICAL JOURNAL

Functional Analysis of a Unique Troponin C Mutation, GLY159ASP, that Causes Familial Dilated Cardiomyopathy, Studied in Explanted Heart Muscle

(2009) Emma C. Dyer et al.   Circulation-Heart Failure

Identification of a Unique “Stability Control Region” that Controls Protein Stability of Tropomyosin: A Two-stranded α-Helical Coiled-coil

(2009) Robert S. Hodges et al.   JOURNAL OF MOLECULAR BIOLOGY

What makes tropomyosin an actin binding protein? A perspective

(2009) Sarah E. Hitchcock-DeGregori et al.   JOURNAL OF STRUCTURAL BIOLOGY

Functional diversity among a family of human skeletal muscle myosin motors

(2009) D. I. Resnicow et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Shared Genetic Causes of Cardiac Hypertrophy in Children and Adults

(2008) Hiroyuki Morita et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structural basis for tropomyosin overlap in thin (actin) filaments and the generation of a molecular swivel by troponin-T

(2008) K. Murakami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of the Head-to-Tail Overlap Region in Smooth and Skeletal Muscle β-Tropomyosin†

(2007) Arthur T. Coulton et al.   BIOCHEMISTRY