Extensive germline genome engineering in pigs

Long-Term Survival of Pig-to-Rhesus Macaque Renal Xenografts is Dependent on CD4 T cell Depletion

(2019) S C Kim et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Viable pigs after simultaneous inactivation of porcine MHC class I and three xenoreactive antigen genes GGTA1, CMAH and B4GALNT2

(2019) Konrad Fischer et al.   XENOTRANSPLANTATION

Transplanting organs from pigs to humans

(2019) Megan Sykes et al.   Science Immunology

Pigs lacking the scavenger receptor cysteine-rich domain 5 of CD163 are resistant to PRRSV-1 infection.

(2018) Christine Burkard et al.   JOURNAL OF VIROLOGY

B4GALNT2 and xenotransplantation: A newly appreciated xenogeneic antigen

(2018) Guerard Byrne et al.   XENOTRANSPLANTATION

Consistent success in life-supporting porcine cardiac xenotransplantation

(2018) Matthias Längin et al.   NATURE

Salmon provides fast and bias-aware quantification of transcript expression

(2017) Rob Patro et al.   NATURE METHODS

Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9

(2017) Dong Niu et al.   SCIENCE

Humoral Reactivity of Renal Transplant-Waitlisted Patients to Cells From GGTA1/CMAH/B4GalNT2, and SLA Class I Knockout Pigs

(2017) Gregory R. Martens et al.   TRANSPLANTATION

Transgenic expression of human leukocyte antigen-E attenuates GalKO.hCD46 porcine lung xenograft injury

(2017) Christopher T. Laird et al.   XENOTRANSPLANTATION

Modifying the sugar icing on the transplantation cake

(2016) David K C Cooper   GLYCOBIOLOGY

Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft

(2016) Muhammad M. Mohiuddin et al.   Nature Communications

Current status and future of clinical islet xenotransplantation

(2016) Shinichi Matsumoto et al.   Journal of Diabetes

Pig BMSCs Transfected with Human TFPI Combat Species Incompatibility and Regulate the Human TF Pathway in Vitro and in a Rodent Model

(2015) Hongchen Ji et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

The role of genetically engineered pigs in xenotransplantation research

(2015) David KC Cooper et al.   JOURNAL OF PATHOLOGY

Genome-wide inactivation of porcine endogenous retroviruses (PERVs)

(2015) L. Yang et al.   SCIENCE

Evaluation of human and non-human primate antibody binding to pig cells lacking GGTA1/CMAH/β4GalNT2 genes

(2015) Jose L. Estrada et al.   XENOTRANSPLANTATION

Current status of pig liver xenotransplantation

(2015) Burcin Ekser et al.   International Journal of Surgery

Immunobiological barriers to xenotransplantation

(2015) David K.C. Cooper et al.   International Journal of Surgery

Highly efficient RNA-guided genome editing in human cells via delivery of purified Cas9 ribonucleoproteins

(2014) S. Kim et al.   GENOME RESEARCH

Xenotransplantation: immunological hurdles and progress toward tolerance

(2014) Adam Griesemer et al.   IMMUNOLOGICAL REVIEWS

Minimizing immunosuppression in islet xenotransplantation

(2014) Jun-Seop Shin et al.   Immunotherapy

CRISPRseek: A Bioconductor Package to Identify Target-Specific Guide RNAs for CRISPR-Cas9 Genome-Editing Systems

(2014) Lihua J. Zhu et al.   PLoS One

Islet cell xenotransplantation: a serious look toward the clinic

(2014) Kannan P. Samy et al.   XENOTRANSPLANTATION

The role of platelets in coagulation dysfunction in xenotransplantation, and therapeutic options

(2014) Hayato Iwase et al.   XENOTRANSPLANTATION

Comparison of the Efficiency of Banna Miniature Inbred Pig Somatic Cell Nuclear Transfer among Different Donor Cells

(2013) Hongjiang Wei et al.   PLoS One

piggyBac transposase tools for genome engineering

(2013) X. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Infection Barriers to Successful Xenotransplantation Focusing on Porcine Endogenous Retroviruses

(2012) J. Denner et al.   CLINICAL MICROBIOLOGY REVIEWS

Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer

(2012) Bruno Bernardes de Jesus et al.   EMBO Molecular Medicine

Transgenic swine: Expression of human CD39 protects against myocardial injury

(2012) Debra G. Wheeler et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

APPRIS: annotation of principal and alternative splice isoforms

(2012) Jose Manuel Rodriguez et al.   NUCLEIC ACIDS RESEARCH

B-Cell Depletion Extends the Survival of GTKO.hCD46Tg Pig Heart Xenografts in Baboons for up to 8 Months

(2011) M. M. Mohiuddin et al.   AMERICAN JOURNAL OF TRANSPLANTATION

A framework for variation discovery and genotyping using next-generation DNA sequencing data

(2011) Mark A DePristo et al.   NATURE GENETICS

Cloning and functional characterization of pig CMP-N-acetylneuraminic acid hydroxylase for the synthesis ofN-glycolylneuraminic acid as the xenoantigenic determinant in pig–human xenotransplantation

(2010) Kwon-Ho Song et al.   BIOCHEMICAL JOURNAL

The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data

(2010) A. McKenna et al.   GENOME RESEARCH

Potential value of human thrombomodulin and DAF expression for coagulation control in pig-to-human xenotransplantation

(2010) Yuko Miwa et al.   XENOTRANSPLANTATION

Fast and accurate short read alignment with Burrows-Wheeler transform

(2009) H. Li et al.   BIOINFORMATICS

Production of Cloned Pigs by Nuclear Transfer of Preadipocytes Following Cell Cycle Synchronization by Differentiation Induction

(2009) Ryo TOMII et al.   JOURNAL OF REPRODUCTION AND DEVELOPMENT

Production Efficiency and Telomere Length of the Cloned Pigs Following Serial Somatic Cell Nuclear Transfer

(2008) Mayuko KUROME et al.   JOURNAL OF REPRODUCTION AND DEVELOPMENT

Recombinant pig TFPI efficiently regulates human tissue factor pathways

(2008) K. F. Eddy Lee et al.   XENOTRANSPLANTATION