Atg8-Family Proteins—Structural Features and Molecular Interactions in Autophagy and Beyond

Temporal inhibition of autophagy reveals segmental reversal of ageing with increased cancer risk

(2020) Liam D. Cassidy et al.   Nature Communications

Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I

(2020) Keisuke Yamamoto et al.   NATURE

Identification of a phosphorylation site on Ulk1 required for genotoxic stress-induced alternative autophagy

(2020) Satoru Torii et al.   Nature Communications

Super-assembly of ER-phagy receptor Atg40 induces local ER remodeling at contacts with forming autophagosomal membranes

(2020) Keisuke Mochida et al.   Nature Communications

Multiple Functions of ATG8 Family Proteins in Plant Autophagy

(2020) Fan Bu et al.   Frontiers in Cell and Developmental Biology

Structure and Dynamics in the ATG8 Family From Experimental to Computational Techniques

(2020) Valentina Sora et al.   Frontiers in Cell and Developmental Biology

Members of the autophagy class III phosphatidylinositol 3-kinase complex I interact with GABARAP and GABARAPL1 via LIR motifs

(2019) Åsa Birna Birgisdottir et al.   Autophagy

An atypical LIR motif within UBA5 (ubiquitin like modifier activating enzyme 5) interacts with GABARAP proteins and mediates membrane localization of UBA5

(2019) Jessica Huber et al.   Autophagy

Human LC3 and GABARAP subfamily members achieve functional specificity via specific structural modulations

(2019) Nidhi Jatana et al.   Autophagy

ATG8-Binding UIM Proteins Define a New Class of Autophagy Adaptors and Receptors

(2019) Richard S. Marshall et al.   CELL

Molecular determinants regulating selective binding of autophagy adapters and receptors to ATG8 proteins

(2019) Martina Wirth et al.   Nature Communications

GABARAPs and LC3s have opposite roles in regulating ULK1 for autophagy induction

(2019) Douglas S. Grunwald et al.   Autophagy

Time-resolved FRET and NMR analyses reveal selective binding of peptides containing the LC3-interacting region to ATG8 family proteins

(2019) Jennifer M Atkinson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective Autophagy: ATG8 Family Proteins, LIR Motifs and Cargo Receptors

(2019) Terje Johansen et al.   JOURNAL OF MOLECULAR BIOLOGY

N-terminal β-strand underpins biochemical specialization of an ATG8 isoform

(2019) Erin K. Zess et al.   PLOS BIOLOGY

TBK1‐mediated phosphorylation of LC3C and GABARAP‐L2 controls autophagosome shedding by ATG4 protease

(2019) Lina Herhaus et al.   EMBO REPORTS

Selective Autophagy Receptors in Neuronal Health and Disease

(2019) Owen Conway et al.   JOURNAL OF MOLECULAR BIOLOGY

A Diversity of Selective Autophagy Receptors Determines the Specificity of the Autophagy Pathway

(2019) Vladimir Kirkin et al.   MOLECULAR CELL

Allele-selective lowering of mutant HTT protein by HTT–LC3 linker compounds

(2019) Zhaoyang Li et al.   NATURE

The SCOP database in 2020: expanded classification of representative family and superfamily domains of known protein structures

(2019) Antonina Andreeva et al.   NUCLEIC ACIDS RESEARCH

Selective autophagy maintains centrosome integrity and accurate mitosis by turnover of centriolar satellites

(2019) Søs Grønbæk Holdgaard et al.   Nature Communications

Solution structure of the autophagy-related protein LC3C reveals a polyproline II motif on a mobile tether with phosphorylation site

(2019) Carsten Krichel et al.   Scientific Reports

Monitoring LC3- or GABARAP-positive autophagic membranes using modified RavZ-based probes

(2019) Sang-Won Park et al.   Scientific Reports

Negative regulation of autophagy by UBA6-BIRC6–mediated ubiquitination of LC3

(2019) Rui Jia et al.   eLife

NIMA-related kinase 9–mediated phosphorylation of the microtubule-associated LC3B protein at Thr-50 suppresses selective autophagy of p62/sequestosome 1

(2019) Birendra Kumar Shrestha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Potent and specific Atg8-targeting autophagy inhibitory peptides from giant ankyrins

(2018) Jianchao Li et al.   Nature Chemical Biology

Mechanism and medical implications of mammalian autophagy

(2018) Ivan Dikic et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

HUWE1 E3 ligase promotes PINK1/PARKIN-independent mitophagy by regulating AMBRA1 activation via IKKα

(2018) Anthea Di Rita et al.   Nature Communications

A helical LC3-interacting region mediates the interaction between the retroviral restriction factor Trim5α and mammalian autophagy-related ATG8 proteins

(2018) Jeremy R. Keown et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ankyrin-G regulates forebrain connectivity and network synchronization via interaction with GABARAP

(2018) A. D. Nelson et al.   MOLECULAR PSYCHIATRY

Lipidation-independent vacuolar functions of Atg8 rely on its noncanonical interaction with a vacuole membrane protein

(2018) Xiao-Man Liu et al.   eLife

Optineurin promotes autophagosome formation by recruiting the autophagy-related Atg12-5-16L1 complex to phagophores containing the Wipi2 protein

(2017) Megha Bansal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ATG8 Expansion: A Driver of Selective Autophagy Diversification?

(2017) Ronny Kellner et al.   TRENDS IN PLANT SCIENCE

The crystal structure of mouse LC3B in complex with the FYCO1 LIR reveals the importance of the flanking region of the LIR motif

(2017) Shunya Sakurai et al.   Acta Crystallographica Section F-Structural Biology Communications

Plasmodium UIS3 sequesters host LC3 to avoid elimination by autophagy in hepatocytes

(2017) Eliana Real et al.   Nature Microbiology

Phosphorylation of the mitochondrial autophagy receptor Nix enhances its interaction with LC3 proteins

(2017) Vladimir V. Rogov et al.   Scientific Reports

Structural basis of FYCO1 and MAP1LC3A interaction reveals a novel binding mode for Atg8-family proteins

(2016) Xiaofang Cheng et al.   Autophagy

hfAIM: A reliable bioinformatics approach for in silico genome-wide identification of autophagy-associated Atg8-interacting motifs in various organisms

(2016) Qingjun Xie et al.   Autophagy

Structural basis for the phosphorylation of FUNDC1 LIR as a molecular switch of mitophagy

(2016) Yao Kuang et al.   Autophagy

iLIR database: A web resource for LIR motif-containing proteins in eukaryotes

(2016) Anne-Claire Jacomin et al.   Autophagy

Fluorescence‐based ATG8 sensors monitor localization and function of LC3/GABARAP proteins

(2016) Alexandra Stolz et al.   EMBO JOURNAL

Structural and Functional Analysis of a Novel Interaction Motif within UFM1-activating Enzyme 5 (UBA5) Required for Binding to Ubiquitin-like Proteins and Ufmylation

(2016) Sabrina Habisov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms of Selective Autophagy

(2016) Gabriele Zaffagnini et al.   JOURNAL OF MOLECULAR BIOLOGY

The ATG conjugation systems are important for degradation of the inner autophagosomal membrane

(2016) Kotaro Tsuboyama et al.   SCIENCE

Mechanism of cargo-directed Atg8 conjugation during selective autophagy

(2016) Dorotea Fracchiolla et al.   eLife

Conformational Polymorphism in Autophagy-Related Protein GATE-16

(2015) Peixiang Ma et al.   BIOCHEMISTRY

FYCO1 Contains a C-terminally Extended, LC3A/B-preferring LC3-interacting Region (LIR) Motif Required for Efficient Maturation of Autophagosomes during Basal Autophagy

(2015) Hallvard L. Olsvik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role for autophagy in cancer

(2015) Eileen White   JOURNAL OF CLINICAL INVESTIGATION

CUL3-KBTBD6/KBTBD7 Ubiquitin Ligase Cooperates with GABARAP Proteins to Spatially Restrict TIAM1-RAC1 Signaling

(2015) Heide Marika Genau et al.   MOLECULAR CELL

Activation of ULK Kinase and Autophagy by GABARAP Trafficking from the Centrosome Is Regulated by WAC and GM130

(2015) Justin Joachim et al.   MOLECULAR CELL

Deacetylation of Nuclear LC3 Drives Autophagy Initiation under Starvation

(2015) Rui Huang et al.   MOLECULAR CELL

Phosphorylation of LC3 by the Hippo Kinases STK3/STK4 Is Essential for Autophagy

(2015) Deepti S. Wilkinson et al.   MOLECULAR CELL

Regulation of endoplasmic reticulum turnover by selective autophagy

(2015) Aliaksandr Khaminets et al.   NATURE

The Autophagy Receptor TAX1BP1 and the Molecular Motor Myosin VI Are Required for Clearance of Salmonella Typhimurium by Autophagy

(2015) David A. Tumbarello et al.   PLoS Pathogens

iLIR

(2014) Ioanna Kalvari et al.   Autophagy

Atomistic Autophagy: The Structures of Cellular Self-Digestion

(2014) James H. Hurley et al.   CELL

Molecular Mechanism of Autophagic Membrane-Scaffold Assembly and Disassembly

(2014) Anna Kaufmann et al.   CELL

Structural determinants in GABARAP required for the selective binding and recruitment of ALFY to LC3B-positive structures

(2014) A. H. Lystad et al.   EMBO REPORTS

Interactions between Autophagy Receptors and Ubiquitin-like Proteins Form the Molecular Basis for Selective Autophagy

(2014) Vladimir Rogov et al.   MOLECULAR CELL

Autophagy-targeted vaccine of LC3–LpqH DNA and its protective immunity in a murine model of tuberculosis

(2014) Dong Hu et al.   VACCINE

Autophagy Is Required for Glucose Homeostasis and Lung Tumor Maintenance

(2014) G. Karsli-Uzunbas et al.   Cancer Discovery

Structural basis for phosphorylation-triggered autophagic clearance ofSalmonella

(2013) Vladimir V. Rogov et al.   BIOCHEMICAL JOURNAL

Historical landmarks of autophagy research

(2013) Yoshinori Ohsumi   CELL RESEARCH

Interaction of Bcl-2 with the Autophagy-related GABAAReceptor-associated Protein (GABARAP)

(2013) Peixiang Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alternative fates of newly formed PrPSc upon prion conversion on the plasma membrane

(2013) R. Goold et al.   JOURNAL OF CELL SCIENCE

Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells

(2013) Charleen T. Chu et al.   NATURE CELL BIOLOGY

Structural Basis of the Autophagy-Related LC3/Atg13 LIR Complex: Recognition and Interaction Mechanism

(2013) Hironori Suzuki et al.   STRUCTURE

Modulation of Serines 17 and 24 in the LC3-interacting Region of Bnip3 Determines Pro-survival MitophagyversusApoptosis

(2012) Yanyan Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ATG8 Family Proteins Act as Scaffolds for Assembly of the ULK Complex

(2012) Endalkachew Ashenafi Alemu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of murine anti-human Fab antibodies for use in an immunoassay for generic quantification of human Fab fragments in non-human serum samples including cynomolgus monkey samples

(2012) Kay Stubenrauch et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

LC3C, Bound Selectively by a Noncanonical LIR Motif in NDP52, Is Required for Antibacterial Autophagy

(2012) Natalia von Muhlinen et al.   MOLECULAR CELL

The Role of Atg Proteins in Autophagosome Formation

(2011) Noboru Mizushima et al.   Annual Review of Cell and Developmental Biology

Dissecting the involvement of LC3B and GATE-16 in p62 recruitment into autophagosomes

(2011) Elena Shvets et al.   Autophagy

LC3 and GATE-16 N Termini Mediate Membrane Fusion Processes Required for Autophagosome Biogenesis

(2011) Hilla Weidberg et al.   DEVELOPMENTAL CELL

Characterization of the Interaction of GABARAPL-1 with the LIR Motif of NBR1

(2011) Alexis Rozenknop et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural Basis of Atg8 Activation by a Homodimeric E1, Atg7

(2011) Nobuo N. Noda et al.   MOLECULAR CELL

Phosphorylation of the Autophagy Receptor Optineurin Restricts Salmonella Growth

(2011) P. Wild et al.   SCIENCE

Role of plant autophagy in stress response

(2011) Shaojie Han et al.   Protein & Cell

Atg8: an autophagy-related ubiquitin-like protein family

(2011) Tomer Shpilka et al.   GENOME BIOLOGY

The autophagosomal protein LGG-2 acts synergistically with LGG-1 in dauer formation and longevity in C. elegans

(2010) Adriana Alberti et al.   Autophagy

Protein kinase C inhibits autophagy and phosphorylates LC3

(2010) Houbo Jiang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

ATG12 Conjugation to ATG3 Regulates Mitochondrial Homeostasis and Cell Death

(2010) Lilliana Radoshevich et al.   CELL

LC3 and GATE-16/GABARAP subfamilies are both essential yet act differently in autophagosome biogenesis

(2010) Hilla Weidberg et al.   EMBO JOURNAL

Atg8-family interacting motif crucial for selective autophagy

(2010) Nobuo N. Noda et al.   FEBS LETTERS

Regulation of the autophagy protein LC3 by phosphorylation

(2010) Salvatore J. Cherra et al.   JOURNAL OF CELL BIOLOGY

Network organization of the human autophagy system

(2010) Christian Behrends et al.   NATURE

The origin of the autophagosomal membrane

(2010) Sharon A. Tooze et al.   NATURE CELL BIOLOGY

Regulation and Cellular Roles of Ubiquitin-Specific Deubiquitinating Enzymes

(2009) Francisca E. Reyes-Turcu et al.   Annual Review of Biochemistry

Discovery of Atg5/Atg7-independent alternative macroautophagy

(2009) Yuya Nishida et al.   NATURE

An Indole‐Binding Site is a Major Determinant of the Ligand Specificity of the GABA Type A Receptor‐Associated Protein GABARAP

(2008) Yvonne Thielmann et al.   CHEMBIOCHEM

Structural basis of target recognition by Atg8/LC3 during selective autophagy

(2008) Nobuo N. Noda et al.   GENES TO CELLS

Structural Basis for Sorting Mechanism of p62 in Selective Autophagy

(2008) Yoshinobu Ichimura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ligand Binding Mode of GABAA Receptor-Associated Protein

(2008) Oliver H. Weiergräber et al.   JOURNAL OF MOLECULAR BIOLOGY

An Atg4B Mutant Hampers the Lipidation of LC3 Paralogues and Causes Defects in Autophagosome Closure

(2008) Naonobu Fujita et al.   MOLECULAR BIOLOGY OF THE CELL

The Atg16L Complex Specifies the Site of LC3 Lipidation for Membrane Biogenesis in Autophagy

(2008) Naonobu Fujita et al.   MOLECULAR BIOLOGY OF THE CELL