Article
Cell Biology
Jian Du, Zihui Wang, Xiao Liu, Cecilia Hu, Kevin J. J. Yarema, Xiaofeng Jia
Summary: In this study, metabolic glycoengineering technology is used to enhance the differentiation of adipose-derived stem cells (ASCs) into Schwann cells (SCs). This improvement can potentially contribute to neuronal regeneration and the future use of ASCs in regenerative medicine.
Article
Cell Biology
Silvan Klein, Andreas Siegmund, Andreas Eigenberger, Valerie Hartmann, Felix Langewost, Nicolas Hammer, Alexandra Anker, Konstantin Klein, Christian Morsczeck, Lukas Prantl, Oliver Felthaus
Summary: The study investigated three differentiation protocols for differentiating rat ASCs into specialized SC phenotypes, comparing their expressions of neurotrophins and myelin markers. The results showed diverse expression profiles of differentiated ASCs, with different protocols inducing varying levels of expression of neurotrophins and myelin markers.
Article
Biochemistry & Molecular Biology
Carina Hromada, Jaana Hartmann, Johannes Oesterreicher, Anton Stoiber, Anna Daerr, Barbara Schaedl, Eleni Priglinger, Andreas H. Teuschl-Woller, Wolfgang Holnthoner, Johannes Heinzel, David Hercher
Summary: This study reveals increased lymphangiogenesis after peripheral nerve injury and repair. The findings suggest that Schwann cells may have an inhibitory effect on lymphatic vessel formation.
Review
Neurosciences
Qian Wang, Fang-Yu Chen, Zhuo-Min Ling, Wen-Feng Su, Ya-Yu Zhao, Gang Chen, Zhong-Ya Wei
Summary: Peripheral neuropathy is a common neurological issue with limited treatment options. Schwann cell transplantation plays a crucial role in resolving peripheral neuropathy, and stem cells have the potential to differentiate into Schwann-like cells. These studies provide insights into cell therapy and uncover prospective therapeutic strategies for peripheral neuropathy.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Atsuhiko Okura, Koichi Inoue, Eisuke Sakuma, Hiroshi Takase, Takatoshi Ueki, Mitsuhito Mase
Summary: Schwann cells are crucial for peripheral myelination and the activation of the SGK1 signaling pathway plays a significant role in determining cell fate during nerve injury and repair.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Neurosciences
Emily L. Errante, Anthony Diaz, Taylor Smartz, Aisha Khan, Risset Silvera, Adriana E. Brooks, Yee-Shuan Lee, S. Shelby Burks, Allan D. Levi
Summary: Peripheral nerve injury (PNI) is common in trauma patients, and severe PNI can be challenging to treat. The use of cell therapies, particularly Schwann cells, has shown effectiveness in PNI treatment. Our laboratory has demonstrated the effectiveness of Schwann cells in the treatment of severe PNI when used with axon guidance channels, but optimal cellular placement techniques are crucial.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Neurosciences
Frederic A. A. Vallejo, Anthony Diaz, Emily L. L. Errante, Taylor Smartz, Aisha Khan, Risset Silvera, Adriana E. E. Brooks, Yee-Shuan Lee, Stephen Shelby Burks, Allan D. D. Levi
Summary: This study systematically evaluated the therapeutic use of Schwann cells (SC) in the repair of peripheral nerve injuries. The results showed that SCs have clear potential in improving morphological and functional outcomes in animal studies of long gap peripheral nerve injuries. However, the optimal nerve conduit or graft for delivering and retaining SCs for nerve regeneration has yet to be determined.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Neurosciences
Deepak Prasad Gupta, Anup Bhusal, Md Habibur Rahman, Jae-Hong Kim, Youngshik Choe, Jaemyung Jang, Hyun Jin Jung, Un-Kyung Kim, Jin-Sung Park, Lee-so Maeng, Kyoungho Suk, Gyun Jee Song
Summary: This study reveals the essential role of EBP50 in the repair function of Schwann cells and regeneration following nerve injury. EBP50 deficiency leads to deficits in Schwann cell functions and delays nerve repair and functional recovery. Additionally, EBP50 enhances regeneration by binding and activating ErbB2.
PROGRESS IN NEUROBIOLOGY
(2023)
Article
Neurosciences
Yunsong Zhang, Yinying Shen, Li Zhao, Qian Zhao, Lili Zhao, Sheng Yi
Summary: Nerve injury-induced Schwann cell dedifferentiation promotes axon growth by creating a favorable microenvironment. Transcription factor BCL11A plays a crucial role in Schwann cell reprogramming during peripheral nerve regeneration. Silencing Bcl11a reduces Schwann cell viability, proliferation, migration rates, and debris clearance ability. Bcl11a deficiency leads to restricted axon elongation and myelin wrapping, resulting in failed recovery. Mechanistically, BCL11A regulates Schwann cell activity by binding to the Nr2f2 promoter and modulating Nr2f2 expression. In conclusion, BCL11A is essential for Schwann cell activation and peripheral nerve regeneration, making it a potential therapeutic target for peripheral nerve injury treatment.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yaxian Wang, Fuchao Zhang, Yunsong Zhang, Qi Shan, Wei Liu, Fengyuan Zhang, Feiyu Zhang, Sheng Yi
Summary: Research findings indicate that Btc plays essential roles in regulating Schwann cell migration and axon elongation, suggesting the potential application of Btc as a regenerative strategy for treating peripheral nerve injury.
MOLECULAR MEDICINE
(2021)
Article
Medicine, Research & Experimental
Andres Fuentes-Flores, Cristian Geronimo-Olvera, Karina Girardi, David Necunir-Ibarra, Sandip Kumar Patel, Joanna Bons, Megan C. Wright, Daniel Geschwind, Ahmet Hoke, Jose A. Gomez-Sanchez, Birgit Schilling, Daniela L. Rebolledo, Judith Campisi, Felipe A. Court
Summary: Reparative Schwann cells transition into a senescent phenotype in aging and chronic denervation, leading to inhibition of axonal regeneration. Elimination of senescent cells improves nerve regeneration and functional recovery.
EMBO MOLECULAR MEDICINE
(2023)
Review
Neurosciences
Jenica Acheta, Shannon B. Z. Stephens, Sophie Belin, Yannick Poitelon
Summary: This review discusses the known and possible molecular mechanisms activated in repair Schwann cells in response to low-intensity ultrasound (LIU), drawing support and attention to LIU as a compelling regenerative treatment for peripheral nerve injury.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Neurosciences
Xiangyun Yao, Zhiwen Yan, Xiaojing Li, Yanhao Li, Yuanming Ouyang, Cunyi Fan
Summary: Peripheral nerve injuries are common traumatic injuries worldwide, and the use of FK506-stimulated ADSCs has shown potential in promoting nerve regeneration, offering hope for the treatment of severe PNIs.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Biology
Tian-Kun Hui, Xin-Sheng Lai, Xia Dong, Hongyang Jing, Ziyang Liu, Erkang Fei, Wen-Bing Chen, Shunqi Wang, Dongyan Ren, Suqi Zou, Hai-Tao Wu, Bing-Xing Pan
Summary: Schwann cells play a crucial role in peripheral nerve regeneration, while the conditional knockout of Lrp4 in SCs contributes to enhanced nerve regeneration by promoting SC proliferation and myelin debris clearance. These results suggest a novel role for Lrp4 in peripheral nerve recovery and provide a potential therapeutic target.
Review
Biotechnology & Applied Microbiology
Jue Ling, Chang He, Shuxuan Zhang, Yahong Zhao, Meifeng Zhu, Xiaoxuan Tang, Qiaoyuan Li, Liming Xu, Yumin Yang
Summary: This article provides an overview of evaluation methods used to study scaffold-based therapies for peripheral nerve injury (PNI) in experimental animal models, with particular focus on Schwann cell functions and axonal growth within the regenerated nerve.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Ophthalmology
Yu Xiao, Yijun Hu, Wuxiu Quan, Yahan Yang, Weiyi Lai, Xun Wang, Xiayin Zhang, Bin Zhang, Yuqing Wu, Qiaowei Wu, Baoyi Liu, Xiaomin Zeng, Zhanjie Lin, Ying Fang, Yu Hu, Songfu Feng, Ling Yuan, Hongmin Cai, Tao Li, Haotian Lin, Honghua Yu
Summary: This study successfully developed deep learning models for classification of macular hole etiology and prediction of postoperative macular hole status using a multimodal deep fusion network. The models showed high accuracy and sensitivity.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Environmental Sciences
Jingwen Wang, Shiye Cheng, Ning Liu, Na Lu, Kefeng Shang, Nan Jiang, Jie Li, Yan Wu
Summary: This paper investigates the power characteristics and power factor optimization in a coaxial tube-tube dielectric barrier discharge reactor. The effects of various parameters on discharge power and power factor were evaluated. The results show that increasing discharge voltage, discharge frequency, and electrode length can enhance discharge power. However, the power factor initially increases and then decreases with increasing discharge frequency. Response surface method and artificial neural network were used for power factor optimization, and their results were consistent. The degradation experiment of toluene in the reactor reveals a positive correlation between the toluene degradation rate and power factor, with discharge voltage, gas flow rate, and initial concentration playing key roles. The importance of these parameters is demonstrated when the power factor reaches 0.34 and the toluene degradation rate reaches 74.3% at a discharge voltage of 10 kV, gas flow rate of 70 mL/min, and initial concentration of 50 ppm.
ENVIRONMENTAL TECHNOLOGY
(2023)
Article
Development Studies
Yingzhi Xu, Ruijie Zhang, Biying Dong, Jingjing Wang
Summary: This study examines the impact of low-carbon city construction on haze pollution in China using the VAR model and DID-PSM method. The results show that the construction of low-carbon cities has not effectively reduced haze pollution, and the ineffectiveness of technical innovation effect, industrial structure effect, and population quality effect, as well as regional heterogeneity, may be the reasons. Several recommendations for alleviating China's haze pollution through low-carbon city construction are proposed.
JOURNAL OF ENVIRONMENTAL PLANNING AND MANAGEMENT
(2023)
Article
Environmental Sciences
Bin Zhao, Yanping Yang, Chen Zhao, Chunchun Zhang, Zhaohui Zhang, Liang Wang, Shang Wang, Jingfeng Wang
Summary: This study investigates the metabolic mechanisms of glycogen accumulating organisms (GAOs) and reveals the crucial metabolic pathways in a GAOs enrichment system. It also provides insights into the potential application of Ca. Contendobacter for wastewater treatment.
JOURNAL OF ENVIRONMENTAL SCIENCES
(2023)
Article
Management
Jingyu Yu, Anying Chan, Bo Wang, Yong Liu, Jingfeng Wang
Summary: This study investigates the critical success factors for the adoption of assembled buildings with the steel structure (ABSS) method in China. The results identify six critical success factors: market, organization, government, project, professional, and social factors. The government factor is found to be the most important influence on the use of the ABSS method.
INTERNATIONAL JOURNAL OF CONSTRUCTION MANAGEMENT
(2023)
Article
Meteorology & Atmospheric Sciences
Jingzhi Wang, Xiao-Feng Li, Shaofeng Liu, Ting Liu, Yongjiu Dai, Song Yang, Hayley J. Fowler
Summary: This study identifies the dominant wind patterns over the western Tibet Plateau using MV-EOF analysis. It finds that the wind field in most seasons over the plateau shows high similarity to the Western Tibetan Vortex.
Article
Biochemistry & Molecular Biology
Fengyi Chen, Yanping Wang
Summary: Neuromyelitis optica (NMO) is an inflammatory demyelinating disorder associated with upregulated osteopontin (OPN). This study found that downregulation of OPN alleviated demyelination and other pathological features, while increasing neurotrophic factors levels. Furthermore, OPN was shown to activate the IFN-γ/NF-kB/IL-12 signaling pathway, promoting microglia activation and contributing to the pathogenesis of NMO.
MOLECULAR & CELLULAR TOXICOLOGY
(2023)
Article
Psychology, Developmental
Zhongjie Wang, Xuezhen Wang, Ying Peng, Cuijing Liu, Jingke He
Summary: This study aims to investigate whether psychache mediates the relationship between recalled childhood maltreatment and suicide risk among college students, as well as whether meaning in life moderates this indirect path. The findings reveal that recalled childhood maltreatment is positively associated with suicide risk, with psychache partially mediating this relationship. Moreover, meaning in life moderates the association between psychache and suicide risk, indicating that higher levels of meaning in life weaken the impact of psychache on suicide risk. These findings highlight the importance of considering these risk and protective factors when assessing suicide risk and developing prevention and intervention strategies.
JOURNAL OF ADULT DEVELOPMENT
(2023)
Article
Chemistry, Physical
Anlian Zhu, Jingyi Wang, Mingyue Wang, Dongshuang Fan, Lingjun Li
Summary: A series of ionic liquids were synthesized and their synergetic effects on the Cu catalyzed one-pot A(3) coupling reactions were investigated for the synthesis of propargylamines. The combined catalytic system based on ionic liquid [MEA] [H2PO4 ] and CuI showed excellent catalytic activity and selectivity for propargylamine synthesis, achieving good to excellent yields for various aromatic and heteroaromatic aldehydes.
Review
Food Science & Technology
Lu Qiao, Jinhua Xu, Zhen Yang, Xingyang Li, Lu Chen, Huiwu Sun, Yingchun Mu
Summary: This paper provides an overview of the residual risk and toxicity of Avermectins (AVMs) in animal-derived food products, as well as summarizing the analytical methods used for their detection. It highlights the need for further research on the environmental impacts of AVMs and the potential toxicological significance of food contamination.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Engineering, Electrical & Electronic
Wei-Hua Shang-Guan, Rong-Bing Zhao, Jin-Qing Wang, Zhi-Chao Wang, Qing-Hui Liu, Xiao-Yu Hong, Guang-Li Wang, Wei-Min Zheng, Xiu-Zhong Zhang, Tao Shuai, Zhen Yan, Yi-Dan Huang, Xue-Jiang Lu, Lin-Feng Yu, Yong-Bin Jiang, Chao Zhang, Mao-Li Ma, Wei-Ye Zhong, Ren-Jie Zhu, Wen-Bin Wang, Juan Zhang, Bo Xia, Chu-Yuan Zhang
Summary: China plans to launch a relay satellite in the future to conduct lunar orbit very-long-baseline interferometry (LOVEX) experiments, aiming to improve the accuracy of spacecraft orbit determination and scientific observation capabilities. In order to verify the key technologies of the LOVEX system, a LOVEX ground validation system with similar performance has been established. Experimental results using this system show the feasibility of LOVEX time-delay calibration.
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
(2023)
Article
Biochemistry & Molecular Biology
Chongyang Huang, Wenjun Deng, Huan-zhou Xu, Chen Zhou, Fan Zhang, Junfei Chen, Qinjia Bao, Xin Zhou, Maili Liu, Jing Li, Chaoyang Liu
Summary: Short-chain fatty acids (SCFAs) have anticancer activity in colon cancer. Acetate, propionate, and butyrate are the major SCFAs produced from dietary fiber by gut microbiota fermentation and have beneficial effects on human health. This study systematically analyzed the effects of acetate, propionate, and butyrate on ROS levels and metabolic and transcriptomic signatures in human colorectal adenocarcinoma cells, showing elevated levels of ROS and regulated signatures in pathways related to ROS production.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Geochemistry & Geophysics
Rongqi Tang, Xiaodan Wu, Jingping Wang, Zheng Li, Qicheng Zeng, Jianguang Wen, Qing Xiao
Summary: Validation of satellite albedo products commonly uses reference values obtained within the validation pixel's nominal spatial extent. However, geometric errors can cause geolocation mismatch, leading to large uncertainty in validation results. This study proposes a geometric location matching method to accurately establish the position of the validation pixel on a coarse pixel scale. The method significantly reduces the uncertainty and improves the accuracy of satellite albedo products.
IEEE GEOSCIENCE AND REMOTE SENSING LETTERS
(2023)
Article
Medicine, Research & Experimental
Yintang Wang, Yu Geng, Ou Zhang, Qin Xu, Yajun Xue, Boda Zhou, Ping Zhang, Aihua Li, Bao Li, Biao Xu, Guangshu Han, Bin Li, Bin Liu, Bin Wang, Bing Fu, Bo Yu, Bosong Yang, Caidong Luo, Changqian Wang, Changyong Liu, Chuanliang Liang, Chuanyu Gao, Chunlin Lai, Chuntong Wang, Chunyan Zhang, Chunyang Wu, Congliang Zhang, Cui Bin, Lan Huang, Daoquan Peng, Dawen Xu, Di Wu, Dongmei Zhu, Dongsheng Chai, Dongyan Li, Fakuan Tang, Jun Xiao, Fang Zhao, Fangfang Huang, Fanju Meng, Fengwei Li, Fudong Gan, Gang Xu, Gengsheng Sang, Genshan Ma, Guixia Zhang, Guizhou Tao, Guo Li, Guoduo Chen, Guoqin Xin, Guoqing Li, Guosheng Fu, Guoxiong Chen, Hailong Lin, Haiping Guo, Haiyun Lin, Hong Jiang, Hong Liu, Hong Luan, Hong Zhang, Honghua Deng, Hongwei Li, Honhju Wang, Hualing Liu, Hui Dong, Hui Liu, Huifang Zhang, Huifeng Wang, Huimin Chu, Jiabin Xi, Jian Yang, Jianfeng Ye, Jianhao Li, Jianhong Tao, Jianwen Liu, JiaoMei Yang, Jiawang Ding, Jiayi Tong, Jie Chen, Jie Jiang, Jie Yang, Jifu Li, Jinchuan Yan, Jing Hu, Jing Xu, Jingfeng Wang, Jinglan Diao, Jingshan Zhao, Jinru Wei, Jinxing Yi, Jinzi Su, Jiong Tang, Jiyan Chen, Jiyan Yin, Juexin Fan, Jun Guan, Junbo Ge, Junming Liu, Junping Deng, Junping Fang, Junxia Li, Kaihong Chen, Kalan Luo, Keng Wu, Lang Ji, Lang Li, Li Jiang, Li Wei, Lijun Meng, Likun Ma, Lilong Tang, Lin Wang, Lin Wei, Ling Li, Ling Tao, Liqiong Yang, Lirong Wu, Man Zhang, Kaiming Chen, Meisheng Lai, Miao Tian, Mingcheng Bai, Minghua Han, Moshui Chen, Naiyi Liang, Nan Jia, Peiying Zhang, Peng Qu, Pengfei Zhang, Ping Chen, Ping Hou, Ping Xie, Pingshuan Dong, Qiang Wu, Qiang Xie, Qiaoqing Zhong, Qichun Wang, Qinfeng Su, Rong Chang, Rong Lin, Ruiping Zhao, Shaobin Jia, Shaoping Nie, Shaowu Ye, Shenghu He, Shengyong Chen, Shixin Ma, Shuangbin Li, Shuanli Xin, Shudong Xia, Shuhua Zhang, Shuqiu Qu, Shuren Ma, Siding Wang, Songbai Li, Suxin Luo, Tao Liu, Tao Zhang, Tian Tuo, Tianchang Li, Tianlun Yang, Tianmin Du, Tongguo Wu, Wei Liu, Wei Mao, Wei Tuo, Wei Wang, Weihong Jiang, Weijian Huang, Weijun Liu, Weiqing Fan, Weiting Xu, Wenhua Lin, Xi Su, Xia Chen, Xianan Zhang, Xianghua Fu, Xiangjun Yang, Xianxian Zhao, Xiaochuan Ma, Xiaofei Sun, Xiaojun Wang, Xiaolan Li, Xiaolei Li, Xiaoli Yang, Xiaoping Chen, Xiaoqin Zhang, Xiaoshu Cheng, Xiaowei Peng, Xiaowen Ma, Xiaoyong Qi, Xiaoyun Feng, Ximing Chen, Xin Tang, Xingsheng Tang, Xingsheng Zhao, Xiufeng Chen, Xudong Li, Xue Li, Xuebo Liu, Xuemei Peng, Yaling Han, Yan Wang, Yanbo Niu, Yang Yu, Yang Zheng, Yanli Wang, Yanlie Zheng, Yansong Guo, Yanzong Yang, Yi Huang, Yin Liu, Ying Guo, Yingchao Luo, Yinglu Hao, Yingxian Sun, Yingzhong Lin, Yitong Ma, Yong Guo, Yong Li, Yongdong Li, Yonglin Zhang, Yuanzhe Jin, Yue Li, Yuehua Huang, Yuemin Sun, Yuheng Yang, Yuhua Zhu, Yuhuan Shi, Yulan Zhao, Yuqing Hou, Zeqi Zheng, Zesheng Xu, Zewei Ouyang, Zeyuan He, Zhan Lv, Zhanquan Li, Zhaofa He, Zheng Ji, Zheng Zhang, Zhenguo Ji, Zhenqi Su, Zhenyu Yang, Zhihong Ou, Zhijian Yang, Zhiming Yang, Zhirong Wang, Zhiyuan Song, Zhongshan Wang, Zuyi Yuan
Summary: In patients with NSTEACS who were already taking P2Y12 receptor inhibitors, reloading of these inhibitors was associated with a decreased risk of in-hospital major adverse cardiac events (MACE) and all-cause death, without an increased risk of major bleeding.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Letter
Surgery
Binghao Zhao, Hao Xing, Wenbin Ma
