Clinical Importance of the Human Umbilical Artery Potassium Channels

Isoform-Selective KCNA1 Potassium Channel Openers Built from Glycine

(2020) Rían W. Manville et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

New insights into KATP channel gene mutations and neonatal diabetes mellitus

(2020) Tanadet Pipatpolkai et al.   Nature Reviews Endocrinology

Screening Technologies for Inward Rectifier Potassium Channels: Discovery of New Blockers and Activators

(2020) Kenneth B. Walsh   SLAS Discovery

Two-Pore Domain Potassium Channels as Drug Targets: Anesthesia and Beyond

(2020) Alistair Mathie et al.   Annual Review of Pharmacology and Toxicology

Calcium-activated potassium channels: implications for aging and age-related neurodegeneration

(2020) Marina Trombetta-Lima et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Relaxant Effect of Monoterpene (−)-Carveol on Isolated Human Umbilical Cord Arteries and the Involvement of Ion Channels

(2020) Renata Evaristo Rodrigues da Silva et al.   MOLECULES

Mechanosensitive TREK-1 two-pore-domain potassium (K2P) channels in the cardiovascular system

(2020) Felix Wiedmann et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

A constricted opening in Kir channels does not impede potassium conduction

(2020) Katrina A. Black et al.   Nature Communications

Pregnancy-induced hypertension decreases Kv1.3 potassium channel expression and function in human umbilical vein smooth muscle

(2020) Vladimir Djokic et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Mutation of a single residue promotes gating of vertebrate and invertebrate two-pore domain potassium channels

(2019) Ismail Ben Soussia et al.   Nature Communications

Potassium Channels in Vascular Smooth Muscle: A Pathophysiological and Pharmacological Perspective

(2019) Muhammed Fatih Dogan et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Genetic Discovery of ATP-Sensitive K + Channels in Cardiovascular Diseases

(2019) Yan Huang et al.   Circulation-Arrhythmia and Electrophysiology

Pharmacology of Small- and Intermediate-Conductance Calcium-Activated Potassium Channels

(2019) Brandon M. Brown et al.   Annual Review of Pharmacology and Toxicology

Conduction through a narrow inward-rectifier K+ channel pore

(2019) Harald Bernsteiner et al.   JOURNAL OF GENERAL PHYSIOLOGY

Pregnancy-induced hypertension is associated with down-regulation of Kir6.1 in human myometrium

(2019) Qingyou Du et al.   Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health

Preeclampsia: Risk Factors, Diagnosis, Management, and the Cardiovascular Impact on the Offspring

(2019) Rachael Fox et al.   Journal of Clinical Medicine

Effect of gestational diabetes mellitus and pregnancy-induced hypertension on human umbilical vein smooth muscle KATP channels

(2019) Vladimir Djokic et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Role of ATP-sensitive potassium channels and inflammatory response of basilar artery smooth muscle cells in subarachnoid hemorrhage of rabbit and immune-modulation by shikonin

(2019) Xianqing Shi et al.   FOOD AND CHEMICAL TOXICOLOGY

The role of KATP channels in cerebral ischemic stroke and diabetes

(2018) Vivian Szeto et al.   ACTA PHARMACOLOGICA SINICA

4-Aminopyridine: a pan voltage-gated potassium channel inhibitor that enhances Kv 7.4 currents and inhibits noradrenaline-mediated contraction of rat mesenteric small arteries

(2018) Makhala M Khammy et al.   BRITISH JOURNAL OF PHARMACOLOGY

Pharmacologic targeting of endothelial Ca2+-activated K+ channels: A strategy to improve cardiovascular function

(2018) Cini Mathew John et al.   Channels

Impaired Trafficking of β1 Subunits Inhibits BK Channels in Cerebral Arteries of Hypertensive Rats

(2018) M. Dennis Leo et al.   HYPERTENSION

Chronic interval exercise training prevents BKCa channel-mediated coronary vascular dysfunction in aortic-banded miniswine

(2018) T. Dylan Olver et al.   JOURNAL OF APPLIED PHYSIOLOGY

Hypertensive Disorders of Pregnancy: Overview and Current Recommendations

(2018) Diane M. Folk   JOURNAL OF MIDWIFERY & WOMENS HEALTH

How is the human umbilical artery regulated?

(2018) Margarida Lorigo et al.   JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH

KV channel trafficking and control of vascular tone

(2018) Raquibul Hasan et al.   MICROCIRCULATION

KV channels and the regulation of vascular smooth muscle tone

(2018) William F. Jackson   MICROCIRCULATION

Dofetilide for suppression of atrial fibrillation in hypertrophic cardiomyopathy: A case series and literature review

(2018) JoEllyn C. Moore et al.   PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY

Alterations of ATP-sensitive K+ channels in human umbilical arterial smooth muscle during gestational diabetes mellitus

(2018) Hongliang Li et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

The expression and function of KCNQ potassium channels in human chorionic plate arteries from women with normal pregnancies and pre-eclampsia

(2018) Xiaohong Wei et al.   PLoS One

Inwardly Rectifying Potassium (Kir) Channels Represent a Critical Ion Conductance Pathway in the Nervous Systems of Insects

(2018) Rui Chen et al.   Scientific Reports

Maternal pregnancy-induced hypertension increases subsequent neonatal necrotizing enterocolitis risk

(2018) Chih-Chieh Yang et al.   MEDICINE

The two-pore domain potassium channel TREK-1 mediates cardiac fibrosis and diastolic dysfunction

(2018) Dennis M. Abraham et al.   JOURNAL OF CLINICAL INVESTIGATION

TASK-1 (KCNK3) channels in the lung: from cell biology to clinical implications

(2017) Andrea Olschewski et al.   EUROPEAN RESPIRATORY JOURNAL

ATP sensitive potassium channel openers: A new class of ocular hypotensive agents

(2017) Uttio Roy Chowdhury et al.   EXPERIMENTAL EYE RESEARCH

Impairment of BKca channels in human placental chorionic plate arteries is potentially relevant to the development of preeclampsia

(2017) Mengzhou He et al.   HYPERTENSION RESEARCH

Activation of TREK-1, but Not TREK-2, Channel by Mood Stabilizers

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Involvement of dysregulated IK Ca and SK Ca channels in preeclampsia

(2017) Fan-fan Li et al.   PLACENTA

Increased oxidative stress and cytokinesis-block micronucleus cytome assay parameters in pregnant women with gestational diabetes mellitus and gestational arterial hypertension

(2017) Mina Toljic et al.   REPRODUCTIVE TOXICOLOGY

Expression and localisation of two-pore domain (K2P) background leak potassium ion channels in the mouse retina

(2017) Steven Hughes et al.   Scientific Reports

Cyclic guanosine monophosphate compartmentation in human vascular smooth muscle cells

(2016) Joana Feiteiro et al.   CELLULAR SIGNALLING

Potassium Channel Subfamily K Member 3 (KCNK3) Contributes to the Development of Pulmonary Arterial HypertensionCLINICAL PERSPECTIVE

(2016) Fabrice Antigny et al.   CIRCULATION

Therapeutic targeting of two-pore-domain potassium (K2P) channels in the cardiovascular system

(2016) F. Wiedmann et al.   CLINICAL SCIENCE

Altered KATP Channel Subunits Expression and Vascular Reactivity in Spontaneously Hypertensive Rats With Age

(2016) Xiaojing Liu et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

The Action of Smooth Muscle Cell Potassium Channels in the Pathology of Pulmonary Arterial Hypertension

(2016) Yasunobu Hayabuchi   PEDIATRIC CARDIOLOGY

Heterodimerization within the TREK channel subfamily produces a diverse family of highly regulated potassium channels

(2016) Joshua Levitz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Roles of ion channels in regulation of acetylcholine-mediated vasoconstrictions in umbilical cords of rabbit/rats

(2016) Zhoufeng Zhu et al.   REPRODUCTIVE TOXICOLOGY

Mechanism of inhibition of mouse Slo3 (KCa5.1) potassium channels by quinine, quinidine and barium

(2015) David C Wrighton et al.   BRITISH JOURNAL OF PHARMACOLOGY

Structure of potassium channels

(2015) Qie Kuang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Ca2+-Activated K+ Channels as Therapeutic Targets for Myocardial and Vascular Protection

(2015) Richard T. Clements et al.   CIRCULATION JOURNAL

The family of K2Pchannels: salient structural and functional properties

(2015) Sylvain Feliciangeli et al.   JOURNAL OF PHYSIOLOGY-LONDON

Vascular Inward Rectifier K+Channels as External K+Sensors in the Control of Cerebral Blood Flow

(2015) Thomas A. Longden et al.   MICROCIRCULATION

Much more than a leak: structure and function of K2P-channels

(2015) Vijay Renigunta et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Activation of K V 7 channels stimulates vasodilatation of human placental chorionic plate arteries

(2015) T.A. Mills et al.   PLACENTA

TWIK-2 Channel Deficiency Leads to Pulmonary Hypertension Through a Rho-Kinase–Mediated Process

(2014) Lavannya M. Pandit et al.   HYPERTENSION

The potassium current carried by TREK-1 channels in rat cardiac ventricular muscle

(2014) Mandy Bodnár et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Margatoxin is a non-selective inhibitor of human Kv1.3 K+ channels

(2014) Adam Bartok et al.   TOXICON

A disulphide-linked heterodimer of TWIK-1 and TREK-1 mediates passive conductance in astrocytes

(2014) Eun Mi Hwang et al.   Nature Communications

BK channel activators and their therapeutic perspectives

(2014) Bo H. Bentzen et al.   Frontiers in Physiology

A High-Throughput Functional Screen Identifies Small Molecule Regulators of Temperature- and Mechano-Sensitive K2P Channels

(2013) Sviatoslav N. Bagriantsev et al.   ACS Chemical Biology

Efficient and specific cardiac IK1 inhibition by a new pentamidine analogue

(2013) H. Takanari et al.   CARDIOVASCULAR RESEARCH

Potassium Channels and Uterine Vascular Adaptation to Pregnancy and Chronic Hypoxia

(2013) Ronghui Zhu et al.   Current Vascular Pharmacology

Testosterone and Atrial Natriuretic Peptide Share the Same Pathway to Induce Vasorelaxation of Human Umbilical Artery

(2013) Joana Feiteiro et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Oxygen Sensitivity, Potassium Channels, and Regulation of Placental Vascular Tone

(2013) Mark Wareing   MICROCIRCULATION

A splice variant of the two-pore domain potassium channel TREK-1 with only one pore domain reduces the surface expression of full-length TREK-1 channels

(2013) Susanne Rinné et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Ion channel remodeling in vascular smooth muscle during hypertension: Implications for novel therapeutic approaches

(2013) Biny K. Joseph et al.   PHARMACOLOGICAL RESEARCH

Diversity of Potassium Channels in Human Umbilical Artery Smooth Muscle Cells

(2013) Pedro Martín et al.   Reproductive Sciences

Hypotension Due to Kir6.1 Gain‐of‐Function in Vascular Smooth Muscle

(2013) Anlong Li et al.   Journal of the American Heart Association

Oleic Acid Inhibits the KATP Channel Subunit Kir6.1 and the KATP Current in Human Umbilical Artery Smooth Muscle Cells

(2012) Xiao-Jun Bai et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Different Potassium Channels are Involved in Relaxation of Rat Renal Artery Induced by P1075

(2012) Aleksandra Novakovic et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

One man's side effect is another man's therapeutic opportunity: targeting Kv7 channels in smooth muscle disorders

(2012) TA Jepps et al.   BRITISH JOURNAL OF PHARMACOLOGY

Bupivacaine inhibits large conductance, voltage- and Ca2+- activated K+channels in human umbilical artery smooth muscle cells

(2012) Pedro Martín et al.   Channels

Long- and short-term effects of androgens in human umbilical artery smooth muscle

(2012) Paulo A Saldanha et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Function and regulation of large conductance Ca2+-activated K+ channel in vascular smooth muscle cells

(2012) Xiang-Qun Hu et al.   DRUG DISCOVERY TODAY

High blood pressure associates with the remodelling of inward rectifier K+channels in mice mesenteric vascular smooth muscle cells

(2012) Sendoa Tajada et al.   JOURNAL OF PHYSIOLOGY-LONDON

BK potassium channel modulation by leucine-rich repeat-containing proteins

(2012) J. Yan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective Inhibition of the Kir2 Family of Inward Rectifier Potassium Channels by a Small Molecule Probe: The Discovery, SAR, and Pharmacological Characterization of ML133

(2011) Hao-Ran Wang et al.   ACS Chemical Biology

Disruption of K 2P 6.1 Produces Vascular Dysfunction and Hypertension in Mice

(2011) Eric E. Lloyd et al.   HYPERTENSION

Two-Pore Domain K + Channels

(2011) Asif R. Pathan et al.   HYPERTENSION

Novel Expression and Regulation of Voltage-Dependent Potassium Channels in Placentas From Women With Preeclampsia

(2011) Hiten D. Mistry et al.   HYPERTENSION

Open structure of the Ca2+ gating ring in the high-conductance Ca2+-activated K+ channel

(2011) Peng Yuan et al.   NATURE

Update on treatment options for Lambert–Eaton myasthenic syndrome: focus on use of amifampridine

(2011) Martin Stangel et al.   Neuropsychiatric Disease and Treatment

PKG is involved in testosterone-induced vasorelaxation of human umbilical artery

(2010) Elisa Cairrão et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Large conductance, Ca2+ -activated K+ channels (BKCa ) and arteriolar myogenic signaling

(2010) Michael A. Hill et al.   FEBS LETTERS

Inwardly Rectifying Potassium Channels: Their Structure, Function, and Physiological Roles

(2010) Hiroshi Hibino et al.   PHYSIOLOGICAL REVIEWS

Flecainide increases Kir2.1 currents by interacting with cysteine 311, decreasing the polyamine-induced rectification

(2010) R. Caballero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BK channel activation: structural and functional insights

(2010) Urvi S. Lee et al.   TRENDS IN NEUROSCIENCES

Spadin, a Sortilin-Derived Peptide, Targeting Rodent TREK-1 Channels: A New Concept in the Antidepressant Drug Design

(2010) Jean Mazella et al.   PLOS BIOLOGY

Effects of gestational diabetes on fetal oxygen and glucose levels in vivo

(2009) E Taricco et al.   BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY

Bioengineering aspects of the umbilical cord

(2009) Virginia L. Ferguson et al.   European Journal of Obstetrics & Gynecology and Reproductive Biology

Isolation and culture of human umbilical artery smooth muscle cells expressing functional calcium channels

(2009) E. Cairrão et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

Structure of the BK potassium channel in a lipid membrane from electron cryomicroscopy

(2009) Liguo Wang et al.   NATURE

Voltage-gated potassium channels as therapeutic targets

(2009) Heike Wulff et al.   NATURE REVIEWS DRUG DISCOVERY

Single-nucleotide polymorphisms in vascular Ca2+-activated K+-channel genes and cardiovascular disease

(2009) Ralf Köhler   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Pathophysiology of voltage-gated K+ channels in vascular smooth muscle cells: Modulation by protein kinases

(2009) Eun A. Ko et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Molecular mechanisms of BK channel activation

(2008) J. Cui et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Decreased expression of aortic KIR6.1 and SUR2B in hypertension does not correlate with changes in the functional role of KATP channels

(2008) Javier Blanco-Rivero et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Alternative Translation Initiation in Rat Brain Yields K2P2.1 Potassium Channels Permeable to Sodium

(2008) Dierk Thomas et al.   NEURON

Physiological role of inward rectifier K+ channels in vascular smooth muscle cells

(2008) Won Sun Park et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

The molecular basis of chloroquine block of the inward rectifier Kir2.1 channel

(2008) A. A. Rodriguez-Menchaca et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Potassium channels in the regulation of pulmonary artery smooth muscle cell proliferation and apoptosis: pharmacotherapeutic implications

(2007) E D Burg et al.   BRITISH JOURNAL OF PHARMACOLOGY