One man's side effect is another man's therapeutic opportunity: targeting Kv7 channels in smooth muscle disorders
Published 2012 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
One man's side effect is another man's therapeutic opportunity: targeting Kv7 channels in smooth muscle disorders
Authors
Keywords
-
Journal
BRITISH JOURNAL OF PHARMACOLOGY
Volume 168, Issue 1, Pages 19-27
Publisher
Wiley
Online
2012-08-08
DOI
10.1111/j.1476-5381.2012.02133.x
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Pharmacological dissection of Kv7.1 channels in systemic and pulmonary arteries
- (2012) Preet S Chadha et al. BRITISH JOURNAL OF PHARMACOLOGY
- The mechanism of action of retigabine (ezogabine), a first-in-class K+ channel opener for the treatment of epilepsy
- (2012) Martin J. Gunthorpe et al. EPILEPSIA
- The spectrum of anticonvulsant efficacy of retigabine (ezogabine) in animal models: Implications for clinical use
- (2012) Charles H. Large et al. EPILEPSIA
- The urinary safety profile and secondary renal effects of retigabine (ezogabine): A first-in-class antiepileptic drug that targets KCNQ (Kv7) potassium channels
- (2012) Neil Brickel et al. EPILEPSIA
- Reduced KCNQ4-Encoded Voltage-Dependent Potassium Channel Activity Underlies Impaired β-Adrenoceptor–Mediated Relaxation of Renal Arteries in Hypertension
- (2012) Preet S. Chadha et al. HYPERTENSION
- Ezogabine AKA Retigabine: Is More Better? Trying to Find the Right Dose From Clinical Trials
- (2012) Cynthia L. Harden Epilepsy Currents
- Kv7 potassium channels in airway smooth muscle cells: signal transduction intermediates and pharmacological targets for bronchodilator therapy
- (2011) Lioubov I. Brueggemann et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- Kv7 Positive Modulators Reduce Detrusor Overactivity and Increase Bladder Capacity in Rats
- (2011) Julie Svalø et al. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
- Characteristics and molecular basis of celecoxib modulation on Kv7 potassium channels
- (2011) XN Du et al. BRITISH JOURNAL OF PHARMACOLOGY
- Activation of vascular KCNQ (Kv7) potassium channels reverses spasmogen-induced constrictor responses in rat basilar artery
- (2011) Bharath K Mani et al. BRITISH JOURNAL OF PHARMACOLOGY
- Guide to Receptors and Channels (GRAC), 5th edition
- (2011) SPH Alexander et al. BRITISH JOURNAL OF PHARMACOLOGY
- Vasodilator signals from perivascular adipose tissue
- (2011) Maik Gollasch BRITISH JOURNAL OF PHARMACOLOGY
- Downregulation of Kv7.4 Channel Activity in Primary and Secondary Hypertension
- (2011) Thomas A. Jepps et al. CIRCULATION
- Novel Medications for Epilepsy
- (2011) Cinzia Fattore et al. DRUGS
- Randomized, double-blind, placebo-controlled trial of ezogabine (retigabine) in partial epilepsy
- (2011) J. A. French et al. NEUROLOGY
- KV7 channels regulate muscle tone and nonadrenergic noncholinergic relaxation of the rat gastric fundus
- (2011) V. Ipavec et al. PHARMACOLOGICAL RESEARCH
- Driving With No Brakes: Molecular Pathophysiology of Kv7 Potassium Channels
- (2011) Maria Virginia Soldovieri et al. PHYSIOLOGY
- Expression and function of the K+ channel KCNQ genes in human arteries
- (2010) Fu Liang Ng et al. BRITISH JOURNAL OF PHARMACOLOGY
- Functional effects of the KCNQ modulators retigabine and XE991 in the rat urinary bladder
- (2010) Frederik Rode et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- The contribution of Kv7 channels to pregnant mouse and human myometrial contractility
- (2010) Laura A. McCallum et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Systemic peripheral artery relaxation by KCNQ channel openers and hydrogen sulfide
- (2010) Johanna Schleifenbaum et al. JOURNAL OF HYPERTENSION
- Participation ofKCNQ(Kv7) potassium channels in myogenic control of cerebral arterial diameter
- (2010) Xi Zoë Zhong et al. JOURNAL OF PHYSIOLOGY-LONDON
- Diclofenac Distinguishes among Homomeric and Heteromeric Potassium Channels Composed of KCNQ4 and KCNQ5 Subunits
- (2010) L. I. Brueggemann et al. MOLECULAR PHARMACOLOGY
- Efficacy and safety of adjunctive ezogabine (retigabine) in refractory partial epilepsy
- (2010) M. J. Brodie et al. NEUROLOGY
- Differential Effects of ICA-27243 on Cloned KV7 Channels
- (2010) Sigrid Marie Blom et al. PHARMACOLOGY
- Molecular and functional characterization of Kv7 K+ channel in murine gastrointestinal smooth muscles
- (2009) Thomas A. Jepps et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- New tricks for old dogs: KCNQ expression and role in smooth muscle
- (2009) Iain A Greenwood et al. BRITISH JOURNAL OF PHARMACOLOGY
- Treatment with the Kv7 potassium channel activator flupirtine is beneficial in two independent mouse models of pulmonary hypertension
- (2009) I Morecroft et al. BRITISH JOURNAL OF PHARMACOLOGY
- KCNQ Modulators Reveal a Key Role for KCNQ Potassium Channels in Regulating the Tone of Rat Pulmonary Artery Smooth Muscle
- (2009) S. Joshi et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- KCNQ Currents and Their Contribution to Resting Membrane Potential and the Excitability of Interstitial Cells of Cajal From the Guinea Pig Bladder
- (2009) Ursula A. Anderson et al. JOURNAL OF UROLOGY
- Differential Effects of Selective Cyclooxygenase-2 Inhibitors on Vascular Smooth Muscle Ion Channels May Account for Differences in Cardiovascular Risk Profiles
- (2009) L. I. Brueggemann et al. MOLECULAR PHARMACOLOGY
- The KCNQ2/3 selective channel opener ICA-27243 binds to a novel voltage-sensor domain site
- (2009) Karen Padilla et al. NEUROSCIENCE LETTERS
- Expression and function of Kv7 channels in murine myometrium throughout oestrous cycle
- (2009) Laura A. McCallum et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- Bimodal effects of the Kv7 channel activator retigabine on vascular K+currents
- (2008) S Y M Yeung et al. BRITISH JOURNAL OF PHARMACOLOGY
- In Vivo Profile of ICA-27243 [N-(6-Chloro-pyridin-3-yl)-3,4-difluoro-benzamide], a Potent and Selective KCNQ2/Q3 (Kv7.2/Kv7.3) Activator in Rodent Anticonvulsant Models
- (2008) R. Roeloffs et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Vascular KCNQ Potassium Channels as Novel Targets for the Control of Mesenteric Artery Constriction by Vasopressin, Based on Studies in Single Cells, Pressurized Arteries, and in Vivo Measurements of Mesenteric Vascular Resistance
- (2008) A. R. Mackie et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Refinement of the Binding Site and Mode of Action of the Anticonvulsant Retigabine on KCNQ K+ Channels
- (2008) W. Lange et al. MOLECULAR PHARMACOLOGY
- Activation of Kv7 (KCNQ) voltage-gated potassium channels by synthetic compounds
- (2008) Q XIONG et al. TRENDS IN PHARMACOLOGICAL SCIENCES
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now