Therapeutic miRNA-Enriched Extracellular Vesicles: Current Approaches and Future Prospects

Extracellular vesicles as drug delivery systems: Why and how?

(2020) Omnia M. Elsharkasy et al.   ADVANCED DRUG DELIVERY REVIEWS

RNA delivery by extracellular vesicles in mammalian cells and its applications

(2020) Killian O’Brien et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Astrocyte-Derived Small Extracellular Vesicles Regulate Dendritic Complexity through miR-26a-5p Activity

(2020) Alejandro Luarte et al.   Cells

Extracellular Vesicle- and Extracellular Vesicle Mimetics-Based Drug Delivery Systems: New Perspectives, Challenges, and Clinical Developments

(2020) Prakash Gangadaran et al.   Pharmaceutics

Improved loading of plasma derived-extracellular vesicles to encapsulate antitumor miRNAs

(2019) Margherita Alba Carlotta Pomatto et al.   Molecular Therapy-Methods & Clinical Development

Mesenchymal Stem Cell-Derived Extracellular Vesicle Therapy for Stroke: Challenges and Progress

(2019) Oh Young Bang et al.   Frontiers in Neurology

Human Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles Inhibit Endometrial Cancer Cell Proliferation and Migration through Delivery of Exogenous miR-302a

(2019) Xin Li et al.   Stem Cells International

Extracellular microRNAs exhibit sequence-dependent stability and cellular release kinetics

(2019) Anna M. L. Coenen-Stass et al.   RNA Biology

Exosome-transmitted miR-128-3p increase chemosensitivity of oxaliplatin-resistant colorectal cancer

(2019) Tong Liu et al.   Molecular Cancer

Differential miRNA Loading Underpins Dual Harmful and Protective Roles for Extracellular Vesicles in Atherogenesis

(2019) Mark C. Blaser et al.   CIRCULATION RESEARCH

Mesenchymal stromal cell-derived exosomes attenuate myocardial ischaemia-reperfusion injury through miR-182-regulated macrophage polarization

(2019) Jinxuan Zhao et al.   CARDIOVASCULAR RESEARCH

Drug Delivery with Extracellular Vesicles: From Imagination to Innovation

(2019) Olivier G. de Jong et al.   ACCOUNTS OF CHEMICAL RESEARCH

Caveolin-1 selectively regulates microRNA sorting into microvesicles after noxious stimuli

(2019) Heedoo Lee et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Increases in miR-124-3p in Microglial Exosomes Confer Neuroprotective Effects by Targeting FIP200-Mediated Neuronal Autophagy Following Traumatic Brain Injury

(2019) Dai Li et al.   NEUROCHEMICAL RESEARCH

Delivery of mesenchymal stem cells-derived extracellular vesicles with enriched miR-185 inhibits progression of OPMD

(2019) Lin Wang et al.   Artificial Cells Nanomedicine and Biotechnology

Exosomes derived from miR‐375‐overexpressing human adipose mesenchymal stem cells promote bone regeneration

(2019) Si Chen et al.   CELL PROLIFERATION

Human CAP cells represent a novel source for functional, miRNA-loaded exosome production

(2019) Nikolas Zeh et al.   PLoS One

YBX-1 mediated sorting of miR-133 into hypoxia/reoxygenation-induced EPC-derived exosomes to increase fibroblast angiogenesis and MEndoT

(2019) Fengxia Lin et al.   Stem Cell Research & Therapy

Functional exosome-mediated co-delivery of doxorubicin and hydrophobically modified microRNA 159 for triple-negative breast cancer therapy

(2019) Chunai Gong et al.   JOURNAL OF NANOBIOTECHNOLOGY

Engineered exosomes: A new promise for the management of musculoskeletal diseases

(2018) D. Bellavia et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Biophysical properties of extracellular vesicles in diagnostics

(2018) Lucia Paolini et al.   Biomarkers in Medicine

Surface functionalized exosomes as targeted drug delivery vehicles for cerebral ischemia therapy

(2018) Tian Tian et al.   BIOMATERIALS

Exosomes from MiR-30d-5p-ADSCs Reverse Acute Ischemic Stroke-Induced, Autophagy-Mediated Brain Injury by Promoting M2 Microglial/Macrophage Polarization

(2018) Mei Jiang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Transplanted Mesenchymal Stem Cells Reduce Autophagic Flux in Infarcted Hearts via the Exosomal Transfer of mir-125b

(2018) Changchen Xiao et al.   CIRCULATION RESEARCH

Increased miR-124-3p in microglial exosomes following traumatic brain injury inhibits neuronal inflammation and contributes to neurite outgrowth via their transfer into neurons

(2018) Shan Huang et al.   FASEB JOURNAL

Exosome miR-335 as a novel therapeutic strategy in hepatocellular carcinoma

(2018) Fang Wang et al.   HEPATOLOGY

Role of Exosomes Derived from miR-133b Modified MSCs in an Experimental Rat Model of Intracerebral Hemorrhage

(2018) Haitao Shen et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

BMSCs-derived miR-223-containing exosomes contribute to liver protection in experimental autoimmune hepatitis

(2018) Lu Chen et al.   MOLECULAR IMMUNOLOGY

Identification of RNA-binding proteins in exosomes capable of interacting with different types of RNA: RBP-facilitated transport of RNAs into exosomes

(2018) Luisa Statello et al.   PLoS One

Designer exosomes produced by implanted cells intracerebrally deliver therapeutic cargo for Parkinson’s disease treatment

(2018) Ryosuke Kojima et al.   Nature Communications

Exosomes derived from miR-92a-3p-overexpressing human mesenchymal stem cells enhance chondrogenesis and suppress cartilage degradation via targeting WNT5A

(2018) Guping Mao et al.   Stem Cell Research & Therapy

Exosome-mediated delivery of functionally active miRNA-142-3p inhibitor reduces tumorigenicity of breast cancer in vitro and in vivo

(2018) Zahra Naseri et al.   International Journal of Nanomedicine

Exosomes Derived From miR-133b-Modified Mesenchymal Stem Cells Promote Recovery After Spinal Cord Injury

(2018) Dong Li et al.   Frontiers in Neuroscience

Immature Exosomes Derived from MicroRNA-146a Overexpressing Dendritic Cells Act as Antigen-Specific Therapy for Myasthenia Gravis

(2017) Weifan Yin et al.   INFLAMMATION

Exosomes derived from miR-181-5p-modified adipose-derived mesenchymal stem cells prevent liver fibrosis via autophagy activation

(2017) Ying Qu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Milk-derived exosomes for oral delivery of paclitaxel

(2017) Ashish K. Agrawal et al.   Nanomedicine-Nanotechnology Biology and Medicine

MEX3C interacts with adaptor-related protein complex 2 and involves in miR-451a exosomal sorting

(2017) Pin Lu et al.   PLoS One

Cell-based therapy using miR-302-367 expressing cells represses glioblastoma growth

(2017) Mohamed Fareh et al.   Cell Death & Disease

Stroma-derived extracellular vesicles deliver tumor-suppressive miRNAs to pancreatic cancer cells

(2017) Song Han et al.   Oncotarget

Exosomes derived from miR-140-5p-overexpressing human synovial mesenchymal stem cells enhance cartilage tissue regeneration and prevent osteoarthritis of the knee in a rat model

(2017) Shi-Cong Tao et al.   Theranostics

Interleukin 3- receptor targeted exosomes inhibit in vitro and in vivo Chronic Myelogenous Leukemia cell growth

(2017) Daniele Bellavia et al.   Theranostics

Evaluation of electroporation-induced adverse effects on adipose-derived stem cell exosomes

(2016) Kasper Bendix Johnsen et al.   CYTOTECHNOLOGY

Targeted therapeutic delivery using engineered exosomes and its applications in cardiovascular diseases

(2016) Dang Xitong et al.   GENE

Good things come in small packages: Overcoming challenges to harness extracellular vesicles for therapeutic delivery

(2016) Dominique Ingato et al.   JOURNAL OF CONTROLLED RELEASE

PEGylated and targeted extracellular vesicles display enhanced cell specificity and circulation time

(2016) S.A.A. Kooijmans et al.   JOURNAL OF CONTROLLED RELEASE

Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes

(2016) Joanna Kowal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The RNA-Binding Protein SYNCRIP Is a Component of the Hepatocyte Exosomal Machinery Controlling MicroRNA Sorting

(2016) Laura Santangelo et al.   Cell Reports

Investigation of Content, Stoichiometry and Transfer of miRNA from Human Neural Stem Cell Line Derived Exosomes

(2016) Lara Stevanato et al.   PLoS One

Hepatocellular Carcinoma From Epidemiology to Prevention: Translating Knowledge into Practice

(2015) Amit G. Singal et al.   Clinical Gastroenterology and Hepatology

Targeted exosome-mediated delivery of opioid receptor Mu siRNA for the treatment of morphine relapse

(2015) Yuchen Liu et al.   Scientific Reports

Exosomal miR-223 Contributes to Mesenchymal Stem Cell-Elicited Cardioprotection in Polymicrobial Sepsis

(2015) Xiaohong Wang et al.   Scientific Reports

Quantitative and stoichiometric analysis of the microRNA content of exosomes

(2014) J. R. Chevillet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sorting it out: Regulation of exosome loading

(2014) Carolina Villarroya-Beltri et al.   SEMINARS IN CANCER BIOLOGY

Maximizing exosome colloidal stability following electroporation

(2013) Joshua L. Hood et al.   ANALYTICAL BIOCHEMISTRY

Exosomes from marrow stromal cells expressing miR-146b inhibit glioma growth

(2013) Mark Katakowski et al.   CANCER LETTERS

Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs

(2013) Carolina Villarroya-Beltri et al.   Nature Communications

Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells

(2012) Shin-ichiro Ohno et al.   MOLECULAR THERAPY

Concise Review: Defining Characteristics of Mammalian Spermatogenic Stem Cells

(2012) Michael D. Griswold et al.   STEM CELLS

Exosome-Mediated Transfer of miR-133b from Multipotent Mesenchymal Stromal Cells to Neural Cells Contributes to Neurite Outgrowth

(2012) Hongqi Xin et al.   STEM CELLS

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells

(2011) María Mittelbrunn et al.   Nature Communications