Human Mesenchymal Stromal Cell Secretome Promotes the Immunoregulatory Phenotype and Phagocytosis Activity in Human Macrophages

A Phase 3, Single-Arm, Prospective Study of Remestemcel-L, Ex Vivo Culture-Expanded Adult Human Mesenchymal Stromal Cells for the Treatment of Pediatric Patients Who Failed to Respond to Steroid Treatment for Acute Graft-versus-Host Disease

(2020) Joanne Kurtzberg et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Eicosapentaenoic acid potentiates the therapeutic effects of adipose tissue-derived mesenchymal stromal cells on lung and distal organ injury in experimental sepsis

(2019) Johnatas D. Silva et al.   Stem Cell Research & Therapy

Mechanism of Enhanced MerTK-Dependent Macrophage Efferocytosis by Extracellular Vesicles

(2019) Geoffrey de Couto et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Polyunsaturated fatty acids modify the extracellular vesicle membranes and increase the production of proresolving lipid mediators of human mesenchymal stromal cells

(2019) Minna Holopainen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Regulation and Function of the PD-L1 Checkpoint

(2018) Chong Sun et al.   IMMUNITY

Differential effects of graphene oxide nanosheets on Candida albicans phagocytosis by murine peritoneal macrophages

(2018) R. Diez-Orejas et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Shedding light on the cell biology of extracellular vesicles

(2018) Guillaume van Niel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mesenchymal Stromal Cells and Their Extracellular Vesicles Enhance the Anti-Inflammatory Phenotype of Regulatory Macrophages by Downregulating the Production of Interleukin (IL)-23 and IL-22

(2018) Kati Hyvärinen et al.   Frontiers in Immunology

Eicosapentaenoic Acid Enhances the Effects of Mesenchymal Stromal Cell Therapy in Experimental Allergic Asthma

(2018) Soraia Carvalho Abreu et al.   Frontiers in Immunology

DHRS9 Is a Stable Marker of Human Regulatory Macrophages

(2017) Paloma Riquelme et al.   TRANSPLANTATION

Mesenchymal Stem Cell-Derived Extracellular Vesicles as Mediators of Anti-Inflammatory Effects: Endorsement of Macrophage Polarization

(2017) Claudia Lo Sicco et al.   Stem Cells Translational Medicine

Good responses but high TRM in adult patients after MSC therapy for GvHD

(2016) U Salmenniemi et al.   BONE MARROW TRANSPLANTATION

Carbon Monoxide Improves Efficacy of Mesenchymal Stromal Cells During Sepsis by Production of Specialized Proresolving Lipid Mediators*

(2016) Konstantin Tsoyi et al.   CRITICAL CARE MEDICINE

Metabolism and phospholipid assembly of polyunsaturated fatty acids in human bone marrow mesenchymal stromal cells

(2016) Feven Tigistu-Sahle et al.   JOURNAL OF LIPID RESEARCH

Expanded allogeneic adipose-derived mesenchymal stem cells (Cx601) for complex perianal fistulas in Crohn's disease: a phase 3 randomised, double-blind controlled trial

(2016) Julián Panés et al.   LANCET

MerTK cleavage limits proresolving mediator biosynthesis and exacerbates tissue inflammation

(2016) Bishuang Cai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human mesenchymal stem cells alter the gene profile of monocytes from patients with Type 2 diabetes and end-stage renal disease

(2016) Andrea F Wise et al.   Regenerative Medicine

Mesenchymal Stromal Cells Induce Peculiar Alternatively Activated Macrophages Capable of Dampening Both Innate and Adaptive Immune Responses

(2016) Laura Chiossone et al.   STEM CELLS

Mitochondrial Transfer via Tunneling Nanotubes is an Important Mechanism by Which Mesenchymal Stem Cells Enhance Macrophage Phagocytosis in the In Vitro and In Vivo Models of ARDS

(2016) Megan V. Jackson et al.   STEM CELLS

Mesenchymal stem cells promote CD206 expression and phagocytic activity of macrophages through IL-6 in systemic lupus erythematosus

(2015) Wei Deng et al.   CLINICAL IMMUNOLOGY

Exosomal miR-223 Contributes to Mesenchymal Stem Cell-Elicited Cardioprotection in Polymicrobial Sepsis

(2015) Xiaohong Wang et al.   Scientific Reports

Extracellular Vesicles Improve Post-Stroke Neuroregeneration and Prevent Postischemic Immunosuppression

(2015) Thorsten R. Doeppner et al.   Stem Cells Translational Medicine

Therapeutic potential of bone marrow-derived mesenchymal stem cells in formed aortic aneurysms of a mouse model

(2014) A. Yamawaki-Ogata et al.   EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY

Proresolving Lipid Mediators and Mechanisms in the Resolution of Acute Inflammation

(2014) Christopher D. Buckley et al.   IMMUNITY

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Interleukin-10 Receptor Signaling in Innate Immune Cells Regulates Mucosal Immune Tolerance and Anti-Inflammatory Macrophage Function

(2014) Dror S. Shouval et al.   IMMUNITY

Systemic Administration of Exosomes Released from Mesenchymal Stromal Cells Promote Functional Recovery and Neurovascular Plasticity After Stroke in Rats

(2013) Hongqi Xin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Human Placental Mesenchymal Stem Cells (pMSCs) Play a Role as Immune Suppressive Cells by Shifting Macrophage Differentiation from Inflammatory M1 to Anti-inflammatory M2 Macrophages

(2013) M. H. Abumaree et al.   Stem Cell Reviews and Reports

Mesenchymal Stem Cells Secrete Immunologically Active Exosomes

(2013) Bin Zhang et al.   STEM CELLS AND DEVELOPMENT

CD163 and Inflammation: Biological, Diagnostic, and Therapeutic Aspects

(2012) Anders Etzerodt et al.   ANTIOXIDANTS & REDOX SIGNALING

Regulatory macrophages as therapeutic targets and therapeutic agents in solid organ transplantation

(2012) Christiane Broichhausen et al.   Current Opinion in Organ Transplantation

Autologous Expanded Adipose-Derived Stem Cells for the Treatment of Complex Cryptoglandular Perianal Fistulas

(2012) M.D. Herreros et al.   DISEASES OF THE COLON & RECTUM

Mechanisms of mesenchymal stromal cell immunomodulation

(2012) Karen English   IMMUNOLOGY AND CELL BIOLOGY

Efficient Clearance of Early Apoptotic Cells by Human Macrophages Requires M2c Polarization and MerTK Induction

(2012) G. Zizzo et al.   JOURNAL OF IMMUNOLOGY

Human Mesenchymal Stem/Stromal Cells Cultured as Spheroids are Self-activated to Produce Prostaglandin E2 that Directs Stimulated Macrophages into an Anti-inflammatory Phenotype

(2012) Joni H. YlÖstalo et al.   STEM CELLS

Resolvins and Protectins in Inflammation Resolution

(2011) Charles N. Serhan et al.   CHEMICAL REVIEWS

Mesenchymal stem cells attenuate angiotensin II-induced aortic aneurysm growth in apolipoprotein E-deficient mice

(2011) Ryotaro Hashizume et al.   JOURNAL OF VASCULAR SURGERY

The Effect of Mesenchymal Stromal Cell–Hyaluronic Acid Hydrogel Constructs on Immunophenotype of Macrophages

(2011) Summer E. Hanson et al.   TISSUE ENGINEERING PART A

Mesenchymal stem cell–educated macrophages: A novel type of alternatively activated macrophages

(2009) Jaehyup Kim et al.   EXPERIMENTAL HEMATOLOGY

Mesenchymal Stem Cell-Derived Microvesicles Protect Against Acute Tubular Injury

(2009) S. Bruno et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The opposing effects of n−3 and n−6 fatty acids

(2007) Gerd Schmitz et al.   PROGRESS IN LIPID RESEARCH