Fasciola hepatica-Derived Molecules as Regulators of the Host Immune Response

Post-genomic progress in helminth parasitology

(2020) Paul McVeigh   PARASITOLOGY

Fasciola hepatica GST downregulates NF-κB pathway effectors and inflammatory cytokines while promoting survival in a mouse septic shock model

(2019) Vasti Aguayo et al.   Scientific Reports

Anti-inflammatory Trained Immunity Mediated by Helminth Products Attenuates the Induction of T Cell-Mediated Autoimmune Disease

(2019) Shauna M. Quinn et al.   Frontiers in Immunology

Helminth-microbiota cross-talk – A journey through the vertebrate digestive system

(2019) Alba Cortés et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Immune Regulation of Metabolic Homeostasis by Helminths and Their Molecules

(2019) Hendrik J.P. van der Zande et al.   TRENDS IN PARASITOLOGY

Therapeutic exploitation of IPSE, a urogenital parasite-derived host modulatory protein, for chemotherapy-induced hemorrhagic cystitis

(2018) Evaristus C. Mbanefo et al.   FASEB JOURNAL

Advances in Fasciola hepatica research using ‘omics’ technologies

(2018) Krystyna Cwiklinski et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

The parasitic 68-mer peptide FhHDM-1 inhibits mixed granulocytic inflammation and airway hyperreactivity in experimental asthma

(2018) Akane Tanaka et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Soil-transmitted helminth infections

(2018) Peter Mark Jourdan et al.   LANCET

Fibrinogen and fibrin are novel substrates for Fasciola hepatica cathepsin L peptidases

(2018) Mirjam M. Mebius et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Human fascioliasis infection sources, their diversity, incidence factors, analytical methods and prevention measures

(2018) S. Mas-Coma et al.   PARASITOLOGY

Helminth Modulation of Lung Inflammation

(2018) Christian Schwartz et al.   TRENDS IN PARASITOLOGY

The Untapped Pharmacopeic Potential of Helminths

(2018) Janina Kahl et al.   TRENDS IN PARASITOLOGY

IL-33/ST2 signalling and crosstalk with FcεRI and TLR4 is targeted by the parasitic worm product, ES-62

(2018) Dimity H. Ball et al.   Scientific Reports

Worms: Pernicious parasites or allies against allergies?

(2018) Henry J. McSorley et al.   PARASITE IMMUNOLOGY

Modulation of Host Immunity by Helminths: The Expanding Repertoire of Parasite Effector Molecules

(2018) Rick M. Maizels et al.   IMMUNITY

The immune modulatory peptide FhHDM-1 secreted by the helminth Fasciola hepatica prevents NLRP3 inflammasome activation by inhibiting endolysosomal acidification in macrophages

(2017) Raquel Alvarado et al.   FASEB JOURNAL

HpARI Protein Secreted by a Helminth Parasite Suppresses Interleukin-33

(2017) Megan Osbourn et al.   IMMUNITY

Recent Advances in Type-2-Cell-Mediated Immunity: Insights from Helminth Infection

(2017) Nicola L. Harris et al.   IMMUNITY

Global issues in allergy and immunology: Parasitic infections and allergy

(2017) Alvaro A. Cruz et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Autoreactive T cells in type 1 diabetes

(2017) Alberto Pugliese   JOURNAL OF CLINICAL INVESTIGATION

A review on epidemiology, global prevalence and economical losses of fasciolosis in ruminants

(2017) Khalid Mehmood et al.   MICROBIAL PATHOGENESIS

Making Mouse Models That Reflect Human Immune Responses

(2017) Lili Tao et al.   TRENDS IN IMMUNOLOGY

Exploiting Helminth–Host Interactomes through Big Data

(2017) Javier Sotillo et al.   TRENDS IN PARASITOLOGY

A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells

(2017) Chris J. C. Johnston et al.   Nature Communications

Dendritic cells provide a therapeutic target for synthetic small molecule analogues of the parasitic worm product, ES-62

(2017) Felicity E. Lumb et al.   Scientific Reports

Schistosome egg antigens, including the glycoprotein IPSE/alpha-1, trigger the development of regulatory B cells

(2017) Simone Haeberlein et al.   PLoS Pathogens

Fasciola hepatica Immune Regulates CD11c+ Cells by Interacting with the Macrophage Gal/GalNAc Lectin

(2017) Ernesto Rodríguez et al.   Frontiers in Immunology

A mucin-like peptide from Fasciola hepatica instructs dendritic cells with parasite specific Th1-polarizing activity

(2017) Verónica Noya et al.   Scientific Reports

Fasciola hepatica glycoconjugates immuneregulate dendritic cells through the Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin inducing T cell anergy

(2017) Ernesto Rodríguez et al.   Scientific Reports

Recombinant Fasciola hepatica fatty acid binding protein suppresses toll-like receptor stimulation in response to multiple bacterial ligands

(2017) Marcos J. Ramos-Benítez et al.   Scientific Reports

Unexpected Activity of a Novel Kunitz-type Inhibitor

(2016) David Smith et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A prospective view of animal and human Fasciolosis

(2016) K. Cwiklinski et al.   PARASITE IMMUNOLOGY

Fasciola hepatica induces eosinophil apoptosis in the migratory and biliary stages of infection in sheep

(2016) A. Escamilla et al.   VETERINARY PARASITOLOGY

The parasitic worm-derived immunomodulator, ES-62 and its drug-like small molecule analogues exhibit therapeutic potential in a model of chronic asthma

(2016) J. C. Coltherd et al.   Scientific Reports

A Trematode Parasite Derived Growth Factor Binds and Exerts Influences on Host Immune Functions via Host Cytokine Receptor Complexes

(2016) Azad A. Sulaiman et al.   PLoS Pathogens

The helminth product, ES-62 modulates dendritic cell responses by inducing the selective autophagolysosomal degradation of TLR-transducers, as exemplified by PKCδ

(2016) Russell J. Eason et al.   Scientific Reports

A parasite-derived 68-mer peptide ameliorates autoimmune disease in murine models of Type 1 diabetes and multiple sclerosis

(2016) Maria E. Lund et al.   Scientific Reports

Human helminth therapy to treat inflammatory disorders- where do we stand?

(2015) Helena Helmby   BMC IMMUNOLOGY

A parasitic helminth-derived peptide that targets the macrophage lysosome is a novel therapeutic option for autoimmune disease

(2015) Raquel Alvarado et al.   IMMUNOBIOLOGY

Worms as therapeutic agents for allergy and asthma: Understanding why benefits in animal studies have not translated into clinical success

(2015) Holly Evans et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Experimental hookworm infection and gluten microchallenge promote tolerance in celiac disease

(2015) John Croese et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Fasciola hepaticaFatty Acid Binding Protein Inhibits TLR4 Activation and Suppresses the Inflammatory Cytokines Induced by Lipopolysaccharide In Vitro and In Vivo

(2015) Ivelisse Martin et al.   JOURNAL OF IMMUNOLOGY

Helminth Products Protect against Autoimmunity via Innate Type 2 Cytokines IL-5 and IL-33, Which Promote Eosinophilia

(2015) Conor M. Finlay et al.   JOURNAL OF IMMUNOLOGY

Fasciola hepatica mucin-encoding gene: expression, variability and its potential relevance in host–parasite relationship

(2015) MARTÍN CANCELA et al.   PARASITOLOGY

Glycans from Fasciola hepatica Modulate the Host Immune Response and TLR-Induced Maturation of Dendritic Cells

(2015) Ernesto Rodríguez et al.   PLoS Neglected Tropical Diseases

What helminth genomes have taught us about parasite evolution

(2014) MAGDALENA ZAROWIECKI et al.   PARASITOLOGY

Secreted Proteins from the Helminth Fasciola hepatica Inhibit the Initiation of Autoreactive T Cell Responses and Prevent Diabetes in the NOD Mouse

(2014) Maria E. Lund et al.   PLoS One

Fasciola hepatica Kunitz Type Molecule Decreases Dendritic Cell Activation and Their Ability to Induce Inflammatory Responses

(2014) Cristian R. Falcón et al.   PLoS One

Eosinophils Are Important for Protection, Immunoregulation and Pathology during Infection with Nematode Microfilariae

(2014) Emma T. Cadman et al.   PLoS Pathogens

Immunomodulatory molecules of Fasciola hepatica: Candidates for both vaccine and immunotherapeutic development

(2013) John P. Dalton et al.   VETERINARY PARASITOLOGY

Cathelicidin-like Helminth Defence Molecules (HDMs): Absence of Cytotoxic, Anti-microbial and Anti-protozoan Activities Imply a Specific Adaptation to Immune Modulation

(2013) Karine Thivierge et al.   PLoS Neglected Tropical Diseases

Helminth defence molecules—immunomodulators designed by parasites!

(2013) Mark W. Robinson et al.   Frontiers in Microbiology

A helminth cathelicidin-like protein suppresses antigen processing and presentation in macrophages via inhibition of lysosomal vATPase

(2012) Mark W. Robinson et al.   FASEB JOURNAL

The Sigma Class Glutathione Transferase from the Liver Fluke Fasciola hepatica

(2012) E. James LaCourse et al.   PLoS Neglected Tropical Diseases

Human Schistosomiasis Is Associated with Endotoxemia and Toll-Like Receptor 2- and 4-Bearing B Cells

(2011) Daniel Onguru et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Molecular and immunological characterization of Fasciola antigens recognized by the MM3 monoclonal antibody

(2011) L. Muiño et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Probiotic helminth administration in relapsing–remitting multiple sclerosis: a phase 1 study

(2011) JO Fleming et al.   Multiple Sclerosis Journal

A Family of Helminth Molecules that Modulate Innate Cell Responses via Molecular Mimicry of Host Antimicrobial Peptides

(2011) Mark W. Robinson et al.   PLoS Pathogens

Survey of transcripts expressed by the invasive juvenile stage of the liver fluke Fasciola hepatica

(2010) Martín Cancela et al.   BMC GENOMICS

Helminth secretions induce de novo T cell Foxp3 expression and regulatory function through the TGF-β pathway

(2010) John R. Grainger et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Major Secretory Antigens of the Helminth Fasciola hepatica Activate a Suppressive Dendritic Cell Phenotype That Attenuates Th17 Cells but Fails To Activate Th2 Immune Responses

(2009) D. J. Dowling et al.   INFECTION AND IMMUNITY

Helminth Cysteine Proteases Inhibit TRIF-dependent Activation of Macrophages via Degradation of TLR3

(2009) Sheila Donnelly et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Infection with a Helminth Parasite Attenuates Autoimmunity through TGF- -Mediated Suppression of Th17 and Th1 Responses

(2009) K. P. Walsh et al.   JOURNAL OF IMMUNOLOGY

An Integrated Transcriptomics and Proteomics Analysis of the Secretome of the Helminth PathogenFasciola hepatica

(2009) Mark W. Robinson et al.   MOLECULAR & CELLULAR PROTEOMICS

The Importance of pH in Regulating the Function of the Fasciola hepatica Cathepsin L1 Cysteine Protease

(2009) Jonathan Lowther et al.   PLoS Neglected Tropical Diseases

Helminth 2-Cys peroxiredoxin drives Th2 responses through a mechanism involving alternatively activated macrophages

(2008) Sheila Donnelly et al.   FASEB JOURNAL

The roles of IL-10 and TGF-β in controlling IL-4 and IFN-γ production during experimental Fasciola hepatica infection

(2008) Robin J. Flynn et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Proteomics and Phylogenetic Analysis of the Cathepsin L Protease Family of the Helminth PathogenFasciola hepatica

(2008) Mark W. Robinson et al.   MOLECULAR & CELLULAR PROTEOMICS

Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets

(2008) Masato Furuhashi et al.   NATURE REVIEWS DRUG DISCOVERY