Article
Oncology
Cristina Vazquez-Carballo, Carmen Herencia, Melania Guerrero-Hue, Cristina Garcia-Caballero, Sandra Rayego-Mateos, Jose Luis Morgado-Pascual, Lucas Opazo-Rios, Cristian Gonzalez-Guerrero, Mercedes Vallejo-Mudarra, Isabel Cortegano, Maria Luisa Gaspar, Belen de Andres, Jesus Egido, Juan Antonio Moreno
Summary: Massive intravascular hemolysis leads to the release of large amounts of heme into circulation, causing damage to vulnerable organs such as the kidney, liver, and spleen. The study found that Toll-like receptor 4 (TLR4) is a key molecule involved in the renal inflammatory response triggered by hemolysis. Inhibition of TLR4 can alleviate kidney damage.
JOURNAL OF PATHOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jinlong Wei, Qin Zhao, Yuyu Zhang, Weiyan Shi, Huanhuan Wang, Zhuangzhuang Zheng, Lingbin Meng, Ying Xin, Xin Jiang
Summary: This study investigated the protective effect of sulforaphane on radiation-induced skin injury, finding that sulforaphane can suppress oxidative stress by upregulating the expression and function of Nrf2, thereby alleviating inflammation and DNA damage, and preventing and alleviating RISI.
Article
Biochemistry & Molecular Biology
Chand Basha Davuljigari, Frederick Adams Ekuban, Cai Zong, Alzahraa A. M. Fergany, Kota Morikawa, Gaku Ichihara
Summary: The activation of Nrf2 signaling pathway provides protection against acrylamide-induced neurotoxicity by suppressing oxidative stress and inflammation. Nrf2 remains an important target for the strategic prevention of acrylamide-induced neurotoxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Nutrition & Dietetics
Scott E. Liebman, Thu H. Le
Summary: This article discusses the impact of oxidative stress in chronic kidney disease and the role of the Nrf2 pathway in kidney disease, as well as the promising therapeutic potential of sulforaphane.
Article
Environmental Sciences
Zhiqiang Feng, Tengfei Wang, Yawen Sun, Siying Chen, Haisheng Hao, Weihua Du, Huiying Zou, Dawei Yu, Huabin Zhu, Yunwei Pang
Summary: Sulforaphane (SFN), extracted from cruciferous plants, plays a vital role in eliminating oxidative free radicals and protecting cells through activation of the Nrf2-mediated signaling pathway. This study found that SFN can attenuate paraquat-induced damage to bovine in vitro-matured oocytes and enhance their maturation and fertilization rates. SFN reduces oxidative stress, inhibits cell apoptosis, and activates antioxidative-related genes through the Nrf2 pathway, providing novel evidence for the protective role of SFN against paraquat-induced injury.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Medicine, Research & Experimental
Ya Zhang, Qifang Wu, Jian Liu, Zhongshan Zhang, Xiaojing Ma, Yaoyue Zhang, Jiawen Zhu, Ronald W. Thring, Mingjiang Wu, Yitian Gao, Haibin Tong
Summary: Sulforaphane extracted from high-risk diet can improve insulin resistance by increasing glucose uptake and insulin signaling.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biotechnology & Applied Microbiology
Liyuan Zhou, Changchen Hu, Yujun Li, Binquan Wang
Summary: This study investigated the therapeutic effect of Sulforaphane (SFP) on hypoxic vestibular vertigo (HVV) using a rat model. The results showed that SFP treatment helped to maintain the balance of escape latency and concentrations of nitric oxide (NO), glutathione (GSH) and superoxide dismutase (SOD), and restored the inhibited expression of NRF2. SFP treatment also increased the production of NO and cyclic guanosine monophosphate (cGMP) in a dose-dependent manner.
Article
Plant Sciences
Dan Sun, Shichao Cui, Haijian Ma, Pengfei Zhu, Ni Li, Xinwen Zhang, Lina Zhang, Lijiang Xuan, Jingya Li
Summary: This study validates the therapeutic effect of salvianolate on kidney injury caused by ischemia-reperfusion and explores its potential pharmacological mechanism. The results indicate that salvianolate effectively alleviates renal dysfunction, improves epithelial tubular injury, oxidative stress, and inflammatory response. Furthermore, salvianolate exerts anti-apoptotic effects through the activation of the Keap1-Nrf2-ARE signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Jose Angel Alonso-Pineiro, Almudena Gonzalez-Rovira, Ismael Sanchez-Gomar, Juan Antonio Moreno, Ma Carmen Duran-Ruiz
Summary: Atherosclerosis, the underlying cause of cardiovascular diseases and high mortality rates, progresses with the formation of atherosclerotic plaques due to oxidative stress. Strategies aimed at reducing oxidative damage, including the use of antioxidant molecules such as Nrf2 and HO-1, have been studied to inhibit the progression of atherosclerosis.
Article
Endocrinology & Metabolism
Takayuki Nabeshima, Manabu Tsukamoto, Ke-Yong Wang, Yosuke Mano, Daisuke Arakawa, Kenji Kosugi, Takafumi Tajima, Yoshiaki Yamanaka, Hitoshi Suzuki, Makoto Kawasaki, Soshi Uchida, Eiichiro Nakamura, Kagaku Azuma, Akinori Sakai
Summary: The effect of COPD pathogenesis on bone fracture healing is unclear. This study found that delayed bone healing and impaired nuclear translocation of Nrf2 are involved in the delayed cortical bone healing in COPD mice. Sulforaphane, an Nrf2 activator, improved the delayed cortical bone healing in the mice model. These findings suggest that Nrf2 may be a potential target for bone fracture treatment in COPD patients.
Article
Biochemistry & Molecular Biology
Marija Petkovic, Ermelindo C. Leal, Ines Alves, Chanda Bose, Philip T. Palade, Preeti Singh, Sanjay Awasthi, Elisabet Borsheim, Louise T. Dalgaard, Sharda P. Singh, Eugenia Carvalho
Summary: The study found that dietary supplementation with SFN increased antioxidant capacities and gene expression related to the Nrf2 pathway in the skin of old mice. Protein levels for Nrf2 were also increased, while ROS and MMP9 levels decreased significantly. Furthermore, collagen deposition was improved in young mice and significantly improved in old mice with SFN treatment, indicating that SFN can ameliorate skin aging.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Razia Sultana Mohammad, Mustafa F. Lokhandwala, Anees A. Banday
Summary: Age is a risk factor for chronic diseases, including kidney diseases. Oxidative stress and mitochondrial dysfunction play a pathogenic role in aging kidney disease. Activation of the NRF2 signaling pathway can improve kidney and mitochondrial function in aged rats.
Review
Engineering, Biomedical
Ivan S. Pires, Francois Berthiaume, Andre F. Palmer
Summary: Hemolysis can lead to the accumulation of cell-free hemoglobin, heme, and iron in the circulation, causing various side effects. Different therapeutic strategies are being developed, including supplementation with plasma scavenger proteins and engineered protein constructs. This review provides an overview of hemolysis, plasma-derived protein scavengers, and novel engineering approaches to address the toxicity of hemolytic by-products.
ANNUAL REVIEW OF BIOMEDICAL ENGINEERING
(2023)
Article
Cell Biology
Huanhuan Wang, Ge Yang, Yuan Tian, Jinjie Li, Lingbin Meng, Xin Jiang, Ying Xin
Summary: Sulforaphane (SFN) prevents angiotensin II-induced cardiomyocyte apoptosis by activating Nrf2 and inhibiting HDACs, leading to increased histone H3 acetylation levels.
Article
Biochemistry & Molecular Biology
Sarah Tauber, Maria Katharina Sieckmann, Katrin Erler, Wilhelm Stahl, Lars-Oliver Klotz, Holger Steinbrenner
Summary: The study found that the Se status had no major effect on Nrf2 signaling in HepG2 cells, although electrophiles could enhance the expression of Nrf2 target genes independent of cellular Se status.
Editorial Material
Transplantation
Alberto Ortiz, Francesco Mattace-Raso, Maria Jose Soler, Denis Fouque
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Transplantation
Jilske A. Huijben, Anneke Kramer, Julia Kerschbaum, Johan de Meester, Frederic Collart, Olga Lucia Rodriguez Arevalo, Jaakko Helve, Mathilde Lassalle, Runolfur Palsson, Marc ten Dam, Anna Casula, Shona Methven, Alberto Ortiz, Pietro Manuel Ferraro, Marten Segelmark, Pablo Ucio Mingo, Mustafa Arici, Anna Varberg Reisaeter, Maria Stendahl, Vianda S. Stel, Kitty J. Jager
Summary: This study describes the trends in incidence, prevalence, and survival of patients on kidney replacement therapy (KRT) for end-stage kidney disease (ESKD) in Europe from 2008 to 2017. The incidence of KRT remained stable initially but increased slightly in recent years, primarily driven by an increase in older male patients. Diabetes mellitus was found to be a leading cause of kidney failure. The prevalence of KRT increased over the study period, and patient survival on KRT improved.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Editorial Material
Transplantation
Alberto Ortiz, Christoph Wanner, Ron Gansevoort
Summary: The European Society of Cardiology 2021 guideline on cardiovascular disease prevention has significant implications for CV risk screening and kidney health. The guideline proposes specific strategies for individuals with established CVD, diabetes, hypercholesterolemia, or CKD. This includes the assessment of albuminuria as an entry-level step in CVD risk assessment, which could change current clinical practice. Further research is needed to determine the optimal method for CV risk assessment, including CKD assessment in the general population.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Transplantation
Rianne Boenink, Anneke Kramer, Rosalie E. Tuinhout, Emilie Savoye, Anders Asberg, Alma Idrizi, Julia Kerschbaum, Ieva Ziedina, Edita Ziginskiene, Emanuel Farrugia, Liliana Garneata, Elena Zakharova, Samira Bell, Miha Arnol, Marten Segelmark, Kyriakos Ioannou, Kristine Hommel, Mai Rosenberg-Ots, Evgueniy Vazelov, Jaakko Helve, Sandor Mihaly, Runolfur Palsson, Maurizio Nordio, Nikola Gjorgjievski, Aiko P. J. de Vries, Nurhan Seyahi, Winnie A. Magadi, Halima Resic, Aleh Kalachyk, Axel O. Rahmel, Ana A. Galvao, Radomir Naumovic, Torbjörn Lundgren, Mustafa Arici, Johan M. de Meester, Alberto Ortiz, Kitty J. Jager, Vianda S. Stel
Summary: This study aimed to analyze the trends in kidney transplantation rates in European countries. The results showed an overall increase in kidney transplantation rates from 2010 to 2018, including both deceased donor and living donor transplants, with substantial variations among different countries.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Editorial Material
Transplantation
Giovanni Gambaro, Lazaros Tzelves, Andreas Skolarikos, Mehmet Kanbay, Alberto Ortiz, Mario Cozzolino
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Transplantation
Borja Quiroga, Maria Jose Soler, Alberto Ortiz, Carlos Jesus Jarava Mantecon, Virginia Olinda Gomes Perez, Antoni Bordils, Jose Lacueva, Antonio Jose Marin Franco, Pablo Delgado Conde, Patricia Munoz Ramos, Carmen Calderon Gonzalez, Juan Manuel Cazorla Lopez, Jinny Sanchez-Rodriguez, Ana Sanchez Horrillo, Tania Raquel Monzon Vazquez, Alba Leyva, Jose Rojas, Ron T. Gansevoort, Patricia de Sequera
Summary: This study evaluated the humoral response and effectiveness of the fourth dose of COVID-19 vaccines in chronic kidney disease (CKD) patients. The fourth dose increased antibody levels in CKD patients undergoing hemodialysis and non-dialysis CKD patients, and seroconverted previously negative patients. However, CKD patients with lower pre-booster antibody titres or kidney transplant recipients derived the least benefit in terms of antibody levels.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Endocrinology & Metabolism
Jason Mighty, Alfonso Rubio-Navarro, Cui Shi, Jing Zhou, Miguel Flores-Bellver, Soren Heissel, Onyekwere Onwumere, Linda Einbond, Rajendra Gharbaran, Daniel S. Casper, Alberto Benito-Martin, Stephen Redenti
Summary: Diabetic Retinopathy (DR) is a retinal disorder caused by diabetes. The lack of disease predictors makes the prognosis poor, leading to irreversible retinal damage and vision loss. Extracellular Vesicles (EVs) have the potential to be used as pre-symptomatic biomarkers for DR. EV proteins derived from urine may serve as noninvasive biomarkers.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Urology & Nephrology
Victor Martinez, Monica Furlano, Laia Sans, Lissett Pulido, Rebeca Garcia, Maria Vanessa Perez-Gomez, Jinny Sanchez-Rodriguez, Miquel Blasco, Cristina Castro-Alonso, Gema Fernandez-Fresnedo, Nicolas Roberto Robles, Maria Pau Valenzuela, Javier Naranjo, Nadia Martin, Melissa Pilco, Irene Agraz-Pamplona, Juan David Gonzalez-Rodriguez, Nayara Panizo, Gloria Fraga, Loreto Fernandez, Maria Teresa Lopez, Cecilia Dall'Anese, Alberto Ortiz, Roser Torra, Luis Marcas, Asuncion Rius, Patricia Tomas, Leonor Garcia, Enrique Luna, Maria Adoracion Martin, Pablo Inigo, Judith Martins, Fernanda Ramos, Rosa Garcia, Laura del Rio Garcia, Maria del Carmen Merino, M. Jose Fernandez-Reyes, Leire Madariaga, Cristina Canal, Ana Maria Martinez, Rocio Echarri, Hanane Bouarich, Antonio Cabezas
Summary: This study analyzed the clinical characteristics of autosomal dominant polycystic kidney disease (ADPKD) in young adults and found that they have a higher morbidity rate. This highlights the importance of comprehensive assessment for young individuals at risk of ADPKD, in order to enable early diagnosis and treatment of hypertension.
CLINICAL KIDNEY JOURNAL
(2023)
Review
Urology & Nephrology
Mehmet Kanbay, Sidar Copur, Berk Mizrak, Alberto Ortiz, Maria Jose Soler
Summary: Acute kidney injury (AKI) is a common condition in hospitalized patients, with risk factors including postoperative settings, baseline chronic kidney disease (CKD), and congestive heart failure. Intravenous (IV) fluid therapy is an essential component of AKI prevention and treatment. This review discusses the timing, fluid type, amount, and infusion rate of IV fluid therapy in hospitalized patients, as well as the potential adverse effects of different crystalloid and colloid solutions, specifically in patients with AKI, CKD, or heart failure, and their impact on the risk of hospital-acquired AKI.
CLINICAL KIDNEY JOURNAL
(2023)
Review
Biochemistry & Molecular Biology
Nerea Mendez-Barbero, Jorge Oller, Ana B. Sanz, Adrian M. Ramos, Alberto Ortiz, Marta Ruiz-Ortega, Sandra Rayego-Mateos
Summary: Cardiovascular disease (CVD) often accompanies chronic kidney disease (CKD), and patients with both conditions have an increased risk of all-cause mortality ranging from 20% to 500%. Maintaining mitochondrial homeostasis appears to be a promising therapeutic strategy for the cardio-renal syndrome (CRS). This review explores the role of mitochondrial dysfunction in cardiovascular and renal diseases and how it may guide the development of novel therapeutic strategies for CRS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Flavia Trionfetti, Vanessa Marchant, Guadalupe. T. T. Gonzalez-Mateo, Edyta Kawka, Laura Marquez-Exposito, Alberto Ortiz, Manuel Lopez-Cabrera, Marta Ruiz-Ortega, Raffaele Strippoli
Summary: The global incidence of chronic kidney disease (CKD) is increasing, leading to a significant number of CKD patients developing end-stage renal disease (ESRD) and requiring kidney replacement therapies (KRT). Peritoneal dialysis (PD) is a convenient home therapy for KRT, but it can lead to damage of the peritoneal membrane (PM) due to the exposure to PD fluids containing high concentrations of glucose or other osmotic agents. This damage involves inflammation and fibrosis, which can be worsened by peritonitis episodes. In this article, we review the role of immune cells in PM damage during KRT and infections, as well as the anti-inflammatory properties of current clinical treatments for CKD patients in KRT and their potential effect on preserving PM integrity. Additionally, we discuss the implications of COVID-19 in CKD and KRT.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Alfonso Rubio-Navarro, Nicolas Gomez-Banoy, Lisa Stoll, Friederike Dundar, Alex M. Mawla, Lunkun Ma, Eric Cortada, Paul Zumbo, Ang Li, Moritz Reiterer, Nathalia Montoya-Oviedo, Edwin A. Homan, Norihiro Imai, Ankit Gilani, Chengyang Liu, Ali Naji, Boris Yang, Angie Chi Nok Chong, David E. Cohen, Shuibing Chen, Jingli Cao, Geoffrey S. Pitt, Mark O. Huising, Doron Betel, James C. C. Lo
Summary: The pancreatic islets consist of hormone-producing cells that regulate systemic glucose balance. A subset of beta cells marked by high CD63 levels exhibits enhanced mitochondrial metabolism and insulin secretion. CD63-high beta cells are reduced in mouse models and humans with type 2 diabetes. Transplantation of CD63-high beta cell-derived pseudo-islets restores glucose homeostasis in diabetic mice.
NATURE CELL BIOLOGY
(2023)
Editorial Material
Pharmacology & Pharmacy
Zeba Farooqui, Juan Antonio Moreno, Alfonso Rubio-Navarro
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Maria D. Sanchez-Nino, Maria I. Ceballos, Sol Carriazo, Aranzazu Pintor-Chocano, Ana B. Sanz, Moin A. Saleem, Alberto Ortiz
Summary: The interaction between diabetes and Fabry disease may increase the severity of kidney damage by modulating the Gb3 synthesis pathway and downregulating kidney protective genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Alvaro Morales-Molina, Miguel angel Rodriguez-Milla, Stefano Gambera, Teresa Cejalvo, Belen de Andres, Maria-Luisa Gaspar, Javier Garcia-Castro
Summary: Cancer immunotherapy aims to activate the immune system and deliver immunotherapeutic agents to tumors using carrier cells. This study found that using carrier cells with a low proinflammatory profile resulted in better tumor homing and improved antitumor responses, highlighting the importance of selecting appropriate cells for cell-based therapies in cancer treatment.
CANCER RESEARCH COMMUNICATIONS
(2023)