Obesity Genomics and Metabolomics: a Nexus of Cardiometabolic Risk

Heart Disease and Stroke Statistics—2020 Update: A Report From the American Heart Association

(2020) Salim S. Virani et al.   CIRCULATION

Metabolic profiling of tissue-specific insulin resistance in human obesity: results from the Diogenes study and the Maastricht Study

(2020) Nicole Vogelzangs et al.   INTERNATIONAL JOURNAL OF OBESITY

Leptin-mediated changes in the human metabolome

(2020) Katherine Lawler et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Use of genetic variation to separate the effects of early and later life adiposity on disease risk: mendelian randomisation study

(2020) Tom G Richardson et al.   BMJ-British Medical Journal

Tryptophan Metabolic Pathways Are Altered in Obesity and Are Associated With Systemic Inflammation

(2020) Sofia Cussotto et al.   Frontiers in Immunology

Relation of Whole Blood Amino Acid and Acylcarnitine Metabolome to Age, Sex, BMI, Puberty, and Metabolic Markers in Children and Adolescents

(2020) Josephin Hirschel et al.   Metabolites

Exome Sequencing Identifies Genes and Gene Sets Contributing to Severe Childhood Obesity, Linking PHIP Variants to Repressed POMC Transcription

(2020) Gaëlle Marenne et al.   Cell Metabolism

Metabolomic and genetic associations with insulin resistance in pregnancy

(2020) Yu Liu et al.   DIABETOLOGIA

A Description of Risk Factors for Non-alcoholic Fatty Liver Disease in the Southern Community Cohort Study: A Nested Case-Control Study

(2020) Sudipa Sarkar et al.   Frontiers in Nutrition

Branched-chain amino acids in disease

(2019) Phillip J. White et al.   SCIENCE

Polygenic Prediction of Weight and Obesity Trajectories from Birth to Adulthood

(2019) Amit V. Khera et al.   CELL

Whole exome sequencing reveals novel LEPR frameshift mutation in severely obese children from Western India

(2019) Arpan Bhatt et al.   Molecular Genetics & Genomic Medicine

Body mass index and body composition in relation to 14 cardiovascular conditions in UK Biobank: a Mendelian randomization study

(2019) Susanna C Larsson et al.   EUROPEAN HEART JOURNAL

Genetic predictors of weight loss in overweight and obese subjects

(2019) Itziar Lamiquiz-Moneo et al.   Scientific Reports

Plasma High‐Resolution Metabolomics Differentiates Adults with Normal Weight Obesity from Lean Individuals

(2019) Moriah P. Bellissimo et al.   Obesity

Causal relationships between obesity and the leading causes of death in women and men

(2019) Jenny C. Censin et al.   PLoS Genetics

Dietary branched-chain amino acid restriction alters fuel selection and reduces triglyceride stores in hearts of Zucker fatty rats

(2019) Robert W. McGarrah et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Metabolomic Profiles of Overweight/Obesity Phenotypes During Adolescence: A Cross‐Sectional Study in Project Viva

(2019) Wei Perng et al.   Obesity

The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase

(2018) Phillip J. White et al.   Cell Metabolism

The case of GWAS of obesity: does body weight control play by the rules?

(2018) Manfred J. Müller et al.   INTERNATIONAL JOURNAL OF OBESITY

Toward Precision Approaches for the Prevention and Treatment of Obesity

(2018) Susan Z. Yanovski et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Effect of Low-Fat vs Low-Carbohydrate Diet on 12-Month Weight Loss in Overweight Adults and the Association With Genotype Pattern or Insulin Secretion

(2018) Christopher D. Gardner et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Obesity-Related Metabolomic Profiles and Discrimination of Metabolically Unhealthy Obesity

(2018) Minoo Bagheri et al.   JOURNAL OF PROTEOME RESEARCH

Serum Metabolomics of Activity Energy Expenditure and its Relation to Metabolic Syndrome and Obesity

(2018) Marie S. A. Palmnäs et al.   Scientific Reports

Evidence for a strong genetic influence on childhood adiposity despite the force of the obesogenic environment

(2018) Jane Wardle et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

OUP accepted manuscript

(2018)   AMERICAN JOURNAL OF CLINICAL NUTRITION

Critical Enzymatic Functions of FTO in Obesity and Cancer

(2018) Xiaolan Deng et al.   Frontiers in Endocrinology

Profound Perturbation of the Metabolome in Obesity Is Associated with Health Risk

(2018) Elizabeth T. Cirulli et al.   Cell Metabolism

Maternal metabolites during pregnancy are associated with newborn outcomes and hyperinsulinaemia across ancestries

(2018) Rachel Kadakia et al.   DIABETOLOGIA

Association of Genetic Variants Related to Gluteofemoral vs Abdominal Fat Distribution With Type 2 Diabetes, Coronary Disease, and Cardiovascular Risk Factors

(2018) Luca A. Lotta et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

(2018) Jeffrey D Stanaway et al.   LANCET

Genetics and epigenetics in obesity

(2018) Kerstin Rohde et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Genetic Susceptibility for Childhood BMI has no Impact on Weight Loss Following Lifestyle Intervention in Danish Children

(2018) Mette Hollensted et al.   Obesity

Association of BMI with overall and cause-specific mortality: a population-based cohort study of 3·6 million adults in the UK

(2018) Krishnan Bhaskaran et al.   Lancet Diabetes & Endocrinology

Body mass index, abdominal fatness, fat mass and the risk of atrial fibrillation: a systematic review and dose–response meta-analysis of prospective studies

(2017) Dagfinn Aune et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

Trans-ethnic fine-mapping of genetic loci for body mass index in the diverse ancestral populations of the Population Architecture using Genomics and Epidemiology (PAGE) Study reveals evidence for multiple signals at established loci

(2017) Lindsay Fernández-Rhodes et al.   HUMAN GENETICS

Gene–obesogenic environment interactions in the UK Biobank study

(2017) Jessica Tyrrell et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Genetic Association of Waist-to-Hip Ratio With Cardiometabolic Traits, Type 2 Diabetes, and Coronary Heart Disease

(2017) Connor A. Emdin et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Genome-wide association study identifies 112 new loci for body mass index in the Japanese population

(2017) Masato Akiyama et al.   NATURE GENETICS

The Ala55Val and -866G>A polymorphisms of the UCP2 gene could be biomarkers for weight loss in patients who had Roux-en-Y gastric bypass

(2017) Carolina F. Nicoletti et al.   NUTRITION

A systematic review of genetic syndromes with obesity

(2017) Y. Kaur et al.   Obesity Reviews

Assessment of plasma acylcarnitines before and after weight loss in obese subjects

(2016) Marieke G. Schooneman et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Nutrigenomics, the Microbiome, and Gene-Environment Interactions: New Directions in Cardiovascular Disease Research, Prevention, and Treatment

(2016) Jane F. Ferguson et al.   Circulation-Cardiovascular Genetics

Whole-Exome Sequencing SuggestsLAMB3as a Susceptibility Gene for Morbid Obesity

(2016) Hong Jiao et al.   DIABETES

Associations of maternal BMI and insulin resistance with the maternal metabolome and newborn outcomes

(2016) Victoria Sandler et al.   DIABETOLOGIA

Mutations inC8ORF37cause Bardet Biedl syndrome (BBS21)

(2016) Elise Heon et al.   HUMAN MOLECULAR GENETICS

Lipidomics Reveals Associations of Phospholipids With Obesity and Insulin Resistance in Young Adults

(2016) Sebastian Rauschert et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Identification of a novel mutation confirms the implication of IFT172 (BBS20) in Bardet–Biedl syndrome

(2016) Elise Schaefer et al.   JOURNAL OF HUMAN GENETICS

The association between body mass index and preeclampsia: a meta-analysis

(2016) Jalal Poorolajal et al.   Journal of Maternal-Fetal & Neonatal Medicine

Association of Plasma Small-Molecule Intermediate Metabolites With Age and Body Mass Index Across Six Diverse Study Populations

(2016) William E. Kraus et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Venous thromboembolism has the same risk factors as atherosclerosis

(2016) Yuhong Mi et al.   MEDICINE

Human gut microbes impact host serum metabolome and insulin sensitivity

(2016) Helle Krogh Pedersen et al.   NATURE

Body-Mass Index in 2.3 Million Adolescents and Cardiovascular Death in Adulthood

(2016) Gilad Twig et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Genome-Wide Association Study in isolated populations reveals new genes associated to common food likings

(2016) Nicola Pirastu et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Decreased Consumption of Branched-Chain Amino Acids Improves Metabolic Health

(2016) Luigi Fontana et al.   Cell Reports

Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis

(2016) Luca A. Lotta et al.   PLOS MEDICINE

Nutrigenomics, the Microbiome, and Gene-Environment Interactions: New Directions in Cardiovascular Disease Research, Prevention, and Treatment

(2016) Jane F. Ferguson et al.   Circulation-Cardiovascular Genetics

Using Metabolomic Profiles as Biomarkers for Insulin Resistance in Childhood Obesity: A Systematic Review

(2016) Xue Zhao et al.   Journal of Diabetes Research

Branched-chain amino acid restriction in Zucker-fatty rats improves muscle insulin sensitivity by enhancing efficiency of fatty acid oxidation and acyl-glycine export

(2016) Phillip J. White et al.   Molecular Metabolism

Dominance Genetic Variation Contributes Little to the Missing Heritability for Human Complex Traits

(2015) Zhihong Zhu et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Personalized Nutrition by Prediction of Glycemic Responses

(2015) David Zeevi et al.   CELL

Bardet-Biedl syndrome: Is it only cilia dysfunction?

(2015) Rossina Novas et al.   FEBS LETTERS

The metabolome profiling and pathway analysis in metabolic healthy and abnormal obesity

(2015) H-H Chen et al.   INTERNATIONAL JOURNAL OF OBESITY

Metabolomic Profile Associated With Insulin Resistance and Conversion to Diabetes in the Insulin Resistance Atherosclerosis Study

(2015) Nicholette D. Palmer et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Genetic studies of body mass index yield new insights for obesity biology

(2015) Adam E. Locke et al.   NATURE

Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index

(2015) Jian Yang et al.   NATURE GENETICS

FTO Obesity Variant Circuitry and Adipocyte Browning in Humans

(2015) Melina Claussnitzer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Weight change in the first 2 months of a lifestyle intervention predicts weight changes 8 years later

(2015) Jessica L. Unick et al.   Obesity

Metabolomic analysis reveals altered skeletal muscle amino acid and fatty acid handling in obese humans

(2015) Peter R. Baker et al.   Obesity

Childhood obesity as a predictor of morbidity in adulthood: a systematic review and meta-analysis

(2015) A. Llewellyn et al.   Obesity Reviews

Acylcarnitines activate proinflammatory signaling pathways

(2014) Jennifer M. Rutkowsky et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Genetics of the human metabolome, what is next?

(2014) Harish Dharuri et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Hypomorphism for RPGRIP1L, a Ciliary Gene Vicinal to the FTO Locus, Causes Increased Adiposity in Mice

(2014) George Stratigopoulos et al.   Cell Metabolism

Prepregnancy body mass index is an independent risk factor for gestational hypertension, gestational diabetes, preterm labor, and small- and large-for-gestational-age infants

(2014) Dayeon Shin et al.   Journal of Maternal-Fetal & Neonatal Medicine

Obesity-associated variants within FTO form long-range functional connections with IRX3

(2014) Scott Smemo et al.   NATURE

Measuring missing heritability: Inferring the contribution of common variants

(2014) David Golan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fried food consumption, genetic risk, and body mass index: gene-diet interaction analysis in three US cohort studies

(2014) Q. Qi et al.   BMJ-British Medical Journal

Whole Exome Sequencing of Extreme Morbid Obesity Patients: Translational Implications for Obesity and Related Disorders

(2014) Gilberto Paz-Filho et al.   Genes

Weight Loss after Gastric Bypass Is Associated with a Variant at 15q26.1

(2013) Ida J. Hatoum et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Validation of the association between a branched chain amino acid metabolite profile and extremes of coronary artery disease in patients referred for cardiac catheterization

(2013) Sayanti Bhattacharya et al.   ATHEROSCLEROSIS

Genetics of nonsyndromic obesity

(2013) Yung Seng Lee   CURRENT OPINION IN PEDIATRICS

Effect of Roux-en-Y Gastric Bypass and Laparoscopic Adjustable Gastric Banding on Branched-Chain Amino Acid Metabolism

(2013) Faidon Magkos et al.   DIABETES

Excess S-adenosylmethionine reroutes phosphatidylethanolamine towards phosphatidylcholine and triglyceride synthesis

(2013) Maite Martínez-Uña et al.   HEPATOLOGY

Association of All-Cause Mortality With Overweight and Obesity Using Standard Body Mass Index Categories

(2013) Katherine M. Flegal et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Weight Change and Health Outcomes at 3 Years After Bariatric Surgery Among Individuals With Severe Obesity

(2013) Anita P. Courcoulas   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Association Between Duration of Overall and Abdominal Obesity Beginning in Young Adulthood and Coronary Artery Calcification in Middle Age

(2013) Jared P. Reis et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A link between FTO, ghrelin, and impaired brain food-cue responsivity

(2013) Efthimia Karra et al.   JOURNAL OF CLINICAL INVESTIGATION

Plasma lipid profiling in a large population-based cohort

(2013) Jacquelyn M. Weir et al.   JOURNAL OF LIPID RESEARCH

2013 AHA/ACC/TOS Guideline for the Management of Overweight and Obesity in Adults

(2013) Michael D. Jensen et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Branched chain amino acids are novel biomarkers for discrimination of metabolic wellness

(2013) Bryan C. Batch et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Whole-Exome sequencing identifies novelLEPRmutations in individuals with severe early onset obesity

(2013) Richard Gill et al.   Obesity

Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice

(2013) V. K. Ridaura et al.   SCIENCE

Five Years of GWAS Discovery

(2012) Peter M. Visscher et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Obesity-related hypertension and its remission following gastric bypass surgery – A review of the mechanisms and predictive factors

(2012) Simon Timothy adams et al.   BLOOD PRESSURE

Interplay between Lipids and Branched-Chain Amino Acids in Development of Insulin Resistance

(2012) Christopher B. Newgard   Cell Metabolism

Television Watching, Leisure Time Physical Activity, and the Genetic Predisposition in Relation to Body Mass Index in Women and Men

(2012) Qibin Qi et al.   CIRCULATION

Acylcarnitines

(2012) Marieke G. Schooneman et al.   DIABETES

Health Benefits of Gastric Bypass Surgery After 6 Years

(2012) Ted D. Adams et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010

(2012) Stephen S Lim et al.   LANCET

Sugar-Sweetened Beverages and Genetic Risk of Obesity

(2012) Qibin Qi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Bariatric Surgery versus Intensive Medical Therapy in Obese Patients with Diabetes

(2012) Philip R. Schauer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Childhood Obesity Is Associated with Changes in the Serum Metabolite Profile

(2012) Simone Wahl et al.   Obesity Facts

Metabolomic Profiling Reveals Mitochondrial-Derived Lipid Biomarkers That Drive Obesity-Associated Inflammation

(2012) Brante P. Sampey et al.   PLoS One

Plasma Lysophosphatidylcholine Levels Are Reduced in Obesity and Type 2 Diabetes

(2012) Melissa N. Barber et al.   PLoS One

Association between cardiovascular disease risk factors and occurrence of venous thromboembolism

(2012) Pamela L. Lutsey et al.   THROMBOSIS AND HAEMOSTASIS

Genome-wide association studies with metabolomics

(2012) Jerzy Adamski   Genome Medicine

Branching Out for Detection of Type 2 Diabetes

(2011) Svati H. Shah et al.   Cell Metabolism

Branched-chain amino acid levels are associated with improvement in insulin resistance with weight loss

(2011) S. H. Shah et al.   DIABETOLOGIA

Genome partitioning of genetic variation for complex traits using common SNPs

(2011) Jian Yang et al.   NATURE GENETICS

Metabolite profiles and the risk of developing diabetes

(2011) Thomas J Wang et al.   NATURE MEDICINE

Problems in identifying predictors and correlates of weight loss and maintenance: implications for weight control therapies based on behaviour change

(2011) J. Stubbs et al.   Obesity Reviews

Differential Metabolic Impact of Gastric Bypass Surgery Versus Dietary Intervention in Obese Diabetic Subjects Despite Identical Weight Loss

(2011) B. Laferrere et al.   Science Translational Medicine

Physical Activity Attenuates the Influence of FTO Variants on Obesity Risk: A Meta-Analysis of 218,166 Adults and 19,268 Children

(2011) Tuomas O. Kilpeläinen et al.   PLOS MEDICINE

Association of a Peripheral Blood Metabolic Profile With Coronary Artery Disease and Risk of Subsequent Cardiovascular Events

(2010) Svati H. Shah et al.   Circulation-Cardiovascular Genetics

Comparison of waist-to-hip ratio and other obesity indices as predictors of cardiovascular disease risk in people with type-2 diabetes: a prospective cohort study from ADVANCE

(2010) Sébastien Czernichow et al.   EUROPEAN JOURNAL OF CARDIOVASCULAR PREVENTION & REHABILITATION

The obesity-associated SNPs in intron 1 of the FTO gene affect primary transcript levels

(2010) Tea Berulava et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

(2010) Elizabeth K Speliotes et al.   NATURE GENETICS

Increased Levels of Plasma Acylcarnitines in Obesity and Type 2 Diabetes and Identification of a Marker of Glucolipotoxicity

(2010) Stephanie J. Mihalik et al.   Obesity

Laparoscopic Roux-en-Y gastric bypass: 10-year follow-up

(2010) Kelvin Higa et al.   Surgery for Obesity and Related Diseases

Genomic insights into early-onset obesity

(2010) Hélène Choquet et al.   Genome Medicine

A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance

(2009) Christopher B. Newgard et al.   Cell Metabolism

Relationships Between Circulating Metabolic Intermediates and Insulin Action in Overweight to Obese, Inactive Men and Women

(2009) K. M. Huffman et al.   DIABETES CARE

Lysophosphatidylcholine Activates Adipocyte Glucose Uptake and Lowers Blood Glucose Levels in Murine Models of Diabetes

(2009) Kyungmoo Yea et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies

(2009) Prospective Studies Collaboration   LANCET

Plasma LCAT Activity and Lipid Subfraction Composition in Obese Beagles Undergoing Weight Loss

(2009) Rebecca Angell et al.   LIPIDS

Inactivation of the Fto gene protects from obesity

(2009) Julia Fischer et al.   NATURE

A genome-wide perspective of genetic variation in human metabolism

(2009) Thomas Illig et al.   NATURE GENETICS

Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations

(2009) David Meyre et al.   NATURE GENETICS

The Obese Without Cardiometabolic Risk Factor Clustering and the Normal Weight With Cardiometabolic Risk Factor Clustering

(2008) Rachel P. Wildman   ARCHIVES OF INTERNAL MEDICINE

The Impact of Obesity on Cardiovascular Disease Risk Factors and Subclinical Vascular Disease

(2008) Gregory L. Burke et al.   ARCHIVES OF INTERNAL MEDICINE

Mitochondrial Overload and Incomplete Fatty Acid Oxidation Contribute to Skeletal Muscle Insulin Resistance

(2008) Timothy R. Koves et al.   Cell Metabolism

Heritability of body size and muscle strength in young adulthood: a study of one million Swedish men

(2008) Karri Silventoinen et al.   GENETIC EPIDEMIOLOGY

Effect of Weight Loss by Gastric Bypass SurgeryVersusHypocaloric Diet on Glucose and Incretin Levels in Patients with Type 2 Diabetes

(2008) Blandine Laferrère et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Variations in DNA elucidate molecular networks that cause disease

(2008) Yanqing Chen et al.   NATURE

Common variants near MC4R are associated with fat mass, weight and risk of obesity

(2008) Ruth J F Loos et al.   NATURE GENETICS

Cellular cholesterol trafficking and compartmentalization

(2008) Elina Ikonen   NATURE REVIEWS MOLECULAR CELL BIOLOGY

TheFTOGene Is Associated With Adulthood Obesity in the Mexican Population

(2008) Marisela Villalobos-Comparán et al.   Obesity

Mutations in ligands and receptors of the leptin–melanocortin pathway that lead to obesity

(2008) I Sadaf Farooqi et al.   Nature clinical practice. Endocrinology & metabolism