Endothelial TGF-β signaling instructs smooth muscle cell development in the cardiac outflow tract

Focal adhesions are essential to drive zebrafish heart valve morphogenesis

(2019) Felix Gunawan et al.   JOURNAL OF CELL BIOLOGY

Genetic compensation triggered by mutant mRNA degradation

(2019) Mohamed A. El-Brolosy et al.   NATURE

Single-Cell RNA-Seq of the Developing Cardiac Outflow Tract Reveals Convergent Development of the Vascular Smooth Muscle Cells

(2019) Xuanyu Liu et al.   Cell Reports

Mechanically activated piezo channels modulate outflow tract valve development through the Yap1 and Klf2-Notch signaling axis

(2019) Anne-Laure Duchemin et al.   eLife

Activated Endothelial TGFβ1 Signaling Promotes Venous Thrombus Non-Resolution in Mice Via Endothelin-1: Potential Role for Chronic Thromboembolic Pulmonary Hypertension

(2019) Magdalena Ludmila Bochenek et al.   CIRCULATION RESEARCH

Mechanistic insight into contextual TGF-β signaling

(2018) Ying E Zhang   CURRENT OPINION IN CELL BIOLOGY

Pericyte ALK5/TIMP3 Axis Contributes to Endothelial Morphogenesis in the Developing Brain

(2018) Jui M. Dave et al.   DEVELOPMENTAL CELL

The in-silico zebrafish matrisome: A new tool to study extracellular matrix gene and protein functions

(2018) Pauline Nauroy et al.   MATRIX BIOLOGY

Endothelium as a Potential Target for Treatment of Abdominal Aortic Aneurysm

(2018) Jingyuan Sun et al.   Oxidative Medicine and Cellular Longevity

HHEX is a transcriptional regulator of the VEGFC/FLT4/PROX1 signaling axis during vascular development

(2018) Sébastien Gauvrit et al.   Nature Communications

Continuous addition of progenitors forms the cardiac ventricle in zebrafish

(2018) Anastasia Felker et al.   Nature Communications

Cardiac Remodeling: Endothelial Cells Have More to Say Than Just NO

(2018) Vincent F. M. Segers et al.   Frontiers in Physiology

TGF-β Signaling-Related Genes and Thoracic Aortic Aneurysms and Dissections

(2018) Norifumi Takeda et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris

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Screening for insulin-independent pathways that modulate glucose homeostasis identifies androgen receptor antagonists

(2018) Sri Teja Mullapudi et al.   eLife

The flow responsive transcription factor Klf2 is required for myocardial wall integrity by modulating Fgf signaling

(2018) Seyed Javad Rasouli et al.   eLife

Reduced aggrecan expression affects cardiac outflow tract development in zebrafish and is associated with bicuspid aortic valve disease in humans

(2017) Pierre Rambeau et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

TGF-β Signaling in Control of Cardiovascular Function

(2017) Marie-José Goumans et al.   Cold Spring Harbor Perspectives in Biology

Opposite effects of Activin type 2 receptor ligands on cardiomyocyte proliferation during development and repair

(2017) Deepika Dogra et al.   Nature Communications

Regulation of cardiomyocyte behavior in zebrafish trabeculation by Neuregulin 2a signaling

(2017) S. Javad Rasouli et al.   Nature Communications

Visualizing the structure of RNA-seq expression data using grade of membership models

(2017) Kushal K. Dey et al.   PLoS Genetics

Genetic and Epigenetic Regulation of Aortic Aneurysms

(2017) Ha Won Kim et al.   Biomed Research International

Thoracic Aortic Aneurysm Development in Patients with Bicuspid Aortic Valve: What Is the Role of Endothelial Cells?

(2017) Vera van de Pol et al.   Frontiers in Physiology

Endothelial and Smooth Muscle Cell Interactions in the Pathobiology of Pulmonary Hypertension

(2016) Yuansheng Gao et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Vascular smooth muscle cells in Marfan syndrome aneurysm: the broken bricks in the aortic wall

(2016) Gianluca L. Perrucci et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Clarification of mural cell coverage of vascular endothelial cells by live imaging of zebrafish

(2016) Koji Ando et al.   DEVELOPMENT

The AP-1 transcription factor component Fosl2 potentiates the rate of myocardial differentiation from the zebrafish second heart field

(2016) Leila Jahangiri et al.   DEVELOPMENT

Interactions between mural cells and endothelial cells stabilize the developing zebrafish dorsal aorta

(2016) Amber N. Stratman et al.   DEVELOPMENT

Hypoxia and Transforming Growth Factor β Cooperate to Induce Fibulin-5 Expression in Pancreatic Cancer

(2016) Mary Topalovski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Radial glia regulate vascular patterning around the developing spinal cord

(2016) Ryota L Matsuoka et al.   eLife

Chamber Specific Gene Expression Landscape of the Zebrafish Heart

(2016) Angom Ramcharan Singh et al.   PLoS One

Smooth muscle cell-specific Tgfbr1 deficiency promotes aortic aneurysm formation by stimulating multiple signaling events

(2016) Pu Yang et al.   Scientific Reports

Smad4 Deficiency in Smooth Muscle Cells Initiates the Formation of Aortic AneurysmNovelty and Significance

(2015) Peng Zhang et al.   CIRCULATION RESEARCH

Two developmentally distinct populations of neural crest cells contribute to the zebrafish heart

(2015) Ann M. Cavanaugh et al.   DEVELOPMENTAL BIOLOGY

High-throughput gene targeting and phenotyping in zebrafish using CRISPR/Cas9

(2015) Gaurav K. Varshney et al.   GENOME RESEARCH

Alk1 and Alk5 inhibition by Nrp1 controls vascular sprouting downstream of Notch

(2015) Irene Maria Aspalter et al.   Nature Communications

A Smad3 transgenic reporter reveals TGF-beta control of zebrafish spinal cord development

(2014) Alessandro Casari et al.   DEVELOPMENTAL BIOLOGY

Tgfbr2 disruption in postnatal smooth muscle impairs aortic wall homeostasis

(2014) Wei Li et al.   JOURNAL OF CLINICAL INVESTIGATION

We Have Contact: Endothelial Cell-Smooth Muscle Cell Interactions

(2014) Brenda Lilly   PHYSIOLOGY

Efficient Mutagenesis by Cas9 Protein-Mediated Oligonucleotide Insertion and Large-Scale Assessment of Single-Guide RNAs

(2014) James A. Gagnon et al.   PLoS One

Cardiac Cell Lineages that Form the Heart

(2014) S. M. Meilhac et al.   Cold Spring Harbor Perspectives in Medicine

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

Genetics of Thoracic Aortic Aneurysm

(2013) Elisabeth Gillis et al.   CIRCULATION RESEARCH

Novel bone morphogenetic protein signaling through Smad2 and Smad3 to regulate cancer progression and development

(2013) Alisha Holtzhausen et al.   FASEB JOURNAL

Kraken: A set of tools for quality control and analysis of high-throughput sequence data

(2013) Matthew P.A. Davis et al.   METHODS

Deep mRNA Sequencing Analysis to Capture the Transcriptome Landscape of Zebrafish Embryos and Larvae

(2013) Hongxing Yang et al.   PLoS One

Cardiac outflow tract anomalies

(2013) Zachary Neeb et al.   Wiley Interdisciplinary Reviews-Developmental Biology

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Transforming Growth Factor   Inhibits Bone Morphogenetic Protein-Induced Transcription through Novel Phosphorylated Smad1/5-Smad3 Complexes

(2012) E. Gronroos et al.   MOLECULAR AND CELLULAR BIOLOGY

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

TGFβ signalling in context

(2012) Joan Massagué   NATURE REVIEWS MOLECULAR CELL BIOLOGY

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

(2012) Guangchuang Yu et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Transforming Growth Factor-β Signaling in Myogenic Cells Regulates Vascular Morphogenesis, Differentiation, and Matrix Synthesis

(2011) Mia Jaffe et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Regulation of endothelial cell plasticity by TGF-β

(2011) Laurens A. van Meeteren et al.   CELL AND TISSUE RESEARCH

Distinct Cellular Mechanisms of Blood Vessel Fusion in the Zebrafish Embryo

(2011) Lukas Herwig et al.   CURRENT BIOLOGY

Rapid BAC selection for tol2-mediated transgenesis in zebrafish

(2011) J. Bussmann et al.   DEVELOPMENT

Zebrafish cardiac development requires a conserved secondary heart field

(2011) D. Hami et al.   DEVELOPMENT

Semaphorin-PlexinD1 Signaling Limits Angiogenic Potential via the VEGF Decoy Receptor sFlt1

(2011) Tomasz Zygmunt et al.   DEVELOPMENTAL CELL

Retinoic Acid Production by Endocardium and Epicardium Is an Injury Response Essential for Zebrafish Heart Regeneration

(2011) Kazu Kikuchi et al.   DEVELOPMENTAL CELL

Systematic identification of long noncoding RNAs expressed during zebrafish embryogenesis

(2011) A. Pauli et al.   GENOME RESEARCH

Latent TGF-β binding protein 3 identifies a second heart field in zebrafish

(2011) Yong Zhou et al.   NATURE

High Cleavage Efficiency of a 2A Peptide Derived from Porcine Teschovirus-1 in Human Cell Lines, Zebrafish and Mice

(2011) Jin Hee Kim et al.   PLoS One

Moesin1 and Ve-cadherin are required in endothelial cells during in vivo tubulogenesis

(2010) Y. Wang et al.   DEVELOPMENT

Phylogeny informs ontogeny: a proposed common theme in the arterial pole of the vertebrate heart

(2010) Adrian C. Grimes et al.   EVOLUTION & DEVELOPMENT

TGF-β signaling in aortic aneurysm: another round of controversy

(2010) Fuyu Lin et al.   Journal of Genetics and Genomics

MicroRNA-mediated integration of haemodynamics and Vegf signalling during angiogenesis

(2010) Stefania Nicoli et al.   NATURE

Signaling by members of the TGF-β family in vascular morphogenesis and disease

(2010) Evangelia Pardali et al.   TRENDS IN CELL BIOLOGY

Endothelial-Mural Cell Signaling in Vascular Development and Angiogenesis

(2009) Konstantin Gaengel et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Fibulin-2 and Fibulin-5 Cooperatively Function to Form the Internal Elastic Lamina and Protect From Vascular Injury

(2009) Shelby L. Chapman et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Endoglin plays distinct roles in vascular smooth muscle cell recruitment and regulation of arteriovenous identity during angiogenesis

(2009) Maria L. Mancini et al.   DEVELOPMENTAL DYNAMICS

Absence of TGFβ signaling in embryonic vascular smooth muscle leads to reduced lysyl oxidase expression, impaired elastogenesis, and aneurysm

(2009) Bibha Choudhary et al.   GENESIS

The outflow tract of the heart in fishes: anatomy, genes and evolution

(2009) A. C. Grimes et al.   JOURNAL OF FISH BIOLOGY

Fibulin-5, an integrin-binding matricellular protein: its function in development and disease

(2009) Hiromi Yanagisawa et al.   Journal of Cell Communication and Signaling

Signaling via the Tgf-β type I receptor Alk5 in heart development

(2008) Somyoth Sridurongrit et al.   DEVELOPMENTAL BIOLOGY

Transforming Growth Factor-β Signaling in Thoracic Aortic Aneurysm Development: A Paradox in Pathogenesis

(2008) Jeffrey A. Jones et al.   JOURNAL OF VASCULAR RESEARCH

High-resolution in situ hybridization to whole-mount zebrafish embryos

(2007) Christine Thisse et al.   Nature Protocols