Vascular smooth muscle cells in Marfan syndrome aneurysm: the broken bricks in the aortic wall

The role of β-arrestin2-dependent signaling in thoracic aortic aneurysm formation in a murine model of Marfan syndrome

(2015) James W. Wisler et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Vascular Smooth Muscle Cell Phenotypic Changes in Patients With Marfan SyndromeSignificance

(2015) Eva Crosas-Molist et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Dimorphic Effects of Transforming Growth Factor-β Signaling During Aortic Aneurysm Progression in Mice Suggest a Combinatorial Therapy for Marfan SyndromeSignificance

(2015) Jason R. Cook et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Beneficial Outcome of Losartan Therapy Depends on Type ofFBN1Mutation in Marfan SyndromeCLINICAL PERSPECTIVE

(2015) Romy Franken et al.   Circulation-Cardiovascular Genetics

Marfan Sartan: a randomized, double-blind, placebo-controlled trial

(2015) Olivier Milleron et al.   EUROPEAN HEART JOURNAL

Losartan versus atenolol in the Marfan aorta—how to treat?

(2015) Romy Franken et al.   Nature Reviews Cardiology

Genetic analysis of the contribution of LTBP-3 to thoracic aneurysm in Marfan syndrome

(2015) Lior Zilberberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Beneficial Outcome of Losartan Therapy Depends on Type ofFBN1Mutation in Marfan SyndromeCLINICAL PERSPECTIVE

(2015) Romy Franken et al.   Circulation-Cardiovascular Genetics

Regional changes in elastic fiber organization and transforming growth factor β signaling in aortas from a mouse model of marfan syndrome

(2014) David W. Howell et al.   CELL AND TISSUE RESEARCH

Atenolol versus Losartan in Children and Young Adults with Marfan's Syndrome

(2014) Ronald V. Lacro et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dysfunctional Mechanosensing in Aneurysms

(2014) J. D. Humphrey et al.   SCIENCE

The revised role of TGF-β in aortic aneurysms in Marfan syndrome

(2014) R. Franken et al.   Netherlands Heart Journal

Modifications of Chromatin Dynamics Control Smad2 Pathway Activation in Aneurysmal Smooth Muscle Cells

(2013) Delphine Gomez et al.   CIRCULATION RESEARCH

Conundrum of angiotensin II and TGF-β interactions in aortic aneurysms

(2013) Xiaofeng Chen et al.   CURRENT OPINION IN PHARMACOLOGY

Losartan reduces aortic dilatation rate in adults with Marfan syndrome: a randomized controlled trial

(2013) M. Groenink et al.   EUROPEAN HEART JOURNAL

Circulating transforming growth factor-β as a prognostic biomarker in Marfan syndrome

(2013) Romy Franken et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Losartan Added to β-Blockade Therapy for Aortic Root Dilation in Marfan Syndrome: A Randomized, Open-Label Pilot Study

(2013) Hsin-Hui Chiu et al.   MAYO CLINIC PROCEEDINGS

Smooth Muscle LDL Receptor-Related Protein-1 Deletion Induces Aortic Insufficiency and Promotes Vascular Cardiomyopathy in Mice

(2013) Joshua E. Basford et al.   PLoS One

MMP-2 Regulates Erk1/2 Phosphorylation and Aortic Dilatation in Marfan Syndrome

(2012) Wanfen Xiong et al.   CIRCULATION RESEARCH

Smooth Muscle Cell Plasticity

(2012) Anh T. Nguyen et al.   CIRCULATION RESEARCH

Inhibition of microRNA-29b reduces murine abdominal aortic aneurysm development

(2012) Lars Maegdefessel et al.   JOURNAL OF CLINICAL INVESTIGATION

Importance of initial aortic properties on the evolving regional anisotropy, stiffness and wall thickness of human abdominal aortic aneurysms

(2012) J. S. Wilson et al.   Journal of the Royal Society Interface

Structure and function of the mammalian fibrillin gene family: Implications for human connective tissue diseases

(2012) Margaret R. Davis et al.   MOLECULAR GENETICS AND METABOLISM

Loss-of-function mutations in TGFB2 cause a syndromic presentation of thoracic aortic aneurysm

(2012) Mark E Lindsay et al.   NATURE GENETICS

TGFB2 mutations cause familial thoracic aortic aneurysms and dissections associated with mild systemic features of Marfan syndrome

(2012) Catherine Boileau et al.   NATURE GENETICS

A Multi-Layered Computational Model of Coupled Elastin Degradation, Vasoactive Dysfunction, and Collagenous Stiffening in Aortic Aging

(2011) A. Valentín et al.   ANNALS OF BIOMEDICAL ENGINEERING

MicroRNA-29 in Aortic Dilation: Implications for Aneurysm Formation

(2011) Reinier A. Boon et al.   CIRCULATION RESEARCH

miR-29b Participates in Early Aneurysm Development in Marfan Syndrome

(2011) Denis R. Merk et al.   CIRCULATION RESEARCH

Selective MicroRNA Suppression in Human Thoracic Aneurysms

(2011) Jeffrey A. Jones et al.   Circulation-Cardiovascular Genetics

Applying massive parallel sequencing to molecular diagnosis of Marfan and Loeys-Dietz syndromes

(2011) Machteld Baetens et al.   HUMAN MUTATION

Cystic medial necrosis: pathological findings and clinical implications

(2011) Shi-Min Yuan et al.   Revista Brasileira de Cirurgia Cardiovascular

Noncanonical TGF  Signaling Contributes to Aortic Aneurysm Progression in Marfan Syndrome Mice

(2011) T. M. Holm et al.   SCIENCE

Epigenetic control of vascular smooth muscle cells in Marfan and non-Marfan thoracic aortic aneurysms

(2010) Delphine Gomez et al.   CARDIOVASCULAR RESEARCH

Marfan Syndrome Decreases Ca2+ Wave Frequency and Vasoconstriction in Murine Mesenteric Resistance Arteries without Changing Underlying Mechanisms

(2010) H.T. Syyong et al.   JOURNAL OF VASCULAR RESEARCH

Integrins and Extracellular Matrix in Mechanotransduction

(2010) M. A. Schwartz   Cold Spring Harbor Perspectives in Biology

Mechanics of Carotid Arteries in a Mouse Model of Marfan Syndrome

(2009) J. F. Eberth et al.   ANNALS OF BIOMEDICAL ENGINEERING

Dysfunction of endothelial and smooth muscle cells in small arteries of a mouse model of Marfan syndrome

(2009) HT Syyong et al.   BRITISH JOURNAL OF PHARMACOLOGY

Proteomic Analysis in Aortic Media of Patients With Marfan Syndrome Reveals Increased Activity of Calpain 2 in Aortic Aneurysms

(2009) Christiane Pilop et al.   CIRCULATION

LRP1 Regulates Architecture of the Vascular Wall by Controlling PDGFRβ-Dependent Phosphatidylinositol 3-Kinase Activation

(2009) Li Zhou et al.   PLoS One

Role of microRNAs in vascular diseases, inflammation, and angiogenesis

(2008) C. Urbich et al.   CARDIOVASCULAR RESEARCH

Long-Term Doxycycline Is More Effective Than Atenolol to Prevent Thoracic Aortic Aneurysm in Marfan Syndrome Through the Inhibition of Matrix Metalloproteinase-2 and -9

(2008) Ada W.Y. Chung et al.   CIRCULATION RESEARCH

Peroxisome Proliferator-Activated Receptor-γ–Mediated Effects in the Vasculature

(2008) Sheng Zhong Duan et al.   CIRCULATION RESEARCH

Signaling via the Tgf-β type I receptor Alk5 in heart development

(2008) Somyoth Sridurongrit et al.   DEVELOPMENTAL BIOLOGY

Integrins and the activation of latent transforming growth factor β1 – An intimate relationship

(2008) P WIPFF et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

p38 MAPK Is an Early Determinant of Promiscuous Smad2/3 Signaling in the Aortas of Fibrillin-1 (Fbn1)-null Mice

(2008) Luca Carta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Angiotensin II activates the Smad pathway during epithelial mesenchymal transdifferentiation

(2008) Gisselle Carvajal et al.   KIDNEY INTERNATIONAL

Proteomics Identification of Cyclophilin A as a Potential Prognostic Factor and Therapeutic Target in Endometrial Carcinoma

(2008) Zhengyu Li et al.   MOLECULAR & CELLULAR PROTEOMICS

Marfan Syndrome—Diagnosis and Management

(2007) Naser M. Ammash et al.   CURRENT PROBLEMS IN CARDIOLOGY

Calpain counteracts mechanosensitive apoptosis of vascular smooth muscle cells in vitro and in vivo

(2007) Daniel G. Sedding et al.   FASEB JOURNAL