Rebelled epigenome: histone H3S10 phosphorylation and H3S10 kinases in cancer biology and therapy

AURKB promotes gastric cancer progression via activation of CCND1 expression

(2020) Min Nie et al.   Aging-US

Tyrosine kinase inhibitor discontinuation in patients with chronic myeloid leukemia: a single-institution experience

(2019) Kamal Chamoun et al.   Journal of Hematology & Oncology

R-Loops as Cellular Regulators and Genomic Threats

(2019) Madzia P. Crossley et al.   MOLECULAR CELL

Epidrugs: targeting epigenetic marks in cancer treatment

(2019) Cristiana Libardi Miranda Furtado et al.   Epigenetics

The timeline of epigenetic drug discovery: from reality to dreams

(2019) A. Ganesan et al.   Clinical Epigenetics

HP1α targets the chromosomal passenger complex for activation at heterochromatin before mitotic entry

(2018) Jan G Ruppert et al.   EMBO JOURNAL

Aurora B opposes PP1 function in mitosis by phosphorylating the conserved PP1-binding RVxF motif in PP1 regulatory proteins

(2018) Isha Nasa et al.   Science Signaling

Aurora B opposes PP1 function in mitosis by phosphorylating the conserved PP1-binding RVxF motif in PP1 regulatory proteins

(2018) Isha Nasa et al.   Science Signaling

TPX2/Aurora kinase A signaling as a potential therapeutic target in genomically unstable cancer cells

(2018) Stephanie E. van Gijn et al.   ONCOGENE

Coordinated histone modifications and chromatin reorganization in a single cell revealed by FRET biosensors

(2018) Qin Peng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

H3S10ph broadly marks early-replicating domains in interphase ESCs and shows reciprocal antagonism with H3K9me2

(2017) Carol C.L. Chen et al.   GENOME RESEARCH

Differential control of Toll-like receptor 4–induced interleukin-10 induction in macrophages and B cells reveals a role for p90 ribosomal S6 kinases

(2017) Ruhcha V. Sutavani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In search of AKT kinase inhibitors as anticancer agents: structure-based design, docking, and molecular dynamics studies of 2,4,6-trisubstituted pyridines

(2017) Pedro Josué Trejo-Soto et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Mitogen-induced distinct epialleles are phosphorylated at either H3S10 or H3S28, depending on H3K27 acetylation

(2017) Dilshad H. Khan et al.   MOLECULAR BIOLOGY OF THE CELL

R-ChIP Using Inactive RNase H Reveals Dynamic Coupling of R-loops with Transcriptional Pausing at Gene Promoters

(2017) Liang Chen et al.   MOLECULAR CELL

Histone Mutants Separate R Loop Formation from Genome Instability Induction

(2017) Desiré García-Pichardo et al.   MOLECULAR CELL

Histone and DNA methylation control by H3 serine 10/threonine 11 phosphorylation in the mouse zygote

(2017) Jie Lan et al.   Epigenetics & Chromatin

Repo-Man/PP1 regulates heterochromatin formation in interphase

(2017) Inês J. de Castro et al.   Nature Communications

Inhibition of CDK8 mediator kinase suppresses estrogen dependent transcription and the growth of estrogen receptor positive breast cancer

(2017) Martina S.J. McDermott et al.   Oncotarget

Aurora kinases: novel therapy targets in cancers

(2017) Anqun Tang et al.   Oncotarget

Regulation of Methyllysine Readers through Phosphorylation

(2016) Forest H. Andrews et al.   ACS Chemical Biology

H3S10 phosphorylation-mediated transcriptional regulation by Aurora kinase A

(2016) Se-Ryeon Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Small-molecule kinase inhibitors: an analysis of FDA-approved drugs

(2016) Peng Wu et al.   DRUG DISCOVERY TODAY

Immunogold electron microscopy and confocal analyses reveal distinctive patterns of histone H3 phosphorylation during mitosis in MCF-7 cells

(2016) Yitang Yan et al.   GENES CHROMOSOMES & CANCER

Preferential Phosphorylation on Old Histones during Early Mitosis in Human Cells

(2016) Shu Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein kinase Msk1 physically and functionally interacts with the KMT2A/MLL1 methyltransferase complex and contributes to the regulation of multiple target genes

(2016) Maaike Wiersma et al.   Epigenetics & Chromatin

Set1/COMPASS and Mediator are repurposed to promote epigenetic transcriptional memory

(2016) Agustina D'Urso et al.   eLife

Coordinated regulation of Nrf2 and histone H3 serine 10 phosphorylation in arsenite-activated transcription of the human heme oxygenase-1 gene

(2015) Paul D. Ray et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

The Novel ATP-Competitive MEK/Aurora Kinase Inhibitor BI-847325 Overcomes Acquired BRAF Inhibitor Resistance through Suppression of Mcl-1 and MEK Expression

(2015) M. S. Phadke et al.   MOLECULAR CANCER THERAPEUTICS

MKP1 phosphatase mediates G1-specific dephosphorylation of H3Serine10P in response to DNA damage

(2015) Ajit K. Sharma et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Mediator kinase inhibition further activates super-enhancer-associated genes in AML

(2015) Henry E. Pelish et al.   NATURE

FDA-approved small-molecule kinase inhibitors

(2015) Peng Wu et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Immunostaining of phospho-histone H3 and Ki-67 improves reproducibility of recurrence risk assessment of gastrointestinal stromal tumors

(2015) Arnaud Uguen et al.   VIRCHOWS ARCHIV

Histone H3 Phosphorylation in GBM: a New Rational to Guide the Use of Kinase Inhibitors in anti-GBM Therapy

(2015) Romain Pacaud et al.   Theranostics

Analysis of Phosphorylation-Dependent Protein–Protein Interactions of Histone H3

(2014) Rebecca Klingberg et al.   ACS Chemical Biology

Cigarette sidestream smoke induces histone H3 phosphorylation via JNK and PI3K/Akt pathways, leading to the expression of proto-oncogenes

(2014) Yuko Ibuki et al.   CARCINOGENESIS

Genome accessibility is widely preserved and locally modulated during mitosis

(2014) Chris C.-S. Hsiung et al.   GENOME RESEARCH

Histone Cross-talk Connects Protein Phosphatase 1α (PP1α) and Histone Deacetylase (HDAC) Pathways to Regulate the Functional Transition of Bromodomain-containing 4 (BRD4) for Inducible Gene Expression

(2014) Xiangming Hu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Formaldehyde-induced histone H3 phosphorylation via JNK and the expression of proto-oncogenes

(2014) Ikuma Yoshida et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

A Cascade of Histone Modifications Induces Chromatin Condensation in Mitosis

(2014) Bryan J. Wilkins et al.   SCIENCE

Increased phosphorylation of histone H3 at serine 10 is involved in Epstein-Barr virus latent membrane protein-1-induced carcinogenesis of nasopharyngeal carcinoma

(2013) Binbin Li et al.   BMC CANCER

HIF1A Employs CDK8-Mediator to Stimulate RNAPII Elongation in Response to Hypoxia

(2013) Matthew D. Galbraith et al.   CELL

GC skew at the 5' and 3' ends of human genes links R-loop formation to epigenetic regulation and transcription termination

(2013) P. A. Ginno et al.   GENOME RESEARCH

Analysis of Transcriptional Regulation of the Human miR-17-92 Cluster; Evidence for Involvement of Pim-1

(2013) Maren Thomas et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Immunodetection of phosphohistone H3 as a surrogate of mitotic figure count and clinical outcome in cutaneous melanoma

(2013) Michael T Tetzlaff et al.   MODERN PATHOLOGY

R Loops Are Linked to Histone H3 S10 Phosphorylation and Chromatin Condensation

(2013) Maikel Castellano-Pozo et al.   MOLECULAR CELL

Activating RNAs associate with Mediator to enhance chromatin architecture and transcription

(2013) Fan Lai et al.   NATURE

Mitogen- and Stress-Activated Protein Kinases 1 and 2 Are Required for Maximal Trefoil Factor 1 Induction

(2013) Protiti Khan et al.   PLoS One

Basal aurora kinase B activity is sufficient for histone H3 phosphorylation in prophase

(2013) L.-T.-T. Le et al.   Biology Open

Chromosome Translocation, B Cell Lymphoma, and Activation-Induced Cytidine Deaminase

(2012) Davide F. Robbiani et al.   Annual Review of Pathology-Mechanisms of Disease

Proliferation indices of phosphohistone H3 and Ki67: strong prognostic markers in a consecutive cohort with stage I/II melanoma

(2012) Patricia S Nielsen et al.   MODERN PATHOLOGY

Phosphorylation of histone H3 Ser10 establishes a hierarchy for subsequent intramolecular modification events

(2012) Stamatios Liokatis et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Heterochromatin protein 1 gamma and IκB kinase alpha interdependence during tumour necrosis factor gene transcription elongation in activated macrophages

(2012) James L. Thorne et al.   NUCLEIC ACIDS RESEARCH

Mice Lacking MSK1 and MSK2 Show Reduced Skin Tumor Development in a Two-Stage Chemical Carcinogenesis Model

(2011) Simon Chang et al.   CANCER INVESTIGATION

Repo-Man Coordinates Chromosomal Reorganization with Nuclear Envelope Reassembly during Mitotic Exit

(2011) Paola Vagnarelli et al.   DEVELOPMENTAL CELL

R-loop-mediated genomic instability is caused by impairment of replication fork progression

(2011) W. Gan et al.   GENES & DEVELOPMENT

Comprehensive analysis of kinase inhibitor selectivity

(2011) Mindy I Davis et al.   NATURE BIOTECHNOLOGY

A chromatin-modifying function of JNK during stem cell differentiation

(2011) Vijay K Tiwari et al.   NATURE GENETICS

Pim1 kinase is required to maintain tumorigenicity in MYC-expressing prostate cancer cells

(2011) J Wang et al.   ONCOGENE

A Midzone-Based Ruler Adjusts Chromosome Compaction to Anaphase Spindle Length

(2011) G. Neurohr et al.   SCIENCE

Pim1 promotes human prostate cancer cell tumorigenicity and c-MYC transcriptional activity

(2010) Jongchan Kim et al.   BMC CANCER

Quantitative Interaction Proteomics and Genome-wide Profiling of Epigenetic Histone Marks and Their Readers

(2010) Michiel Vermeulen et al.   CELL

MYST-family histone acetyltransferases: beyond chromatin

(2010) Vasileia Sapountzi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Phosphorylation of serine-10 of histone H3 shields modified lysine-9 selectively during mitosis

(2010) Young Sun Jeong et al.   GENES TO CELLS

Role of MSK1 in the Malignant Phenotype ofRas-transformed Mouse Fibroblasts

(2010) Beatriz Pérez-Cadahía et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Phosphorylation Switch Regulates the Transcriptional Activation of Cell Cycle Regulator p21 by Histone Deacetylase Inhibitors

(2010) Elisabeth Simboeck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CDK8 is a positive regulator of transcriptional elongation within the serum response network

(2010) Aaron J Donner et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Promoter chromatin remodeling of immediate-early genes is mediated through H3 phosphorylation at either serine 28 or 10 by the MSK1 multi-protein complex

(2010) Bojan Drobic et al.   NUCLEIC ACIDS RESEARCH

Epigenetic Regulation of a Murine Retrotransposon by a Dual Histone Modification Mark

(2010) Reinhard Brunmeir et al.   PLoS Genetics

Histone Crosstalk between H3S10ph and H4K16ac Generates a Histone Code that Mediates Transcription Elongation

(2009) Alessio Zippo et al.   CELL

Visualizing histone modifications in living cells: spatiotemporal dynamics of H3 phosphorylation during interphase

(2009) Yoko Hayashi-Takanaka et al.   JOURNAL OF CELL BIOLOGY

Validating the prognostic value of proliferation measured by Phosphohistone H3 (PPH3) in invasive lymph node-negative breast cancer patients less than 71 years of age

(2008) Ivar Skaland et al.   BREAST CANCER RESEARCH AND TREATMENT

Mitogen- and Stress-Activated Kinase 1-Mediated Histone H3 Phosphorylation Is Crucial for Cell Transformation

(2008) H.-G. Kim et al.   CANCER RESEARCH

Ectopic histone H3S10 phosphorylation causes chromatin structure remodeling in Drosophila

(2008) H. Deng et al.   DEVELOPMENT

Dissecting the role of Aurora A during spindle assembly

(2008) Teresa Sardon et al.   EMBO JOURNAL

Effects of the aurora kinase inhibitors AZD1152-HQPA and ZM447439 on growth arrest and polyploidy in acute myeloid leukemia cell lines and primary blasts

(2008) E. Walsby et al.   HAEMATOLOGICA

The Human CDK8 Subcomplex Is a Histone Kinase That Requires Med12 for Activity and Can Function Independently of Mediator

(2008) M. T. Knuesel et al.   MOLECULAR AND CELLULAR BIOLOGY

14-3-3 Interaction with Histone H3 Involves a Dual Modification Pattern of Phosphoacetylation

(2008) W. Walter et al.   MOLECULAR AND CELLULAR BIOLOGY

E2F1 represses β-catenin transcription and is antagonized by both pRB and CDK8

(2008) Erick J. Morris et al.   NATURE

CDK8 is a colorectal cancer oncogene that regulates β-catenin activity

(2008) Ron Firestein et al.   NATURE

The kinase p38α serves cell type–specific inflammatory functions in skin injury and coordinates pro- and anti-inflammatory gene expression

(2008) Chun Kim et al.   NATURE IMMUNOLOGY

The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling

(2008) Olga Ananieva et al.   NATURE IMMUNOLOGY

Pim kinase-dependent inhibition of c-Myc degradation

(2008) Y Zhang et al.   ONCOGENE

Cot, a novel kinase of histone H3, induces cellular transformation through up-regulation of c-fos transcriptional activity

(2007) Hong Seok Choi et al.   FASEB JOURNAL